Search Results 1-20 of 6848

  • Novel method for rapid and accurate diagnosis of heparin-induced thrombocytopenia  [in Japanese]

    半下石 明

    血液内科 = Hematology 82(1), 97-103, 2021-01

  • Management of a COVID-19 Patient during ECMO: Paying Attention to Acquired von Willebrand Syndrome

    Hayakawa Masaki , Takano Keisuke , Kayashima Michinori , Kasahara Kei , Fukushima Hidetada , Matsumoto Masanori

    … Anticoagulation such as heparin is essential for COVID-19 patients on ECMO; … however, bleeding might be caused by not only heparin, but also acquired von Willebrand syndrome (AVWS). … The patient was successfully treated with cryoprecipitate in bleeding during ECMO without a reduction in heparin, which might have induced thromboembolism. … In such cases, physicians should think of AVWS in addition to the side effect of heparin and DIC.</p> …

    Journal of Atherosclerosis and Thrombosis 28(4), 396-401, 2021

    J-STAGE 

  • A successful case of postoperative evaluation for digital circulatory failure in secondary reconstruction of amputated finger by using the fish-mouth incision  [in Japanese]

    Okino Takahide , Miyabe Kenta , Sato Nobuhiro , Kadomatsu Kouichi , Ohkubo Fumio

    指尖部に対するfish-mouth incisionは,切断指再接着術後の鬱血予防法の一つであるが,指動脈の開存状態の評価にも有用であるとの報告もある.本症例はプレス機で受傷した右示指,中指完全切断で,玉井分類zoneⅢであった.再接着し得たが,指神経は縫合困難であった.腓腹神経を用いた二次再建施行時,空気止血帯の使用や手術操作による指動脈攣縮による一時的な示指の血流不全を認めた.手術直後に,fi …

    Journal of The Showa University Society 81(1), 47-52, 2021

    J-STAGE 

  • Lipoprotein Profiles before Heparin Administration in Patients with or without Coronary Thrombosis Following Atherosclerosis

    Koizumi Tomomi , Kaneda Hideaki , Komiyama Nobuyuki , Inoue Ikuo , Muramatsu Toshihiro , Nakajima Katsuyuki

    … The correlation between lipoproteins and arterial thrombosis is not fully elucidated, and no data exist in terms of lipoprotein profiles before heparin administration in patients with coronary arterial thrombosis (CAT). … This cross-sectional study aimed to evaluate the lipoprotein profile before heparin administration in 63 ST-segment elevation myocardial infarction (STEMI) patients with CAT.</p><p><b>Methods:</b> …

    Annals of Vascular Diseases 14(1), 31-38, 2021

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  • Delayed recurrent posterior circulation infarction after C1-C2 posterior fusion treated with endovascular parent artery occlusion: a case report  [in Japanese]

    Hirayama Takuro , Yoshimura Shunsuke , Miyazaki Teiichiro , Shiraishi Hirokazu , Iki Yusuke , Morofuji Yoichi , Horie Nobutaka , Izumo Tsuyoshi , Tsujino Akira , Tateishi Yohei , Kanamoto Tadashi , Yamashita Kairi , Tsujino Shuhei , Fukushima Kaori , Shima Tomoaki , Ohta Rie , Nagaoka Atsushi

    <p><b>要旨</b>:症例は79歳男性.8カ月前に C1-C2 後方固定術が施行された.突然の構音障害で発症し,昏睡となり,当院へ搬送された.頭部MRIで後方循環系の多発脳梗塞を認めたが,アルテプラーゼ静注療法後に症状は改善した.CT angiography で右椎骨動脈がV3レベルでスクリューと接していた.アスピリンとクロピドグレルによる抗血小板薬2剤併用 …

    Japanese Journal of Stroke 43(2), 153-157, 2021

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  • Mast Cell-derived Granular Complex: A Naturally-generated Delivery System with the Aid of Carbohydrates  [in Japanese]

    Higashi Nobuaki

    <p>マスト細胞はその巨大な細胞内分泌顆粒によって特徴づけられるが、この顆粒内にはグリコサミノグリカン、すなわちヘパリンや高硫酸化コンドロイチンが大量に蓄積されている。顆粒複合体は一種のタンパク質–高分子電解質複合体であり、グリコサミノグリカン、プロテアーゼ、生理活性アミンや他の様々なメディエータから構成されている。近年の知見から、マスト細胞から放出された後の顆粒複合体の運命が多様であ …

    Trends in Glycoscience and Glycotechnology 33(192), J27-J32, 2021

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  • Mast Cell-derived Granular Complex: A Naturally-generated Delivery System with the Aid of Carbohydrates

    Higashi Nobuaki

    … <p>Mast cells are characterized by large, intracellular secretory granules that accumulate large amounts of glycosaminoglycans, heparin and highly sulfated chondroitin depending on the mast cell type. … The choice of fate is greatly influenced by carbohydrates in the granular complex, especially by processed heparin <i>via</i> …

    Trends in Glycoscience and Glycotechnology 33(192), E27-E32, 2021

    J-STAGE 

  • A case of cancer of the floor of the mouth with Trousseau syndrome  [in Japanese]

    INOUE Yutaka , FUKUZAWA Satoshi , YAMAGATA Kenji , TERADA Kazuhiro , UCHIDA Fumihiko , BUKAWA Hiroki

    … Based on the diagnosis of Trousseau syndrome, continuous intravenous administration of heparin was performed. … At the end of the palliative irradiation for lumbar vertebrae, bleeding from the primary cancer occurred and heparin had to be discontinued. …

    Japanese Journal of Oral and Maxillofacial Surgery 67(1), 29-34, 2021

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  • Exploratory studies on novel therapeutic targets for intraocular vascular lesions  [in Japanese]

    Hara Hideaki , Nakamura Shinsuke

    … In this symposium, as a part of the exploratory research conducted in our laboratory, the findings on heparin binding-epidermal growth factor-like growth factor (HB-EGF), Apo-E and adiponectin will be introduced. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 3-S26-2, 2021

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  • The alteration of molecular properties in plasma extracellular vesicles from spontaneously hypertensive rats  [in Japanese]

    Otani Kosuke , Okada Muneyoshi , Yamawaki Hideyuki

    … [Methods] Male Wistar Kyoto rats (WKY) and SHR at 5-7-week-old were used for collecting heparin-anticoagulated plasma and organs. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 2-Y-E3-2, 2021

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  • Maintenance of mouse trophoblast stem cells in KSR-based medium allows conventional 3D culture

    SUN Shuai , YANO Shota , NAKANISHI Momo O , HIROSE Michiko , NAKABAYASHI Kazuhiko , HATA Kenichiro , OGURA Atsuo , TANAKA Satoshi

    … Under conventional culture conditions, in a medium supplemented with 20% fetal bovine serum (FBS), fibroblast growth factor 4 (FGF4), and heparin and in the presence of mouse embryonic fibroblast cells (MEFs) as feeder cells, TSCs maintain their undifferentiated, proliferative status. …

    Journal of Reproduction and Development, 2021

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  • Challenges in the Management of Cardiopulmonary Bypass Using Argatroban in a Patient With Heparin-induced Thrombocytopenia: A Case Report  [in Japanese]

    OTA Yusuke , NAGAHASHI Kiwamu , KOJIMA Yasuhiro , UEHARA Hirokazu

    72歳,女性。大動脈弁狭窄症による心不全のため大動脈弁置換術を予定していたが,血小板減少を認めヘパリン起因性血小板減少症Ⅱ型と診断された。手術の延期が考慮されたが,循環動態が不安定であったため予定通り大動脈弁置換術を施行した。<br> 手術開始時にアルガトロバンを4μg/kg/minで持続静注を開始し,人工心肺開始時にメシル酸ナファモスタットを30mg/hで開始した。活性化凝固時間の推 …

    JOURNAL OF THE JAPANESE ASSOCIATION OF RURAL MEDICINE 69(5), 530-534, 2021

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  • A Case of Two Times Parturition by Caesarean Section after Stent-assisted Coil Embolization for the Ruptured Basilar Trunk Artery Aneurysm  [in Japanese]

    KATO Naoki , IZUMI Takashi , NISHIHORI Masahiro , TSUKADA Tetsuya , ARAKI Yoshio , YOKOYAMA Kinya , UDA Kenji , MATSUBARA Noriaki , KOKETSU Naoki

    <p>【目的】ステント留置後妊娠において,抗血栓療法に関する明確な基準は認めない.われわれは破裂大型脳底動脈瘤に対してステント支援コイル塞栓術を施行し,2 度の出産を経験した症例を報告する.【症例】27 歳女性.脳底動脈瘤破裂によるくも膜下出血を発症し,ステント支援コイル塞栓術を施行した.33 歳時に体外受精にて妊娠した.抗血小板剤は治療 3 年後に中止となっていたが,妊娠時の過凝固を …

    No Kekkannai Chiryo, 2021

    J-STAGE 

  • Prasugrel is effective for in-stent thrombosis after carotid artery stenting  [in Japanese]

    Takahara Masaki , Fukuda Kenji , Kouzaki Takamichi , Yoshinaga Shintaro , Horio Yoshinobu , Iwaasa Mitsutoshi , Inoue Tooru

    <p><b>要旨</b>:70歳男性.1年前に症候性左内頸動脈狭窄症に対して頸動脈内膜剝離術を施行されたが,再狭窄を認め,頸動脈ステント留置術を行う方針とした.クロピドグレル 75 mg内服中であり,バイアスピリン 100 mgを追加した.血小板凝集能検査でcollagenの凝集能抑制が不十分であり,術当日はバイアスピリンを 200 mgに増量しステントを留置し …

    Japanese Journal of Stroke, 2021

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  • Successful Conservative Treatment of Cardiac Rupture Associated with Takotsubo Syndrome

    Mano Yoshinori , Baba Akiyasu , Sukegawa Hiroaki , Sawano Mitsuaki , Nishiyama Takafumi , Ohki Takahiro

    … therefore, we discontinued heparin treatment. …

    Internal Medicine, 2021

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  • Is Antithrombotic Drug Interruption Necessary for Cranioplasty Following Decompressive Craniectomy for Cerebral Infarction Caused by Main-trunk Occlusion?  [in Japanese]

    SASE Taigen , ONO Hajime , TANAKA Yuichiro

    Heparin was given to 3 patients who we collectively referred to as the heparin group. … Among them, 55% were in the interrupted group, while the remaining 45% of cases occurred in all of the patients in the heparin and administration groups. …

    Surgery for Cerebral Stroke 49(1), 59-63, 2021

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  • Acute infectious purpura fulminans due to <i>E. coli</i> in a hemodialysis patient  [in Japanese]

    Ito Furano , Oyama Satoko , Saito Kaiji , Hori Kenichiro , Sasaki Natsue , Tamura Hiroyuki , Tomita Kimio

    <p>【症例】81歳,女性.4年前に維持透析導入となる.透析中に呼吸困難,ショック,汎血球減少,DICをきたし,入院となる.第1病日より抗菌薬にて治療を開始した.血液培養にて大腸菌が検出された.第5病日に上下肢,鼠径,背部に辺縁に紫斑を伴う灰白色斑を認め,徐々に壊死が進行し電撃性紫斑病(purpura fulminans: PF)と診断した.第8病日にはプロテインC活性35%と低値であ …

    Nihon Toseki Igakkai Zasshi 54(1), 45-49, 2021

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  • Cardiac arrest during lung cancer surgery: A report of four cases  [in Japanese]

    Iwai Shun , Yamagata Aika , Sekimura Atsushi , Motono Nozomu , Usuda Katsuo , Uramoto Hidetaka

    <p>肺癌手術における偶発症として迷走神経反射や胸腔内温蒸留水による心機能異常は稀に認められる.しかし,術中の偶発的な心停止はその頻度,機序や患者背景などについての報告は認められない.今回,我々は術中に心臓への機械的圧迫や,破滅的な大出血を来たしていないにもかかわらず,突然心停止を来たした症例を4例経験した.1例は縦隔リンパ節郭清中に,3例は胸腔内の温蒸留水による洗浄中に心停止に至って …

    The Journal of the Japanese Association for Chest Surgery 35(1), 37-43, 2021

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  • Direct oral anticoagulant for the treatment of cancer-associated thrombosis  [in Japanese]

    大森 司

    血液内科 = Hematology 81(5), 713-718, 2020-11

    Ichushi Web 

  • COVID-19 induced coagulopathy  [in Japanese]

    朝倉 英策

    血液内科 = Hematology 81(5), 649-658, 2020-11

    Ichushi Web 

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