Search Results 1-20 of 6391

  • A single nucleotide polymorphism in <i>Prostate Stem Cell Antigen</i> is associated with endoscopic grading in Kyoto classification of gastritis

    Toyoshima Osamu , Matsuda Koichi , Nishizawa Toshihiro , Sekiba Kazuma , Matsuno Tatsuya , Kondo Ryo , Watanabe Hidenobu , Suzuki Hidekazu , Tanikawa Chizu , Koike Kazuhiko

    … In multivariate analysis, the Kyoto score was independently associated with <i>PSCA</i> …

    Journal of Clinical Biochemistry and Nutrition 68(1), 73-77, 2021

    J-STAGE 

  • Otolaryngological Medical Care in Digital Transformation (DX) Era  [in Japanese]

    Omori Koichi , Fujimura Shintaro , Mizuno Kayoko

    … Big data aggregates information about electronic medical records, insurance receipts, patients' registries, genome/omics, and biological information from wearable devices. … AI health programs enable automatic analysis of endoscopic images, CT images, MR images, and voice data to enable diseases to be diagnosed by machine learning of the inputs gathered from thousands of data sets. …

    Practica Oto-Rhino-Laryngologica 114(1), 1-10, 2021

    J-STAGE 

  • A Case of Stimulator of Interferon Genes-associated Vasculopathy with an Onset in Infancy Diagnosed after the Development of Atypical Pulmonary Lesions During Treatment as Juvenile Idiopathic Arthritis

    Nishida Tomoya , Nakano Kazuhisa , Inoue Yoshino , Narumi-Kishimoto Yoko , Kaname Tadashi , Akashi Koichi , Tanaka Yoshiya

    … analysis revealed a gain-of-function mutation in <i>TMEM173</i> …

    Internal Medicine, 2021

    J-STAGE 

  • Structural dynamics of double-stranded DNA with epigenome modification

    Furukawa Ayako , Walinda Erik , Arita Kyohei , Sugase Kenji

    … 2020-12-23.Modification of cytosine plays an important role in epigenetic regulation of gene expression and genome stability. … Here, we have carried out a semi-quantitative analysis of the dynamics of double-stranded DNA (dsDNA) containing various epigenetic modifications by combining data from imino 1H exchange and imino 1H R1ρ relaxation dispersion NMR experiments in a complementary way. …

    Nucleic Acids Research, 2020-12-18

    IR 

  • DNA methyltransferase 3B plays a protective role against hepatocarcinogenesis caused by chronic inflammation via maintaining mitochondrial homeostasis

    Iguchi Eriko , Takai Atsushi , Takeda Haruhiko , Kumagai Ken , Arasawa Soichi , Eso Yuji , Shimizu Takahiro , Ueda Yoshihide , Marusawa Hiroyuki , Seno Hiroshi

    … Whole-genome bisulfite sequencing verified a lower CG methylation level in the Dnmt3b-deficient liver, demonstrating differentially methylated regions throughout the genome. … Transcriptome analysis revealed decreased expression of genes related to oxidative phosphorylation in the Dnmt3b-deficient liver. …

    Scientific Reports (10), 2020-12-04

    IR 

  • Delayed Methotrexate Elimination after Administration of a Medium Dose of Methotrexate in a Patient with Genetic Variants Associated with Methotrexate Clearance

    Tatebe Yasuhisa , Kanamitsu Kiichiro , Kanzaki Hirotaka , Ishida Hisashi , Fujiwara Kaori , Washio Kana , Kitamura Yoshihisa , Sendo Toshiaki , Shimada Akira , Tsukahara Hirokazu

    … Recent genome-wide association studies have revealed that the SLCO1B1 T521C variant is associated with methotrexate elimination. … Subsequent genetic analysis showed that he was a carrier of dys-functional genetic variants associated with methotrexate clearance. …

    Acta Medica Okayama 74(6), 545-550, 2020-12

    IR  DOI 

  • Attitudes toward and current status of disclosure of secondary findings from next-generation sequencing: a nation-wide survey of clinical genetics professionals in Japan

    Tsuchiya Mio , Yamada Takahiro , Akaishi Rina , Hamanoue Haruka , Hirasawa Akira , Hyodo Maki , Imoto Issei , Kosho Tomoki , Kurosawa Kenji , Murakami Hiromi , Nakatani Kaname , Nomura Fumio , Sasaki Aiko , Shimizu Kenji , Tamai Mariko , Umemura Hiroshi , Watanabe Atsushi , Yoshida Akiko , Yoshihashi Hiroshi , Yotsumoto Junko , Kosugi Shinji

    … The management of secondary findings (SFs), which are beyond the intended purpose of the analysis, from clinical comprehensive genomic analysis using next generation sequencing (NGS) presents challenges. … We conducted a questionnaire survey of clinical genetics professionals at two time points (2013 and 2019) to determine the enforcement of the SF management policy in cases of comprehensive genetic analysis of intractable diseases and clinical cancer genome profiling testing. …

    Journal of human genetics (65), 1045-1053, 2020-12

    IR 

  • Postharvest Properties of Ultra-Late Maturing Peach Cultivars and Their Attributions to Melting Flesh (M) Locus: Re-evaluation of M Locus in Association With Flesh Texture

    Nakano Ryohei , Kawai Takashi , Fukamatsu Yosuke , Akita Kagari , Watanabe Sakine , Asano Takahiro , Takata Daisuke , Sato Mamoru , Fukuda Fumio , Ushijima Koichiro

    … DNA-seq analysis showed that tandem endo-polygalacturonase (endoPG) genes located at melting flesh (M) locus, Pp-endoPGM (PGM), and Pp-endoPGF (PGF), were deleted in DJ. …

    Frontiers in Plant Science (11), 554158, 2020-11-26

    IR 

  • Multiple wheat genomes reveal global variation in modern breeding

    Walkowiak Sean , Gao Liangliang , Monat Cecile , Haberer Georg , Kassa Mulualem T. , Brinton Jemima , Ramirez-Gonzalez Ricardo H. , Kolodziej Markus C. , Delorean Emily , Thambugala Dinushika , Klymiuk Valentyna , Byrns Brook , Gundlach Heidrun , Bandi Venkat , Siri Jorge Nunez , Nilsen Kirby , Aquino Catharine , Himmelbach Axel , Copetti Dario , Ban Tomohiro , Venturini Luca , Bevan Michael , Clavijo Bernardo , Koo Dal-Hoe , Ens Jennifer , Wiebe Krystalee , N'Diaye Amidou , Fritz Allen K. , Gutwin Carl , Fiebig Anne , Fosker Christine , Fu Bin Xiao , Accinelli Gonzalo Garcia , Gardner Keith A. , Fradgley Nick , Gutierrez-Gonzalez Juan , Halstead-Nussloch Gwyneth , Hatakeyama Masaomi , Koh Chu Shin , Deek Jasline , Costamagna Alejandro C. , Fobert Pierre , Heavens Darren , Kanamori Hiroyuki , Kawaura Kanako , Kobayashi Fuminori , Krasileva Ksenia , Kuo Tony , McKenzie Neil , Murata Kazuki , Nabeka Yusuke , Paape Timothy , Padmarasu Sudharsan , Percival-Alwyn Lawrence , Kagale Sateesh , Scholz Uwe , Sese Jun , Juliana Philomin , Singh Ravi , Shimizu-Inatsugi Rie , Swarbreck David , Cockram James , Budak Hikmet , Tameshige Toshiaki , Tanaka Tsuyoshi , Tsuji Hiroyuki , Wright Jonathan , Wu Jianzhong , Steuernagel Burkhard , Small Ian , Cloutier Sylvie , Keeble-Gagnère Gabriel , Muehlbauer Gary , Tibbets Josquin , Nasuda Shuhei , Melonek Joanna , Hucl Pierre J. , Sharpe Andrew G. , Clark Matthew , Legg Erik , Bharti Arvind , Langridge Peter , Hall Anthony , Uauy Cristobal , Mascher Martin , Krattinger Simon G. , Handa Hirokazu , Shimizu Kentaro K. , Distelfeld Assaf , Chalmers Ken , Keller Beat , Mayer Klaus F. X. , Poland Jesse , Stein Nils , McCartney Curt A. , Spannagl Manuel , Wicker Thomas , Pozniak Curtis J.

    日本コムギ農林61号など世界15品種の高精度ゲノム解読に成功 --ゲノム情報を利用した迅速な分子育種技術の開発に期待--. 京都大学プレスリリース. 2020-12-02.

    Nature, 2020-11-25

    IR 

  • Genome-wide analysis of nucleosome positioning  [in Japanese]

    清水 光弘 , 加藤 太陽

    アグリバイオ = Agricultural biotechnology 4(12), 1112-1118, 2020-11

  • A Reference Genome from the Symbiotic Hydrozoan, Hydra viridissima

    Hamada Mayuko , Satoh Noriyuki , Khalturin Konstantin

    … In order to provide an important reference for genetic studies, the Hydra magnipapillata genome (species name has been changed to H. … vulgaris) was sequenced a decade ago (Chapman et al., 2010) and the updated genome assembly, Hydra 2.0, was made available by the National Human Genome Research Institute in 2017. … Here we report a draft 280-Mbp genome assembly for Hydra viridissima strain A99, with a scaffold N50 of 1.1 Mbp. …

    G3: Genes | Genomes | Genetics 10(11), 3883-3895, 2020-11

    IR 

  • Common risk variants in NPHS1 and TNFSF15 are associated with childhood steroid-sensitive nephrotic syndrome

    Jia Xiaoyuan , Yamamura Tomohiko , Gbadegesin Rasheed , McNulty Michelle T. , Song Kyuyong , Nagano China , Hitomi Yuki , Lee Dongwon , Aiba Yoshihiro , Khor Seik-Soon , Ueno Kazuko , Kawai Yosuke , Nagasaki Masao , Noiri Eisei , Horinouchi Tomoko , Kaito Hiroshi , Hamada Riku , Okamoto Takayuki , Kamei Koichi , Kaku Yoshitsugu , Fujimaru Rika , Tanaka Ryojiro , Shima Yuko , Baek Jiwon , Kang Hee Gyung , Ha Il-Soo , Han Kyoung Hee , Yang Eun Mi , Abeyagunawardena Asiri , Lane Brandon , Chryst-Stangl Megan , Esezobor Christopher , Solarin Adaobi , Dossier Claire , Deschenes Georges , Vivarelli Marina , Debiec Hanna , Ishikura Kenji , Matsuo Masafumi , Nozu Kandai , Ronco Pierre , Il Cheong Hae , Sampson Matthew G. , Tokunaga Katsushi , Iijima Kazumoto

    … To understand the genetics of steroid-sensitive nephrotic syndrome (SSNS), we conducted a genome-wide association study in 987 childhood SSNS patients and 3,206 healthy controls with Japanese ancestry. … Beyond known associations in the HLA-DR/DQ region, common variants in NPHS1-KIRREL2 (rs56117924, P=4.94E-20, odds ratio (OR) =1.90) and TNFSF15 (rs6478109, P=2.54E-8, OR=0.72) regions achieved genome-wide significance and were replicated in Korean, South Asian and African populations. …

    Kidney International 98(5), 1308-1322, 2020-11

    IR 

  • Genomic analysis of disease genes of skeletal dysplasia : present and future  [in Japanese]

    池川 志郎

    整形外科 = Orthopedic surgery 71(11), 1205-1208, 2020-10

  • Genetic Signatures of Evolution of the Pluripotency Gene Regulating Network across Mammals

    Endo Yoshinori , Kamei Ken-ichiro , Inoue-Murayama Miho

    哺乳類の多能性幹細胞における機能性遺伝子のネットワークとその多様性を解析. 京都大学プレスリリース. 2020-08-11.

    Genome Biology and Evolution 12(10), 1806-1818, 2020-10

    IR 

  • Proposal of Distributed Parallel Homology Search System GHOSTZ PW/GF  [in Japanese]

    町田 健太 , 建部 修見

    メタゲノム解析では，ある環境サンプルから直接得られた大量のゲノムDNAを一度に用いて環境中に含まれる微生物の群集構造や機能の解析を行う．メタゲノムデータは，代表的なビッグデータの1つであり，次世代シーケンサの性能向上や普及により得られるデータの量は年々増大している．メタゲノム解析の過程で行われる相同性検索とは，未知のDNA配列をクエリとして，既知のDNA配列データベースから相同なものを収集する手法 …

    情報処理学会論文誌コンピューティングシステム（ACS） 13(2), 13-27, 2020-09-17

    IPSJ 

  • Cutting edge in asthma genetic analysis  [in Japanese]

    藤本 源 , 小林 哲

    呼吸器内科 = Respiratory medicine 38(3), 257-261, 2020-09

    Ichushi Web 

  • Expression profiles of genes for enzymes involved in capsidiol production in Nicotiana benthamiana

    Rin Soriya , Imano Sayaka , Camagna Maurizio , Suzuki Takamasa , Tanaka Aiko , Sato Ikuo , Chiba Sotaro , Kawakita Kazuhito , Takemoto Daigo

    … In the genome of N. … Expression analysis of control and NbWIPK/SIPK/NTF4-silenced plants indicated that most of the MVA genes are not under the control of these MAP kinases. …

    Journal of General Plant Pathology 86(5), 340-349, 2020-09

    IR 

  • Construction of chromosome level genome assembly database of Rorippa aquatica  [in Japanese]

    坂本 智昭 , 木村 成介

    Rorippa aquatica は北米原産のアブラナ科植物であり、周囲の環境に応答して葉の形態を変化させる異形葉性を示す。また、葉断片から完全な植物体を形成することが出来るという特性を持つ。このように興味深い特性を示す本種であるが、それらの根底にある分子機構は完全には明らかになっていない。それらを解明するための手法として次世代シーケンサーを用いた様々な網羅的な解析が行われている。ゲノムアセンブリ …

    京都産業大学総合学術研究所所報 (15), 1-10, 2020-09

    IR 

  • Ancient Jomon genome sequence analysis sheds light on migration patterns of early East Asian populations

    Gakuhari Takashi , Nakagome Shigeki , Rasmussen Simon , Allentoft Morten E. , Sato Takehiro , Korneliussen Thorfinn , Chuinneagain Blanaid Ni , Matsumae Hiromi , Koganebuchi Kae , Schmidt Ryan , Mizushima Souichiro , Kondo Osamu , Shigehara Nobuo , Yoneda Minoru , Kimura Ryosuke , Ishida Hajime , Masuyama Tadayuki , Yamada Yasuhiro , Tajima Atsushi , Shibata Hiroki , Toyoda Atsushi , Tsurumoto Toshiyuki , Wakebe Tetsuaki , Shitara Hiromi , Hanihara Tsunehiko , Willerslev Eske , Sikora Martin , Oota Hiroki

    … Here, we analyze the whole-genome sequence of a 2,500-year-old individual (IK002) from the main-island of Japan that is characterized with a typical Jomon culture. …

    Communications Biology 3(1), 2020-08-25

    IR 

  • Genome-wide analysis of nucleosome positioning  [in Japanese]

    清水 光弘 , 加藤 太陽

    細胞 52(9), 503-507, 2020-08

    Ichushi Web 

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