Search Results 1-20 of 235

  • Protective role of podocyte autophagy against glomerular endothelial dysfunction in diabetes.

    YOSHIBAYASHI Mamoru , KUME Shinji , YASUDA-YAMAHARA Mako , YAMAHARA Kosuke , TAKEDA Naoko , OSAWA Norihisa , Chin-Kanasaki Masami , Nakae Yuki , YOKOI Hideki , MUKOYAMA Masashi , ASANUMA Katsuhiko , MAEGAWA Hiroshi , ARAKI Shin-ichi

    … To examine the cell-protective role of podocyte autophagy against glomerular endothelial dysfunction in diabetes, we analyzed the renal phenotype of tamoxifen (TM)-inducible podocyte-specific Atg5-deficient (iPodo-Atg5-/-) mice with experimental endothelial dysfunction. …

    Biochemical and biophysical research communications 525(2), 319-325, 2020-04-30

    IR 

  • Spontaneous membranoproliferative glomerulonephritis in a young Crl:CD-1(ICR) mouse

    TOCHITANI Tomoaki , KOUCHI Mami , FUJI Yuta , YOSHINO Yuka , MATSUMOTO Izumi

    … Histologically, the kidneys showed diffuse, bilateral glomerular lesions. … The lesions were characterized by thickening and double contour of the basement membrane and an increase in mesangial cells and matrix, resulting in the narrowing of the capillary lumen. …

    Journal of Toxicologic Pathology, 2020

    J-STAGE 

  • Serum Indoxyl Sulfate as a Potential Independent Biomarker of Arterial Stiffness in Patients with Coronary Artery Disease  [in Japanese]

    Lin Tsung-Jen , Hsu Bang-Gee , Wang Ji-Hung , Lai Yu-Hsien , Liu Chin-Hung

    … <p>Indoxyl sulfate (IS) is a low molecular weight metabolite and a uremic toxin which induces oxidative stress in myocardial, vascular smooth muscle cells, vascular endothelial cells and also involves in cardiovascular (CV) diseases. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-P-317, 2020

    J-STAGE 

  • BMP4 regulates both podocyte injury and mesangial expansion in the diabetic nephropathy  [in Japanese]

    藤田 結衣 , 冨永 辰也 , 寒川 裕未 , 長井 幸二郎 , 安部 秀斉 , 土井 俊夫

    … Podocyte injury and loss have been indicated as constituting the crucial pathogenesis of glomerular injury ; … In the glomerulus, three kinds of cells (endothelial, mesangial, and parietal epithelial) react to podocyte injury. … Endothelial and mesangial cells are connected with podocyte cells across the glomerular basement membrane. …

    四国医学雑誌 = Shikoku acta medica 75(1・2), 55-62, 2019-04-25

    IR  Ichushi Web 

  • Proteomic Analysis Reveals the Renoprotective Effect of <i>Tribulus terrestris</i> against Obesity-Related Glomerulopathy in Rats

    Jiang Yue-Hua , Jiang Ling-Yu , Wu Sai , Jiang Wen-Jun , Xie Lifang , Li Wei , Yang Chuan-Hua

    … against oxidized-low density lipoprotein (ox-LDL) induced human renal glomerular endothelial cells (HRGECs) was 4 mg/L. …

    Biological and Pharmaceutical Bulletin 41(9), 1430-1439, 2018

    J-STAGE  Ichushi Web 

  • A case of focal segmental glomerulosclerosis inferred by bevacizumab  [in Japanese]

    Hisatomi Ryutaro , Fujimaru Rika , Ueda Hiroaki , Hara Junichi

    … <p>Bevacizumab (BV) はvascular endothelial growth factor (VEGF)に対するモノクローナル抗体で,血管新生を阻害して抗腫瘍効果を発揮する分子標的薬である。 …

    Nihon Shoni Jinzobyo Gakkai Zasshi 31(1), 57-62, 2018

    J-STAGE  Ichushi Web 

  • The relationships among hyperuricemia, body mass index and impaired renal function in type 2 diabetic patients

    Li Yongmei , Fan Xing , Li Chunjun , Zhi Xinyue , Peng Liyuan , Han Hongling , Sun Bei

    … experiments indicate that reactive oxygen species (ROS) production increased with UA treatment in human renal glomerular endothelial cells (HRGECs), while endothelial nitric oxide synthase (eNOS) production level dropped. … Taken together, our results indicate that high concentrations of UA lead to endothelial dysfunction through the activation of the inflammatory response and induction of oxidative stress, even in non-obese T2DM patients.</p> …

    Endocrine Journal 65(3), 281-290, 2018

    J-STAGE  Ichushi Web 

  • Nitrite Activates 5′AMP-Activated Protein Kinase-Endothelial Nitric Oxide Synthase Pathway in Human Glomerular Endothelial Cells

    Miyamoto Licht , Ikeda Yasumasa , Tamaki Toshiaki , Tsuchiya Koichiro , Yamane Megumi , Tomida Yosuke , Kono Mai , Yamaoka Tomomi , Kawasaki Aya , Hatano Aya , Tsuda Katsunori , Xu Wenting

    … We investigated effects of nitrite on endothelial NO synthase (eNOS) using human glomerular endothelial cells to reveal potential glomerular-protective actions of nitrites with its underlying molecular mechanism. … Thus, nitrites should facilitate AMPK–eNOS pathway in an energy level-dependent manner in endothelial cells. …

    Biological and Pharmaceutical Bulletin 40(11), 1866-1872, 2017

    J-STAGE  Ichushi Web 

  • Cell biology of diabetic nephropathy: Roles of endothelial cells, tubulointerstitial cells and podocytes

    MAEZAWA Yoshiro , TAKEMOTO Minoru , YOKOTE Koutaro

    … Diabetes affects all cell types of the kidney, including endothelial cells, tubulointerstitial cells, podocytes and mesangial cells. … Glomerular endothelial damage is already present in the normoalbuminuric stage of the disease when podocyte injury starts. … Genetic targeting of mice that cause endothelial injury leads to accelerated diabetic nephropathy. …

    JOURNAL OF DIABETES INVESTIGATION 6(1), 3-15, 2015-01

    IR  Ichushi Web 

  • <b>Three-dimensional microanatomy of the pericapillary mesangial tissues in the renal glomerulus: Comparative observations in four vertebrate </b><b>classes </b>

    TAKAHASHI-IWANAGA Hiromi

    … The renal glomeruli in lower vertebrates display mesangium-like cells and matrices interposed between the capillary endothelium and the basement membrane, while those in mammals reportedly lack such interpositions except in pathological conditions. … This tissue type corresponded with extracellular matrices held in subendothelial grooves which were supported by fine endothelial projections anchored to the basement membrane. …

    Biomedical Research 36(5), 331-341, 2015

    J-STAGE  Ichushi Web 

  • Evaluation of cytochrome c in hemolytic uremic syndrome  [in Japanese]

    Tanaka Etsuko , Konomoto Takao , Imamura Hideaki , Orita Mayuko , Sakaguchi Hiromi , Nakahara Akihiko , Nunoi Hiroyuki

    要旨 溶血性尿毒症症候群(HUS)の病態形成にアポトーシスが関与する可能性が報告されている。チトクロームc はアポトーシスの指標であり急性脳症で上昇するが,HUSに合併した脳症やHUS での検討はない。我々は,腸管出血性大腸菌感染(EHEC)O-157 によるHUS に脳症を合併した症例を経験した。本症例のチトクロームc は高値であり,脳症症状に相関して推移した。過去に当科で経験したEHEC 感染 …

    Nihon Shoni Jinzobyo Gakkai Zasshi 28(1), 68-74, 2015

    J-STAGE  Ichushi Web 

  • <b>Blood pressure, renal biochemical parameters and histopathology in an original rat model of essential hypertension (SHRSP/Kpo </b><b>strain) </b>

    KATO Takashi , MIZUGUCHI Nobuyuki , ITO Akihiko

    … We lastly focused on changes in glomerular cells of SHRSP/Kpo. … PECAM-1 expression was increased in SHRSP/Kpo glomeruli, indicating the thickening of glomerular endothelial cells. …

    Biomedical Research 36(3), 169-177, 2015

    J-STAGE  Ichushi Web 

  • Glomerular Capillary and Endothelial Cell Injury is Associated with the Formation of Necrotizing and Crescentic Lesions in Crescentic Glomerulonephritis

    Fujita Emiko , Tsuruoka Shuichi , Nagahama Kiyotaka , Shimizu Akira , Aoki Michiko , Higo Seiichiro , Yasuda Fumihiko , Mii Akiko , Fukui Megumi , Kaneko Tomohiro

    … <b>Background: </b>The associations of glomerular capillary and endothelial injury with the formation of necrotizing and crescentic lesions in cases of crescentic glomerulonephritis (GN) have not been evaluated in detail. …

    Journal of Nippon Medical School 82(1), 27-35, 2015

    J-STAGE  Ichushi Web 

  • Exacerbation of diabetic renal alterations in mice lacking vasohibin-1

    Hinamoto Norikazu , Maeshima Yohei , Yamasaki Hiroko , Nasu Tatsuyo , Saito Daisuke , Watatani Hiroyuki , Ujike Haruyo , Tanabe Katsuyuki , Masuda Kana , Arata Yuka , Sugiyama Hitoshi , Sato Yasufumi , Makino Hirofumi

    … Vasohibin-1 (VASH1) is a unique endogenous inhibitor of angiogenesis that is induced in endothelial cells by pro-angiogenic factors. … In the diabetic VASH1(+/-) mice, albuminuria were significantly exacerbated compared with the diabetic wild-type littermates, in association with the dysregulated distribution of glomerular slit diaphragm related proteins, nephrin and ZO-1, glomerular basement membrane thickening and reduction of slit diaphragm density. …

    Plos One 9(9), e107934, 2014-09-25

    IR 

  • Renal Distribution of Vasohibin-1 in Patients with Chronic Kidney Disease

    Hinamoto Norikazu , Maeshima Yohei , Saito Daisuke , Yamasaki Hiroko , Tanabe Katsuyuki , Nasu Tatsuyo , Watatani Hiroyuki , Ujike Haruyo , Kinomura Masaru , Sugiyama Hitoshi , Sonoda Hikaru , Kanomata Naoki , Sato Yasufumi , Makino Hirofumi

    … VASH-1 was observed in renal endothelial/mesangial cells, crescentic lesions and interstitial inflammatory cells. …

    Acta Medica Okayama 68(4), 219-233, 2014-08

    IR  DOI  Ichushi Web 

  • Pathology of Cyanotic Nephropathy  [in Japanese]

    Honda Kazuho , Oda Hideaki , Nishikawa Toshio

    チアノーゼ腎症(cyanotic nephropathy: CN)は、チアノーゼ型先天性心疾患(cyanotic congenital heart disease: CCHD)に合併する腎障害である。一般にCNの臨床症状は軽いが、ネフローゼ症候群を合併したり腎不全に進行したりする症例が稀に存在する。CNの腎糸球体形態変化は極めて顕著で、その発症機序に対する関心が高い。その特徴的な病理変化は、糸球体 …

    Journal of Tokyo Women's Medical College 84(臨増2), E237-243, 2014-03

    IR  Ichushi Web 

  • A Decrease in Glomerular Endothelial Cells and Endothelial-mesenchymal Transition during Glomerulosclerosis in the <i>Tensin2</i>-deficient Mice (ICGN strain)

    Kato Takashi , Mizuno Shinya , Ito Akihiko

    … In general, glomerular endothelial cells (ECs) function as a barrier through tight attachment of glomerular basement membrane to podocytes, while decreased ECs can worsen renal failure. … Nevertheless, it is still unknown whether glomerular ECs are altered under the tensin-2-deficient states during the manifestation of chronic renal failure. …

    ACTA HISTOCHEMICA ET CYTOCHEMICA 47(6), 265-271, 2014

    J-STAGE 

  • A Novel Transgenic Mouse Model Carrying Human Tribbles Related Protein 3 (TRB3) Gene and Its Site Specific Phenotype

    Sakai Yuto , Fukamachi Katsumi , Futakuchi Mitsuru , Miyoshi Ichiro , Tsuda Hiroyuki , Suzui Masumi , Hayashi Hidetoshi

    … In our recent study, an introduction of human TRB3 gene into mouse mammary tumor cells caused an increase of proliferation of tumor cells and their nuclear size. … Expression of this protein was also seen in lymphocytes in the spleen, glomerular endothelial cells, and epithelial cells of collecting duct of the kidney. …

    Biological and Pharmaceutical Bulletin 37(6), 1068-1074, 2014

    J-STAGE  Ichushi Web 

  • Regeneration of Injured Renal Tubules

    Yoshida Makoto , Honma Shigeyoshi

    … Acute kidney injury (AKI), clinically defined by high serum creatinine and low urine flow, has many complicated pathophysiological features including tubular and glomerular injury. … Although renal tubules are thought to be constituted by highly differentiated epithelial cells, it is possible to repair injured nephrons by the healing process. …

    Journal of Pharmacological Sciences 124(2), 117-122, 2014

    J-STAGE  Ichushi Web 

  • Expression of Toll-Like Receptor 4 in Glomerular Endothelial Cells under Diabetic Conditions

    Takata Shunsuke , Sawa Yoshihiko , Uchiyama Takanobu , Ishikawa Hiroyuki

    … Diabetic conditions promote glomerulosclerosis by mesangial cells but the mechanisms are not fully elucidated. … The present study evaluated the expression of toll-like receptor 4 in glomerular endothelial cells in the streptozotocin (STZ)-induced type 1 diabetic mouse (ICR-STZ) and the type 2 diabetic KK/TaJcl mouse which were fed a high fat diet feed (KK/Ta-HF). …

    ACTA HISTOCHEMICA ET CYTOCHEMICA 46(1), 35-42, 2013

    J-STAGE  Ichushi Web 

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