Search Results 1-20 of 1195

  • Big data deconvolution of functional genomics and ceRBP concept  [in Japanese]

    鈴木 洋

    臨床免疫・アレルギー科 = Clinical immunology & allergology 71(1), 92-96, 2019-01

  • Combined linkage and association mapping reveal candidate loci for kernel size and weight in maize  [in Japanese]

    Hao Derong , Xue Lin , Zhang Zhenliang , Cheng Yujing , Chen Guoqing , Zhou Guangfei , Li Pengcheng , Yang Zefeng , Xu Chenwu

    <p>Yield improvement is a top priority for maize breeding. Kernel size and weight are important determinants of maize grain yield. In this study, a recombinant inbred line (RIL) population and a …

    Breeding Science, 2019

    J-STAGE 

  • High Level Estradiol Induces EBV Reactivation and EBV gp350/220(+)CD138(+) Double-positive B Cell Population in Graves' Disease Patients and Healthy Controls

    Hara Sayuri , Nagata Keiko , Nakayama Yuji , Higaki Katsumi , Matsushita Michiko , Kuwamoto Satoshi , Kato Masako , Hayashi Kazuhiko

    <p>Graves' disease occurs predominantly in women. Epstein-Barr virus (EBV) mainly persists in human B lymphocytes, and its reactivation stimulates antibody …

    Yonago Acta Medica 62(2), 240-243, 2019

    J-STAGE 

  • Improvement of <i>Agrobacterium</i>-mediated transformation for tannin-producing sorghum

    Kuriyama Tomoko , Shimada Setsuko , Matsui Minami

    … This improved protocol of <i>Agrobacterium</i>-mediated transformation for tannin-producing sorghum BTx623 could be a useful tool for functional genomics using this plant.</p> …

    Plant Biotechnology 36(1), 43-48, 2019

    J-STAGE 

  • Prediction of Human Hepatic Clearance for Cytochrome P450 Substrates <i>via</i> a New Culture Method Using the Collagen Vitrigel Membrane Chamber and Fresh Hepatocytes Isolated from Liver Humanized Mice

    Watari Ryuji , Kakiki Motoharu , Yamasaki Chihiro , Ishida Yuji , Tateno Chise , Kuroda Yukie , Ishida Seiichi , Kusano Kazutomi

    … of candidate drugs, a new method of culturing hepatocytes that activates their functional properties, including CYP activities, is in high demand. …

    Biological and Pharmaceutical Bulletin 42(3), 348-353, 2019

    J-STAGE 

  • Probucol induces the generation of lipid peroxidation products in erythrocytes and plasma of male cynomolgus macaques

    Shichiri Mototada , Ishida Noriko , Hagihara Yoshihisa , Yoshida Yasukazu , Kume Aiko , Suzuki Hiroshi

    We previously reported that probucol, a lipid lowering agent, protected mice from malaria infection via depletion in plasma α tocopherol. The antioxidant αtocopherol in host circulation is necessary f …

    Journal of Clinical Biochemistry and Nutrition 64(2), 129-142, 2019

    IR  J-STAGE 

  • Amphioxus functional genomics and the origins of vertebrate gene regulation

    Ferdinand Marlétaz , Panos N. Firbas , Ignacio Maeso , Juan J. Tena , Ozren Bogdanovic , Malcolm Perry , Christopher D. R. Wyatt , Elisa de la Calle-Mustienes , Stephanie Bertrand , Demian Burguera , Rafael D. Acemel , Simon J. van Heeringen , Silvia Naranjo , Carlos Herrera-Ubeda , Ksenia Skvortsova , Sandra Jimenez-Gancedo , Daniel Aldea , Yamile Marquez , Lorena Buono , Iryna Kozmikova , Jon Permanyer , Alexandra Louis , Beatriz Albuixech-Crespo , Yann Le Petillon , Anthony Leon , Lucie Subirana , Piotr J. Balwierz , Paul Edward Duckett , Ensieh Farahani , Jean-Marc Aury , Sophie Mangenot , Patrick Wincker , Ricard Albalat , Èlia Benito-Gutiérrez , Cristian Cañestro , Filipe Castro , Salvatore D'Aniello , David E. K. Ferrier , Shengfeng Huang , Vincent Laudet , Gabriel A. B. Marais , Pierre Pontarotti , Michael Schubert , Hervé Seitz , Ildiko Somorjai , Tokiharu Takahashi , Olivier Mirabeau , Anlong Xu , Jr-Kai Yu , Piero Carninci , Juan Ramon Martinez-Morales , Hugues Roest Crollius , Zbynek Kozmik , Matthew T. Weirauch , Jordi Garcia-Fernàndez , Ryan Lister , Boris Lenhard , Peter W. H. Holland , Hector Escriva , Jose Luis Gómez-Skarmeta , Manuel Irimia

    Vertebrates have greatly elaborated the basic chordate body plan and evolved highly distinctive genomes that have been sculpted by two whole-genome duplications. Here we sequence the genome of the Med …

    Nature 564(7734), 64-70, 2018-11-21

    IR 

  • Shoot nitrate underlies a perception of nitrogen satiety to trigger local and systemic signaling cascades in Arabidopsis thaliana

    Okamoto Yuki , Suzuki Takamasa , Sugiura Daisuke , Kiba Takatoshi , Sakakibara Hitoshi , Hachiya Takushi

    Soil Science and Plant Nutrition 65(1), 56-64, 2018-10-27

    DOI 

  • Microbial Genome Analysis and Its Functional Genomics  [in Japanese]

    吉川 博文 , Hirofumi Yoshikawa

    ワトソン・クリックのDNA二重らせんモデル以来,遺伝子の本体であるDNAの塩基配列は分子生物学の発展と共に生物学者の大きな関心の的となった。1980年,サンガーとギルバートが塩基配列決定法でノーベル賞を受賞するが,筆者は1978年にいち早くサンガー法,マクサム・ギルバート法を試みた。その後,キット化によりサンガー法が世の主流になり,蛍光試薬の利用による非RI化,自動化,さらにキャピラリー化による大 …

    東京農業大学農学集報 = Journal of agriculture science, Tokyo University of Agriculture 63(1), 26-34, 2018-06

    IR 

  • The association between glutamine repeats in the androgen receptor gene and personality traits in dromedary camel (Camelus dromedarius)

    Ramadan Sherif , Nowier Amira M. , Hori Yusuke , Inoue-Murayama Miho

    … However, further studies, employing functional genomics and linkage analysis are necessary for confirming the relationship between fearfulness and genetic variation. …

    PLOS ONE 13(2), 2018-02-07

    IR 

  • A global ocean atlas of eukaryotic genes

    Carradec Quentin , Pelletier Eric , Da Silva Corinne , Alberti Adriana , Seeleuthner Yoann , Blanc-Mathieu Romain , Lima-Mendez Gipsi , Rocha Fabio , Tirichine Leila , Labadie Karine , Kirilovsky Amos , Bertrand Alexis , Engelen Stefan , Madoui Mohammed-Amin , Méheust Raphaël , Poulain Julie , Romac Sarah , Richter Daniel J. , Yoshikawa Genki , Dimier Céline , Kandels-Lewis Stefanie , Picheral Marc , Searson Sarah , Jaillon Olivier , Aury Jean-Marc , Karsenti Eric , Sullivan Matthew B. , Sunagawa Shinichi , Bork Peer , Not Fabrice , Hingamp Pascal , Raes Jeroen , Guidi Lionel , Ogata Hiroyuki , de Vargas Colomban , Iudicone Daniele , Bowler Chris , Wincker Patrick

    … While our knowledge about the roles of microbes and viruses in the ocean has increased tremendously due to recent advances in genomics and metagenomics, research on marine microbial eukaryotes and zooplankton has benefited much less from these new technologies because of their larger genomes, their enormous diversity, and largely unexplored physiologies. … The catalog is used to unveil functions expressed by eukaryotic marine plankton, and to assess their functional biogeography. …

    Nature Communications (9), 2018-01-25

    IR 

  • Single-cell genomics of multiple uncultured stramenopiles reveals underestimated functional diversity across oceans

    Seeleuthner Yoann , , Mondy Samuel , Lombard Vincent , Carradec Quentin , Pelletier Eric , Wessner Marc , Leconte Jade , Mangot Jean-François , Poulain Julie , Labadie Karine , Logares Ramiro , Sunagawa Shinichi , de Berardinis Véronique , Salanoubat Marcel , Dimier Céline , Kandels-Lewis Stefanie , Picheral Marc , Searson Sarah , Pesant Stephane , Poulton Nicole , Stepanauskas Ramunas , Bork Peer , Bowler Chris , Hingamp Pascal , Sullivan Matthew B. , Iudicone Daniele , Massana Ramon , Aury Jean-Marc , Henrissat Bernard , Karsenti Eric , Jaillon Olivier , Sieracki Mike , de Vargas Colomban , Wincker Patrick

    … Here, we exploit single-cell genomics and metagenomics data from the circumglobal Tara Oceans expedition to analyze the genome content and apparent oceanic distribution of seven prevalent lineages of uncultured heterotrophic stramenopiles. …

    Nature Communications (9), 2018-01-22

    IR 

  • Time-course transcriptome analysis of human cellular reprogramming from multiple cell types reveals the drastic change occurs between the mid phase and the late phase

    Kuno Akihiro , Nishimura Ken , Takahashi Satoru , 高橋 智 , 西村 健

    … Moreover, functional annotation of gene clusters classified by gene expression patterns showed the mesenchymal-epithelial transition from day 0 to 3, transient upregulation of epidermis related genes from day 7 to 15, and upregulation of pluripotent genes from day 20, which were partially similar to the reprogramming process of mouse embryonic fibroblasts. …

    BMC genomics (19), 9, 2018-01

    IR 

  • Abscisic acid-mediated developmental flexibility of stigmatic papillae in response to ambient humidity in <i>Arabidopsis thaliana</i>

    Takeda Seiji , Watanabe Masao , Suwabe Keita , Ochiai Kohki , Kagaya Yasuaki , Egusa Wataru , Morimoto Hiroaki , Sakazono Satomi , Osaka Masaaki , Nabemoto Moe , Suzuki Go

    <p>Stigmatic papillae develop at the apex of the gynoecium and play an important role as a site of pollination. The papillae in Brassicaceae are of the dry and unicellular type, and more than 15 …

    Genes & Genetic Systems 93(5), 209-220, 2018

    J-STAGE 

  • Abscisic acid–mediated developmental flexibility of stigmatic papillae in response to ambient humidity in <i>Arabidopsis thaliana</i>

    Takeda Seiji , Watanabe Masao , Suwabe Keita , Ochiai Kohki , Kagaya Yasuaki , Egusa Wataru , Morimoto Hiroaki , Sakazono Satomi , Osaka Masaaki , Nabemoto Moe , Suzuki Go

    <p>Stigmatic papillae develop at the apex of the gynoecium and play an important role as a site of pollination. The papillae in Brassicaceae are of the dry and unicellular type, and more than 15 …

    Genes & Genetic Systems, 2018

    J-STAGE 

  • Characterization of mycosporine-like amino acids in the cyanobacterium <i>Nostoc verrucosum</i>

    Inoue-Sakamoto Kaori , Sakamoto Toshio , Nazifi Ehsan , Tsuji Chieri , Asano Tomoya , Nishiuchi Takumi , Matsugo Seiichi , Ishihara Kenji , Kanesaki Yu , Yoshikawa Hirofumi

    <p>The aquatic cyanobacterium <i>Nostoc verrucosum</i> forms macroscopic colonies in streams, and its appearance is superficially similar to that of the terrestrial cyanobacterium &l …

    The Journal of General and Applied Microbiology 64(5), 203-211, 2018

    J-STAGE 

  • Comparison of the Effect of Soy and Casein-Derived Peptide Administration on Tyrosine and Catecholamine Metabolism in the Mouse Brain

    HINO Yukako , KOYANAGI Ayumi , MAEBUCHI Motohiro , ICHINOSE Takashi , FURUYA Shigeki

    <p>The effect of soy and casein peptide intake on the metabolism of amino acids and monoamine neurotransmitters in the serum and brain were examined in C57BL/6 mice. Acute oral administration of …

    Journal of Nutritional Science and Vitaminology 64(5), 329-334, 2018

    J-STAGE  Ichushi Web 

  • The impact of next generation sequencing technologies on functional genomics and MHC analysis of Macaca fascicularis  [in Japanese]

    MANABE Ri-ichiroh

    <p>医薬品や治療法の研究・開発において、その効能効果とともに安全性評価がとても重要である。現在、様々な動物モデルが利用されているが、その中でも霊長類はひとへの副作用、有害事象をより正確に評価できる系として期待されている。ゲノム情報を用いた次世代シーケンサーによる解析手法は、多様な機能性ゲノム情報を短時間に網羅的に得られることから、これら評価のための不可欠な技術となっている。一方、霊長 …

    Annual Meeting of the Japanese Society of Toxicology 45.1(0), W8-1, 2018

    J-STAGE 

  • Characterization of mycosporine-like amino acids in the cyanobacterium <i>Nostoc verrucosum</i>

    Inoue-Sakamoto Kaori , Sakamoto Toshio , Nazifi Ehsan , Tsuji Chieri , Asano Tomoya , Nishiuchi Takumi , Matsugo Seiichi , Ishihara Kenji , Kanesaki Yu , Yoshikawa Hirofumi

    <p>The aquatic cyanobacterium <i>Nostoc verrucosum</i> forms macroscopic colonies in streams, and its appearance is superficially similar to that of the terrestrial cyanobacterium &l …

    The Journal of General and Applied Microbiology, 2018

    J-STAGE 

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