Search Results 1-20 of 56

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  • Drug development and safety evaluation of epigenetic drugs  [in Japanese]

    TAKI Kenji , HORII Ikuo

    … <p>For safety assessment of epigenetic drugs, indirect effects associated with changes in gene expression should be considered in addition to the direct effects of DNA methylation, demethylation and histone-modification. …

    Annual Meeting of the Japanese Society of Toxicology 47.1(0), S29-4, 2020

    J-STAGE 

  • Treatment of iron overload in myelodysplastic syndromes and other bone marrow failure syndromes  [in Japanese]

    KOBUNE Masayoshi

    … <p>Iron is essential to maintain cellular homeostasis, such as hemoglobin synthesis, mitochondrial respiratory chain formation, DNA replication, DNA demethylation, and histone demethylation. …

    Rinsho Ketsueki 61(7), 753-763, 2020

    J-STAGE  Ichushi Web 

  • JB Commentary : Epigenetic interplays between DNA demethylation and histone methylation for protecting oncogenesis

    Furuya Kanji , Ikura Masae , Ikura Tsuyoshi

    The journal of biochemistry 165(4), 297–299, 2019-04

  • Sleep and Neurochemical Modulation by DZNep and GSK-J1 : Potential Link With Histone Methylation Status

    Murillo-Rodríguez Eric , Arankowsky-Sandoval Gloria , Barros Jorge Aparecido , Rocha Nuno Barbosa , Yamamoto Tetsuya , Machado Sérgio , Budde Henning , Telles-Correia Diogo , Monteiro Diogo , Cid Luis , Veras André Barciela

    Histone methylation/demethylation plays an important modulatory role in chromatin restructuring, RNA transcription and is essential for controlling a plethora of biological processes. … Due to many human diseases have been related to histone methylation/demethylation, several compounds such as 3-deazaneplanocin A (DZNep) or 3-((6-(4,5-Dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoic acid; …

    Frontiers in Neuroscience (13), 237, 2019-03-15

    IR 

  • Lysine demethylase, KDM2B, demethylates serum response factor K165 to inhibit myogenic differentiation  [in Japanese]

    Hosouk Joung , Ju Young Kang , Sang Beom Seo , Hyun Kook

    … <p>Histone lysine demethylation, as one of the most important mediator in the regulation of transcription, is associated with a various physiological status. … KDM2B is a novel histone H3K4 and H3K36 demethylase involved in transcriptional activation. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), JKP-06, 2019

    J-STAGE 

  • Lysine-Specific Demethylase 1 (LSD1/KDM1A) Is a Novel Target Gene of c-Myc

    Nagasaka Mai , Tsuzuki Kaori , Ozeki Yu , Tokugawa Muneshige , Ohoka Nobumichi , Inoue Yasumichi , Hayashi Hidetoshi

    … <p>Lysine-specific demethylase 1 (LSD1/KDM1A) is a histone demethylase and specifically catalyzes the demethylation of mono- and di-methylated histone H3 lysine 4 (H3K4). … The LSD1-mediated demethylation of H3K4 promotes the assembly of the c-Myc-induced transcription initiation complex. …

    Biological and Pharmaceutical Bulletin 42(3), 481-488, 2019

    J-STAGE  Ichushi Web 

  • Epigenetic regulation of beige adipocyte fate by histone methylation

    Tanimura Kyoko , Suzuki Tomohiro , Vargas Diana , Shibata Hiroshi , Inagaki Takeshi

    … Among them, histone methylation is chemically stable and thus is an appropriate epigenetic mark for mediating cellular memory to induce and maintain the beige adipocyte characteristics. … The enzymes that catalyze the methylation or demethylation of H3K27 and H3K9 regulate brown adipocyte biogenesis through their catalytic activity-dependent and -independent mechanisms. …

    Endocrine Journal 66(2), 115-125, 2019

    J-STAGE  Ichushi Web 

  • Combined Loss of JMJD1A and JMJD1B Reveals Critical Roles for H3K9 Demethylation in the Maintenance of Embryonic Stem Cells and Early Embryogenesis

    Kuroki Shunsuke , Nakai Yuji , Maeda Ryo , Okashita Naoki , Akiyoshi Mika , Yamaguchi Yutaro , Kitano Satsuki , Miyachi Hitoshi , Nakato Ryuichiro , Ichiyanagi Kenji , Shirahige Katsuhiko , Kimura Hiroshi , Shinkai Yoichi , Tachibana Makoto

    Histone H3 lysine 9 (H3K9) methylation is unevenly distributed in mammalian chromosomes. … Here, we show that JMJD1A and JMJD1B preferentially target H3K9 demethylation of gene-dense regions of chromosomes, thereby establishing an H3K9 hypomethylation state in euchromatin. … These results indicate that JMJD1A/JMJD1B-meditated H3K9 demethylation has critical roles for early embryogenesis and ESC maintenance. …

    Stem Cell Reports 10(4), 1340-1354, 2018-04-10

    IR 

  • CXCR7/CXCR4 heterodimer-induced histone demethylation: a new mechanism of colorectal tumorigenesis

    Qu Xianjun , Song Zhiyu , Wang Feng , Cui Shuxiang

    … </p><p>Methods: The expression of two CXCRs, CXCR7/CXCR4 heterodimer and histone demethylase JMJD2A in human colorectal rectal cancer (CRC) tissue was detected by western blot and immunohistochemistry. … We then studied the role of the CXCR7/CXCR4 heterodimer in CRC tumorigenesis in Villin-CXCR7-CXCR4 transgenic mice and APCMin/+/villin-CXCR7-CXCR4 mice.</p><p>Results: CXCR 7 and 4 can form heterodimers in vivo and promote colorectal tumorigenesis through histone demethylation. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), PO2-10-4, 2018

    J-STAGE 

  • Rescuing the aberrant sex development of H3K9 demethylase Jmjd1a-deficient mice by modulating H3K9 methylation balance

    Kuroki Shunsuke , Okashita Naoki , Baba Shoko , Maeda Ryo , Miyawaki Shingo , Yano Masashi , Yamaguchi Miyoko , Kitano Satsuki , Miyachi Hitoshi , Itoh Akihiro , Yoshida Minoru , Tachibana Makoto

    Histone H3 lysine 9 (H3K9) methylation is a hallmark of heterochromatin. … H3K9 demethylation is crucial in mouse sex determination; …

    PLOS Genetics 13(9), e1007034, 2017-09-26

    IR 

  • An up-date on epigenetic and molecular markers in testicular germ cell tumors

    Chieffi Paolo

    … Gene expression in TGCT is regulated, at least in part, by DNA and histone modifications, and the epigenetic profile of these tumours is characterised by genome-wide demethylation. …

    Intractable & Rare Diseases Research 6(4), 319-321, 2017

    J-STAGE  Ichushi Web 

  • Epigenetic Targeted Therapy for Diffuse Intrinsic Pontine Glioma

    HASHIZUME Rintaro

    … The recent discovery of somatic oncogenic histone gene mutations affecting chromatin regulation in DIPG has dramatically improved our understanding of the disease pathogenesis in DIPG, and these findings have stimulated the development of novel therapeutic approaches targeting epigenetic regulators for disease treatment. … This review will discuss about the role of histone modification in chromatin machinery and epigenetic therapeutic strategies for the treatment of DIPG.</p> …

    Neurologia medico-chirurgica 57(7), 331-342, 2017

    J-STAGE  Ichushi Web 

  • Tumor necrosis factor-α decreases EC-SOD expression through DNA methylation

    Morisawa Shunpei , Yasuda Hiroyuki , Kamiya Tetsuro , Hara Hirokazu , Adachi Tetsuo

    … Epigenetics have been defined as mitotically heritable changes in gene expression that do not affect the DNA sequence, and include DNA methylation and histone modifications. … In DNA methylation and demethylation, cytosine is methylated to 5-methylcytosine (5mC) by DNA methyltransferase (DNMT), and 5mC is then converted to 5-hydroxymethylcytosine (5hmC) and cytosine in a stepwise manner by ten-eleven translocation methylcytosine dioxygenases (TETs). …

    Journal of Clinical Biochemistry and Nutrition 60(3), 169-175, 2017

    J-STAGE  Ichushi Web 

  • Preferential 5-Methylcytosine Oxidation in the Linker Region of Reconstituted Positioned Nucleosomes by Tet1 Protein

    Kizaki Seiichiro , Zou Tingting , Li Yue , Han Yong Woon , Suzuki Yuki , Harada Yoshie , Sugiyama Hiroshi

    … Tet (ten-eleven translocation) family proteins oxidize 5-methylcytosine (mC) to 5-hydroxymethylcytosine (hmC), 5-formylcytosine (fC), and 5-carboxycytosine (caC), and are suggested to be involved in the active DNA demethylation pathway. … In this study, we reconstituted positioned mononucleosomes using CpG-methylated 382bp DNA containing the Widom 601 sequence and recombinant histone octamer, and subjected the nucleosome to treatment with Tet1 protein. …

    Chemistry - A European Journal (22), 16598-16601, 2016-11-07

    IR 

  • Preferential demethylation of DNA cytosine on the chromosomes restricted to germ cells in the spermatocytes but not the spermatogonia in the inshore hagfish, <i>Eptatretus burgeri</i>

    Goto Yuji , Osawa Daiki , Kubota Souichirou

    … DNA methylcytosine (5mC) and histone modifications have been identified as markers of the eliminated DNA and chromatins in ciliate and finch. … an intermediate of active DNA demethylation) in the male testicular cells of the inshore hagfish <i>Eptatretus burgeri</i> …

    Chromosome Science 19(1-4), 11-18, 2016

    J-STAGE 

  • Aryl hydrocarbon receptor drives active demethylation and epigenetic memory at the Cyp1a1 promoter  [in Japanese]

    AMENYA Hesbon , TOHYAMA Chiharu , OHSAKO Seiichiroh

    … TCDD also induced a rapid Cyp1a1 promoter DNA demethylation in Ahr wild-type (Ahr<sup>+/+</sup>) but not in Ahr knockout (Ahr<sup>-/-</sup>) mice. … Increases of H3K4me3 and H4ac as well as loss of H4K20me3 accompanied the Cyp1a1 promoter demethylation. … The histone marks and DNA hypomethylation persisted to 40 days post TCDD administration, and constituted epigenetic memorization of the initial TCDD administration. …

    Annual Meeting of the Japanese Society of Toxicology 43.1(0), O-48, 2016

    J-STAGE 

  • Exendin-4 promotes extracellular-superoxide dismutase expression in A549 cells through DNA demethylation

    Yasuda Hiroyuki , Mizukami Koji , Hayashi Mutsuna , Kamiya Tetsuro , Hara Hirokazu , Adachi Tetsuo

    … It has also been suggested to affect gene expression through epigenetic regulation, such as DNA methylation and/or histone modifications. … In the present study, we demonstrated that exendin-4 induced the demethylation of DNA in A549 cells, which, in turn, affected the expression of EC-SOD. …

    Journal of Clinical Biochemistry and Nutrition 58(1), 34-39, 2016

    J-STAGE  Ichushi Web 

  • Leg regeneration is epigenetically regulated by histone H3K27 methylation in the cricket Gryllus bimaculatus

    Hamada Yoshimasa , Bando Tetsuya , Nakamura Taro , Ishimaru Yoshiyasu , Mito Taro , Noji Sumihare , Tomioka Kenji , Ohuchi Hideyo

    … To clarify the molecular basis of epigenetic regulation during regeneration, we focused on the function of the Gryllus Enhancer of zeste [Gb'E(z)] and Ubiquitously transcribed tetratricopeptide repeat gene on the X chromosome (Gb'Utx) homologues, which regulate methylation and demethylation of histone H3 lysine 27 (H3K27), respectively. … Methylated histone H3K27 in the regenerating leg was diminished by Gb'E(z)RNAi and was increased by Gb'UtxRNAi. …

    Development 142(17), 2916-2927, 2015-09

    IR 

  • Measurement of lysine-specific demethylase-1 activity in the nuclear extracts by flow-injection based time-of-flight mass spectrometry

    Sakane Chiharu , Ohta Hiromichi , Shidoji Yoshihiro

    … Lysine-specific demethylase 1 (LSD1/KDM1A), a histone-modifying enzyme, is upregulated in many cancers, especially in neuroblastoma, breast cancer and hepatoma. … We have established a simple method to measure LSD1 activity using a synthetic <i>N</i>-terminal 21-mer peptide of histone H3, which is dimethylated at Lys-4 (H3K4me2). … values of hLSD1 for the first and second demethylation reactions were found to be in the range of reported values. …

    Journal of Clinical Biochemistry and Nutrition 56(2), 123-131, 2015

    J-STAGE  Ichushi Web 

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