Search Results 1-20 of 480

  • Molecular Pathogenesis and Treatment of Myelodysplastic Syndromes

    Nakajima Hideaki

    … Recurrent mutational targets in MDS are the genes involved in RNA splicing, DNA methylation, histone modification, transcription, signal transduction, cohesin complex and DNA repair. …

    Internal Medicine 60(1), 15-23, 2021

    J-STAGE 

  • LncRNA MEG3 inhibits the progression of prostate cancer by facilitating H3K27 trimethylation of EN2 through binding to EZH2

    Zhou Yaojun , Yang Hongqiong , Xia Wei , Cui Li , Xu Renfang , Lu Hao , Xue Dong , Tian Zinong , Ding Tao , Cao Yunjie , Shi Qianqian , He Xiaozhou

    The journal of biochemistry 167(3), 295-301, 2020-03

  • Molecular mechanisms of salt-sensitive hypertension  [in Japanese]

    下澤 達雄

    日本臨床 = Japanese journal of clinical medicine 78(2), 210-214, 2020-02

  • The PHD finger of Arabidopsis SIZ1 recognizes trimethylated histone H3K4 mediating SIZ1 function and abiotic stress response

    三浦 謙治 , 壽崎 拓哉 , Kenji MIURA , Na Renhu , Takuya SUZAKI

    … Tri-methylated histone H3K4 (H3K4me3) was recognized by PHD, not by PHD(C162S). … PHD interacts with ATX, which mediates methylation of histone, probably leading to suppression of ATX's function. … These results suggest that the PHD finger of SIZ1 is important for recognition of the histone code and is required for SIZ1 function and transcriptional suppression. …

    Communications Biology (3), 23, 2020-01

    IR 

  • By a grant from Research Institute for Integrated Science, Kanagawa University : Epigenetics of Vascular Formation during Zebrafish Hindbrain Development

    Fujita Misato , Izumi Susumu

    Science journal of Kanagawa University = 神奈川大学理学誌 31, 15-20, 2020

  • Drug Resistance in Cancer Therapy and the Role of Epigenetics

    Asano Takeshi

    … Alterations of target gene expression and increased export pump function might be caused by epigenetic changes, such as alterations in methylation status, as well as by changes in histone acetylation status. …

    Journal of Nippon Medical School 87(5), 244-251, 2020

    J-STAGE 

  • (–)-Isostemonamine Can Enhance the Anti-Proliferative Activity of Trichostatin A Against Human Breast Cancer MDA-MB-231 Cells

    Hirao-Suzuki Masayo , Takeda Shuso , Iwata Takayuki , Fujita Satoshi , Tomiyama Taishi , Takiguchi Masufumi , Toda Akihisa , Shindo Mitsuru

    … Epigenetic changes, such as DNA methylation and histone modification, are involved in the progression of many cancers, including breast cancer. … a class I/II histone deacetylase inhibitor), and etoposide (a DNA topoisomerase IIα inhibitor). …

    BPB Reports 3(2), 56-59, 2020

    J-STAGE 

  • Recent advances in the treatment of myelofibrosis  [in Japanese]

    TAKENAKA Katsuto

    … Moreover, other gene mutations, including methylation-related regulators, histone modification-related factors, and RNA splicing molecules, also contribute to the pathogenesis of MPN development. …

    Rinsho Ketsueki 61(9), 1195-1204, 2020

    J-STAGE 

  • Pronuclear size regulates histone methylation level in zygote  [in Japanese]

    KYOGOKU Hirohisa , KITAJIMA Tomoya

    <p>【目的】 受精卵は精子から形成される雄性前核と卵子から形成される雌性前核と呼ばれる2つの大きな核を形成します。多くの哺乳類で，雄性前核の方が雌性前核よりも大きく異なったヒストンメチル化修飾状態を持つことが知られている。しかしながら，雌雄前核のサイズの違いを生み出す要因や，その生物学的意味はほとんど分かっていない。そこで，受精卵の核サイズの違いが，異なったヒストンメチル化修飾の状態 …

    The Journal of Reproduction and Development Supplement 113(0), P-56-P-56, 2020

    J-STAGE 

  • The involvement of exogenous methionine in histone methylation in bovine early embryos  [in Japanese]

    OTA Airi , IKEDA Shuntaro , SUGIMOTO Miki , MINAMI Naojiro , OTA Takeshi

    <p>【目的】メチオニンは，代表的なエピジェネティック機構であるDNAやヒストンのメチル化修飾に必要な唯一のメチル基源，S-アデノシルメチオニン（SAM）の前駆物質であることより，初期胚のエピジェネティクスに寄与すると考えられている。実際にメチオニンやその代謝に関連する酵素が，正常な初期胚発生に重要であることが報告されているが（Bonilla <i>et al.</i …

    The Journal of Reproduction and Development Supplement 113(0), P-58-P-58, 2020

    J-STAGE 

  • Epigenetic changes in the genome during early vertebrate development  [in Japanese]

    TAKEDA Hiroyuki

    … Two of the most characterized epigenetic modifications are DNA methylation and histone modification. …

    Annual Meeting of the Japanese Society of Toxicology 47.1(0), S29-2, 2020

    J-STAGE 

  • Drug development and safety evaluation of epigenetic drugs  [in Japanese]

    TAKI Kenji , HORII Ikuo

    … <p>For safety assessment of epigenetic drugs, indirect effects associated with changes in gene expression should be considered in addition to the direct effects of DNA methylation, demethylation and histone-modification. …

    Annual Meeting of the Japanese Society of Toxicology 47.1(0), S29-4, 2020

    J-STAGE 

  • Genome-wide changes in histone modification by repeated administration of chemicals  [in Japanese]

    ONO Ryuichi , AISAKI Ken-ichi , KITAJIMA Satoshi , KANNO Jun

    … <p>Comprehensive bisulfite DNA methylation analyses and comprehensive histone modification analyses of the liver of male mice repeatedly orally exposed to carbon tetrachloride, valproic acid and clofibrate showed no major changes in DNA methylation status but showed genome-wide histone modification changes. … We report the details of these histone modification changes.</p> …

    Annual Meeting of the Japanese Society of Toxicology 47.1(0), S21-5, 2020

    J-STAGE 

  • Synthesis of artificial substrate based on inhibitor for detecting LSD1 activity

    Ohta Yuhei , Kawaguchi Mitsuyasu , Ieda Naoya , Nakagawa Hidehiko

    … <p>Lysine methylation is one of the most important modification, which is regulated by histone lysine methyltransferases and histone lysine demethylases. … Lysine-specific demethylase 1 (LSD1) specifically demethylates mono- and dimethyl-lysine on histone H3 (H3K4Me/Me<sub>2</sub>, H3K9Me/Me<sub>2</sub>) to control chromatin structure, resulting in transcriptional repression or activation of target genes. …

    Journal of Clinical Biochemistry and Nutrition 67(2), 153-158, 2020

    J-STAGE 

  • Histone H3 methylation orchestrates transcriptional program in mouse spermatogenic cell line

    WANG Xiao-fei , TIAN Qing , QIN Wei-bing , YIN Ying , ZENG Ling , TANG Yun-ge , SU Ping , ZHOU Li-quan

    … Changes in histone modifications always correlate with altered transcriptional activities of genes. … Recent studies have shown that the mutation of certain lysine residues to methionine in the histone variant H3.3 can act as a valuable tool to reduce specific H3 methylation levels. …

    Journal of Reproduction and Development 66(3), 223-230, 2020

    J-STAGE 

  • Effect of epigenetic modulation on cancer sphere

    Iwahashi Shuichi , Shimada Mitsuo , Morine Yuji , Imura Satoru , Ikemoto Tetsuya , Saito Yu , Yamada Shinihiro , Utsunomiya Tohru

    … Methods : We made cancer sphere from HepG2 cells, and we added Histone deacetylase (HDAC) inhibitor, valproic acid to cancer sphere. … And we compared methylation status and the gene expression between normal HepG2 and cancer sphere groups, and between cancer sphere and sphere with HDAC inhibitor treatment groups. …

    The Journal of Medical Investigation 67(1.2), 70-74, 2020

    IR  J-STAGE 

  • Lysyl oxidase expression is regulated by the H3K27 demethylase Jmjd3 in tumor-associated M2-like macrophages

    Takemoto Ryuhei , Kamiya Tetsuro , Hara Hirokazu , Adachi Tetsuo

    … Furthermore, the level of histone H3 tri-methylation at lysine 27 was decreased, and a pre-treatment with a H3K27 demethylase inhibitor notably suppressed lysyl oxidase expression in M2-like macrophages. … The present results suggest the mechanism of lysyl oxidase expression in M2-like macrophages as an aspect of epigenetics, particularly histone methylation.</p> …

    Journal of Clinical Biochemistry and Nutrition 66(2), 110-115, 2020

    J-STAGE  Ichushi Web 

  • Novel Strategies of Peptide Ligation for Accelerating Chemical Protein Synthesis  [in Japanese]

    Hayashi Gosuke , Okamoto Akimitsu

    … In fact, we have chemically synthesized histone proteins with PTMs, which play an important role in regulation of gene expression in eukaryotic cells, and analyzed the effects of PTMs such as methylation, acetylation, and phosphorylation. …

    Journal of Synthetic Organic Chemistry, Japan 78(2), 130-139, 2020

    J-STAGE 

  • Targeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation and Transcription Network in Malignant Lymphomas

    Yamagishi Makoto , Hori Makoto , Fujikawa Dai , Ohsugi Takeo , Honma Daisuke , Adachi Nobuaki , Katano Harutaka , Hishima Tsunekazu , Kobayashi Seiichiro , Nakano Kazumi , Nakashima Makoto , Iwanaga Masako , Utsunomiya Atae , Tanaka Yuetsu , Okada Seiji , Tsukasaki Kunihiro , Tobinai Kensei , Araki Kazushi , Watanabe Toshiki , Uchimaru Kaoru

    Although global H3K27me3 reprogramming is a hallmark of cancer, no effective therapeutic strategy for H3K27me3-high malignancies harboring EZH2(WT/WT) has yet been established. We explore epigenome an …

    Cell reports 29(8), 2321-2337, 2019-11-19

    IR 

  • The histone modification H3 lysine 27 tri-methylation has conserved gene regulatory roles in the triplicated genome of Brassica rapa L.

    Akter Ayasha , Takahashi Satoshi , Deng Weiwei , Shea Daniel J. , Itabashi Etsuko , Shimizu Motoki , Miyaji Naomi , Osabe Kenji , Nishida Namiko , Suzuki Yutaka , Helliwell Chris A. , Seki Motoaki , Peacock William James , Dennis Elizabeth S. , Fujimoto Ryo

    … We investigated the distribution of the histone mark tri-methylation of H3K27 (H3K27me3) in B. …

    DNA Research 26(5), 433-443, 2019-10

    IR 

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