Search Results 1-20 of 92

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  • Exposure to environmental tobacco smoke from husband more strongly impacts on the airway obstruction of nonsmoking women

    Suyama Kazuaki , Kozu Ryo , Tanaka Takako , Ishimatsu Yuji , Sawai Terumitsu

    … Background: The impact of airway obstruction of nonsmoking women caused by their husband's smoking is unclear, despite the association between environmental tobacco smoke (ETS) exposure at home and obstructive pulmonary diseases among nonsmoking women. … The aim of this study was to provide evidence that ETS exposure from the husband at home has a more significant influence on the airway obstruction of nonsmoking women than other housemates. …

    International Journal of Chronic Obstructive Pulmonary Disease 13, 149-155, 2018

    IR DOI

  • Risk factors associated with early childhood caries in 18- to 23-month-old children in a Japanese city

    Nakayama Yoshimi , Mori Mitsuru

    … 析は,ロジスティック回帰分析を用いた.</p><p>結果:一人経験う蝕経験歯数(dmft index)は0.11本で,う蝕有病者率は3.2%であった.夜間授乳の習慣のある児は668人(24.1%)であった.環境たばこ煙(ETS)にさらされている児は1,704人(61.5%)であった.多変量解析の結果,う蝕と関連のあった要因は,家庭内喫煙者の存在,喫煙者人数,夜間授乳,授乳期間が18ヶ月以上,夕食後の甘い飲み物やおやつの飲食 …

    Journal of the National Institute of Public Health 66(5), 545-552, 2017

    J-STAGE Ichushi Web

  • Long QT Syndrome with Palmar Hyperhidrosis Treated with Endoscopic Thoracic Sympathectomy  [in Japanese]

    Kumamoto Takashi , Tashiro Katsuya , Iida Chiaki , Matsuo Muneaki

    … 運動制限ならびにβ遮断薬内服を開始した.失神発作を認めなくなったが,精神的に不安定となり不登校となり,また以前より本人が両側の手掌多汗症状に苦痛を感じていたため14歳時に胸腔鏡下胸部交感神経遮断術(endoscopic thoracic sympathectomy: ETS)を施行した.術後は多汗症状の改善が得られ,明らかな合併症を認めることなく経過した.加えて安静時の補正QT時間が570 msから511 msと改善したので報告する.</p> …

    Pediatric Cardiology and Cardiac Surgery 33(4), 326-331, 2017

    J-STAGE Ichushi Web

  • An EWS-FLI1-Induced Osteosarcoma Model Unveiled a Crucial Role of Impaired Osteogenic Differentiation on Osteosarcoma Development.

    Komura Shingo , Semi Katsunori , Itakura Fumiaki , Shibata Hirofumi , Ohno Takatoshi , Hotta Akitsu , Woltjen Knut , Yamamoto Takuya , Akiyama Haruhiko , Yamada Yasuhiro

    iPS細胞を用いた新たな腫瘍モデルにより、肉腫形成メカニズムの一端を解明. 京都大学プレスリリース. 2016-03-18.

    Stem cell reports 6(4), 592-606, 2016-04-12


  • The ETS Factor Myeloid Elf-1-Like Factor (MEF)/Elf4 Is Transcriptionally and Functionally Activated by Hypoxia

    Suico Mary Ann , Taura Manabu , Kudo Eriko , Gotoh Kumiko , Shuto Tsuyoshi , Okada Seiji , Kai Hirofumi

    … Hypoxia-inducible factor (HIF)-1α is a transcription factor belonging to the HIF family that is activated in mammalian cells during conditions of low oxygen tension or hypoxia to induce an adaptive response and promote cell survival. … Here, we found that the E26 transformation-specific (ETS) transcription factor myeloid elf-1-like factor (MEF)/Elf4 is activated by HIF-1α. …

    Biological and Pharmaceutical Bulletin 39(4), 641-647, 2016

    J-STAGE Ichushi Web

  • Pathophysiological roles of Pim-3 kinase in pancreatic cancer development and progression

    Li Ying-Yi , Mukaida Naofumi

    … Pim-3 is a member of the provirus integration site for Moloney murine leukemia virus (Pim) family proteins that exhibit serine/threonine kinase activity. … Pim-3 expression is regulated at transcriptional and post-transcriptional levels by transcription factors (e.g., Ets-1) and post-translational modifiers (e.g., translationally-controlled tumor protein), respectively. …

    World Journal of Gastroenterology 20(28), 9392-9404, 2014-07-28


  • Regulation of Endothelial Cell-specific Robo4 Gene Expression by DNA Methylation and Non-lineage Specific Transcription Factors  [in Japanese]

    Okada Yoshiaki

    … Although the studies of endothelial cell (EC)-specific gene expression has identified several transcriptional activators such as SP1, ETS family proteins, and GATA proteins, their expression and combinations are not likely to be EC-specific. …

    YAKUGAKU ZASSHI 134(7), 817-821, 2014

    J-STAGE Ichushi Web

  • The Mechanisms of M-cell Differentiation

    KANAYA Takashi , OHNO Hiroshi

    … We have found that the ets-family transcription factor Spi-B is essential for functional maturation of M cells. …

    Bioscience of Microbiota, Food and Health 33(3), 91-97, 2014

    J-STAGE Ichushi Web

  • Differential Expression of ETS Family Transcription Factors in NCCIT Human Embryonic Carcinoma Cells upon Retinoic Acid-Induced Differentiation

    Park Sung-Won , Do Hyun-Jin , Ha Woo Tae , Han Mi-Hee , Song Hyuk , Uhm Sang-Jun , Chung Hak-Jae , Kim Jae-Hwan

    … E26 transformation-specific (ETS) transcription factors play important roles in normal and tumorigenic processes during development, differentiation, homeostasis, proliferation, and apoptosis. … To identify critical ETS factor(s) in germ cell-derived cancer cells, we examined the expression patterns of the 27 ETS transcription factors in naive and differentiated NCCIT human embryonic carcinoma cells, which exhibit both pluripotent and tumorigenic characteristics. …

    Biological and Pharmaceutical Bulletin 37(4), 659-665, 2014

    J-STAGE Ichushi Web

  • Status report on exposure to environmental tobacco smoking among young women  [in Japanese]

    Nakamura Kozue

    … Exposure to environmental tobacco smoking (ETS) is associated with a range of adverse health outcomes. … College students are at risk of exposure to ETS in both the home and the workplace of part-time job. … They completed a self-administered questionnaire about their ETS. … They are exposed to secondhand smoke from family members and staffs at work based on the questionnaire. …

    岐阜市立女子短期大学研究紀要 64, 41-44, 2014

    IR DOI

  • Hypoxia-Inducible Factors Activate CD133 Promoter through ETS Family Transcription Factors

    Ohnishi Shunsuke , Maehara Osamu , Nakagawa Koji , Kameya Ayano , Otaki Kanako , Fujita Hirotoshi , Higashi Ryosuke , Takagi Kikuko , Asaka Masahiro , Sakamoto Naoya , Kobayashi Masanobu , Takeda Hiroshi

    … Deletion and mutation analysis identified one of the two E-twenty six (ETS) binding sites (EBSs) in the P5 region as being essential for its promoter activity induced by HIF-1 alpha and HIF-2 alpha. … however, HIF-2 alpha did not bind to Elk1 or ETS1. … Taken together, our results revealed that HIF-1 alpha and HIF-2 alpha activate CD133 promoter through ETS proteins. …

    Plos one 8(6), e66255, 2013-06-20

    IR DOI

  • Cell Density-dependent Nuclear Accumulation of ELK3 is Involved in Suppression of PAI-1 Expression

    Tanaka Shu , Nakao Kazuyuki , Sekimoto Toshihiro , Oka Masahiro , Yoneda Yoshihiro

    … In this study, we showed that the mRNA levels of plasminogen activator inhibitor type 1 (<i>PAI-1</i>) decreased drastically at high cell density, and that ELK3, a member of the Ets transcription factor family, repressed <i>PAI-1</i> … Furthermore, we found that ETS1, a <i>PAI-1</i> …

    Cell Structure and Function 38(2), 145-154, 2013

    J-STAGE Ichushi Web

  • Overexpression of ETS-1 is associated with malignant biological features of prostate cancer.

    Li Bo , Shimizu Yosuke , Kobayashi Takashi , Terada Naoki , Yoshimura Koji , Kamba Tomomi , Mikami Yoshiki , Inoue Takahiro , Nishiyama Hiroyuki , Ogawa Osamu

    … E26 transformation-specific-1 (ETS-1), an ETS family transcription factor, has been reported to play an important role in a variety of physiological and pathological processes, but clinical implications of ETS-1 expression in prostate cancer (PCa), particularly high-risk cases, including response to androgen-deprivation therapy (ADT) have yet to be elucidated. …

    Asian journal of andrology 14(6), 860-863, 2012-11


  • Aiming to Elucidate the Clinical States of Chronic Kidney Disease  [in Japanese]

    Naito Takashi

    … 我々はEMTに関与するmetalloproteinase(MMP)およびその転写調節因子であるEts-1が進行性腎疾患モデルの腎組織で明らかに発現増加をおこすことを以前報告した。 … 最近RA系はこのEts系とcross talkingすることが解明された。 … RA-Ets連関はCKD進行に関与している可能性があり、今後の研究が注目される。 …

    Journal of Tokyo Women's Medical College 82(E2), E335-E341, 2012-07-31

  • Aiming to Elucidate the Clinical States of Chronic Kidney Disease  [in Japanese]

    Takashi Naito

    … 我々はEMTに関与するmetalloproteinase(MMP)およびその転写調節因子であるEts-1が進行性腎疾患モデルの腎組織で明らかに発現増加をおこすことを以前報告した。 … 最近RA系はこのEts系とcross talkingすることが解明された。 … RA-Ets連関はCKD進行に関与している可能性があり、今後の研究が注目される。 …

    Journal of Tokyo Women's Medical College 82(臨増), E335-341, 2012-07

    IR Ichushi Web

  • Involvement of PU.1 in Mast Cell/Basophil-Specific Function of the Human <i>IL1RL1/ST2</i> Promoter

    Baba Yosuke , Ogawa Hideoki , Okumura Ko , Nishiyama Chiharu , Maeda Keiko , Yashiro Takuya , Inage Eisuke , Niyonsaba François , Hara Mutsuko , Suzuki Ryuyo , Ohtsuka Yoshikazu , Shimizu Toshiaki

    … Reporter assay demonstrated that a <i>cis</i>-element of typical Ets-family binding sequence was critical for promoter activity in LAD2 and KU812. … An Ets-family transcription factor PU.1 bound to this element in an EMSA. … promoter via Ets-family-related <i>cis</i>-element in mast cells and basophils.<br> …

    Allergology International 61(3), 461-467, 2012


  • Transcriptional Regulation of the Endothelial Cell-specific Receptor, Robo4  [in Japanese]

    Okada Yoshiaki

    …   Roundabout4 (Robo4) is a transmembrane receptor that belongs to the Robo family of neural cell adhesion molecules. … studies demonstrated that the Robo4 promoter is activated by the transcription factors GA-binding protein (GABP) and SP1 through the ETS binding site at −119 and the 2 SP1 binding sites at −42 and −153, respectively. …

    YAKUGAKU ZASSHI 132(9), 1045-1049, 2012

    J-STAGE Ichushi Web

  • Biological Functions of the Duplicated GGAA-motifs in Various Human Promoter Regions  [in Japanese]

    UCHIUMI Fumiaki , MIYAZAKI Satoru , TANUMA Sei-ichi

    … Multiple protein factors including ETS family proteins are known to recognize and bind to the GGAA containing sequences. … In addition, it has been reported that the ETS binding motifs play important roles in regulation of various promoters. …

    YAKUGAKU ZASSHI 131(12), 1787-1800, 2011


  • Intracerebroventricular Administration of an Endothelin ET_B-Receptor Agonist Increases Expression of Matrix Metalloproteinase-2 and -9 in Rat Brain

    KOYAMA Yutaka , TANAKA Kazuhiro

    … Matrix metalloproteinases (MMPs), a family of zinc-endopeptidases, have a critical role in the pathophysiological responses in damaged brains. … To clarify the extracellular signals involved in brain MMP production, the effects of endothelins (ETs), a family of vasoconstricting peptides, were examined. …

    Journal of Pharmacological Sciences 114(4), 433-443, 2010-12-20

    J-STAGE Ichushi Web References (42) Cited by (1)

  • Aberrant Control of Transcription and Transportation of Oncogenic mRNA in Carcinogenesis

    Higashino Fumihiro , Hida Kyoko , Kitamura Tetsuya , Ohga Noritaka , Shindoh Masanobu

    … E1AF is an ets-oncogene family transcription factor, and has been shown to upregulate multiple matrix metalloproteinase (MMP) genes that contribute to the malignant phenotype of cancer cells by inducing invasive and metastatic activities. …

    Oral Science International 7(1), 11-18, 2009


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