Search Results 1-20 of 351

  • Investigation of the Mechanisms Underlying Development and Diseases of the Cerebral Cortex Using Mice and Ferrets  [in Japanese]

    Kawasaki Hiroshi

    … Genes-of-interest can be expressed in the ferret cortex rapidly and efficiently. … We also demonstrated that genes-of-interest can be knocked out in the ferret cortex by combining <i>in utero</i> … Our technique for the ferret cerebral cortex should be useful for investigating the mechanisms underlying the development and diseases of the cerebral cortex that cannot be investigated using mice.</p> …

    YAKUGAKU ZASSHI 141(3), 349-357, 2021

    J-STAGE 

  • Can ferret badgers (Melogale moschata) cross the rabies epidemic boundary in western Taiwan?

    Huang Iang , Lin Han-Yu , Weng Guo-Jing

    Mammal study 45(3), 189-199, 2020-07

    Ichushi Web 

  • Spontaneous abdominal hemangiosarcoma in a ferret

    Nakamura Shin-ichi , Tsukahara Takamitsu

    … Herein, we describe the case of a 6-year-old female ferret that died within a few days of the onset of anorexia and reduced spontaneous locomotor activity. …

    Journal of Toxicologic Pathology 32(4), 283-287, 2019

    J-STAGE  Ichushi Web 

  • A histopathological study on adrenal cysts in ferrets

    Uneyama Mizuho , Chambers James K. , Miyama Kouki , Miwa Yasutsugu , Uchida Kazuyuki , Nakayama Hiroyuki

    … The staining pattern was similar to that of biliary epithelial cells in the ferret. … These results indicate the possibility that these adrenocortical cysts in the ferret originated from the biliary system. …

    Journal of Toxicologic Pathology 32(1), 49-55, 2019

    J-STAGE  Ichushi Web 

  • Discovery of naldemedine: A potent and orally available opioid receptor antagonist for treatment of opioid-induced adverse effects  [in Japanese]

    Inagaki Masanao , Tamura Yoshinori , Kume Masaharu , Kai Hiroyuki , Kanemasa Toshiyuki

    <p>オピオイド鎮痛薬は中等度から重度の痛みに対して広く利用されているが、その副作用として、便秘や悪心・嘔吐がしばしば発現する。オピオイド拮抗薬はこれらオピオイド鎮痛薬により誘発される副作用に効果があることが報告されている。これら副作用を軽減する薬を開発するために、筆者らはモルヒナン誘導体の合成と構造活性相関研究に着手した。そして、強い活性を有する有望で新規なケモタイプを見出すことに成 …

    MEDCHEM NEWS 28(3), 132-136, 2018

    J-STAGE 

  • A Ferret Case of Ventricular Septal Defect Complicated by Third-Degree Atrioventricular Block with Ascites  [in Japanese]

    SAIDA Yuto , KITANO Hisashi , SAIDA Nojiko , YATA Shinpei , FUKUSHIMA Ryuji

    <p>腹水貯留を呈し,心室中隔欠損症に第三度房室ブロックを併発した8歳,雌のフェレットに遭遇した。心室中隔欠損症は,双方向性短絡を呈しており,すでに肺高血圧症を併発していると考えられた。そのため,強心と利尿および肺血管拡張療法を実施した。その結果,僅かな右心室圧負荷所見の軽減を認めたが,腹水貯留に改善は見られなかった。そこで,第三度房室ブロックに対する治療として,シロスタゾールを追加し …

    Advances in Animal Cardiology 51(1), 25-33, 2018

    J-STAGE  JASI  Ichushi Web 

  • Current Issues of Rabies Prevention in Japan  [in Japanese]

    INOUE Satoshi , KANEKO Chiho , YOSHII Kentaro , HOTTA Akitoyo , FEI Andrew Chang-Young

    狂犬病はウイルス性の動物由来感染症(Zoonosis,人獣共通感染症)であり,これにより世界中で毎年59,000人以上が死亡している。患者の99%は狂犬病ウイルス(RABV)に感染したイヌによる咬傷が原因であり,その40%が子供である。イヌの狂犬病を制圧した欧米等ではアジアやアフリカの狂犬病常在地域への渡航者や同行した飼育犬,さらには検疫をすり抜けて持ち込まれたイヌ等が入国後に狂犬病を発症する事例 …

    Journal of Veterinary Epidemiology 22(1), 8-14, 2018

    J-STAGE  JASI  Ichushi Web 

  • Molecular Investigations of the Development and Diseases of Cerebral Cortex Folding using Gyrencephalic Mammal Ferrets

    Kawasaki Hiroshi

    <p>Folds of the cerebral cortex (gyri and sulci) are among the most important properties of the mammalian brain. Uncovering the physiological roles, developmental mechanisms and evolution of the …

    Biological and Pharmaceutical Bulletin 41(9), 1324-1329, 2018

    J-STAGE  Ichushi Web 

  • Development of a quantitative real-time RT-PCR assay for detecting Taiwan ferret badger rabies virus in ear tissue of ferret badgers and mice

    HSU Ai-Ping , TSAI Hsiang-Jung , TSENG Chun-Hsien , LU Yi-Ta , SHIH Yu-Hua , CHOU Chung-Hsi , CHEN Re-Shang , TSAI Kuo-Jung , TU Wen-Jane , CLIQUET Florence

    … <p>In 2013, the first case of Taiwan ferret badger rabies virus (RABV-TWFB) infection was reported in Formosan ferret badgers, and two genetic groups of the virus were distinguished through phylogenetic analysis. … This method had a limit of detection (LOD) of 40 RNA copies/reaction and detected viral RNA in brain and ear tissue specimens of infected and dead Formosan ferret badgers and mice with 100% sensitivity and specificity. …

    Journal of Veterinary Medical Science 80(6), 1012-1019, 2018

    J-STAGE  Ichushi Web 

  • Folding of the Cerebral Cortex Requires Cdk5 in Upper-Layer Neurons in Gyrencephalic Mammals

    Shinmyo Yohei , Terashita Yukari , Duong Tung Anh Dinh , Horiike Toshihide , Kawasumi Muneo , Hosomichi Kazuyoshi , Tajima Atsushi , Kawasaki Hiroshi , 新明 洋平 , 堀池 俊秀 , 細道 一善 , 田嶋 敦 , 河﨑 洋志

    … We show that Cdk5 knockout in the ferret cerebral cortex markedly impaired cortical folding. …

    Cell Reports 20(9), 2131-2143, 2017-08-29

    IR  DOI 

  • Molecular investigations of development and diseases of the brain of higher mammals using the ferret

    KAWASAKI Hiroshi

    <p>The brains of higher mammals such as primates and carnivores contain well-developed unique brain structures. Uncovering the physiological functions, developmental mechanisms and evolution of …

    Proceedings of the Japan Academy, Series B 93(5), 259-269, 2017

    IR  J-STAGE  Ichushi Web 

  • Body weight control in African pygmy hedgehogs through feeding management  [in Japanese]

    Okusu C. , Suzuki K.

    <p><tt>フェレットフードの夜間不断給餌で飼育されてきたヨツユビハリネズミ(1歳9ヶ月齢、雄2個体、雌3個体)について、1日1回夕刻20分間の制限給餌へ食餌時間を4週間かけて変更し、その後の4週間でハリネズミフードへの食餌内容の転換を試みた。フェレットフードの不断給餌を制限給餌に変更したところ、体重は5.2~16.4%減少し、肥満傾向が改善する個体もみられた。ハリネズミ …

    Journal of Pet Animal Nutrition 20(2), 135-140, 2017

    J-STAGE  Ichushi Web 

  • Hodgkin's-like lymphoma in a ferret (<i>Mustela putorius furo</i>)

    MATSUMOTO Isao , UCHIDA Kazuyuki , CHAMBERS James Kenn , NIBE Kazumi , SATO Yu , HAMASU Taku , NAKAYAMA Hiroyuki

    … <p>A 7-year-old castrated male ferret developed unilateral cervical lymphadenomegaly over a 1-month period. …

    Journal of Veterinary Medical Science 79(10), 1660-1663, 2017

    J-STAGE  Ichushi Web 

  • Pathogenic analysis of the pandemic 2009 H1N1 influenza A viruses in ferrets

    TSUDA Yoshimi , WEISEND Carla , MARTELLARO Cynthia , FELDMANN Friederike , HADDOCK Elaine

    <p>The pandemic 2009 H1N1 influenza A virus emerged in humans and caused the first influenza pandemic of the 21st century. Mexican isolates, A/Mexico/4108/2009 (H1N1) (Mex4108) and …

    Journal of Veterinary Medical Science 79(8), 1453-1460, 2017

    IR  J-STAGE  Ichushi Web 

  • An essential role of SVZ progenitors in cortical folding in gyrencephalic mammals

    Toda Tomohisa , Shinmyo Yohei , Dinh Duong Tung Anh , Masuda Kosuke , Kawasaki Hiroshi

    … We found regional differences in the abundance of SVZ progenitors in the developing ferret brain even before cortical folds began to be formed. … When Tbr2 transcription factor was inhibited, intermediate progenitor cells were markedly reduced in the ferret cerebral cortex. …

    Scientific Reports (6), 29578, 2016-07-12

    IR 

  • Establishment of serological test to detect antibody against ferret coronavirus

    MINAMI Shohei , WATANABE Keiichiro , NAGANUMA Yumiko , KANAGAWA Eiichi , NAKAMURA Kaneichi , OHASHI Masanari , TAKAMI Yoshinori , MIWA Yasutsugu , TANOUE Tomoaki , OHWAKI Masao , OHTA Jouji , TERADA Yutaka , UNE Yumi , MAEDA Ken , SHIMODA Hiroshi , TAKIZAWA Masaki , ONUMA Mamoru , OTA Akihiko , OTA Yuichi , AKABANE Yoshihito , TAMUKAI Kenichi

    … Since there is no available serological methods to detect antibodies to ferret coronavirus (FRCoV), an enzyme-linked immunosorbent assay (ELISA) using recombinant partial nucleocapsid (N) proteins of the ferret coronavirus (FRCoV) Yamaguchi-1 strain was developed to establish a serological method for detection of FRCoV infection. … This different reactivity was also confirmed by immunoblot analysis using the serum from the ferret.Therefore, the a.a. …

    Journal of Veterinary Medical Science 78(6), 1013-1017, 2016

    J-STAGE  Ichushi Web 

  • Nutrition of the exotic animal―4. Ferret  [in Japanese]

    Tsuruno Shinkichi

    Journal of Pet Animal Nutrition 19(1), 27-32, 2016

    J-STAGE  Ichushi Web 

  • Isolation of Methicillin-resistant Staphylococcus intermedius Group from a Ferret  [in Japanese]

    MIYAMOTO Tadashi , SHIMADA Eriko , KIMURA Yui , KAKUMOTO Mai , MIYAMOTO Akina , HATOYA Shingo

    メチシリン耐性(MR)Staphylococcus intermedius group (SIG)の世界的な急増が犬と猫で問題になっているが,これまでフェレットにおけるMRSIGの分離報告例はない。今回,4歳齢,去勢雄のフェレットが排尿回数の増加と血尿を主訴に来院し,尿からMRSIGが分離された。このMRSIGはクラブラン酸・アモキシシリン,セファレキシン,セフジニル,エリスロマイシン,クリンダマ …

    Journal of Animal Clinical Medicine 23(2), 76-78, 2016

    J-STAGE  Ichushi Web 

  • Pathophysiological analyses of cortical malformation using gyrencephalic mammals

    Masuda Kosuke , Toda Tomohisa , Shinmyo Yohei , Ebisu Haruka , Hoshiba Yoshio , Wakimoto Mayu , Ichikawa Yoshie , Kawasaki Hiroshi

    … Combining gyrencephalic carnivore ferrets and genetic manipulations using in utero electroporation, here we successfully recapitulated the cortical phenotypes of thanatophoric dysplasia (TD) by expressing fibroblast growth factor 8 in the ferret cerebral cortex. … Strikingly, in contrast to TD mice, our TD ferret model showed not only megalencephaly but also polymicrogyria. …

    Scientific Reports (5), 15370, 2015-10-20

    IR 

  • Pathology : Mixed germ cell-sex cord-stromal tumor with a concurrent interstitial cell tumor in a ferret

    INOUE Saki , YONEMARU Kayoko , YANAI Tokuma [他]

    The journal of veterinary medical science 77(2), 225-228, 2015-02

    Ichushi Web 

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