Search Results 1-20 of 356

  • Effects of Dietary Supplementation with Myo-inositol on Hepatic Expression of Glycolytic and Fructolytic Enzyme Genes in Rats Fed a High-sucrose Diet

    Hibi Mayu , Sugiura Sakura , Nakagawa Tomoyuki , Hayakawa Takashi , Shimada Masaya

    … Supplementation with myo-inositol decreased the hepatic expression of fructolytic enzyme genes, but not that of glycolytic enzyme genes, and the levels of triglycerides, fatty acid synthase, and KHK proteins in high-sucrose diet-induced fatty liver. … The study results suggest that myo-inositol represses primary fructlysis, but not glycolysis, in high-sucrose diet-induced fatty liver.</p> …

    Journal of Oleo Science 70(5), 697-702, 2021

    J-STAGE 

  • Fatty Acid Metabolism during Exercise  [in Japanese]

    Katafuchi Takeshi , Makishima Makoto

    … Endurance exercise is one of the most effective ways to reducefat content and thus prevent metabolic syndrome, as endurance exercise leads to larger amounts of fatty acidsbeing used to create energy with higher efficiency in skeletal muscle. … There are two major types of skeletal musclefibers: type I muscle fibers, which contain a large number of mitochondria and burn fatty acids for energy, andtype II fibers, which contain fewer mitochondria and depend on glycolysis to acquire energy. …

    Journal of Nihon University Medical Association 80(1), 15-19, 2021

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  • Effect of Vitamin E Supplementation on Deposition and Gene Expression Profiling of Abdominal Fat in Broiler Chickens

    Zhang Min , Li Hongyi , Xu Weihua , Zhang Mao , Hung Qichun , Sun Yanfa , Li Jianlei , Zhu Yuting , Wu Qiong , Li Yan , Huang Dingrui , Gan Zhending , Zhong Lipeng , Huang Jingyu

    … Notably, the most enriched pathway, fatty acid biosynthesis, was found to play a key role in lipid metabolism. … Further, the key regulators of lipid metabolism, including fatty acid synthase, acetyl-CoA carboxylase alpha, and acyl-CoA synthetase long-chain family member 1, demonstrated decreased expression following vitamin E supplementation. …

    The Journal of Poultry Science 58(1), 40-50, 2021

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  • Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl‐Chain Length and Hepatic Insulin Sensitivity in Mice

    松坂 賢 , 會田 雄一 , 岩﨑 仁 , 矢藤 繁 , 鈴木 浩明 , 武内 謙憲 , 矢作 直也 , 宮本 崇史 , 関谷 元博 , 高橋 智 , 島野 仁 , Takashi MATSUZAKA , Motoko Kuba , Saori Koyasu , Yuta Yamamoto , Kaori Motomura , Sundaram Arulmozhiraja , Hiroshi Ohno , Rahul Sharma , Takuya Shimura , Yuka Okajima , Song‐iee Han , Yuichi AITA , Yuhei Mizunoe , Yoshinori Osaki , Hitoshi IWASAKI , Shigeru YATOH , Hiroaki SUZUKI , Hirohito Sone , Yoshinori TAKEUCHI , Naoya YAHAGI , Takafumi MIYAMOTO , Motohiro SEKIYA , Yoshimi Nakagawa , Masatsugu Ema , Satoru TAKAHASHI , Hiroaki Tokiwa , Hitoshi SHIMANO

    … Background and AimsDysfunctional hepatic lipid metabolism is a cause of nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disorder worldwide, and is closely associated with insulin resistance and type 2 diabetes. … ELOVL fatty acid elongase 6 (Elovl6) is responsible for converting C16 saturated and monounsaturated fatty acids (FAs) into C18 species. …

    Hepatology 71(5), 1609-1625, 2020-05

    IR 

  • Fructo-oligosaccharides ameliorate steatohepatitis, visceral adiposity, and associated chronic inflammation via increased production of short-chain fatty acids in a mouse model of non-alcoholic steatohepatitis

    Takai Atsuko , Kikuchi Kentaro , Ichimura Mayuko , Tsuneyama Koichi , Moritoki Yuki , Matsumoto Kotaro , Tsunashima Hiromichi , Onda Takeshi , Kuniyoshi Noriyuki , Nariyama Tomoyuki , Ohyatsu Sho , Kubota Juri , Nagumo Kozue , Sato Shinpei , Hara Masumi , Miyakawa Hiroshi

    … Background: Non-alcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome. … Hepatic mRNA expression of lipid metabolism enzymes and SCFA in feces and sera were measured.Results: Hepatic steatosis, inflammatory cell infiltration, and hepatocyte ballooning in the liver and increased hepatic mRNA expression of fatty acid synthase and glycerol-3-phosphate acyltransferase were observed in the MSG-treated mice. …

    BMC Gastroenterology (20), 46, 2020-02-27

    IR 

  • Effects of the extracts of coffee beans roasted at different degrees on liver fat accumulation in rats fed cholesterol-added diets  [in Japanese]

    仲佐 輝子 , 泉谷 祐希 , 坂野 友香 , 塚本 万智 , 川上 小百合 , 高田 智美 , NAKASA Teruko , IZUTANI Yuki , SAKANO Tomoka , TSUKAMOTO Machi , KAWAKAMI Sayuri , TAKATA Satomi

    原著論文

    同志社女子大学生活科学 = DWCLA human life and science (53), 36-44, 2020-02-20

    IR  DOI 

  • Hydrophilic β-conglycinin Peptide Reduces Hepatic Triglyceride Accumulation in Obese Model OLETF Rats

    Wanezaki Satoshi , Saito Shintaro , Inoue Nao , Tachibana Nobuhiko , Yanagita Teruyoshi , Nagao Koji

    … <p>We have previously demonstrated that soy β-conglycinin (βCG) peptide improves obesity and reduces lipid abnormalities in obese model Otsuka Long-Evans Tokushima fatty (OLETF) rats. … After four weeks, hepatic triglyceride levels were lower in OLETF rats of the hydrophilic peptide group than in those of the control group due to decreased activity of hepatic fatty acid synthase, caused by the consumption of hydrophilic peptides. …

    Food Science and Technology Research 26(6), 797-803, 2020

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  • Differences in Breast Muscle Mitochondrial Respiratory Capacity, Reactive Oxygen Species Generation, and Complex Characteristics between 7-week-old Meat- and Laying-type Chickens

    Hakamata Yuki , Toyomizu Masaaki , Kikusato Motoi

    … ATP synthase), and total amount of supercomplexes than did laying-type chickens. …

    The Journal of Poultry Science 57(4), 319-327, 2020

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  • Amelioration of the Lipogenesis, Oxidative Stress and Apoptosis of Hepatocytes by a Novel Proteoglycan from <i>Ganoderma lucidum</i>

    Yuan Shilin , Pan Yanna , Zhang Zeng , He Yanming , Teng Yilong , Liang Haohui , Wu Xiao , Yang Hongjie , Zhou Ping

    … <p>The steatosis and resultant oxidative stress and apoptosis play the important roles in the progression of nonalcoholic fatty liver disease (NAFLD), therefore, searching for the effective drugs against NAFLD has been a hot topic. … extracted from <i>Ganoderma lucidum</i>, inhibiting the palmitic acid (PA)-induced steatosis in HepG2 hepatocytes. …

    Biological and Pharmaceutical Bulletin 43(10), 1542-1550, 2020

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  • Taurine Improves Lipid Metabolism and Increases Resistance to Oxidative Stress

    WANG Zi , OHATA Yoshihisa , WATANABE Yukari , YUAN Yiwen , YOSHII Yuki , KONDO Yoshitaka , NISHIZONO Shoko , CHIBA Takuya

    … Taurine (2-aminoethanesulfonic acid) is an important nutrient for lipid metabolism as it conjugates bile acids. … These results were associated with decreased mRNA expression of <i>fatty acid synthase</i>, and increased mRNA expression of <i>carnitine palmitoyltransferase 1</i>α. … C57BL/6 mice were fed a 5.0% taurine-supplemented diet, and their response to 3-nitropropionic acid-induced oxidative stress was analyzed. …

    Journal of Nutritional Science and Vitaminology 66(4), 347-356, 2020

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  • A polyketide synthase HglE<sub>A</sub>, but not HglE2, synthesizes heterocyst specific glycolipids in <i>Anabaena</i> sp. PCC 7120

    Saito Tsukasa , Awai Koichiro

    … Heterocyst specific glycolipids (Hgls) are constituents of the layer of barrier and amphipathic compounds, synthesized from a very long chain fatty alcohol as a hydrophobic tail and a sugar as a polar head. … PCC 7120, Hgls are made of fatty alcohol with 26 carbons and a glucose, linked by an ether bond in alpha configuration. … The fatty alcohol is synthesized via reactions of a polyketide synthase, HglE<sub>A</sub>. …

    The Journal of General and Applied Microbiology 66(2), 99-105, 2020

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  • Development of novel pesticides in the 21st century

    Umetsu Noriharu , Shirai Yuichi

    … Herbicides possessing varied modes of action, such as acetolactate synthase, <i>p</i>-hydroxyphenylpyruvate dioxygenase, protoporphyrinogen oxidase, and very-long-chain fatty acid elongase inhibition, have been developed, but no herbicides possessing a novel mode action have commercialized in nearly 30 years. …

    Journal of Pesticide Science 45(2), 54-74, 2020

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  • Differentiation-inducing factor-1 accelerates bone marrow-derived mesenchymal stem cells differentiation into adipocyte  [in Japanese]

    Ishikane Shin , Ikushima Eigo , Takiguchi Tomohiro , Toyohira Yumiko , Takahashi Fumi

    … In adipocyte differentiation assay, oil red-O positive area and adipocyte fatty acid-binding protein expression were significantly increased by DIF-1-treatment than control. … Further, the effects of DIF-1 on adipogenic and osteogenic differentiations were attenuated by treatment with glycogen synthase kinase-3 (GSK-3) inhibitor CHIR99021.</p><p><b>Conclusion:</b> …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-O-027, 2020

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  • L-PGDS-produced PGD2 in premature, but not in mature, adipocytes increases obesity and insulin resistance

    ラザルス ミハエル , 大石 陽 , Ko Fujimori , Kosuke Aritake , Yo OISHI , Nanae Nagata , Toko Maehara , Michael LAZARUS , Yoshihiro Urade

    … Lipocalin-type prostaglandin (PG) D synthase (L-PGDS) is responsible for the production of PGD2 in adipocytes and is selectively induced by a high-fat diet (HFD) in adipose tissue. … In this study, we investigated the effects of HFD on obesity and insulin resistance in two distinct types of adipose-specific L-PGDS gene knockout (KO) mice: fatty acid binding protein 4 (fabp4, aP2)-Cre/L-PGDS flox/flox and adiponectin (AdipoQ)-Cre/L-PGDS flox/flox mice. …

    Scientific Reports (9), 1931, 2019-02

    IR 

  • [Special Issue for Honor Award dedicating to Prof Kimito Funatsu]An Electronic-Structure Informatics Study on Inhibitory Activity of Natural Products against Fatty Acid Synthase

    Sugimoto Manabu , Ideo Toshihiro , Algafari Bakti Manggara , Yoshida Kazuki , Inoue Takafumi

    Fatty acid synthase (FASN) inhibitors are known to work as anti-cancer drugs. …

    Journal of Computer Aided Chemistry 20(0), 65-75, 2019

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  • ε-Viniferin is More Effective than Resveratrol in Promoting Favorable Adipocyte Differentiation with Enhanced Adiponectin Expression and Decreased Lipid Accumulation

    Hung Ming-Wei , Wu Che-Wei , Kokubu Daichi , Yoshida Shigeki , Miyazaki Hitoshi

    … ε-Viniferin, but not resveratrol, reduced protein expression of PPARγ and fatty acid synthase that contribute to lipogenesis, and increased expression of adipose triglyceride lipase, a lipolytic enzyme. …

    Food Science and Technology Research 25(6), 817-826, 2019

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  • Dietary intake of probiotic kimchi ameliorated IL-6-driven cancer cachexia

    An Jeong Min , Kang Eun A , Han Young-Min , Oh Ji Young , Lee Dong Yoon , Choi Seung Hye , Kim Duk Hwan , Hahm Ki Baik

    … Significant inhibition of lipolysis gene such as adipose triglyceride lipase (ATGL) and hormone-sensitive ligase (HSL) accompanied with significant induction of fatty acid synthase (FAS) and sterol response element binding protein 1 (SREBP1) was achieved with kimchi. …

    Journal of Clinical Biochemistry and Nutrition 65(2), 109-117, 2019

    J-STAGE  Ichushi Web 

  • The Combination of 'Benifuuki' with Quercetin Suppresses Hepatic Fat Accumulation in High-Fat High-Cholesterol Diet-Fed Rats

    KAMOHARA Tomoko , KOSHIGUCHI Manami , MAEDA-YAMAMOTO Mari , SHINODA Yuki , KAMETANI Norihiro , HIRAI Shizuka , EGASHIRA Yukari

    … Compared with 'Benifuuki' or quercetin alone, supplementation with 'Benifuuki'+quercetin resulted in a low level of fatty acid synthase (<i>FAS</i>) and stearoyl-CoA desaturase1 (<i>SCD1</i>) gene expression levels. …

    Journal of Nutritional Science and Vitaminology 65(2), 196-201, 2019

    J-STAGE  Ichushi Web 

  • A Possible Trifunctional β-Carotene Synthase Gene Identified in the Draft Genome of Aurantiochytrium sp. Strain KH105

    Hiroaki Iwasaka , Ryo Koyanagi , Ryota Satoh , Akiko Nagano , Kenshi Watanabe , Kanako Hisata , Noriyuki Satoh , Tsunehiro Aki

    … Labyrinthulomycetes have been regarded as a promising industrial source of xanthophylls, including astaxanthin and canthaxanthin, polyunsaturated fatty acids such as docosahexaenoic acid and docosapentaenoic acid, ω-3 oils, and terpenic hydrocarbons, such as sterols and squalene. …

    Genes 9(4), 200, 2018-04-09

    IR 

  • Mitochondrial dysfunction induced by ceramide accumulation is involved in the cytotoxicity of 19, 20-epoxydocosapentaenoic acid in H9c2 cells

    Endo Tomoko , Samokvalov Victor , Darwesh Ahmed M , Khey Kevin , El-Sherbeni Ahmed A , El-Kadi Ayman , Machida Takuji , Hirafuji Masahiko , Seubert John M

    … <p>Background: The benefit of dietary n-3 polyunsaturated fatty acids (PUFAs) in the reduction of cardiovascular disease has been recognized for many years. … Mitochondrial function was determined by assessing respiration and enzymatic activities of complex IV and citrate synthase.</p><p>Results: H9c2 cells cultured under normal glucose conditions had lower respiration rates indicating a more glycolytic phenotype compared to cells under low glucose conditions (OXPHOS). …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), PO2-3-21, 2018

    J-STAGE 

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