Search Results 1-20 of 3356

  • Mechanisms for the Attenuation of Salt-induced Hypertension by means of Long-term Miso Intake  [in Japanese]

    上原 誉志夫

    日本海水学会誌 = Bulletin of the Society of Sea Water Science, Japan 74(2), 99-107, 2020-04

  • Hypertension-induced organ damages via mineralocorticoid receptors  [in Japanese]

    森澤 紀彦 , 西山 成

    日本臨床 = Japanese journal of clinical medicine 78(2), 190-195, 2020-02

  • Effect of lidocaine with adrenaline and landiolol on hemodynamics in spontaneously hypertensive rats

    Oshikiri Toru , Iguchi Asami , Sunada Katsuhisa , Fujii Kazuyuki , Sano Kimito

    … <p>Administration of local anesthetics with adrenaline can cause tachycardia and hypertension. … Landiolol-induced changes in PR may be due to blockade of adrenaline-induced β<sub>1 </sub>receptor stimulation, which suppresses cardiac hyperactivity, whereas the early surge of blood pressure in SHR/Izm rats given LLA may be due to the dominant alpha-adrenergic effects of β<sub>1</sub> …

    Journal of Oral Science 62(3), 314-317, 2020


  • Training-Induced Deactivation of the AT<sub>1</sub> Receptor Pathway Drives Autonomic Control and Heart Remodeling During the Transition From the Pre- to Hypertensive Phase in Spontaneously Hypertensive Rats

    da Costa Tassia Santos Rodrigues , Masson Gustavo Santos , Eichler Rosangela Aparecida dos Santos , Silva Juliane Cristina de Souza , Lacchini Silvia , Michelini Lisete Compagno

    … <p><b><i>Background:</i></b>The effects of hypertension and exercise training (T) on the sequential interplay between renin-angiotensin system (RAS), autonomic control and heart remodeling during the development of hypertension in spontaneously hypertensive rats (SHR), was evaluated.</p><p><b><i>Methods and Results:</i></b>Time course changes of these parameters were recorded in 4-week-old SHR submitted to a T or sedentary (S) protocol. …

    Circulation Journal, 2020


  • Reduction of stearoyl-CoA desaturase (SCD) contributes muscle atrophy through the excess endoplasmic reticulum stress in chronic kidney disease

    Niida Yuki , Nikawa Takeshi , Yamamoto Hironori , Miyazaki Makoto , Taketani Yutaka , Masuda Masashi , Adachi Yuichiro , Yoshizawa Aika , Ohminami Hirokazu , Mori Yuki , Ohnishi Kohta , Yamanaka-Okumura Hisami , Uchida Takayuki

    … Next, oleic acid blocked the reduction of the thickness of C2C12 myotubes and the increase of the endoplasmic reticulum stress induced by SCD inhibitor. … Furthermore, endoplasmic reticulum stress inhibitor ameliorated CKD-induced muscle atrophy (the weakness of grip strength and the decrease of muscle fiber size of gastrocnemius muscle) in mice and the reduction of the thickness of C2C12 myotubes by SCD inhibitor. …

    Journal of Clinical Biochemistry and Nutrition, 2020


  • Hypoglycemic Activity and the Mechanisms of Lycium Bark Extract in <i>db</i>/<i>db</i> Mice

    Shimato Yota , Hattori Tatsuhiko , Ohno Takamasa

    … <p>The extract of Lycium bark (LBE), which is the root bark of <i>Lycium chinense</i>, has long been used in China for hypertension, inflammation, and diabetes. … LBE has been reported to ameliorate hyperglycemia in mice with alloxan-induced type 1 diabetes, but evidence on the effect of LBE in diabetes had not been enough. …

    Biological and Pharmaceutical Bulletin 43(6), 946-950, 2020


  • State of the Art Review: Brachial-Ankle PWV

    Tomiyama Hirofumi , Shiina Kazuki

    … Furthermore, arterial stiffness might be involved in a vicious cycle with the development/progression of hypertension, diabetes mellitus and chronic kidney disease. … Increase in the arterial stiffness is thought to contribute to the development of cardiovascular disease via pathophysiological abnormalities induced in the heart, brain, kidney, and also the arteries themselves. …

    Journal of Atherosclerosis and Thrombosis, 2020


  • Plasma small extracellular vesicles in hypertensive rats impair reactivity of isolated blood vessels

    FUJIOKA Yusei , OTANI Kosuke , OKADA Muneyoshi , YAMAWAKI Hideyuki

    … We recently reported that plasma sEV in normotensive Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR), an animal model of human essential hypertension, regulate systemic blood pressure (BP). … An abnormal vascular reactivity is involved in the onset and progression of hypertension. …

    Journal of Veterinary Medical Science, 2020


  • Evaluation of an educational program for midwifery students to enhance clinical judgement about perinatal abnormalities  [in Japanese]

    OGURO Michiko , KATAOKA Yaeko , HIRUTA Akiko

    <p><b>目 的</b></p><p>妊婦の高年齢化に伴いハイリスク妊娠が増えており,助産学生が受け持つ妊産婦が異常に移行する場合が少なくない。研究目的は,助産教育においてハイリスク妊娠・周産期異常の知識の習得に加え,臨床判断力および対応力の向上を目標とした新たな教育方法を用いた教育プログラムを開発し,その評価を行うことである。< …

    Journal of Japan Academy of Midwifery, 2020


  • Superimposition of hypertension on diabetic peripheral neuropathy affects small unmyelinated sensory nerves in the skin and myelinated tibial and sural nerves in rats with alloxan-induced type 1 diabetes

    OZAKI Kiyokazu , MATSUURA Tetsuro

    … <p>Diabetic peripheral neuropathy (DPN) is a major complication of diabetes mellitus, and hypertension is considered to be a risk factor for DPN in patients with type 1 diabetes (T1DM). … However, the morphological effects of hypertension on DPN are unclear. … In this study, we investigated the effect of hypertension on DPN by investigating the changes in unmyelinated and myelinated nerve fibers in hypertensive rats with alloxan (AL)-induced T1DM. …

    Journal of Toxicologic Pathology, 2020


  • Diverse roles of nitric oxide synthases in the pathogenesis of lung diseases  [in Japanese]

    Tsutsui Masato , Yatera Kazuhiro

    … mice as compared with the WT mice, again suggesting a protective role of NOSs in the development of pulmonary hypertension (<i>AJRCCM</i> … 2018). In contrast, ovalbumin-induced bronchial thickening, eosinophilic infiltration, and mucus secretion were markedly mitigated in the triple NOSs<sup>-/-</sup> …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-S34-1, 2020


  • Pressure stress delays the transient cyclooxygenase-2 expression by interleukin-1β stimulation in cultured human pulmonary artery smooth muscle cells.  [in Japanese]

    Hiraide Sachiko , Machida Takuji , Takihana Shota , Ohshita Mikoto , Iizuka Kenji

    … <p>Pulmonary artery smooth muscle cells (PASMCs) play an important role in a sequence of events leading to the formation of pulmonary artery hypertension (PAH). … The aim of this study was to evaluate the effect of pressure stress which simulates PAH on interleukin-1β (IL-1β)-induced cyclooxygenase-2 (COX-2) expression in cultured human PASMCs. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-P-324, 2020


  • Effects of sunitinib perfusion on vascular function in the rat mesenteric arteries.  [in Japanese]

    Chisato Furukawa , Kentaro Nakagawa , Hiromu Kawasaki , Kazuhiko Shibata , Shingo Takatori

    … It has become a clinical problem with sunitinib-induced hypertension, which is one of most common adverse effects related to MKI treatment. … Changes in perfusion pressure were measured with a pressure transducer.</p><p><b>Results</b>: In rat mesenteric vascular beds treated with sodium deoxycholate (SD) to remove vascular endothelial cells with active tone, acetylcholine (ACh)-induced vasodilation was markedly inhibited. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-P-295, 2020


  • Identification of B38-CAP as an ACE2-like enzyme to suppress hypertension and cardiac dysfunction in mice.  [in Japanese]

    Kuba Keiji , Minato Takafumi , Nirasawa Satoru , Sato Teruki , Yamaguchi Tomokazu , Watanabe Hiroyuki , Imai Yumiko , Takahashi Saori

    … Treatment with B38-CAP reduced plasma angiotensin II levels and suppressed angiotensin II-induced hypertension, cardiac hypertrophy and fibrosis in mice. … Moreover, continuous infusion of B38-CAP inhibited pressure overload-induced pathological hypertrophy, myocardial fibrosis, and cardiac dysfunction in mice, without any overt toxicity of liver and kidney. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-P-314, 2020


  • Involvement of mitochondrial Na<sup>+</sup>/Ca<sup>2+</sup> exchanger in hypoxia-induced pulmonary arterial hypertension.  [in Japanese]

    Kita Satomi , Tagashira Hideaki , Kita Tomo , Sinayama Ai , Iwamoto Takahiro

    … <p>Pulmonary arterial hypertension (PAH) is characterized by pulmonary artery remodeling and inappropriate vasoconstriction, which results in a marked increase in pulmonary arterial pressure and right ventricular hypertrophy. … exchanger (NCLX) in the development and progression of PAH, we generated a mouse model of hypoxia-induced PAH using NCLX knockout (NCLX-KO) mice, vascular smooth muscle-specific NCLX transgenic (VSM-NCLX-Tg) mice and wild-type (WT) mice. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-P-315, 2020


  • Vascular remodeling in pulmonary arterial hypertension: roles of CaSR and PDGF  [in Japanese]

    Yamamura Aya

    … <p>Pulmonary arterial hypertension (PAH) is a progressive and fatal disease associated with remodeling of the pulmonary artery. … We previous found that the Ca<sup>2+</sup>-sensing receptor (CaSR) is upregulated in PASMCs from idiopathic pulmonary arterial hypertension (IPAH) patients, and contributes to enhanced Ca<sup>2+</sup> … PDGF-induced activation of PDGF receptors and its downstream molecules (ERK1/2, p38, Akt, and STAT1/3) sustained longer in IPAH-PASMCs. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-S22-4, 2020


  • Age-related differences in responses to hydrogen sulfide in the bladder of spontaneously hypertensive rats  [in Japanese]

    Zou Suo , Hamada Tomoya , Higashi Youichirou , Saito Motoaki , Shimizu Takahiro , Shimizu Shogo , Ono Hideaki , Shimizu Yohei , Hata Yurika , Yamamoto Masaki , Aratake Takaaki , Nagao Yoshiki

    … <p>We have confirmed that hydrogen sulfide (H<sub>2</sub>S) is a possible relaxation factor in the rat bladder, and H<sub>2</sub>S-induced bladder relaxation is impaired in 18-week-old (18W) spontaneously hypertensive rats (SHRs), which show bladder dysfunctions. … M)-induced pre-contracted bladder strips. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-P-203, 2020


  • The inhibitory effect of Orengedokuto on human aortic valve calcification  [in Japanese]

    Liu Xu , Yu Zaiqiang , Yang Wei , Daitoku Kazuyuki , Motomura Shigeru , Imaizumi Tadaatu , Fukuda Ikuo , Furukawa Ken-Ichi , Seya Kazuhiko

    … In this study, we investigated the inhibitory effect of Orengetokuto (OGT) on TNF-α-induced calcification of HAVICs. … OGT is composed of four crude drugs (Coptodis rhizoma, Scutellariae radix, Phellodendri cortex, and Gardeniae fructus) and is used for hypertension, palpitation and others. … HAVICs isolated from aortic valves were cultured in α-MEM including 10% FBS, and calcification was induced by TNF-α (30 ng/μL). …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-P-211, 2020


  • Effects of chemerin-9 on contractility of isolated pulmonary artery from pulmonary artery hypertensive rat  [in Japanese]

    Omori Ayaho , Kodama Tomoko , Goshima Makoto , Kakuda Chiharu , Okada Muneyoshi , Yamawaki Hideyuki

    … Pulmonary artery hypertension (PAH) is a fatal disease caused by the increased PA resistance. … We examined the effects of chemerin-9 on contractility of PA from monocrotaline (MCT)-induced PAH rat. … Chemerin-9-induced contraction was significantly enhanced in PA from MCT rat compared with vehicle-injected control (Cont) rat. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-O-062, 2020


  • Bacterial toxin, streptolysin O caused vascular endothelial dysfunction: Relationship between dysbiosis and hypertension  [in Japanese]

    Mukohda Masashi , Nakamura Sho , Takeya Kosuke , Matsuda Akira , Yano Takanori , Mizuno Risuke , Ozaki Hiroshi

    … genus in hypertension may cause dysregulation of blood pressure. … In contrast, streptolysin O significantly impaired acetylcholine-induced endothelial dependent relaxation in a dose-dependent manner (n=6, p&lt;0.05), while sodium nitroprusside-induced endothelial independent relaxation was unchanged (n=4). …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-O-061, 2020


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