Search Results 1-20 of 40

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  • 2. Nuclear Physics and Nuclear Data

    … In case that corrections are made, an errata will be provided in the following webpage: https://www.rri.kyoto-u.ac.jp/PUB/report/PR/ProgRep2017/ProgRep2017.htmlCO2-1 Study on Neutron Beam Pulse width Dependence in the Nuclear Fuel Measurement by the Neutron Resonance Transmission Analysis /F. … (29041) [99]CO2-2 Measurement of Doppler Effect by Small Accelerator Neutron Source (II) /T. …

    KURRI Progress Report 2017(APRIL 2017 - MARCH 2018), 99-105, 2018-08

    IR 

  • Feasibility Study of Compact-Multichannel Neutron Moderator for BNCT  [in Japanese]

    Koay H.W. , Toki Hiroshi , Fukuda Mitsuhiro , Seki Ryoichi

    … <p>This study aims to develop a compact-multichannel neutron moderator to provide a high flux epithermal neutron beam source to support the new cancer treatment Boron Neutron Captured Therapy (BNCT). … Typical BNCT neutron generators are delivering only a certain type of neutron spectrum through only one channel. …

    Meeting Abstracts of the Physical Society of Japan 72.1(0), 544-544, 2017

    J-STAGE 

  • BNCT for Head and Neck Cancer—History at Our Institution—  [in Japanese]

    Aihara Teruhito , Hiratsuka Jyunichi , Morita Norimasa , Kamitani Nobuhiko , Suzuki Minoru , Ono Koji , Kumada Hiroaki , Harada Tamotsu

    … <p>PURPOSE: Boron neutron capture therapy (BNCT) is among the radiation treatments known to have a selective lethal effect on tumor cells. … BNCT was performed in a single fraction using an epithermal beam at the Kyoto University Research Reactor and the Japan Research Reactor 4.</p><p>RESULTS: The <sup>18</sup>FBPA-PET study showed no difference in the T/N ratio between an SCC and a non-SCC group. …

    Practica oto-rhino-laryngologica. Suppl. 149(0), 227-240, 2017

    J-STAGE  Ichushi Web 

  • Estimation of relative biological effectiveness for boron neutron capture therapy using the PHITS code coupled with a microdosimetric kinetic model

    Horiguchi Hironori , Sato Tatsuhiko , Kumada Hiroaki , Yamamoto Tetsuya , Sakae Takeji , 熊田 博明 , 山本 哲哉 , 榮 武二

    … The absorbed doses deposited by boron neutron capture therapy (BNCT) can be categorized into four components: α and 7Li particles from the 10B(n, α)7Li reaction, 0.54-MeV protons from the 14N(n, p)14C reaction, the recoiled protons from the 1H(n, n) 1H reaction, and photons from the neutron beam and 1H(n, γ)2H reaction. …

    Journal of radiation research 56(2), 382-390, 2015-03

    IR  Ichushi Web 

  • A Comparative Study of the Biological Effects of Neutron Beams with Different Energy Profiles  [in Japanese]

    KITAJIMA Erika , TAKAHASHI Sentaro , KINASHI Yuko , KUBOTA Yoshihisa , OKAYASU Ryuichi , TANAKA Hiroki , TAKADA Masashi , ONO Koji

    中性子ビームの重要な利用法の一つにホウ素中性子捕捉療法(BNCT)がある。近年,加速器を使用したBNCTが計画されているが,その際,がん組織や近傍の正常組織は,装置ごとに異なるエネルギープロファイルを有する中性子ビームを受ける可能性がある。本研究では,エネルギープロファイルの異なる中性子ビームの細胞致死作用とDNA二重鎖切断誘発作用をCHO/K1細胞とその放射線感受性変異株のxrs-5細胞で調べた …

    RADIOISOTOPES 64(5), 291-297, 2015

    J-STAGE  Ichushi Web 

  • Present Status of the Development of Accelerator-Based BNCT in Japan and C-BENS  [in Japanese]

    TANAKA Hiroki

    中性子捕捉療法を実施するためには,ホウ素薬剤と強力な中性子源が必要である。1951年に米国ブルックヘブン国立研究所において世界初のBNCTが実施されてから,これまでに世界中で1000例を超える臨床研究の照射が実施されてきた。研究用原子炉において臨床研究が実施されてきたが,経年化が進み廃炉を決定した研究用原子炉が多くなってきた。2014年9月現在で積極的にBNCTの臨床研究を実施しているのは京都大学 …

    RADIOISOTOPES 64(1), 29-36, 2015

    J-STAGE  Ichushi Web 

  • The Effect of p53 Status of Tumor Cells on Radiosensitivity of Irradiated Tumors With Carbon-Ion Beams Compared With γ-Rays or Reactor Neutron Beams

    Masunaga Shin-ichiro , Uzawa Akiko , Hirayama Ryoichi , Matsumoto Yoshitaka , Sakurai Yoshinori , Tanaka Hiroki , Tano Keizo , Sanada Yu , Suzuki Minoru , Maruhashi Akira , Ono Koji

    … Background: The aim of the study was to clarify the effect of p53 status of tumor cells on radiosensitivity of solid tumors following accelerated carbon-ion beam irradiation compared with γ-rays or reactor neutron beams, referring to the response of intratumor quiescent (Q) cells. … Other tumor-bearing mice received reactor thermal or epithermal neutrons at a reduced dose-rate. …

    World Journal of Oncology 6(4), 398-409, 2015

    IR 

  • Energy resolution of pulsed neutron beam provided by the ANNRI beamline at the J-PARC/MLF

    Kino K. , Furusaka M. , Hiraga F. , Kamiyama T. , Kiyanagi Y. , Furutaka K. , Goko S. , Hara K. Y. , Harada H. , Harada M. , Hirose K. , Kai T. , Kimura A. , Kin T. , Kitatani F. , Koizumi M. , Maekawa F. , Meigo S. , Nakamura S. , Ooi M. , Ohta M. , Oshima M. , Toh Y. , Igashira M. , Katabuchi T. , Mizumoto M. , Hori J.

    … We studied the energy resolution of the pulsed neutron beam of the Accurate Neutron-Nucleus Reaction Measurement Instrument (ANNRI) at the Japan Proton Accelerator Research Complex/Materials and Life Science Experimental Facility (J-PARC/MLF). … A simulation in the energy region from 0.7 meV to 1 MeV was performed and measurements were made at thermal (0.76-62 meV) and epithermal energies (4.8-410 eV). …

    Nuclear instruments & methods in physics research section a-accelerators spectrometers detectors and associated equipment 736, 66-74, 2014-02-01

    IR  DOI 

  • E215 A Feasibility Study on the Multiphase Flow Measurement using the Pulsed Neutron Source J-PARC by Neutron Simulation Codes  [in Japanese]

    KURETA Masatoshi , TAKAMINE Jun , HASHIMOTO Eiko , SEGAWA Mariko

    … High intensity pulsed neutron source J-PARC was constructed and started operating in December, 2008. … The most unique point of this facility is that we can select the neutron beam energy by time-of-flight method. … It means that neutron energy depended projection image can be obtained by the pulsed neutron source for the neutron imaging and multiphase flow measurement. …

    The Proceedings of the National Symposium on Power and Energy Systems 2011.16(0), 411-414, 2011

    J-STAGE 

  • Increase in Irradiation Beam Intensity by Using a Hybrid Target System in Cyclotron-Based Neutron Capture Therapy

    TAKATA Takushi , TANAKA Hiroki , SAKURAI Yoshinori , MARUHASHI Akira

    Journal of Nuclear Science and Technology 47(7), 575-581, 2010-07-01

    References (19)

  • Neutron irradiation techniques to enhance therapeutic dose of neutron capture therapy at JRR-4:(1)Improvement of epithermal neutron beam with removal of graphite in medical neutron beam facility  [in Japanese]

    NAKAMURA Takemi , KUMADA Hiroaki , YAMAMOTO Kazuyoshi , KISHI Toshiaki , WADA Shigeru

    JRR-4でのホウ素中性子捕捉療法では、熱外中性子ビームを主体にした症例が多い。このため、深部線量の増強を図るため、中性子ビーム設備内にある黒鉛を撤去した特性解析を行い、熱外中性子ビームの改善について検討を行った。

    Proceedings of Annual / Fall Meetings of Atomic Energy Society of Japan 2009s(0), 152-152, 2009

    J-STAGE 

  • Boron distribution in the normal rat brain after intravenous injection of boronophenylalanine-fructose

    Shibata Yasushi , 柴田 靖

    … Boron neutron capture therapy (BNCT) is an experimental form of radiation therapy for malignant brain tumors and peripheral melanoma. … In clinical trials of BNCT using an epithermal neutron beam, the radiation dose to the pituitary gland should be carefully evaluated. …

    Journal of neuro-oncology 87(1), 35-41, 2008-03

    IR 

  • Design study on epithermal neutron beam for boron neutron capture therapy(BNCT) with compact accelerator  [in Japanese]

    武川 哲也

    Bulletin of Atomic Energy Research Laboratory, Tokyo City University (35), 81-85, 2008

  • Dosimetry for Neutron Capture Therapy in JRR-4  [in Japanese]

    KUMADA Hiroaki , YAMAMOTO Tetsuya

    … In this paper, an outline of dose estimations for boron neutron capture therapy (BNCT) is presented from standpoint medical physics and biological field. … To perform clinical trials of the BNCT, characteristics of doses given to a patient by neutron irradiation have to be comprehended accurately. … To investigate RBE for several organs with neutron, in-vitro biological experiments involving neutron irradiations were carried out. …

    Japanese Journal of Health Physics 42(1), 23-37, 2007-03-01

    J-STAGE  J-STAGE  Ichushi Web  References (35) Cited by (1)

  • Radiobiological significance of the response of intratumor quiescent cells in vivo to accelerated carbon ion beams compared with gamma-rays and reactor neutron beams  [in Japanese]

    MASUNAGA Shin-ichiro , KINASHI Yuko , MARUHASHI Akira , ONO Koji , ANDO Koichi , UZAWA Akiko , HIRAYAMA Ryoichi , FURUSAWA Yoshiya , SAKURAI Yoshinori , NAGATA Kenji , SUZUKI Minoru , KASHINO Genro

    <B>【目的】</B>γ線及び原子炉中性子線照射と比べた加速炭素イオン線照射に対する固形腫瘍内休止期及び全腫瘍細胞の反応を解析する。<BR><B>【材料・方法】</B>担SCCVII腫瘍マウスに、6cmSOBP(拡大ブラッグピーク)のさまざまな深さで、LET(線エネルギー付与)=74,50,43,18 keV/μmの290MeV/u加速炭 …

    The Japan Radiation Research Society Annual Meeting Abstracts 2007(0), 279-279, 2007

    J-STAGE 

  • Development of a 30MeV accelerator-based epithermal neutron generator for BNCT:Study on the target radiation activity induced by 30 MeV proton beam

    Yokobori Hitoshi , Sasaki Kenji , tahara Yoshihisa , Shiraki Takako , Baba Mamoru , Uddin M.S. , Unno Yasuhiro

    ホウ素中性子捕捉療法(BNCT)の実現を促進するため、ターゲットの放射化量を評価し、その計算精度を実験値との比較により確認した。

    Proceedings of Annual / Fall Meetings of Atomic Energy Society of Japan 2006s(0), 110-110, 2006

    J-STAGE 

  • Design studies of accelerator-based epithermal neutron beam for boron neutron

    matsumoto tetsuo , suzuki shinichi

    加速器を用いるホウ素中性子捕捉療法(BNCT)のために、熱除去に優れる9Beターゲットについて、陽子電流10mAとしたときの中性子発生量を求めた結果1.5x1013 ns-1が得られ、減速材、反射材等の最適設計によりにBNCTに適用できる熱外中性子ビーム8x108 ncm-2s-1を得ることができた

    Proceedings of Annual / Fall Meetings of Atomic Energy Society of Japan 2004f(0), 115-115, 2004

    J-STAGE 

  • Boron neutron capture therapy using mixed neutron beam in patients with malignant glioma  [in Japanese]

    影治 照喜 , 溝渕 佳史 , 永廣 信治 , 中川 義信

    … The purpose of this study was to clarify the clinical interim results of boron neutron capture therapy (BNCT) using mixed epithermal-and thermal neutron beams in patients with malignant glioma. … The mixed neutron beam for BNCT has been used clinically since 1998. …

    四国医学雑誌 59(6), 292-298, 2003-12-25

    IR  Ichushi Web 

  • Sophistication of Dose Calculation Method in the JAERI Computational Dosimetry System (JCDS) for Boron Neutron Capture Therapy

    Kumada Hiroaki , Yamamoto Kazuyoshi , Torii Yoshiya , Matsumura Akira , Nakagawa Yoshinobu

    熱外中性子ビームによるホウ素中性子捕捉療法の実施に不可欠な、患者頭部内の線量分布を数値シミュレーションによって評価する線量評価システム(JCDS)を開発している。このJCDSのボクセル計算手法に対して、計算精度をさらに向上させつつ、効率的な計算を実行できる計算手法について検討を行った。

    Proceedings of Annual / Fall Meetings of Atomic Energy Society of Japan 2003f(0), 085-085, 2003

    J-STAGE 

  • Examination of Epithermal Neutron Beam Intensity Measurement for Boron Neutron Capture Therapy without Craniotomy

    Yamamoto Kazuyoshi , Kumada Hiroaki , Kishi Toshiaki , Torii Yoshiya , Kshimura Takanori , Ohotake Shinichi , Nozawa Akira , Kobayashi Tooru , Sakurai Yoshinori

    非開頭下において熱外中性子を用いたホウ素中性子捕捉療法(BNCT)を実施に向けて、金の共鳴吸収ピーク(4.9eV)による反応率を用いた熱外中性子ビーム測定法について検討した。

    Proceedings of Annual / Fall Meetings of Atomic Energy Society of Japan 2003f(0), 086-086, 2003

    J-STAGE 

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