Search Results 1-20 of 9379

1
2
3
4
5
6
...
469
1 / 469

1

Hepatic Artery Embolization Induces the Local Overexpression of Transforming Growth Factor β1 in a Rat Hepatoma Model

Ueshima Eisuke , Nishiofuku Hideyuki , Takaki Haruyuki , Hirata Yutaka , Kodama Hiroshi , Tanaka Toshihiro , Kichikawa Kimihiko , Yamakado Koichiro , Okada Takuya , Sofue Keitaro , Yamaguchi Masato , Sugimoto Koji , Murakami Takamichi

… Immunohistochemistry (IHC) and quantitative polymerase chain reaction (qPCR) were performed to compare the expression of TGF-β1 and hypoxia-inducible factor 1α (HIF-1α) between the HAE and sham groups. …

Liver Cancer 9(1), 63-72, 2020-02

IR
2

Patterns of Expression of Purinergic Receptor P2RY12, a Putative Marker for Non-Activated Microglia, in Aged and Alzheimer's Disease Brains.

WALKER Douglas Gordon , TANG Tiffany M , MENDSAIKHAN Anarmaa , TOOYAMA Ikuo , SERRANO Geidy E , SUE Lucia I , BEARCH Thomas G , LUE Lih-Fen

… We examined the expression of P2RY12 by dual-color light and fluorescence immunohistochemistry using sections of middle temporal gyrus from AD, high plaque and low plaque non-demented cases in relation to amyloid beta (Aβ) plaques and phosphorylated tau, markers of pathology, and HLA-DR, IBA-1, CD68, and progranulin, microglial phenotype markers. …

International journal of molecular sciences 21(2), E678, 2020-01-20

IR
3

Elucidation of the molecular function using histological analysis [in Japanese]

八月朔日泰和

秋田県医師会雑誌 = Akita medical journal 70(1), 17-24, 2020-01
4

Hedgehog signalling pathway activation in gastrointestinal stromal tumours is mediated by primary cilia

Iruzubieta Pablo , Monzon Marta , Castiella Tomas , Ramirez Teresa , Junquera Concepcion

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 23(1), 64-72, 2020
5

Immunotoxicity evaluation by subchronic oral administration of clothianidin in Sprague-Dawley rats

ONARU Kanoko , OHNO Shuji , KUBO Shizuka , NAKANISHI Satoki , HIRANO Tetsushi , MANTANI Youhei , YOKOYAMA Toshifumi , HOSHI Nobuhiko

… The effects were evaluated by organ and body weights, histopathology, and immunohistochemistry (TCRαβ, CD4, CD8, CD11b, CD68, CD103). … Granulomas of the ear auricles were found in one rat of each of the CLO-30 and 300 groups, but CLO had no apparent effect on the thickness or immunohistochemistry in the ear auricles. …

Journal of Veterinary Medical Science 82(3), 360-372, 2020

J-STAGE
6

Assessment of Developmental Neurotoxicity during Neuronal Differentiation using a Triple-Transgenic Zebrafish Line [in Japanese]

Yuka Adachi , Koiwa Junko , Shiromizu Takashi , Tanaka Toshio , Nishimura Yuhei

… However, assessment of toxicity during progenitor cell differentiation into neurons, astrocytes, and oligodendrocytes often requires immunohistochemistry, which is a reliable but labor-intensive and time-consuming assay. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-P-381, 2020

J-STAGE
7

Prenatal glucocorticoid administration accelerates kidney development in the fetal rats. [in Japanese]

Takeba Yuko , Matsumoto Naoki , Yamamoto Makoto , Nakamura Yuki , Kobayashi Tsukasa , Ootaki Masanori , Ohta Yuki , Kida Keisuke , Watanabe Minoru , Iiri Taroh

… The expression of kidney development-related markers (alpha-SMA, aquaporin1and 2) were evaluated by immunohistochemistry and glomeruli and tubules numbers were calculated by H-E staining in the fetal and neonatal rats with prenatal GC. The expression of kidney development-related markers (alpha-SMA, aquaporin1and 2) were evaluated by immunohistochemistry and glomeruli and tubules numbers in the kidney tissue were measured by H-E staining in the fetal and neonatal rats with prenatal GC. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-P-304, 2020

J-STAGE
8

Establishment of anti-horse podoplanin monoclonal antibody using Cell-Based Immunization and Screening (CBIS) method [in Japanese]

Sayama Yusuke , K. Kaneko Mika , Kato Yukinari

… In this study, we aimed to develop useful anti-horPDPN mAbs for many applications such as flow cytometry (FCM), western blot (WB), and immunohistochemistry (IHC).Methods: We employed a conventional immunization method using synthetic peptides or Cell-Based Immunization and Screening (CBIS) method using horPDPN-expressed mammalian cells for producing anti-horPDPN mAbs. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-O-127, 2020

J-STAGE
9

Development of a new treatment for hyperbilirubinemia induced psychiatric disorders; preclinical study [in Japanese]

Oh-Nishi Arata , Miura Shoko , Tsuchie Keiko , Fukushima Michiyo , Arauchi Ryosuke , Miyaoka Tsuyoshi , Inagaki Masatoshi

… The amounts of serotonin and its metabolites in the Gunn rat were measured by high performance liquid chromatograph, furthermore, serotonergic neurons in the dorsal raphe nucleus were visualized by immunohistochemistry.【Results】Ketanserin injection improved the hyperactivity and agitation like behaviors in Gunn rats. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-O-105, 2020

J-STAGE
10

Role of 5-HT1A receptor in myelin damage caused by maladaptation to stress in mice [in Japanese]

Kurokawa Kazuhiro , Takahashi Kohei , Miyagawa Kazuya , Mochida-Saito Atsumi , Takeda Hiroshi , Tsuji Minoru

… Immunohistochemistry analysis revealed that the expression level of APC was decreased in the dentate gyrus of the hippocampus of stress-maladaptive mice. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-O-101, 2020

J-STAGE
11

Tumor necrosis factor alpha protects retinal ganglion cells against excitotoxicity via reduction of oxidative stress in the mice [in Japanese]

Sakamoto Kenji , Haginoya Yuki , Sakai Hiroki , Asano Daiki , Morita Akane , Mori Asami , Nakahara Tsutomu

… Immunohistochemistry using anti-8-OHdG antibody and Alexa Fluor 488-conjugated anti-NeuN antibody was carried out. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-P-266, 2020

J-STAGE
12

Discovery and evaluation of a novel tau PET tracer [18F]THK-5562 for Alzheimer's disease [in Japanese]

Du Yiqing , Yanai Kazuhiko , Harada Ryuichi , Lerdsirisuk Pradith , Ezura Michinori , Shimizu Yuki , Morito Takahiro , Arai Hiroyuki , Kudo Yukitsuka , Furumoto Shozo

… Besides, [18F]THK-5562 seemed to be specific for 3R/4R tau in AD by autoradiography and immunohistochemistry.In conclusion, preclinical validation suggested the potential usefulness of [18F]THK-5562 in imaging tau aggregation in Alzheimer's disease. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-P-196, 2020

J-STAGE
13

An APJ agonist suppresses the loss of retinal neuronal cells in diabetes model mouse fed a high-fat diet [in Japanese]

Shibagaki Fumiya , Ishimaru Yuki , Akai Kiichi , Tokuda Kana , Yamamuro Akiko , Yoshioka Yasuhiro , Maeda Sadaaki

… In the present study, we investigated the protective effect of endogenous apelin and ML233, an APJ agonist, against retinal neuronal cell death in the diabetes model mice fed the HFD by immunohistochemistry. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-P-213, 2020

J-STAGE
14

β3-adrenoceptor agonist protects dopaminergic neurons in the 6-hydroxydopamine model of Parkinson's disease. [in Japanese]

Yoshioka Yasuhiro , Asakai Kensuke , Isshiki Kento , Motoyama Kiyono , Yamamuro Akiko , Ishimaru Yuki , Maeda Sadaaki

… Mice were injected with 6-OHDA into the right striatum, and the degeneration of dopaminergic neurons was evaluated by tyrosine hydroxylase (TH) immunohistochemistry. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-P-190, 2020

J-STAGE
15

Neuroinflammation aggravates spreading alpha-synuclein oligomerization in Lewy body dementia mice [in Japanese]

Ryo Yamada , Xu Jing , Fukunaga Mako , Fukunaga Kohji

… The alpha-synuclein fibrils are injected into the dorsolateral striatum and its spreading was assessed by immunohistochemistry. [Results] At two months after alpha-synuclein fibril injection, mice exhibited cognitive impairment in novel object recognition task. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-SS-36, 2020

J-STAGE
16

Lansoprazole promotes peritoneal fibrosis by bleomycin [in Japanese]

Yamamoto Yuta , Tanichi Akira , Nasu Shota , Yamagishi Naoko , Ito Takao , Kanai Yoshimitsu

… Furthermore, in the LAP + BLM group, immunohistochemistry indicated M2 macrophages in the visceral peritoneum thickened, and the expression of Tgfβ and Col1a1 gene were increased using real-time PCR. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-P-055, 2020

J-STAGE
17

The effects of ambrisentan, a selective endothelin ETA receptor antagonist for vasogenic edema after traumatic brain injury in mice [in Japanese]

Michinaga Shotaro , Ryu Ryotaro , Yamamoto Hayato , Mizuguchi Hiroyuki , Koyama Yutaka

… Expression of ETA receptors was observed by immunohistochemistry. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-P-038, 2020

J-STAGE
18

M2 muscarinic receptors possibly facilitate oxytocin synthesis in the mouse supraoptic nuclei [in Japanese]

Unno Toshihiro , Inaba Ntsuki , Nagano Hiroshi , Hashimoto Takashi , Iino Satoshi , Matsuyama Hayato , Saito Shouichiro , Tanahashi Yasuyuki

… muscarinic receptor were identified by immunohistochemistry. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-P-010, 2020

J-STAGE
19

Perineural treatment with anti-HMGB1 antibody alleviates nociceptive-like behaviors in mice with chronic constriction injury of distal infraorbital nerve [in Japanese]

Takahiro Kochi , Nakamura Yoki , Nakashima Kazue , Liu Keyue , Waki Hidenori , Nishibori Masahiro , Irifune Masahiro , Morioka Norimitu

… Microglial activity in spinal trigeminal nucleus caudalis (Sp5c) was determined by immunohistochemistry. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-P-017, 2020

J-STAGE
20

Establishment of a novel anti-CD20 monoclonal antibody C20Mab-11 using the Cell-Based Immunization and Screening (CBIS) method for the detection of B cells in many applications [in Japanese]

Furusawa Yoshikazu , Kaneko MiKa K. , Miwa Takashi , Fukui Masato , Kato Yukinari

… Furthermore, C20Mab-11 strongly stained B cells of the lymph follicle via immunohistochemistry (IHC). …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-O-004, 2020

J-STAGE

1
2
3
4
5
6
...
469
1 / 469

Search Results 1-20 of 9379

Related Authors

Related Journals