Search Results 1-20 of 188

  • Effect of Lubiprostone on Urinary Protein Excretion: A Report of Two IgA Nephropathy Patients with Chronic Constipation

    Takeshita Mitsuhide , Tanaka Atsushi , Nakamura Tsukasa , Sato Eiichi , Node Koichi

    … The lubiprostone treatment ameliorated their chronic constipation and, unexpectedly, reduced the urinary protein excretion, urinary liver-type fatty acid binding protein and urine occult blood. …

    Internal Medicine, 2020

    J-STAGE 

  • Comparison of urinary Liver-type Fatty Acid-Binding Protein (L-FABP) and novel nephrotoxicity biomarkers with adenine-induced chronic kidney injury in rats  [in Japanese]

    SUZUKI Yoshiyuki , TAKEDA Masayuki , ICHIKAWA Atsuko , TAKAO Miyuki , KUBOTA Takayuki , IKEDA Genta , KITTA Kumiko , KOMATSU Hiroyuki , SUGAYA Takeshi , AKIE Yasuki

    <p>【目的】我々は,尿中L-FABPが,げっ歯類及び非げっ歯類の急性腎障害モデルにおいて,初期の腎組織障害の検出に有用なバイオマーカー(BM)であることを報告してきた.今回,ラットのアデニン誘発慢性腎障害モデルを用いて,慢性腎障害における尿中L-FABP及び新規腎障害BMの変化を経時的に比較検討したので報告する.</p><p>【方法】6週齢の雄性SDラットにア …

    Annual Meeting of the Japanese Society of Toxicology 46.1(0), P-235, 2019

    J-STAGE 

  • Evaluation of sensitive biomarkers for proximal tubule injuries upon exposure to low-dose cadmium  [in Japanese]

    MASUTOMI Yuki , OOTERA Nobuki , OKA Nanae , JINNO Mei , FUJISHIRO Hitomi , HIMENO Seiichiro

    … 再吸収障害については、albumin、transferrin、β<sub>2</sub>-microglobulin(β<sub>2</sub>-MG)、metallothionein(MT)、liver-type fatty acid binding protein(L-FABP)を蛍光標識し、マウスの近位尿細管のS1, S2部位由来の不死化細胞を用いて、エンドサイトーシスによる細胞内取り込みを測定する系を樹立した。 …

    Annual Meeting of the Japanese Society of Toxicology 46.1(0), P-190, 2019

    J-STAGE 

  • A case of hepatocyte nuclear factor 1α-inactivated hepatocellular adenoma associated with low-dose estrogen progestin use  [in Japanese]

    IWAHASHI Akiko , KAWAGUCHI Hiroshi , MORITA Natsuko , OHASHI Hiroshi , MORIMOTO Osakuni , SASAKI Motoko , IGURA Takumi , TAKEHARA Mikio

    <p>肝細胞腺腫は非硬変肝に生じるまれな良性腫瘍であり,経口避妊薬服用中の若年女性,ステロイド服用者,I型糖原病患者に発症することが多い.近年,分子病理学的に4つの亜型に分類され,診断や予後の予測に用いられるようになった.今回われわれは,月経困難症に対するLEP服用者でAIS罹患を契機に肝細胞腺腫を診断し,手術療法を施行した1例を経験したので報告する.症例は29歳,1妊0産.前医より子 …

    ADVANCES IN OBSTETRICS AND GYNECOLOGY 71(1), 22-29, 2019

    J-STAGE  Ichushi Web 

  • Human-specific dual regulations of FXR-activation for reduction of fatty liver using <i>in vitro</i> cell culture model

    Miyazaki Teruo , Honda Akira , Ikegami Tadashi , Iida Takashi , Matsuzaki Yasushi

    … <p>Nuclear receptor farnesoid X receptor activation inhibits fatty acid synthesis through the liver X receptor-α-sterol regulatory element binding protein-1c pathway universally in animals, but also has human-specific crosstalk with the peroxisome proliferator-activated receptor-α. …

    Journal of Clinical Biochemistry and Nutrition 64(2), 112-123, 2019

    J-STAGE 

  • Preventive Effect of <i>Citrus aurantium</i> Peel Extract on High-Fat Diet-Induced Non-alcoholic Fatty Liver in Mice

    Han Hyoung-Yun , Lee Sung-Kwon , Choi Bong-Keun , Lee Dong-Ryung , Lee Hae Jin , Kim Tae-Won

    … <p>Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic lipid accumulation, which is the most common form of chronic liver disease. … After 8 weeks of treatment, all mice were euthanized, and plasma and liver tissues were analyzed biochemically and histopathologically. … The results indicate that CAE treatment significantly reduced HFD-induced NAFLD, as shown by decreased serum lipid index and prevented liver histopathology. …

    Biological and Pharmaceutical Bulletin 42(2), 255-260, 2019

    J-STAGE 

  • CREBH Regulates Systemic Glucose and Lipid Metabolism

    Nakagawa Yoshimi , Shimano Hitoshi , 中川 嘉

    … The cyclic adenosine monophosphate (cAMP)-responsive element-binding protein H (CREBH, encoded by CREB3L3) is a membrane-bound transcriptional factor that primarily localizes in the liver and small intestine. … CREBH governs triglyceride metabolism in the liver, which mediates the changes in gene expression governing fatty acid oxidation, ketogenesis, and apolipoproteins related to lipoprotein lipase (LPL) activation. …

    International journal of molecular sciences 19(5), 1396, 2018-05

    IR 

  • Increased oxidative stress and coenzyme Q10 deficiency in centenarians

    Nagase Midori , Yamamoto Yorihiro , Matsumoto Nozomi , Arai Yasumichi , Hirose Nobuyoshi

    … Inflammation scores have been determined based on the levels of cytokines and C-reactive protein, however, serum antioxidants and lipid profiles have not been carefully examined. … We found that the redox balance of coenzyme Q10 significantly shifted to the oxidized form and levels of strong antioxidants, such as ascorbic acid and unconjugated bilirubin, decreased significantly compared to 76-year-old controls, indicating an increased oxidative stress in centenarians. …

    Journal of Clinical Biochemistry and Nutrition 63(2), 129-136, 2018

    J-STAGE  Ichushi Web 

  • Increased oxidative stress and renal injury in patients with sepsis

    Yamaguchi Junko , Nagase Midori , Yamamoto Yorihiro , Sakurai Atsushi , Kubo Airi , Mitsuhashi Hikaru , Matsuoka Masaru , Ihara Shingo , Kinoshita Kosaku

    … Increased oxidative stress was confirmed in sepsis patients (<i>n</i> = 18) at the time of hospitalization by a significant decrease in plasma ascorbic acid and a significant increase in the percentage of oxidized form of coenzyme Q10 in total coenzyme Q10 compared to age-matched healthy controls (<i>n</i> = 62). …

    Journal of Clinical Biochemistry and Nutrition 63(2), 137-143, 2018

    J-STAGE  Ichushi Web 

  • Establishment and application of <i>in vitro</i> evaluation system for proximal tubule dysfunctions  [in Japanese]

    FUJISHIRO Hitomi , HIMENO Seiichiro

    … タンパク質として、albumin, transferrin, β<sub>2</sub>-microgloblin, metallothionein, liver-type fatty acid binding protein(L-FABP)を蛍光標識した。 …

    Annual Meeting of the Japanese Society of Toxicology 45.1(0), W6-4, 2018

    J-STAGE 

  • Potential usefulness of serum level of liver-type fatty acid-binding protein (L-FABP) as a biomarker of nonalcoholic steatohepatitis (NASH) using female SDT fatty rats  [in Japanese]

    RYU Kanjiro , KEMURIYAMA Noriko , NAKAE Dai , MIYAJIMA Katsuhiro , TEOH Soon Hui , SHINOHARA Masami , OHTA Takeshi , OHATA Keiichi , OGAWA Shuji , WATANABE Atsushi , UNO Kinuko

    … <p>【目的】本研究は、糖尿病性腎症など腎障害の尿中バイオマーカーとして用いられている肝臓型脂肪酸結合蛋白(L-FABP)の血清量の非アルコール性脂肪性肝炎(NASH)バイオマーカーとしての有用性について検討する目的で、糖尿病のモデル動物でNASH様病態も誘発する雌性SDT fattyラットを用いた検討を行った。 …

    Annual Meeting of the Japanese Society of Toxicology 45.1(0), P-7, 2018

    J-STAGE 

  • Vitamin D Deficiency Increases Lipogenesis and Reduces Beta-Oxidation in the Liver of Diet-Induced Obese Mice

    BORGES Celina Carvalho , SALLES Andreza Fernandes , BRINGHENTI Isabele , MANDARIM-DE-LACERDA Carlos Alberto , AGUILA Marcia Barbosa

    … The study was conducted to understand better the mechanisms involved in liver changes when there is a combination of diet-induced obesity (DIO) and vitamin D deficiency (VDD). … The protein expressions of markers linked with the vitamin D action were altered by VDD (vitamin D receptor VDR, 25-hydroxyvitamin D-24-hydroxylase CYP24A1, CYP27B1, and CYP2R1). …

    Journal of Nutritional Science and Vitaminology 64(2), 106-115, 2018

    J-STAGE 

  • Increased oxidative stress and coenzyme Q10 deficiency in centenarians

    Nagase Midori , Yamamoto Yorihiro , Matsumoto Nozomi , Arai Yasumichi , Hirose Nobuyoshi

    … Inflammation scores have been determined based on the levels of cytokines and C-reactive protein, however, serum antioxidants and lipid profiles have not been carefully examined. … We found that the redox balance of coenzyme Q10 significantly shifted to the oxidized form and levels of strong antioxidants, such as ascorbic acid and unconjugated bilirubin, decreased significantly compared to 76-year-old controls, indicating an increased oxidative stress in centenarians. …

    Journal of Clinical Biochemistry and Nutrition, 2018

    J-STAGE 

  • Increased oxidative stress and renal injury in patients with sepsis

    Yamaguchi Junko , Nagase Midori , Yamamoto Yorihiro , Sakurai Atsushi , Kubo Airi , Mitsuhashi Hikaru , Matsuoka Masaru , Ihara Shingo , Kinoshita Kosaku

    … Increased oxidative stress was confirmed in sepsis patients (<i>n</i> = 18) at the time of hospitalization by a significant decrease in plasma ascorbic acid and a significant increase in the percentage of oxidized form of coenzyme Q10 in total coenzyme Q10 compared to age-matched healthy controls (<i>n</i> = 62). …

    Journal of Clinical Biochemistry and Nutrition, 2018

    J-STAGE 

  • Retinoic acid modulates lipid accumulation glucose concentration dependently through inverse regulation of SREBP-1 expression in 3T3L1 adipocytes

    Abd Eldaim Mabrouk Attia , Matsuoka Shinya , Okamatsu-Ogura Yuko , Kamikawa Akihiro , Ahmed Mohamed Mohamed , Terao Akira , Nakajima Kei-ichi , Kimura Kazuhiro

    … It is well known that retinoic acid (RA) suppresses adipogenesis, although there are some contradicting reports. … These changes were accompanied by parallel alterations in fatty acid synthase (FAS) and sterol regulatory element-binding protein (SREBP)-1 gene expression. …

    Genes to cells 22(6), 568-582, 2017-06

    IR 

  • Fatty acid-binding protein 5 function in hepatocellular carcinoma through induction of epithelial-mesenchymal transition

    Ohata Takanori , Yokoo Hideki , Kamiyama Toshiya , Fukai Moto , Aiyama Takeshi , Hatanaka Yutaka , Hatanaka Kanako , Wakayama Kenji , Orimo Tatsuya , Kakisaka Tatsuhiko , Kobayashi Nozomi , Matsuno Yoshihiro , Taketomi Akinobu

    … The correlation between overexpression of fatty acid-binding protein 5 (FABP5) and malignant potential of tumor growth and metastasis in several cancers has been previously reported. … We compared FABP5 expression and patient characteristics in paired HCC and adjacent noncancerous liver tissues from 243 patients who underwent surgical resection of primary HCC. …

    Cancer medicine 6(5), 1049-1061, 2017-05

    IR  DOI 

  • RENAL-PROTECTIVE EFFECT OF SAXAGLIPTIN ON CHARACTERISTICS OF URINARY ALBUMIN AND URINARY LIVER-TYPE FATTY ACID BINDING PROTEIN  [in Japanese]

    中内 憲二 , ナカウチ ケンジ , Nakauchi Kenji

    東京慈恵会医科大学雑誌 = Tokyo Jikeikai medical journal 132(2), 37-44, 2017-03-15

    IR  Ichushi Web 

  • Toyocamycin attenuates free fatty acid-induced hepatic steatosis and apoptosis in cultured hepatocytes and ameliorates nonalcoholic fatty liver disease in mice

    Takahara Ikuko , Akazawa Yuko , Tabuchi Maiko , Matsuda Katsuya , Miyaaki Hisamitsu , Kido Youko , Kanda Yasuko , Taura Naota , Ohnita Ken , Takeshima Fuminao , Sakai Yusuke , Eguchi Susumu , Nakashima Masahiro , Nakao Kazuhiko

    … Background and aims A high serum level of saturated free fatty acids (FFAs) is associated with the development of nonalcoholic fatty liver disease (NAFLD). … X-box binding protein-1 (XBP-1) is activated by FFA treatment upon splicing. … Methods Huh-7 cells and isolated rat primary hepatocytes were treated with palmitic acid (PA), which is a saturated FFA, in the presence or absence of toyocamycin. …

    PLOS ONE 12(3), e0170591, 2017-03-09

    IR  DOI 

  • Use of Urinary Biomarkers for Early Diagnosis of Acute Kidney Injury After Descending Thoracic Aorta Surgery

    Takaaki Kamada , Ryoichi Ochiai

    Original Article

    Toho journal of medicine 3(1), 26-33, 2017-03

    IR  DOI  Ichushi Web 

Page Top