Search Results 1-20 of 2769

  • Glioma cells require one-carbon metabolism to survive glutamine starvation

    Tanaka Kazuhiro , Sasayama Takashi , Nagashima Hiroaki , Irino Yasuhiro , Takahashi Masatomo , Izumi Yoshihiro , Uno Takiko , Satoh Naoko , Kitta Akane , Kyotani Katsusuke , Fujita Yuichi , Hashiguchi Mitsuru , Nakai Tomoaki , Kohta Masaaki , Uozumi Yoichi , Shinohara Masakazu , Hosoda Kohkichi , Bamba Takeshi , Kohmura Eiji

    … Metabolic and functional studies in GBM cells demonstrated that serine availability and one-carbon metabolism support glioma cell survival following glutamine deprivation. … In clinical samples, MTHFD2 expression was highest in the nutrient-poor areas around "pseudopalisading necrosis." Genetic suppression of MTHFD2 and autophagy inhibition caused tumor cell death and growth inhibition of glioma cells upon glutamine deprivation. …

    Acta Neuropathologica Communications 9(1), 16, 2021-12-19

    IR 

  • Differentiated glioblastoma cells accelerate tumor progression by shaping the tumor microenvironment via CCN1-mediated macrophage infiltration

    Uneda Atsuhito , Kurozumi Kazuhiko , Fujimura Atsushi , Fujii Kentaro , Ishida Joji , Shimazu Yosuke , Otani Yoshihiro , Tomita Yusuke , Hattori Yasuhiko , Matsumoto Yuji , Tsuboi Nobushige , Makino Keigo , Hirano Shuichiro , Kamiya Atsunori , Date Isao

    Glioblastoma (GBM) is the most lethal primary brain tumor characterized by significant cellular heterogeneity, namely tumor cells, including GBM stem-like cells (GSCs) and differentiated GBM cells (DG …

    Acta Neuropathologica Communications 9(1), 29, 2021-02-22

    IR 

  • Tumor of medulla oblongata  [in Japanese]

    橋詰 良夫

    脳神経内科 = Neurology 94(1), 84-88, 2021-01

    Ichushi Web 

  • Phosphorylation of Smurf2, a novel therapeutic target, regulates stemness and tumorigenicity of glioma stem cells  [in Japanese]

    Iezaki Takashi , Hinoi Eiichi

    … Although the role of Smurf2 in glioblastoma has been investigated previously, here we show that phosphorylation of Smurf2 at Thr249 plays an essential role in maintenance of stemness of glioma-initiating cells (GICs). …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 2-S21-1, 2021

    J-STAGE 

  • Biological significance of CYLD expression in malignant characteristics of glioblastoma multiforme.  [in Japanese]

    Ito Yuki , Yamaoka Michiko , Shirakawa Yuki , Hide Takuichiro , Saito Hideyuki , Jono Hirofumi

    <p><b><u>Introduction:</u></b>  Cylindromatosis (CYLD) regulates various cell signaling pathways by acting as a deubiquitinating enzyme. Although it was shown that loss o …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 2-O-D2-2, 2021

    J-STAGE 

  • CDK8 maintains stemness and tumorigenicity of glioma stem cells by controlling the c-MYC pathway  [in Japanese]

    Fukasawa Kazuya , Tokumura Kazuya , Iwahashi Sayuki , Iezaki Takashi , Hinoi Eiichi

    Glioma stem cells (GSCs) play a key role in tumor initiation and progression. Cyclin-dependent kinase 8 (CDK8), which belongs to the transcription-related CDK family, is considered both an oncogene and a tumor suppressor. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 2-O-D2-1, 2021

    J-STAGE 

  • Chemical Exchange Saturation Transfer (CEST) MR Imaging for the Diagnosis of Brain Tumors  [in Japanese]

    OKUCHI Sachi , FUSHIMI Yasutaka , OKADA Tomohisa , NAKAJIMA Satoshi , SAKATA Akihiko , HINODA Takuya , NAKAMOTO Yuji

    … In this article, we review the principle and diagnostic value of CEST imaging and discuss (1) its diagnostic performance for grading gliomas, (2) its accuracy for predicting glioma molecular subtypes, (3) the differentiation of gliomas from other brain tumor types, and (4) the distinction of tumor recurrence from treatment-related changes.</p> …

    Japanese Journal of Magnetic Resonance in Medicine 41(1), 14-21, 2021

    J-STAGE 

  • Aiming for AI and Robot Implementation High-performance Smart Treatment Room Hyper SCOT  [in Japanese]

    Muragaki Yoshihiro

    … Integrated information, including intraoperative MRI, are displayed at strategic desks in operating rooms and medical offices and can provide important information in glioma resection with unclear boundaries. …

    Journal of Tokyo Women's Medical University 91(1), 82-87, 2021

    J-STAGE 

  • Stroke Mimics and Chameleons from the Radiological Viewpoint of Glioma Diagnosis

    SASAGAWA Ayaka , MIKAMI Takeshi , KIMURA Yusuke , AKIYAMA Yukinori , SUGITA Shintaro , HASEGAWA Tadashi , WANIBUCHI Masahiko , MIKUNI Nobuhiro

    … In this study, we analyzed stroke mimics and stroke chameleons in glioma and discussed the diagnostic perplexity.</p><p>We retrospectively reviewed cases that were removed from lesions that were considered to be brain tumors. … This study enrolled 214 patients who underwent tumor resection for suspected glioma. …

    Neurologia medico-chirurgica 61(2), 134-143, 2021

    J-STAGE 

  • Basic Research and Preclinical Evaluation of Photodynamic Therapy (PDT) for Malignant Brain Tumors to Improve Further Clinical Effectiveness  [in Japanese]

    Ishikawa Eiichi , Kohzuki Hidehiro , Tsurubuchi Takao , Matsumura Akira

    <p>光線力学的療法(Photodynamic therapy: PDT)の主たる腫瘍殺傷効果は生成された一重項酸素による腫瘍細胞のアポトーシスやネクローシスとされており,その効果はおおむねレーザーの組織深達度に依存している.PDTは既に悪性神経膠腫を含む脳腫瘍に臨床応用されているが,更なる治療効果の向上が望まれる.その向上のために単純にレーザー強度をあげることは周辺正常組織損傷助長の …

    Nippon Laser Igakkaishi 41(4), 329-335, 2021

    J-STAGE 

  • Photosensitizer and Radio-Dynamic Therapy (RDT)  [in Japanese]

    Yamamoto Junkoh , Kitagawa Takehiro , Miyaoka Ryo , Suzuki Kohei , Takamatsu Seishiro , Saito Takeshi , Nakano Yoshiteru

    <p>光感受性物質を利用した診断・治療はすでに臨床現場で広く利用されている.ポルフィリンに代表される光感受性物質は,光感受性のみならず放射線感受性を有することがしられている.5-アミノレブリン酸(ALA)は,悪性神経膠腫の術中蛍光診断薬として利用されている.近年,この5-ALAと放射線治療を組み合わせた治療の研究が進んでいる.5-ALAは,腫瘍細胞においてヘム代謝の過程で,ミトコンドリ …

    Nippon Laser Igakkaishi 41(4), 343-347, 2021

    J-STAGE 

  • Sonodynamic Therapy Using Transcranial Focused Ultrasound for Malignant Gliomas  [in Japanese]

    Kobayashi Hiroyuki

    <p>悪性神経膠腫は予後不良な原発性脳腫瘍である.本疾患の治療では外科的摘出率が予後を大きく左右するが,それは裏を返せば後療法に十分な腫瘍制御効果が無いことを意味している.つまり既存の治療とは全く異なる考え方,手法の開発が必須である.その中で個性的な存在を示してきたのが光線力学療法(photodynamic therapy: PDT)で,当科においても5-aminolevulinic …

    Nippon Laser Igakkaishi 41(4), 308-317, 2021

    J-STAGE 

  • Benefits and Problems of Photodynamic Diagnosis in Brain Tumor Treatment  [in Japanese]

    Nitta Masayuki , Muragaki Yoshihiro

    <p>正確かつ安全に悪性神経膠腫を最大限に摘出することは容易ではなく,(5-aminolevulinic acid: 5-ALA)を用いた光線力学的診断(Photodynamic diagnosis: PDD)を始め多くのモダリティが応用される.5-ALAは腫瘍内に選択的に集積し,その代謝産物である(Protoporphyrin IX: PpIX)の蛍光によって,腫瘍の存在を非常に簡便 …

    Nippon Laser Igakkaishi 41(4), 336-342, 2021

    J-STAGE 

  • A Case of Anti-LGI1 Encephalitis Developing Immunoglobulin Responsive Orthostatic Hypotension after Remission

    Orimo Kenta , Iwata Nobue K , Kawai Mizuho , Nakajima Hideki , Takeda Katsuhiko , Murai Hiroyuki , Goto Jun

    … <p>Anti-leucine-rich glioma-inactivated 1 (LGI1) antibody is associated with limbic encephalitis. …

    Internal Medicine, 2021

    J-STAGE 

  • Isolation and characterization of cancer stem cells derived from human glioblastoma

    , , , , , ,

    … U-251MGSC1 cells will be a good tool to develop effective therapeutic agents against CSCs and to elucidate the properties of glioma derived CSCs and the mechanism of tumor development in brain. …

    American Journal of Cancer Research 11(2), 441-457, 2021

    IR 

  • Effect of Epirubicin Against Glioma Initiating Cells

    NAKAJIMA Atsushi , SAMPETREAN Oltea , KOIKE Naoyoshi , NITTA Masayuki , KAWAMATA Takakazu , SAYA Hideyuki , MURAGAKI Yoshihiro

    Tokyo Women's Medical University Journal (4), 69-76, 2020-12-25

    IR 

  • A case of acquired esotropia with acute onset developed by diffuse midline glioma  [in Japanese]

    坂井 翔太 , 小澤 憲司 , 犬塚 将之 , 矢ヶ﨑 礼香 , 矢野 大仁 , 大江 直行 , 安江 志保 , 遠渡 沙緒理 , 小関 道夫 , 望月 清文

    眼科 62(13), 1481-1487, 2020-12

    Ichushi Web 

  • Self-assembling A6K peptide nanotubes as a mercaptoundecahydrododecaborate (BSH) delivery system for boron neutron capture t (BNCT)

    Michiue Hiroyuki , Kitamatsu Mizuki , Fukunaga Asami , Tsuboi Nobushige , Fujimura Atsushi , Matsushita Hiroaki , Igawa Kazuyo , Kasai Tomonari , Kondo Natsuko , Matsui Hideki , Furuya Shuichi

    … BSH has been used to treat malignant glioma patients in clinical trials and its drug safety and availability have been confirmed; … Microscopy observation showed intracellular localization of A6K/BSH in the perinuclear region and endosome in human glioma cells. … Neutron irradiation of glioma cells treated with A6K/BSH showed the inhibition of cell proliferation in a colony formation assay. …

    Journal of Controlled Release (330), 788-196, 2020-11-11

    IR 

  • Current management of optic pathway glioma in children  [in Japanese]

    柳澤 隆昭

    眼科 62(10), 961-969, 2020-10

    Ichushi Web 

  • Autoimmune encephalitis : Update on the clinical features and the management of patients  [in Japanese]

    原 誠 , 中嶋 秀人

    臨床免疫・アレルギー科 = Clinical immunology & allergology 74(4), 364-372, 2020-10

    Ichushi Web 

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