Search Results 1-20 of 29

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  • The master transcription factors for T cell exhaustion  [in Japanese]

    関谷 高史

    臨床免疫・アレルギー科 = Clinical immunology & allergology 74(5), 530-536, 2020-11

  • Immune therapy and tumor angiogenesis  [in Japanese]

    TAKAKURA Nobuyuki

    … Hypoxia also induces exhaustion of immune cells. … Moreover, drug delivery, including anti-cancer drugs and immune checkpoint inhibitors, is limited. …

    Rinsho Ketsueki 61(9), 1440-1445, 2020


  • Immune exhaustion during mycoplasma infection in cattle  [in Japanese]

    今内 覚 , 後藤 伸也 , 岡川 朋弘 , 前川 直也 , 村田 史郎 , 大橋 和彦

    日本マイコプラズマ学会雑誌 = Japanese journal of mycoplasmology (46), 31-33, 2019-05-24

  • Accumulation of exhausted CD8+ T cells in extramammary Paget's disease

    Iga Natsuko , Otsuka Atsushi , Yamamoto Yosuke , Nakashima Chisa , Honda Tetsuya , Kitoh Akihiko , Nakajima Saeko , Egawa Gyohei , Nomura Takashi , Dainichi Teruki , Matsushita Shigeto , Tanizaki Hideaki , Yamamoto Yuki , Funakoshi Takeru , Fujisawa Yasuhiro , Fujimura Taku , Hata Hiroo , Ishida Yoshihiro , Kabashima Kenji , Kenji Kabashima

    … Little is known, however, about the involvement of the immune system in extramammary Paget's disease (EMPD). … IDO expression seemed more relevant in inducing CD8 exhaustion than PD-1 upregulation or PD-L1 expression by immune cells. …

    PLOS ONE 14(1), e0211135, 2019-01


  • KS-1 Immunosenescence in Critical Care

    Inoue Shigeaki

    … In such an aging society, the number of age-related diseases such as malignant tumors, diabetes, and severe infections including sepsis is increasing, and patients with such disorders often find themselves in the ICU.<br>Age-related diseases are closely related to age-induced immune dysfunction, by which reductions in the efficiency and specificity of the immune system are collectively termed "immunosenescence." The most noticeable is a decline in the antigen-specific acquired immune response. …

    The Japanese Journal of SURGICAL METABOLISM and NUTRITION 53(3), 51-51, 2019

    J-STAGE  Ichushi Web 

  • The gut microbiota positively regulates anti-tumor immune responses through the activation of CD8<sup>+</sup> Tcells

    Wakamatsu Ei , Abe Ryo

    … Inhibitors of the immune checkpoint molecules PD1 and CTLA4 have been used to enhance the T cell anti-tumor immune response, leading to successful treatment for some tumor types. … Recently, it was reported that the gut microbiota boosts the anti-tumor immune response to immune checkpoint therapy. …

    ADC Letter for Infectious Disease Control 6(1), 28-31, 2019


  • Metformin Promotes the Protection of Mice Infected With Plasmodium yoelii Independently of γδ T Cell Expansion

    Miyakoda Mana , Bayarsaikhan Ganchimeg , Kimura Daisuke , Akbari Masoud , Udono Heiichiro , Yui Katsuyuki

    … Adaptive immune responses are critical for protection against infection with Plasmodium parasites. … Recent findings suggest that metformin, a medication for treating type-II diabetes, enhances T-cell immune responses … However, these γδ T cells expressed inhibitory receptors and had severe defects in cytokine production, suggesting that they were in a state of exhaustion. …

    Frontiers in Immunology (9), 2942, 2018-12-13


  • Immunosenescence in neurocritical care

    Inoue Shigeaki , Saito Masafumi , Kotani Joji

    … In such an aging society, the number of age-related diseases such as malignant tumors, diabetes, and severe infections including sepsis is increasing, and patients with such disorders often find themselves in the ICU.Main body: Age-related diseases are closely related to age-induced immune dysfunction, by which reductions in the efficiency and specificity of the immune system are collectively termed "immunosenescence." The most noticeable is a decline in the antigen-specific acquired immune response. …

    Journal of Intensive Care (6), 65, 2018-10-12


  • BST-2 controls T cell proliferation and exhaustion by shaping the early distribution of a persistent viral infection

    Urata Shuzo , Kenyon Elizabeth , Nayak Debasis , Cubitt Beatrice , Kurosaki Yohei , Yasuda Jiro , de la Torre Juan C. , McGavern Dorian B.

    … These data demonstrate that BST-2 is important in shaping the anatomical distribution and adaptive immune response against a persistent viral infection in vivo. …

    PLOS Pathogens 14(7), e1007172, 2018-07-20


  • Mechanism of immune checkpoint and T-cell exhaustion  [in Japanese]

    油田 さや子 , 北野 滋久

    血液内科 = Hematology 76(6), 801-805, 2018-06

    Ichushi Web 

  • Biomarkers to predict antitumor reactivity of immune checkpoint inhibitors  [in Japanese]

    各務 博

    呼吸器内科 = Respiratory medicine 31(4), 354-360, 2017-04

    Ichushi Web 

  • Metformin-dependent metabolic reprogramming contributes to efficient anti-tumor immunity  [in Japanese]

    友信 奈保子 , 榮川 伸吾 , 鵜殿 平一郎

    日本臨床 = Japanese journal of clinical medicine 75(2), 323-328, 2017-02

  • Immune exhaustion during chronic infections in cattle

    KONNAI Satoru , MURATA Shiro , OHASHI Kazuhiko

    … <p>Recently, dysfunction of antigen-specific T cells is well documented as T-cell exhaustion and has been defined by the loss of effector functions during chronic infections and cancer in human. … Recent our studies have revealed that immunoinhibitory molecules including PD-1/ programmed death-ligand 1 (PD-L1) play critical roles in immune exhaustion and disease progression in case of bovine leukemia virus (BLV) infection, Johne's disease and bovine anaplasmosis. …

    Journal of Veterinary Medical Science 79(1), 1-5, 2017

    J-STAGE  Ichushi Web 

  • An IL-27/Stat3 axis induces expression of programmed cell death 1 ligands (PD-L1/2) on infiltrating macrophages in lymphoma

    Horlad Hasita , Ma Chaoya , Yano Hiromu , Pan Cheng , Ohnishi Koji , Fujiwara Yukio , Endo Shinya , Kikukawa Yoshitaka , Okuno Yutaka , Matsuoka Masao , Takeya Motohiro , Komohara Yoshihiro

    Immune escape and tolerance in the tumor microenvironment are closely involved in tumor progression, and are caused by T-cell exhaustion and mediated by the inhibitory signaling of immune checkpoint molecules including programmed death-1 (PD-1), cytotoxic T-lymphocyte associated protein 4, and T-cell immunoglobulin and mucin domaincontaining molecule-3. …

    Cancer Science 107(11), 1696-1704, 2016-11

    IR  Ichushi Web 

  • Mechanisms of Action, Efficacy and Side Effects of Nivolumab and Its Therapeutic Use at Itabashi Hospital, Nihon University School of Medicine  [in Japanese]

    Izaki Satoshi , Hayama Koremasa , Terui Tadashi

    … Nivolumab is an immune checkpoint inhibitor that targets programmed cell death-1 (PD-1) receptors. … PD-1 is expressed on many immune cells, including T cells, B cells and natural killer cells. … Engagement of PD-1 with its ligands (PD-L1 and PD-L2) induces functional exhaustion of the cytotoxic immune response. … Nivolumab inhibits the PD-1 pathway, and thus activates the cytotoxic immune response. …

    Journal of Nihon University Medical Association 75(4), 156-160, 2016

    J-STAGE  Ichushi Web 

  • Follicular Lymphoma: The Role of the Tumor Microenvironment in Prognosis

    Sugimoto Takumi , Watanabe Takashi

    … T-cell immunoglobulin and mucin domain protein (TIM) 3 are markers of T-cell exhaustion, and T cells co-expressing programed death 1 (PD1) in peripheral blood and lymph nodes secrete interleukin (IL)-12 in the serum. … Agents for manipulation of the microenvironment surrounding FL cells include the immunomodulatory drug lenalidomide, immune check-point inhibitors, and cyclophosphamide prior to rituximab. …

    Journal of Clinical and Experimental Hematopathology 56(1), 1-19, 2016

    IR  J-STAGE  Ichushi Web 

  • Chronic Fatigue Syndrome (CFS)(Controversial Psychiatric Comorbidity of Somatic Diseases)  [in Japanese]

    Kuratsune Hirohiko

    … Lots of people are suffering from unexplained prolonged fatigue, low grade fever, headache, myalgia, arthralgia, a sense of exhaustion, cognitive dysfunction, depression, and sleep disturbance because of CFS. … Under these conditions, a reactivation of various kinds of herpes virus infections and/or chronic mycoplasma infection might occur as a result of immune dysfunction, causing the abnormal production of several cytokines. …

    Japanese Journal of Psychosomatic Medicine 54(11), 1002-1009, 2014

    J-STAGE  Ichushi Web 

  • Cancer immunotherapy with blocking of immune checkpoints  [in Japanese]

    Udono Heiichiro

    … 織という特殊な環境が禍している.T細胞は癌塊内に入り込み莫大な数の癌細胞と遭遇する.癌組織内での繰り返す抗原認識の過程でT細胞は疲弊し,次第に本来あるべき機能を喪失していく.この疲弊(exhaustion)と呼ばれる現象は,T細胞に発現する複数の免疫抑制性分子―免疫チェックポイント分子―と腫瘍に発現するそのリガンドの結合によってもたらされる.代表的なチェックポイント分子の機能を抑制し, …

    Okayama Igakkai Zasshi (Journal of Okayama Medical Association) 125(1), 13-18, 2013

    IR  J-STAGE  Ichushi Web 



    … Hepatitis B virus (HBV) is susceptible to the cellular immune responses, especially to the signal of interferon (IFN)-γ. … Therefore, therapeutic vaccination to induce cellular immune responses to HBV is a promising approach for controlling chronic HBV infection. …

    Nagoya Journal of Medical Science 74(3-4), 217-232, 2012-08

    IR  DOI 

  • A case suspected of diabetes bellitus characterized by rapid onset and absence of diabetes-related antibodies  [in Japanese]


    … It has been recently noted that there is a rare subtype of type 1 diabetes mellitus that is free from auto-immune etiology and shows a rapid onset. … level at the onset, 4) exhaustion of insulin secretion with a urine C-peptide level less than 10μg/day at the onset, 5) increased exocrine pancreatic enzyme level in blood at onset. …

    Juntendo medical journal 48(4), 516-519, 2003-03-28

    Ichushi Web  References (3)

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