Search Results 1-20 of 94

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  • Effects of autonomic nervous system on relationships between sleep-disordered breathing and cardiovascular disease  [in Japanese]

    Ishiwata Sayaki , Shitara Jun , Kasai Takatoshi

    … Mechanisms linking between SDB and cardiovascular disease include a reduction in cardiac output induced by negative inspiratory intrathoracic pressure during obstructive sleep apnea, oxidative stress, enhanced inflammatory reaction caused by repeated intermittent hypoxia, and augmented sympathetic nerve activity. … Hypoxia and hypercapnia induced by apnea, reduced cardiac output, diminished stimulations of lung stretch receptor, and arousals enhance sympathetic nerve activity in SDB patients. …

    The Autonomic Nervous System 56(4), 216-220, 2019

    J-STAGE 

  • Central chemoreflex activation resets the baroreflex neural arc without compromising its dynamic and static function  [in Japanese]

    Saku Keita , Sakamoto Takafumi , Tohyama Takeshi , Nishikawa Takuya , Kishi Takuya , Sunagawa Kenji

    … <p>BACKGROUNDS: While hypercapnia activates central chemoreflex and induces sympatho-excitation, its interaction with the baroreflex regulation of sympathetic nerve activity (SNA) has not been quantified. … Hypercapnia was induced by inhalation of 3% CO2 gas. … Hypercapnia markedly increased SNA (δSNA=53.4±7.1%, p<0.01) irrespective of CSP, indicating the resetting of the neural arc (CSP-SNA relation). …

    Transactions of Japanese Society for Medical and Biological Engineering 54Annual(27PM-Abstract), S175-S175, 2016

    J-STAGE 

  • Permissive hypoxemia: another strategy  [in Japanese]

    Okamoto Kazufumi

    Journal of the Japanese Society of Intensive Care Medicine 23(2), 113-116, 2016

    J-STAGE  Ichushi Web 

  • Extracorporeal Membrane Oxygenation for Anesthesia Induction in a Patient with Severe Cardiorespiratory Impairment due to Mediastinal Angiosarcoma  [in Japanese]

    松川 志乃 , 大条 紘樹 , 溝田 敏幸 [他] , 福田 和彦

    … Spirometry indicated a forced vital capacity of 0.66/, while arterial blood gas analysis under noninvasive positive pressure ventilation indicated hypercapnia (pH 7.44; … After achieving a stable circulation and adequate gas exchange, anesthesia was induced, and mechanical ventilation with intratracheal intubation was initiated. …

    麻酔 64(2), 180-184, 2015-02

    IR  Ichushi Web 

  • Case Report of an Oldest-old Patient with COPD Who Suffered Aspiration Pneumonia after Oral Surgery under General Anesthesia  [in Japanese]

    Kimura Yukifumi , Takuma Shigeru , Shibuya Makiko , Fujisawa Toshiaki

    … General anesthesia was induced with propofol(50 mg)and rocuronium(40 mg). … Although PaCO<sub>2 </sub>levels were high(55-58 mmHg), we followed the theory of permissive hypercapnia, while maintaining low airway pressure and adequate expiratory time. …

    Ronen Shika Igaku 30(3), 326-331, 2015

    J-STAGE  Ichushi Web 

  • Impairment of CO<sub>2</sub> reactivity in RBC velocity and CBF after cortical spreading depression in anesthetized mice

    Unekawa Miyuki , Tomita Yutaka , Toriumi Haruki , Osada Takashi , Masamoto Kazuto , Kawaguchi Hiroshi , Itoh Yoshiaki , Kanno Iwao , Suzuki Norihiro

    … inhalation for 1min. CSD was induced by microapplication of 1M KCl through a tiny cranial hole posterior to the cranial window.<br><b>Results:</b> … During hypercapnia, CBF and RBC velocity averaged in each mouse increased by 14.1±11.3% and 17.7±19.0% with significant correlation between the increases (<i>r</i>=0.79, n=8). …

    Microvascular Reviews and Communications 7(1), 33a-33a, 2014

    J-STAGE  Ichushi Web 

  • Anesthetic and Cardiorespiratory Effects of Propofol, Medetomidine, Lidocaine and Butorphanol Total Intravenous Anesthesia in Horses

    ISHIZUKA Tomohito , ITAMI Takaharu , TAMURA Jun , SAITOH Yasuo , SAITOH Motoaki , UMAR Mohammed A. , MIYOSHI Kenjirou , YAMASHITA Kazuto , MUIR William W.

    … Anesthesia was induced by administration of 1% propofol (3 mg/kg, IV) at a rate of 1 mg/kg/min (n=5, group-1) or 2% propofol administered at a rate of 6 mg/kg/min (n=5, group-2) following administration of lidocaine (1 mg/kg, IV) and then maintained by infusions of propofol, medetomidine (3.5 μg/kg/hr), lidocaine (3 mg/kg/hr) and butorphanol (24 μg/kg/hr). … Heart rate and arterial blood pressure were maintained within acceptable ranges, but hypercapnia occurred during anesthesia in both groups. …

    Journal of Veterinary Medical Science 75(2), 165-172, 2013

    IR  J-STAGE  Ichushi Web 

  • A Case of Anesthesia in a Pregnant Woman Undergoing Thoracotomy for Spontaneous Pneumothorax  [in Japanese]

    WATANABE Eiko , HIRO Kanako , SHIMIZU Mie , HASEGAWA Takashi

    … General anesthesia was induced with thiopental, vecuronium and fentanyl and, maintained with sevoflurane. … In our case, one-lung ventilation led to hypercapnia, but avoided prolonged fetal acidosis by returning to bilateral lung ventilation. …

    THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA 31(5), 888-891, 2011

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  • Clinical Evaluation of Total Intravenous Anesthesia Using a Combination of Propofol and Medetomidine following Anesthesia Induction with Medetomidine, Guaifenesin and Propofol for Castration in Thoroughbred Horses

    OKU Kazuomi , KAKIZAKI Masashi , ONO Keiichi , OHTA Minoru

    … After premedication with medetomidine (5.0 μg/kg, intravenously), anesthesia was induced with guaifenesin (100 mg/kg, intravenously) and propofol (3.0 mg/kg, intravenously) and maintained with constant rate infusions of medetomidine (0.05 μg/kg/min) and propofol (0.1 mg/kg/min). … Decreases in respiratory rate and hypercapnia were observed in all horses. …

    Journal of Veterinary Medical Science 73(12), 1639-1643, 2011

    J-STAGE  Ichushi Web 

  • Effects of arterial carbon dioxide manipulation on cerebral oxidative metabolism during hemorrhagic hypotension in dogs

    Tada Toshihiko M.D. Ph.D. , Miura Yoshihide M.D. Ph.D. , Oda Shinya M.D. , Okada Masayuki M.D. , Takata Kosuke M.D. , Takaoka Seiji M.D. Ph.D.

    … There is possibility that PaC02 manipulation affects brain acidosis induced deterioration of cerebral oxidative metabolism by influencing the brain acid- base equilibrium. … Brain acidosis was developed regardless of the PaC02 ma-nipulation used, being most acidotic with hypercapnia. … Hypercapnia was accompanied by a significant decrease in phosphocreatinine and an increase in the L/P ratio com-pared to hypocapnia and normocapnia. …

    Yamagata medical journal 27(1), 41-50, 2009-02

    IR  Ichushi Web 

  • Effects of Trait Anxiety on Breathlessness and Respiratory Patterns during Repeated Breath-holds

    SAKURAI Shunsuke , MASAOKA Yuri , ITABASHI Kazuo , HOMMA Ikuo

    … Breathlessness is an unpleasant sensation related to respiration and is induced by hypercapnia or hypoxia. … In this study we investigated how trait anxiety affected breathlessness induced by repetitive breath-holds. …

    The Showa University Journal of Medical Sciences 21(3), 189-195, 2009

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  • Dorsomedial medullary 5-HT release and hypercapnic airway response in infant rats

    Kanamaru Mitsuko , Homma Ikuo

    … However, whether there was dose dependency for inspired-CO<SUB>2</SUB>-induced increase in 5-HT release in the DMM was not clear. … at intervals of 10 min. The 5-HT increase induced by CO<SUB>2</SUB> … Our results suggest that inspired-CO<SUB>2</SUB>-induced increases in 5-HT release in the DMM were dose-dependent and occurred with airway narrowing and ventilatory augmentation in infant rats. …

    Proceedings of Annual Meeting of the Physiological Society of Japan 2008(0), 119-119, 2008

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  • Malignant hyperthermia-like reactions in Duchenne or Becker muscular dystrophy: review and hypothesis

    Takagi Akio , Nakase Hirofumi

    … About 60% of myolysis cases were associated with muscle contracture (rigidity) or other hypermetabolic signs such as hypercapnia, hyperthermia and metabolic acidosis. … These results suggest Ca ion-induced hypermetabolic reactions are also present in dystrophinopathy, which have been assumed as core syndromes of the classical (gene-defined) MH. … Circumstancial evidences suggest that the Ca-induced Ca release (CICR) mechanism might also be involved. …

    Rinsho Shinkeigaku 48(2), 101-105, 2008

    J-STAGE 

  • Loss of CO2-induced Distensibility in Cerebral Arteries with Chronic Hypertension or Vasospasm after Subarachnoid Hemorrhage

    Nakajima Seiji , Kondoh Takeshi , Morishita Akitsugu , Yamashita Haruo , Kohmura Eiji , Sakurai Takashi , Yokono Koichi , Umetani Keiji

    … Twenty-five adult WistarKyoto rats (WKY) and fourteen stroke-prone spontaneously hypertensive rats (SHR)were prepared SAH by double hemorrhage injection method into cisterna magna.Angiography was performed on day 7 and was repeated three times in each rat beforeand after loading of hypercapnia at 100-120 mmHg of PaCO2. … SHA resulted in lossof hypercapnia-induced distention in BA of WKY. …

    The Kobe journal of the medical sciences 53(6), 317-326, 2007-12

    IR  DOI 

  • Loss of CO2-induced Distensibility in Cerebral Arteries with Chronic Hypertension or Vasospasm after Subarachnoid Hemorrhage

    Nakajima Seiji , Kondoh Takeshi , Morishita Akitsugu , Yamashita Haruo , Kohmura Eiji , Sakurai Takashi , Yokono Koichi , Umetani Keiji

    … Twenty-five adult WistarKyoto rats (WKY) and fourteen stroke-prone spontaneously hypertensive rats (SHR)were prepared SAH by double hemorrhage injection method into cisterna magna.Angiography was performed on day 7 and was repeated three times in each rat beforeand after loading of hypercapnia at 100-120 mmHg of PaCO2. … SHA resulted in lossof hypercapnia-induced distention in BA of WKY. …

    The Kobe journal of the medical sciences 53(6), 317-326, 2007-12

    Ichushi Web 

  • Acid-base management affects endothelium-dependent cerebral vasoreactivity in moderately hypothermic rats

    Yuzawa Izumi , Yamada Masaru , Iwamoto Kazuhisa , Fujii Kiyotaka

    … We examined cerebral vasoreactivity to topically administered vasodilators and hypercapnia under conditions of normothermia (37℃), induced hypothermia (30℃) with alpha- and pH-stat management, and rewarmed normothermia in rats. … Results : Ach-induced vasodilation was significantly attenuated under alpha-stat- but not pH-stat management and rewarming completely restored the normal vasodilatory response. …

    The Kitasato medical journal 36(2), 81-88, 2006-09

    Ichushi Web 

  • Impaired response of perforating arteries to hypercapnia in chronic hyperglycemia

    Oizumi Ximena-Sayuri , Akisaki Taichi , Kouta Yoshiyuki , Song Xiu Z , Takata Toshihiro , Kondoh Takeshi , Umetani Keiji , Hirano Masatsugu , Yamasaki Katsuhito , Kohmura Eiji , Yokono Koichi , Sakurai Takashi

    … The goal of the studypresented here was to identify the effects of chronic hyperglycemia onhypercapnia-induced vascular responses (endothelium-dependent vasodilatation) andnitric oxide (NO) donor- induced vascular responses (endothelium-independent) ofperforating arteries and of the deeply located large cerebral arteries. … We found asignificant vasodilatation of rat perforating arteries after hypercapnia with a maximumdiameter of approximately 140% of baseline in normal Wistar rats. …

    The Kobe journal of the medical sciences 52(1/2), 27-35, 2006-01

    IR  DOI 

  • Impaired response of perforating arteries to hypercapnia in chronic hyperglycemia

    Oizumi Ximena-Sayuri , Akisaki Taichi , Kouta Yoshiyuki , Song Xiu Z. , Takata Toshihiro , Kondoh Takeshi , Umetani Keiji , Hirano Masatsugu , Yamasaki Katsuhito , Kohmura Eiji , Yokono Koichi , Sakurai Takashi

    … The goal of the studypresented here was to identify the effects of chronic hyperglycemia onhypercapnia-induced vascular responses (endothelium-dependent vasodilatation) andnitric oxide (NO) donor- induced vascular responses (endothelium-independent) ofperforating arteries and of the deeply located large cerebral arteries. … We found asignificant vasodilatation of rat perforating arteries after hypercapnia with a maximumdiameter of approximately 140% of baseline in normal Wistar rats. …

    The Kobe journal of the medical sciences 52(1/2), 27-35, 2006

    Ichushi Web 

  • Vascular changes in the rat brain during chronic hypoxia in the presence and absence of hypercapnia.

    Miyamoto Osamu , Sumitani kazunori , Takahashi Masaru , Hirakawa Haruhisa , Kusakabe Tatsumi , Hayashida Yoshiaki , Itano Toshifumi

    … Hypoxic adaptation in brain vascularity did not change during 8 wks of hypoxia, and the hypoxia-induced levels measured in the vasculature returned to control levels 2 wks after the termination of hypoxia in areas of the brain other than the cortex and thalamus. … In addition, hypoxia-induced changes in terms of the total vascular area and vessel size distribution were significantly inhibited by the elevation in CO(2), whereas chronic hypercapnia without hypoxia had no effect on brain vascularity. …

    Acta Medica Okayama 59(4), 135-143, 2005-08

    IR  DOI 

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