Search Results 1-20 of 4068

  • Genetic Factors Associated with Heading Responses Revealed by Field Evaluation of 274 Barley Accessions for 20 Seasons

    Sato Kazuhiro , Ishii Makoto , Takahagi Kotaro , Inoue Komaki , Shimizu Minami , Uehara-Yamaguchi Yukiko , Nishii Ryuei , Mochida Keiichi

    … Here, we aimed to understand the factors controlling heading time in barley (Hordeum vulgare). … We examined interactions among accessions, known genetic factors, and an environmental factor to determine the factors controlling heading response. …

    iScience 23(6), 101146, 2020-06-26

    IR 

  • Characteristics of the BDNF Val66Met polymorphism in competitive swimmers and judo athletes

    Asai Taishi , Abe Daisuke , Doi Hirokazu , Tanaka Chikara , Ohishi Kenji , Maeda Hideki , Wada Tadashi , Takahashi Yuusuke , Nakahata Yasukazu , Shinohara Kazuyuki

    … Studies have demonstrated that motivation, aggression, excitation intensity, competitive spirit, and tolerance to psychological stress are included in major psychological factors affecting the performance of athletes. … However, to date, there have not been sufficient scientific studies on the relationship between genetic polymorphisms affecting psychological abilities and competitive strength/sport. …

    Acta medica Nagasakiensia 64(1), 23-29, 2020-06

    IR 

  • A Literature Review on the Trend of Genetic Counseling about Familial Tumor  [in Japanese]

    今井 芳枝 , 宮本 容子 , 吉田 友紀子 , 阿部 彰子 , 村上 好恵 , 川崎 優子 , 武田 祐子 , 浅海 くるみ , 板東 孝枝

    … The purpose of this study was to determine the actual situation of the genetic counseling for familial tumors in overseas literatures. … We searched literatures including key words "genetic counseling" "familial tumor" "heredity" "cancer" "patients" and "genetic diseases" on PubMed published from 2008 to 2018, resulting 209 articles extracted and 21 of those examined. …

    四国医学雑誌 = Shikoku acta medica 76(1・2), 45-54, 2020-04-25

    IR 

  • Ecosystem size predicts the probability of speciation in migratory freshwater fish

    Yamasaki Yo Y. , Takeshima Hirohiko , Kano Yuichi , Oseko Naoharu , Suzuki Toshiyuki , Nishida Mutsumi , Watanabe Katsutoshi

    大きな島で種分化が起きやすいことを解明 --「キバラヨシノボリ」は琉球列島で5回誕生した--. 京都大学プレスリリース. 2020-05-13.

    Molecular Ecology, 2020-04-19

    IR 

  • Integrated DNA methylation analysis reveals a potential role for ANKRD30B in Williams syndrome

    Kimura Ryo , Lardenoije Roy , Tomiwa Kiyotaka , Funabiki Yasuko , Nakata Masatoshi , Suzuki Shiho , Awaya Tomonari , Kato Takeo , Okazaki Shin , Murai Toshiya , Heike Toshio , Rutten Bart P. F. , Hagiwara Masatoshi

    エピゲノム異常がウィリアムズ症候群に関わることを発⾒ --多彩な症状の原因を説明する⼿がかりに--. 京都大学プレスリリース. 2020-04-24.

    Neuropsychopharmacology, 2020-04-18

    IR 

  • Prognostic factors in core binding factor-acute myeloid leukemia  [in Japanese]

    石川 裕一

    血液内科 = Hematology 80(4), 478-485, 2020-04

  • Generalized Pustular Psoriasis: Clinical Management and Update on Autoinflammatory Aspects

    Takeichi Takuya , Akiyama Masashi

    ファイル公開:2021/04/01

    American Journal of Clinical Dermatology 21(2), 227-236, 2020-04

    IR 

  • Recurrent abdominal pain and fever : a case of familial Mediterranean fever diagnosed by identification of an MEFV gene mutation  [in Japanese]

    岩永 光巨 , 亀崎 秀宏 , 黒杉 茜 , 妹尾 純一 , 坂本 大

    [要旨] 腹痛,発熱は日常診療で高頻度に遭遇する症状である。鑑別診断は多岐にわたり,器質的な異常を認めずに診断に難渋することもしばしばある。当院で経験した繰り返す腹痛,発熱の病歴及び家族歴から家族性地中海熱を疑い,MEFV(familial Mediterranean fever)遺伝子解析にて確診を得た1 例について報告する。症例は28歳男性。2年前より間欠的に腹痛,発熱を繰り返し,複数の医療機 …

    千葉医学 = Chiba medical journal 96(2), 25-29, 2020-04

    IR  DOI 

  • Effects of habitat loss on the genetic diversity of Embiratermes neotenicus (Isoptera) in a fragmented landscape of the Atlantic Forest, Brazil

    Alane Ayana Vieira de Oliveira Couto , Simon Hellemans , Yves Roisin , Martín Alejandro Montes , Alexandre Vasconcellos

    … The effects of this process depend on factors such as the dispersal ability and breeding systems of each species, the type of land use surrounding the habitat remnants and the position of fragments in the landscape.2. …

    Insect Conservation and Diversity, 2020-03-10

    IR 

  • Agronomic Traits and Grain Quality of Upland Rice Cultivated in Southeast Sulawesi, Indonesia

    Kikuta Mayumi , Makihara Daigo , Pasolon Yulius Barra , Rembon Fransiscus Suramas , Miyazaki Akira , Yamamoto Yoshinori

    … These traditional varieties were highly varied in terms of grain appearance and yield-related factors. … These results indicate that this region contains valuable upland rice varieties, and this information is useful for future genetic resource studies. …

    農学国際協力 (18), 41-47, 2020-03

    IR  DOI 

  • Antiparkinson Drug Benztropine Suppresses Tumor Growth, Circulating Tumor Cells, and Metastasis by Acting on SLC6A3/DAT and Reducing STAT3

    Sogawa Chiharu , Eguchi Takanori , Tran Manh Tien , Ishige Masayuki , Trin Kilian , Okusha Yuka , Taha Eman Ahmed , Lu Yanyin , Kawai Hotaka , Sogawa Norio , Takigawa Masaharu , Calderwood Stuart K. , Okamoto Kuniaki , Kozaki Ken-Ichi

    … Tumor growth, progression, and therapy resistance are crucial factors in the prognosis of cancer. … Benztropine and GBR-12935 directly targeted the dopamine transporter DAT/SLC6A3, whose genetic alterations such as amplification were correlated with poor prognosis for cancer patients. … In conclusion, we propose the repurposing of benztropine for anticancer research and therapeutics that can suppress tumor progression, CTC, and metastasis of aggressive cancers by reducing key pro-tumorigenic factors. …

    Cancers 12(2), 523, 2020-02-24

    IR 

  • Identification of a novel uterine leiomyoma GWAS locus in a Japanese population

    Sakai Kensuke , Tanikawa Chizu , Hirasawa Akira , Chiyoda Tatsuyuki , Yamagami Wataru , Kataoka Fumio , Susumu Nobuyuki , Terao Chikashi , Kamatani Yoichiro , Takahashi Atsushi , Momozawa Yukihide , Hirata Makoto , Kubo Michiaki , Fuse Nobuo , Takai-Igarashi Takako , Shimizu Atsushi , Fukushima Akimune , Kadota Aya , Arisawa Kokichi , Ikezaki Hiroaki , Wakai Kenji , Yamaji Taiki , Sawada Norie , Iwasaki Motoki , Tsugane Shoichiro , Aoki Daisuke , Matsuda Koichi

    … Uterine leiomyoma is one of the most common gynaecologic benign tumours, but its genetic basis remains largely unknown. … Six previous GWAS identified 33 genetic factors in total. … Our findings elucidated the significance of genetic factors in the pathogenesis of leiomyoma. …

    Scientific Reports (10), 1197, 2020-01-27

    IR 

  • Divergent northern and southern populations and demographic history of the pearl oyster in the western Pacific revealed with genomic SNPs

    Takeshi Takeuchi , Tetsuji Masaoka , Hideo Aoki , Ryo Koyanagi , Manabu Fujie , Noriyuki Satoh

    … In the open ocean without terrain boundaries, marine invertebrates with pelagic larvae can migrate long distances using ocean currents, suggesting reduced genetic diversification. … Contrary to this assumption, however, genetic differentiation is often observed in marine invertebrates. …

    Evolutionary Applications 13(4), 837-853, 2020-01-08

    IR 

  • Pathogenesis of autoimmune hepatitis (genetic and environmental factors, breakdown of immune balance)  [in Japanese]

    大藤 和也 , 根本 朋幸 , 中本 安成

    日本臨床 = Japanese journal of clinical medicine 78(1), 58-64, 2020-01

    Ichushi Web 

  • Claudin 4 in pancreatic β cells is involved in regulating the functional state of adult islets

    Li Hongtu , Neelankal John Abraham , Nagatake Takahiro , Hamazaki Yoko , Jiang Fang‐Xu

    … The functional state (FS) of adult pancreatic islets is regulated by a large array of regulatory molecules including numerous transcription factors. … Furthermore, the genetic deletion of Cldn4 impaired significantly the FS without apparently affecting pancreas morphology, islet architectural structure and cellular distribution, and secretion of enteroendocrine hormones. …

    FEBS Open Bio 10(1), 28-40, 2020-01

    IR 

  • The effect of zebularine on the heat-activated retrotransposon <i>ONSEN</i> in <i>Arabidopsis thaliana</i> and <i>Vigna angularis</i>

    Boonjing Patwira , Masuta Yukari , Nozawa Kosuke , Kato Atsushi , Ito Hidetaka

    … has acquired a heat-responsive element that is recognized by plant heat stress defense factors, resulting in its transcription and the production of full-length extrachromosomal DNA under conditions with elevated temperatures. …

    Genes & Genetic Systems, 2020

    J-STAGE 

  • A New <i>TBX5</i> Loss-of-Function Mutation Contributes to Congenital Heart Defect and Atrioventricular Block

    Zhang Yan , Qiao Qi , Wang Jun , Yang Yi-Qing , Sun Yu-Min , Xu Ying-Jia , Zhao Cui-Mei , Yuan Fang , Guo Xiao-Juan , Guo Yu-Han , Yang Chen-Xi , Gu Jia-Ning

    … Increasing evidence highlights the pivotal roles of genetic etiologies in the pathogenesis of CHD, and pathogenic mutations in multiple genes, including <i>TBX5</i> … However, due to pronounced genetic heterogeneity of CHD, the genetic determinants underlying CHD in most cases remain obscure. … Genetic analysis of the proband's pedigree showed that the mutation co-segregated with the diseases. …

    International Heart Journal 61(4), 761-768, 2020

    J-STAGE 

  • Correlation of UMOD with serum uric acid concentration and blood pressure  [in Japanese]

    Konoshita Tadashi , Furutani Machi , Sato Satsuki , Zenimaru Yasuo , Fujii Miki , Makino Yasukazu , Onoe Tamehito

    <p>高尿酸血症は動脈硬化性疾患としての心腎血管病発症の危険因子と考えられており,血清尿酸値を規定する各種の遺伝子が順次明らかにされている.一方ウロモジュリン(UMOD)遺伝子は家族性若年性高尿酸血症性腎症の原因となることが知られ,さらに近年のGWASの成績などから高血圧や慢性腎臓病の発症・進展に関わることが示されている.しかしながら当該遺伝子の尿酸代謝や血圧値に対する影響については詳 …

    Gout and Uric & Nucleic Acids 44(1), 23-31, 2020

    J-STAGE 

  • The Natural History of Spontaneously Occurred Endometriosis in Cynomolgus Monkeys by Monthly Follow-Up Laparoscopy for Two Years

    Hayashi Kaori , Mori Takahide , Murakami Takashi , Ogasawara Kazumasa , Nakayama Misako , Iwatani Chizuru , Tsuchiya Hideaki , Nakamura Shinichiro , Nonoguchi Kosuke , Itoh Yasushi , Tsuji Shunichiro , Ishigaki Hirohito

    … Endometriosis developed in all monkeys, and the speed of progression varied greatly among individuals that could be attributed to the degree or frequency of retrograde menstruation and genetic factors; … Finding reliable quantification markers and unravelling the underlying factors in correlation with the spatiotemporal development of the disease using a nonhuman primate model would be useful for the better management of endometriosis in humans.</p> …

    The Tohoku Journal of Experimental Medicine 251(4), 241-253, 2020

    J-STAGE 

  • Regional and genetic variation of basal and stem bending in <i>Picea glehnii</i>  [in Japanese]

    Hanaoka So , Itô Hiroki

    <p>北海道における主要造林樹種の一つであるアカエゾマツを対象に,根元曲がりや幹曲がりの程度について,気象条件に差がある検定林間及び家系間変動を検証した。共通家系が植栽された9ヶ所の検定林における20年次の根元曲がりと幹曲がりの程度に関するデータ(1~5の順序カテゴリカルデータ)を供試し,検定林及び検定林内反復,検定林内の植栽プロット,家系,検定林と家系の交互作用の効果を順序ロジットモ …

    Japanese Journal of Forest Environment 62(1), 39-50, 2020

    J-STAGE 

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