Search Results 1-20 of 9703

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PAI-1 derived from cancer-associated fibroblasts in esophageal squamous cell carcinoma promotes the invasion of cancer cells and the migration of macrophages

Sakamoto Hiroki , Koma Yu-ichiro , Higashino Nobuhide , Kodama Takayuki , Tanigawa Kohei , Shimizu Masaki , Fujikawa Masataka , Nishio Mari , Shigeoka Manabu , Kakeji Yoshihiro , Yokozaki Hiroshi

… Based on immunohistochemistry assays of ESCC tissues, higher expression levels of PAI-1 and LRP1 were correlated with poor prognosis in ESCC patients. …

Laboratory Investigation 101(3), 353-368, 2021-03

IR
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Course for Medical Oncologist : Prep test for medical oncologist(130)answer and explanation [in Japanese]

福田直樹

腫瘍内科 = Clinical oncology 27(2), 245-249, 2021-02
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Immunohistochemical Localization of a GnRH-Like Peptide in the Nerve Ganglion of Three Classes of Crustaceans, the Tadpole Shrimp Triops longicaudatus (Branchiopoda), the Barnacle Balanus crenatus (Hexanauplia), and the Hermit Crab Pagurus filholi (Malacostraca)

Amano Masafumi , Amiya Noriko , Okumura Takuji , Kado Ryusuke

Zoological science 38(1), 51-59, 2021-02
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Expression profile of GnRH-like peptide during gonadal sex differentiation in the cephalopod kisslip cuttlefish, Sepia lycidas

Murata Ryosuke , Mushirobira Yuji , Tanaka Yoshiaki , Soyano Kiyoshi

… Here, we show the expression profile of GnRH-like in the brain of the cephalopod kisslip cuttlefish, Sepia lycidas, throughout gonadal sex differentiation, by quantitative real time RT-PCR and immunohistochemistry. …

General and Comparative Endocrinology (304), 113718, 2021-01-19

IR
5

Suppression of Allograft Fibrosis by Regulation of Mammalian Target of Rapamycin-Related Protein Expression in Kidney-Transplanted Recipients Treated with Everolimus and Reduced Tacrolimus

Nishioka Shun , Ishimura Takeshi , Endo Takahito , Yokoyama Naoki , Ogawa Satoshi , Fujisawa Masato

Background: Although renoprotective effects of everolimus (EVR) in kidney transplantation (KTx) have been widely reported, its pathophysiological mechanism remains unclear. Material/Methods: We compar …

Annals of Transplantation (26), e926476, 2021-01-12

IR
6

Expression of neuronal nitric oxide synthase and renin in dysplastic kidneys of young dogs

YABUKI Akira , FURUSAWA Yu , MIYOSHI Noriaki , TANIGUCHI Kazuyuki , YAMATO Osamu

Renin and neuronal nitric oxide synthase in the kidney control the renin-angiotensin and tubuloglomerular feedback systems. The present study investigated the expression of renin and neuronal …

Journal of Veterinary Medical Science, 2021

J-STAGE
7

Huge myxosarcoma arising from the greater omentum in a dog

WADA Atsuhito , NAGATA Katsuyuki

… Immunohistochemistry revealed that the neoplastic cells were positive for vimentin but negative for cytokeratin, S-100 protein, and α-SMA. …

Journal of Veterinary Medical Science 83(3), 461-468, 2021

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Expression of P-glycoprotein and breast cancer resistance protein in three cases of canine lymphoma showing drug resistance

HYOKAI Sachiko , TANAKA Hiroyo , AIHARA Noriyuki , KAMIIE Junichi

In canine lymphoma, drug resistance is the major factor hindering treatment. In this study, we performed immunohistochemical examination of P-glycoprotein (P-gp) and breast cancer resistance …

Journal of Veterinary Medical Science 83(3), 473-477, 2021

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9

The Optimal Dose of Tacrolimus in Combination Therapy with an Anti-TNFα Antibody in a Mouse Colitis Model

Murakami Yuki , Ando Katsuyoshi , Ueno Nobuhiro , Kashima Shin , Moriichi Kentaro , Tanabe Hiroki , Okumura Toshikatsu , Fujiya Mikihiro , Konishi Hiroaki , Isozaki Shotaro , Sugiyama Yuya , Kobayashi Yu , Sasaki Takahiro , Kunogi Takehito , Takahashi Keitaro

… The nuclear factor expression of activated T-cells, cytoplasmic 1 (NFATc1) in the nuclei and the mRNA expression of inflammatory cytokines were assessed by immunohistochemistry and RT-PCR, respectively. …

Biological and Pharmaceutical Bulletin 44(4), 564-570, 2021

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10

Gastric Cancer Producing Granulocyte Colony-Stimulating Factor and Parathyroid Hormone-Related Protein [in Japanese]

Shimomatsuya Takumi , Hashimoto Kyoichi , Takeuchi Gou , Matsuki Goshi , Aoyama Ryouhei , Matsuyama Takehisa , Hinami Junsuke , Kubota Yoshihiro , Nakai Osamu

症例は72歳の女性で，白血球増多，胸部異常陰影にて紹介となった．諸検査で肺癌合併の進行胃癌と診断した．審査腹腔鏡にて肝表面に結節を認め，針生検で胃癌の肝転移と診断し化学療法を開始した．一時腫瘍は縮小するも，経過中白血球は46,500/μl，血清カルシウム値は15.7 mg/dlと高値を示し，胃原発巣，リンパ節転移とも著明に増大していた．血清granulocyte colony-s …

The Japanese Journal of Gastroenterological Surgery 54(3), 173-183, 2021

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11

A retrospective review for clinical experience and evaluation of H3K27-me3 immunohistochemical staining of posterior fossa ependymoma in children at the hospital [in Japanese]

Chiba Kentaro , Aihara Yasuo , Kawamata Takakazu

当院における小児後頭蓋窩上衣腫9症例の検討を行った．同症例では高頻度に再発を認め，積極的あるいは繰り返しの手術によって患児のQOLは低下を認めた．播種再発を認めると病状は着実に進行しその予後は不良であった．これらの臨床経過と病理所見を，近年報告されているPF-A/PF-Bのサブグループ化に基づき後方視的に検討したが特徴的な傾向を捉えることはできなかった．しかし一方で，H3K27- …

Nervous System in Children 46(1), 14-21, 2021

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12

Microglia and presynaptic proteins in dementia [in Japanese]

Ken Sawada Ken

ミクログリアは，貪食やT細胞への抗原提示を行い，神経免疫に寄与している。また，神経発達時に余剰のニューロンやシナプスの除去に関与し，脳組織の恒常性を保つと考えられている。成熟してからも認知機能に関与する。アルツハイマー病においては，プラークや異常タウタンパクを除去すると同時に正常ニューロンやシナプスに傷害を及ぼすことにより，認知機能低下を導いている可能性が示唆されており，特に前シナプス部位の異常が …

Japanese Journal of Biological Psychiatry 32(1), 33-37, 2021

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13

A case of Epstein-Barr virus-positive mucocutaneous ulcer caused by age-related immune reduction [in Japanese]

ABE Kojiro , YAMASHITA Tomomi , HAYASHI Itsuki , MAKITA Hiroki , YAMADA Kouta , TOIDA Makoto

… Immunohistochemistry revealed positive reactions for CD20, CD30, and CD79a, and EBV-encoded small RNA (EBER) was found in many positive cells, which revealed EBVMCU. …

Japanese Journal of Oral and Maxillofacial Surgery 67(1), 35-39, 2021

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14

Evaluation of primate dental pulp regeneration by quantitative fluorescence imaging of macrophages [in Japanese]

Toida Yu , Sato Takanori , Iimura Tadahiro

… We analyzed pulp regeneration process using immunohistochemistry-based quantitative fluorescence imaging. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 3-Y-G3-2, 2021

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15

The alternation of adenosine-related genes likely progress HSC activation in inflammatory condition. [in Japanese]

Dohi Naoki , Yamaguchi Momoka , Saito Sin-ya , Ishikawa Tomohisa

… HSC activation were evaluated by immunohistochemistry. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 3-P2-36, 2021

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16

Prenatal glucocorticoid administration accelerates glomeruli and renal tubules development in the fetal rats. [in Japanese]

Takeba Yuko , Kobayashi Tsukasa , Ootaki Masanori , Ohta Yuki , Kida Kiesuke , Watanabe Minoru , Iiri Taroh , Matsumoto Naoki

… The expression of kidney development-related markers (alpha-SMA, aquaporin1 and 2) were evaluated by immunohistochemistry and glomeruli and tubules numbers were calculated by H-E staining in the fetal and neonatal rats with prenatal GC. The expression of kidney development-related markers (alpha-SMA, aquaporin1and 2) were evaluated by immunohistochemistry and glomeruli and tubules numbers in the kidney tissue were counted in the fetal and neonatal rats with prenatal GC. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 2-P2-22, 2021

J-STAGE
17

Antidepressant-like effect of captopril via hippocampal angiotensin (1-7) / MAS1 pathway in olfactory bulbectomized mice. [in Japanese]

Wakou Miharu , Nakagawasai Osamu , Koyama Taisei , Odaira Takayo , Sakuma Wakana , Yamagata Ryota , Nemoto Wataru , Tan-No Koichi

… The present study performed a series of experiments using biochemical assays, immunohistochemistry, and behavior techniques to examine the effect and mechanism of captopril (CAP) on depressive-like behaviors in OBX mice. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 2-P1-33, 2021

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18

Reduced expression of NMDA receptors (NR2A and NR2B) in the hippocampus of WD repeat domain 3 gene hetero knockout mice [in Japanese]

Momoko Kobayashi , Furuie Hiroki , Miwa Hideki , Yamada Misa , Yamada Mitsuhiko

… Then, we examined the WDR3 expression in the brain of C57BL/6N mouse using immunohistochemistry. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 2-P1-44, 2021

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Generation of cortical organoids with axial polarity from marmoset embryonic stem cells [in Japanese]

Kodera Tomoki , Hara Taiki , Morimoto Nao , Osakada Fumitaka

… Immunohistochemistry revealed that Tbr1+/Ctip2+ …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 1-P1-25, 2021

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20

Amthamine, a selective histamine H2 receptor agonist alleviates cerebrovascular damage after traumatic brain injury in mice [in Japanese]

Michinaga Shotaro , Sonoda Kyomi , Inazuki Naoki , Watano Tomokazu , Mizuguchi Hiroyuki

… receptor were evaluated by western blot and immunohistochemistry. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 1-O-C2-4, 2021

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