Search Results 1-20 of 708

  • Cripto-1 as a Potential Target of Cancer Stem Cells for Immunotherapy

    Ishii Hiroko , Afify Said M. , Hassan Ghmkin , Salomon David S. , Seno Masaharu

    … Since Nodal is a member of the TGF-beta family, which performs an important role in stem cells and cancer stem cells, the inhibition of Cripto-1 could be a strategy by which to block Nodal signaling and thereby suppress cancer stem cells. … The transforming growth factor (TGF)-beta cytokine family possesses broad biological activity and is involved in the induction and/or transdifferentiation of helper T cells, which are important in immunotherapy. …

    Cancers 13(10), 2491, 2021-05-20


  • Attempts to improve University Students' posture to work in difficult situations  [in Japanese]

    樽木 靖夫

    [要約] 本研究は教師が指摘する同僚との協力による困難な場面での対処に注目して,困難な場面で頑張る姿勢に関する尺度を構成し,大学の授業で実施可能な2週に渡る授業を開発し,その効果を検討した。その結果,(1)困難な場面で頑張る姿勢に関する尺度は「仲間関係への方略のなさ」「仲間とともに取り組む」「課題への積極的な対処」「人を参考に困難にも頑張る姿勢」「困難にも頑張る姿勢」の5因子であった。(2)授業実 …

    千葉大学教育学部研究紀要 = Bulletin of the Faculty of Education, Chiba University (69), 11-16, 2021-03-01


  • Quality of Survival of Head and Neck Cancer Patients  [in Japanese]

    Okami Kenji , Sakai Akihiro , Ebisumoto Koji , Maki Daisuke , Aoyama Mayumi , Mitsuhashi Rikito

    … The concept of cancer survivorship refers to the patient showing no signs of cancer after treatment completion, that is, living with, through, and beyond cancer with the family, caregivers, and other survivors. …

    Practica Oto-Rhino-Laryngologica 114(5), 323-332, 2021


  • Prolonged Treatment with Grains of Paradise (<i>Aframomum melegueta</i>) Extract Recruits Adaptive Thermogenesis and Reduces Body Fat in Humans with Low Brown Fat Activity

    YONESHIRO Takeshi , MATSUSHITA Mami , SUGITA Jun , AITA Sayuri , KAMEYA Toshimitsu , SUGIE Hiroki , SAITO Masayuki

    … <p>Increasing adaptive thermogenesis through the activation of brown adipose tissue (BAT) is a promising practical strategy for preventing obesity and related disorders. … Ingestion of a single dose of 40 mg of an extract of Grains of Paradise (GP), a ginger family species, reportedly triggers BAT thermogenesis in individuals with high but not in those with low BAT activity. …

    Journal of Nutritional Science and Vitaminology 67(2), 99-104, 2021


  • Pathological Findings of the Host Immune Reaction in the Tumor Microenvironment of Gastroenteropancreatic Neuroendocrine Neoplasms

    Hasegawa Sho , Nakajima Atsushi , Ichikawa Yasushi , Kobayashi Noritoshi , Okubo Naoki , Tokuhisa Motohiko , Goto Ayumu , Kurita Yusuke , Sato Takamitsu , Hosono Kunihiro , Endo Itaru

    … Targeted immunotherapy is an important treatment strategy in several cancers. … We additionally assessed the expression of programmed death (PD)-1, PD-L1, and the tumor-infiltrating lymphocyte (TIL) markers CD8 and family of transcription factor P3 (FOXP3). … tumors, so an immunological approach may be an appropriate treatment strategy for these tumors. …

    Internal Medicine 60(7), 977-983, 2021


  • ALK7 Acts as a Positive Regulator of Macrophage Activation through Down-Regulation of PPARγ Expression

    Cheng Wen-Lin , Zhang Quan , Cao Jian-Lei , Chen Xi-Lu , Li Wenyan , Zhang Lin , Chao Sheng-ping , Zhao Fang

    … Activin receptor-like kinase 7 (ALK7) acts as a key receptor for TGF-β family members, which play important roles in regulating cardiovascular activity. … The loss-of-function strategy using AdshALK7 was performed for functional study. … Our study demonstrated that ALK7 was a positive regulator for macrophage activation, partially through down-regulation of PPARγ expression, which suggested that neutralizing ALK7 might be promising therapeutic strategy for treating atherosclerosis. …

    Journal of Atherosclerosis and Thrombosis 28(4), 375-384, 2021


  • Identification of scavenger inducing factor for the accelerated removal of inflammatogenic DAMPs  [in Japanese]

    Kento Otani , Tsuyama Jun , Hase Koji , Shichita Takashi

    … </p><p> </p><p>Results: </p><p>The lentiviral overexpression of MSR1 in myeloid cells increased the uptake of DAMP molecules such as amyloid beta peptide and peroxiredoxin family proteins (PRXs). … The TF motif analysis using the DNA sequences of these open chromatin regions revealed the possibility that TF family members such as AP-1 and GATAs bound to the upstream of the <i>Msr1</i> …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 2-Y-F1-3, 2021


  • CDK8 maintains stemness and tumorigenicity of glioma stem cells by controlling the c-MYC pathway  [in Japanese]

    Fukasawa Kazuya , Tokumura Kazuya , Iwahashi Sayuki , Iezaki Takashi , Hinoi Eiichi

    … Glioma stem cells (GSCs) play a key role in tumor initiation and progression. Cyclin-dependent kinase 8 (CDK8), which belongs to the transcription-related CDK family, is considered both an oncogene and a tumor suppressor. … These findings highlight the importance of the CDK8-c-MYC axis in maintaining stemness and tumorigenicity in GSCs, indicating that targeting GSCs through CDK8 inhibition could be a promising strategy against GBM.</p> …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 2-O-D2-1, 2021


  • Subversion and Fratricide : The Problematic Power of Disguise in Suzan-Lori Parks' Topdog/Underdog

    Nakayama Hiroki

    … Meanwhile, the game which causes a fratricide in the ending proposes the deception strategy as a problem among the African American community.An African American Booth's murder to prevent his elderly brother Lincoln from deceiving him out of the bet of his inheritance dramatizes a paradox in an African American family: His affection toward his mother leads to his brother'sdeath. …

    国際研究論叢 = OIU journal of international studies : 大阪国際大学・大阪国際大学短期大学部紀要 34(1), 97-107, 2020-10


  • Improving photosensitivity without changing thermal reactivity in photochromic diarylbenzenes based on accurate prediction by DFT calculations

    Kitagawa Daichi , Takahashi Naoko , Nakahama Tatsumoto , Kobatake Seiya

    … 1,2-Diarylbenzenes (DABs) have been developed as a new family of fast T-type photochromic switches. … However, the molecular design strategy for DABs with desired optical and thermal properties is not established. …

    Photochemical & Photobiological Sciences 19(5), 644-653, 2020-05-01


  • MCL1 inhibition is effective against a subset of small-cell lung cancer with high MCL1 and low BCL-XL expression

    Yasuda Yuto , Ozasa Hiroaki , Kim Young Hak , Yamazoe Masatoshi , Ajimizu Hitomi , Yamamoto Funazo Tomoko , Nomizo Takashi , Tsuji Takahiro , Yoshida Hironori , Sakamori Yuichi , Nakajima Naoki , Menju Toshi , Yoshizawa Akihiko , Date Hiroshi , Hirai Toyohiro

    … MCL1, a member of the anti-apoptotic BCL-2 family, may be a treatment target in several cancers, including SCLC. … However, whether the expression profile of the anti-apoptotic BCL-2 family affects MCL1 inhibition strategy is unknown. … The combination of S63845 with navitoclax, a double BCL-XL/BCL-2 inhibitor, was also employed to examine the comprehensive inhibition of the anti-apoptotic BCL-2 family. …

    Cell Death and Disease (11), 2020-03-09


  • Loss of family with sequence similarity 13, member A exacerbates pulmonary hypertension through accelerating endothelial-to-mesenchymal transition

    Rinastiti Pranindya , Ikeda Koji , Rahardini Elda Putri , Miyagawa Kazuya , Tamada Naoki , Kuribayashi Yuko , Hirata Ken-ichi , Emoto Noriaki

    … Previous genome-wide association studies revealed a significant correlation between the genetic locus of family with sequence similarity 13, member A (FAM13A) and various lung diseases such as chronic obstructive pulmonary disease and pulmonary fibrosis; … Our data revealed a protective role of FAM13A in the development of pulmonary hypertension, and therefore increasing and/or preserving FAM13A expression in pulmonary artery endothelial cells is an attractive therapeutic strategy for the treatment of pulmonary hypertension. …

    PLoS ONE 15(2), e0226049, 2020-02-13


  • A Study on Guidelines for Problem-Solving Learning of Home Economics "Family Relationship" of Junior High School Students : Through attending to problem solving skills using INS model  [in Japanese]

    村田 晋太朗 , 永田 智子 , 小林 裕子

    日本教科教育学会誌 = The bulletin of Japanese curriculum research and development 43(1), 31-41, 2020

  • Examinations of Interactions among Teacher-Training Students through Discussions in Teacher Training:Based on J. P. Gee's Discourse Theory  [in Japanese]

    YAMAUCHI Emiri

    <p>本稿では,教員養成課程の授業内において,教職志望学生が教育問題について価値判断を行う場面に着目し,学生間の相互作用がどのように展開し,学生たちの考え方や学習に影響を及ぼすのかを明らかにした。具体的には,「体罰と教育上の暴言の問題」をテーマとしたディスカッション場面を事例として,ディスコースの視点から学生間の相互作用を分析した。</p><p>その結果明らかに …

    Research Journal of Educational Methods 45(0), 13-23, 2020


  • The Strategy of Successful Exclusive Breastfeeding of Policewomen in Regional Police Department, East Nusa Tenggara

    S. P. R. LOKAT Wiwin , RIWU Rut Rosina , L. NUR Marselinus , J. N. NDUN Helga

    … (6) The family provided support to exclusive breastfeeding by taking care of the babies during work time; … and (8) The strategy for achieving successful exclusive breastfeeding was originated from the willingness and acceptance of the nature as a woman. …

    Journal of Nutritional Science and Vitaminology 66(Supplement), S107-S110, 2020


  • Five cases of pediatric desmoid tumor: A case series  [in Japanese]

    Arakawa Ayumu , Kawai Akira , Kobayashi Eisuke , Iwata Shintaro , Kawakubo Naonori , Kumamoto Tadashi , Ogawa Chitose

    <p>デスモイド腫瘍は,局所浸潤性は強いが遠隔転移はしない線維芽細胞増殖性の軟部腫瘍である.サイズの小さい腫瘍ではwait & see,切除可能な腫瘍では外科的切除が第一選択となるが,腫瘍の増大が速い,あるいは局所浸潤性の強い場合は外科的切除困難であることも多く,治療選択にしばしば苦慮する.今回,当院で治療を行った小児のデスモイド腫瘍の5例について報告する.診断時の年齢中央値は …

    The Japanese Journal of Pediatric Hematology / Oncology 57(5), 366-371, 2020



    TSUBAKI Michihiro , GESHI Eiichi , TOGO Shuusuke , KUMAZAWA Mayumi , TANAKA Shin

    救急終末期における意思決定は家族に委ねられることがほとんどであり,これには臓器提供の意思決定も含まれる.適切なタイミングによる選択肢提示は,家族による患者本人の臓器提供意思の確認や,家族同士の話し合いを促すなど,臓器提供に関連する行動のきっかけにつながる可能性が推測される.これより,アンケートを使用した臓器提供の選択肢提示が家族の行動を促す効果を検証した.対象は三次救急で搬送され,1週間以内に亡く …

    Journal of The Showa University Society 80(6), 546-556, 2020


  • An Infant Case of Anomalous Origin of the Left Coronary Artery from the Pulmonary Artery Successfully Treated with Modified Spiral Cuff Technique  [in Japanese]

    Sasaki Hanae , Kowatari Ryosuke , Suzuki Yasuyuki , Daitoku Kazuyuki , Fukuda Ikuo

    <p>症例は月齢6の女児で,診断は左冠動脈肺動脈起始症(ALCAPA)である.5ヵ月時に発熱を主訴に近医を受診した際に酸素化不良を指摘された.当院小児科に搬送され,挿管呼吸管理が開始された.心臓超音波検査で肺動脈弁左側の交連部直上に左冠動脈起始部を認めた.左室駆出率は9%であり,moderateの僧帽弁逆流が認められた.心臓カテーテル検査では,右冠動脈造影で側副血行路を介して左冠動脈が …

    Japanese Journal of Cardiovascular Surgery 49(6), 325-329, 2020

    J-STAGE  Ichushi Web 

  • Community programs for preventing oral diseases in local governments with inter-professional work  [in Japanese]

    FUKUDA Hideki

    <p>地域における歯科疾患予防対策,とくに歯科の二大疾患であるう蝕予防対策は,集団に対するフッ化物応用などの実践もあり,う蝕予防に対して一定の成果がみられている.しかしながら,乳幼児期・学童期のう蝕有病状況をみると,依然として都道府県間に格差が存在しており,社会経済要因や生活文化など個人を取り巻く社会環境に対するアプローチを含む新たなう蝕予防対策への転換が求められている.一方,歯周病, …

    Journal of the National Institute of Public Health 69(4), 378-387, 2020


  • Loss of Annexin A10 Expression Is Associated with Poor Prognosis in Early Gastric Cancer

    Ishikawa Akira , Kuraoka Kazuya , Zaitsu Junichi , Saito Akihisa , Kuwai Toshio , Suzuki Takahisa , Tashiro Hirotaka , Taniyama Kiyomi , Yasui Wataru

    … The diagnosis and treatment of early GC is a crucial strategy for prognostic improvement of GC. … Annexin A10 (ANXA10), a calcium-/phospholipid-binding protein, is a member of the annexin family. …



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