Search Results 1-20 of 1921

  • In Vitro Studies to Define the Cell-Surface and Intracellular Targets of Polyarginine-Conjugated Sodium Borocaptate as a Potential Delivery Agent for Boron Neutron Capture Therapy

    Fujimura Atsushi , Yasui Seiji , Igawa Kazuyo , Ueda Ai , Watanabe Kaori , Hanafusa Tadashi , Ichikawa Yasuaki , Yoshihashi Sachiko , Tsuchida Kazuki , Kamiya Atsunori , Furuya Shuichi

    … Boron neutron capture therapy (BNCT) requires pharmaceutical innovations and molecular-based evidence of effectiveness to become a standard cancer therapeutic in the future. … Recently, in Japan, 4-borono-L-phenylalanine (BPA) was approved as a boron agent for BNCT against head and neck (H&N) cancers. … However, in other types of cancer including malignant brain tumors, LAT1 is not always highly expressed. …

    Cells 9(10), 2149, 2020-09-23


  • Selective inhibition of PI3K110α as a novel therapeutic strategy for cetuximab‑resistant oral squamous cell carcinoma

    Tsuchihashi Hiroki , Naruse Tomofumi , Yanamoto Souichi , Okuyama Kohei , Furukawa Kohei , Omori Keisuke , Umeda Masahiro

    … High expression of the 110 kDa catalytic subunit of the class IA PI3K (PI3Kp110α) may play an important role in cetuximab resistance exhibited by both colorectal cancer and head and neck squamous cell carcinoma. …

    Oncology Reports 44(3), 863-872, 2020-07-07


  • Secondary Reconstruction for Functional and Aesthetic Improvement After Resection of Head and Neck Tumors  [in Japanese]

    田中 顕太郎 , 岡崎 睦

    形成外科 63(7), 815-826, 2020-07

    Ichushi Web 

  • Oncolytic effect of Midkine promoter-based conditionally replicating adenoviruses expressing EGFR siRNA in head and neck squamous cancer cell line T891

    Uehara Natsumi , Otsuki Naoki , Kubo Mie , Kitamoto Junko , Kojima Yasutaka , Teshima Masanori , Shinomiya Hirotaka , Shirakawa Toshiro , Nibu Ken-ichi

    … Background Epidermal growth factor receptor (EGFR) is overexpressed in head and neck squamous cell carcinomas (HNSCCs). … Midkine expression is restricted in adult tissues but is increased in several malignant tumors, including HNSCCs. … Methods and results A conditionally replicative adenovirus vector controlled by the Midkine promoter, Ad-MK-siEGFR, was generated by integrating gene-expressing siRNA against EGFR. …

    Cancer Reports 3(3), e1231, 2020-06


  • Sinusitis and Neuro-Ophthalmology  [in Japanese]

    Takeda Teppei , Otori Nobuyoshi

    … The paranasal sinuses and orbits are adjacent to each other, separated by the orbital plate. … Inflammation, cystic lesions, and tumors in the sinuses can spread to the orbit and cause orbital symptoms, including impaired eye movement and visual impairment, which can be serious at times. …

    Neuro-Ophthalmology Japan 37(4), 387-393, 2020


  • Epithelial-myoepithelial Carcinoma Arising from the Nasal Cavity Resected by an Endoscopic Approach  [in Japanese]

    Sato Kiminobu , Mihashi Hiroyuki , Umeno Hirohito

    … <p>Epithelial-myoepithelial carcinoma (EMC) is relatively rare among salivary gland tumors, and extremely rare in the nasal cavity. … Computed tomography and magnetic resonance imaging revealed a tumor in the left nasal cavity. … The biopsy specimen was hisotologically diagnosed as EMC and a tumor resection was performed by an endoscopic approach. …

    Nihon Bika Gakkai Kaishi (Japanese Journal of Rhinology) 59(4), 390-397, 2020


  • Development of chemotherapy for head and neck cancer, and current status of treatment strategy in clinical practice  [in Japanese]

    Honma Yoshitaka

    Head and neck cancer is a general term for tumors that have multiple origins and various histological types. … The chemotherapy regimen varies depending on the histological type, and a different treatment strategy is sometimes required by site of occurrence even if the histological type is the same. …

    Journal of Japanese Society of Oral Oncology 32(4), 130-133, 2020


  • A Case of Inflammatory Pseudotumor of the Cheek  [in Japanese]

    Hirata Tomoya , Ishinaga Hajime , Takeuchi Kazuhiko

    … Clinically, these tumors often show neoplastic growth, and it is difficult to differentiate them from neoplastic lesions by imaging findings alone. … Inflammatory pseudotumors have been found to occur at various sites, but are rarely found in the head and neck region. … Although surgical excision and steroid therapy are effective, no evidence has been established yet. …

    Practica Oto-Rhino-Laryngologica 113(12), 775-780, 2020


  • Juvenile angiofibroma that could have been removed by endoscopic sinus surgery  [in Japanese]

    Oyake Koichiro , Shoji Naruo , Takeda Yuki , Takiguchi Shuhei , Nogaki Taketoshi , Hinohira Yasuyuki , Kobayashi Hitome , Kobayashi Sei

    … The primary symptoms of JA are nasal obstruction and recurrent nasal bleeding. … JA grows osteoclastically and invasively. … Thus, depending on the direction of progress of JA, some cases may require treatment approaches based on complete extraction, which are usually used for malignant tumors. …



  • A study diagnostic value of dynamic study by contrast-enhanced MRI for parotid tumor  [in Japanese]

    Takano Tomonari , Yasuhara Kazuo , Mukai Toshiyuki , Sahara Toshihito , Teramura Atsumu

    … We examined the usefulness of dynamic study by contrast-enhanced MRI, and the contribution of dynamic study in addition to fine needle aspiration cytology (FNAC) to the accuracy of preoperative diagnosis of parotid tumors. … We retrospectively reviewed 61 patients with parotid gland surgery who underwent FNAC and contrast-enhanced MRI before surgery. … In the evaluation of the dynamic study, a time-signal intensity curve (TSI curve) was calculated and evaluated. …



  • A clinical study of sinonasal teratocarcinosarcoma: Report of four cases  [in Japanese]

    Shimmi Rie , Sakurai Daiju , Ohki Yuji , Iinuma Tomohisa , Yamasaki Kazuki , Hanazawa Toyoyuki

    … Teratocarcinosarcoma is a highly aggressive rare tumor that develops in the nasal cavity and paranasal sinuses. … It is difficult to diagnose as teratocarcinosarcoma because of the large variety of presentations and histological characteristics. … The number of reports is still small, and a standardized treatment has yet to be established. … The ages ranged from 49 to 77 years (mean, 65 years) with one male and three females. …

    Toukeibu Gan 46(3), 311-316, 2020


  • ADC histogram analysis of MR imaging in the different diagnosis between benign and malignant tumors in the parapharyngeal space  [in Japanese]

    Kunimatsu Natsuko , Tanaka Jumpei , Kitajima Tatsuya , Kunimatsu Akira , Miura Koki , Tada Yuichiro , Masubuchi Tatsuo , Fushimi Chihiro , Okada Takuro , Baba Daisuke , Kitani Yosuke , Yamazaki Morio

    … We sought to elucidate the differences between benign and malignant tumors in the parapharyngeal space by apparent diffusion coefficient (ADC) histogram analyses retrospectively.<br>Our study included 7 patients (3 patients with malignant tumors and 4 patients with benign tumors) in the parapharyngeal space for whom preoperative ADC images were obtained by MRI. …

    Toukeibu Gan 46(3), 248-253, 2020


  • Proposal for classification of surgery of parotid cancer  [in Japanese]

    Kawata Ryo , Higashino Masaaki , Nishikawa Shuji , Terada Tetsuya

    … The important operative procedure for parotid tumor is to remove the tumor completely and handle the facial nerve appropriately. … There have been no reports on the types of surgery for parotid tumors, especially parotid cancer. …

    Toukeibu Gan 46(3), 270-273, 2020


  • A case of advanced carcinoma of the lower gingiva in a patient with Fanconi anemia  [in Japanese]

    SHIBATA Akinobu , YAMADA Shinichi , OHTA Ryosuke , YOKOI Kei , KONDO Eiji , KURITA Hiroshi

    … <p>Fanconi anemia is an inherited genetic disorder characterized by progressive pancytopenia, transition to myelodysplastic syndrome, acute myeloid leukemia, body malformation, and increased risk of certain solid cancers. … Among the solid tumors, there is a high incidence of squamous cell carcinoma of the head and neck. …

    Japanese Journal of Oral and Maxillofacial Surgery 66(8), 360-365, 2020

    J-STAGE  Ichushi Web 

  • Quantitative Evaluation of the Nasopalatine Duct Using CT Texture Analysis: A Comparison of the Normal Nasopalatine Duct with Nasopalatine Duct Cysts  [in Japanese]

    Ito Kotaro , Muraoka Hirotaka , Hirahara Naohisa , Tokunaga Satoshi , Sawada Eri , Kaneda Takashi

    … <b>Purposes</b>: This study aimed to quantitatively evaluate the nasopalatine duct (NPD) and nasopalatine duct cysts (NPDC) using CT texture analysis.<br><b>Materials and Methods</b>: This IRB-approved retrospective study included 31 NPDC patients (21 males, 10 females; … mean age: 44.2, range: 22-83) and 31 age- and sex-matched patients with normal NPD (21 males, 10 females; …

    Shika Hoshasen 60(1), 5-11, 2020


  • Efficacy of Concurrent Intra-arterial Chemotherapy and Radiotherapy for Late-stage Squamous Cell Carcinoma of the Temporal Bone  [in Japanese]

    Sugimoto Hisashi , Hatano Miyako , Yoshizaki Tomokazu

    … Advanced squamous cell carcinoma (SCC) of the temporal bone carries a poor prognosis because of its location in the cranial base and proximity to the great vessels, which pose anatomical barriers to en-bloc resection with an adequate safety margin. … In addition, tumors that invade bone are also known to be resistant to radiotherapy. … We analyzed the disease-free survival, adverse events, and cisplatin dosage in 14 patients who received intra-arterial chemotherapy combined with radiotherapy. …

    Nippon Jibiinkoka Gakkai Kaiho 123(9), 1168-1174, 2020


  • Intraparotid facial nerve schwannoma: A cross-country report of two cases and literature review

    Iriskulova Elmira , Honda Michitaka , Liudchyk Tatiana , Kholtoev Ulugbek , Ganiev Abduavaz , Abdikhakimov Abdulla , Egamberdiev Salim , Khodjibekova Yulduz , Mamarajabov Sobirjon , Sakamoto Junichi

    … We herein report two cases of intraparotid FNS and highlight the diagnostic and surgical approach. … The patient underwent tumor removal without parotidectomy via binocular magnification and a diode laser. … Microsurgical and diode laser approaches in the management of intraparotid FNS resulted in a better overall facial nerve function without recurrence. …

    Annals of Cancer Research and Therapy 28(2), 93-96, 2020


  • Optimization of Both the Diagnosis and Therapeutic Strategy Using Panel Testing for a Case of Pleural Metastasis of Sinus Carcinoma  [in Japanese]

    Ando Takahiro , Miyazaki Yasunari , Nishiyama Naoki , Honda Takayuki , Kirimura Susumu , Sakakibara Rie , Mitsumura Takahiro , Tohyama Kohki , Kano Yoshihito , Ikeda Sadakatsu

    … </i></b>A 51-year-old man underwent total right sinus resection, reconstruction and adjuvant chemoradiotherapy for his right sinus squamous cell carcinoma (cT4N1M0 stage IV). … A pathological review of the left pleura specimens obtained by thoracoscopy suggested malignant mesothelioma and he was therefore transferred to our hospital. …

    Haigan 60(4), 364-370, 2020


  • Rehabilitation for Dysphagia  [in Japanese]

    Oshima Fumiko , Fujiu-Kurachi Masako , Fujishima Ichiro

    … Dysphagia is caused by primary diseases, such as cerebrovascular diseases and neurodegenerative diseases, as well as head and neck tumors. … In addition, disuse muscle atrophy and sarcopenia may cause swallowing disturbances. … However, rehabilitation deals with disorders, thus, it needs to performed comprehensively in context with the patient's ability, activity, and environment. …

    Koutou (THE LARYNX JAPAN) 32(01), 20-28, 2020

    J-STAGE  Ichushi Web 

  • A Case of Masticatory Muscle Tendon Aponeurosis Hyperplasia with Severe Opening Disorder at Laryngeal Microsurgery  [in Japanese]

    Suzuki Eisuke , Higashino Masaaki , Taniuchi Masataka , Suzuki Norio , Kawata Ryo

    … <p>We experienced a case in which laryngeal deployment was difficult due to an unexpected opening disorder during laryngeal microsurgery for laryngeal tumors. … The patient was a 39-year-old man, and the jaws were preoperatively examined. … After intravenous anesthesia with no history of arthropathy and no dental damage, opening obstruction was noted, but we were still able to perform intubation using a McGRATH<sup>®</sup> …

    Koutou (THE LARYNX JAPAN) 32(01), 58-62, 2020

    J-STAGE  Ichushi Web 

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