Search Results 1-20 of 243

  • Human asymptomatic/smoldering Waldenstrom's macroglobulinemia-like condition in a dog

    Nakajima Kosei , Koitabashi Yoshimi , Shirakawa Miho , Okubo Fumiyo

    <p>長期的なIgM型単クローン性高ガンマグロブリン血症を呈するラブラドール・レトリーバーが来院した。発見時から臨床症状は認められなかったものの、骨髄生検にて顕著に増加したリンパ形質細胞が確認された。包括的なスクリーニングによって高グロブリン血症を伴う可能性のある疾患を除外し、無症候性マクログロブリン血症と診断した。人医学と同様に、高グロブリン血症が確認された際には類症鑑別に含める必要 …

    Journal of Japan Veterinary Cancer Society 8(1), 1-7, 2019

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  • IgA-producing lymphoplasmacytic lymphoma carrying the chromosomal abnormality t(8;14)

    Gotoh Yuta , Takahashi Takayuki , Aoyama Yumi , Tsunemine Hiroko , Idei Yuka , Mori Ayano , Kodaka Taiichi , Iba Sachiko , Tomita Akihiro , Itoh Tomoo

    … <p>IgA-producing lymphoplasmacytic lymphoma (LPL) is rare and <i>IgH/c-myc</i> … Circulating lymphoplasmacytic cells with the same phenotype and karyotype were observed, and increased in number. …

    Journal of Clinical and Experimental Hematopathology 59(3), 124-129, 2019

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  • Gamma-heavy chain monoclonal gammopathy with undetermined significance (MGUS)

    Zushi Yuriko , Sasaki Miho , Saitoh Toshiharu , Aoyama Yumi , Gotoh Yuta , Tsunemine Hiroko , Kodaka Taiichi , Okamura Atsuo , Takahashi Takayuki

    … The clinical features of γ-HCD are heterogeneous, similar to lymphoplasmacytic lymphoma, and most patients have generalized and progressive disease. … Bone marrow aspirate demonstrated a small number of lymphoplasmacytic cells that were positive for CD19, CD38, CD138, and cyIgG, but negative for cyκ- and -λ light chains on flow cytometry. …

    Journal of Clinical and Experimental Hematopathology 59(3), 119-123, 2019

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  • Waldenström macroglobulinemia: Japanese perception  [in Japanese]

    SEKIGUCHI Naohiro

    <p>原発性マクログロブリン血症(WM)は稀少な低悪性度リンパ腫である。本稿では本邦から得られた知見を中心に解説する。疫学:2016年の日本血液学会疾患登録結果よりWM,リンパ形質細胞リンパ腫と診断された症例は229,125例(成熟リンパ系腫瘍の1.97%),年間発症数は2.8人/100万人であった。6番染色体長腕欠失(6q del): 6q delは代表的な染色体異常であり,かつ,予 …

    Rinsho Ketsueki 60(8), 988-997, 2019

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  • Successful detection of MYD88 L265P mutation in Waldenström's macroglobulinemia complicated with myelofibrosis using highly sensitive digital PCR  [in Japanese]

    NAWATA Ryohei , SUGIYAMA Akiko , HARADA Keisuke , SHINOHARA Kenji , YUJIRI Toshiaki

    <p>症例は78歳男性。Hb 9.6 g/d<i>l</i>の貧血およびIgM 3,577 mg/d<i>l</i>と異常値を認め当科受診。初診時の骨髄穿刺はdry tapであり,骨髄生検はCD20陽性リンパ形質細胞の増生が確認され,Waldenströmマクログロブリン血症と診断した。同時に骨髄線維化を呈し,血漿TGF-βの上昇が認めら …

    Rinsho Ketsueki 60(8), 903-909, 2019

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  • Lymphoplasmacytic lymphoma with the <i>MYD88</i><sup>L265P</sup> mutation, producing non-IgM monoclonal immunoglobulins: 4 case reports

    Nakayama Yoichi , Ohno Hitoshi , Iioka Futoshi , Toda Yusuke , Maruyama Wataru , Nagai Yuya , Akasaka Takashi , Maekawa Fumiyo , Hayashida Masahiko , Honjo Gen

    <p>我々は,主病変が骨髄にあり,IgM以外(non-IgM) のクラスのM蛋白と<i>MYD88</i><sup>L265P</sup>変異を認めたB細胞リンパ腫の4症例を報告する.年齢は50代から80代で,いずれも男性であった.初期症状や検査データは様々であったが,骨病変,腎障害,高カルシウム血症や,過粘稠症候群に伴う症候は認めなかっ …

    Tenri Medical Bulletin 22(1), 12-28, 2019

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  • Sjögren's-like syndrome in a dog

    NABETA Rina , KAMBE Naoki , NAKAGAWA Yuki , CHIBA Shiori , XIANTAO Hou , FURUYA Tetsuya , KISHIMOTO Miori , UCHIDE Tsuyoshi

    … Ultrasonographic examination detected multifocal hypoechoic areas within the swollen submandibular salivary glands, which were histopathologically diagnosed as lymphoplasmacytic sialoadenitis. …

    Journal of Veterinary Medical Science 81(6), 886-889, 2019

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  • Tumefactive fibroinflammatory lesion successfully treated with Rituximab

    Bishop Jessica L , Bryan Locke J. , Savage Natasha M. , Byrd J. Kenneth

    … Biopsy revealed benign fibromuscular and adipose tissue with lymphoplasmacytic infiltrate, giving a diagnosis of TFIL. …

    Intractable & Rare Diseases Research 8(2), 138-141, 2019

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  • Intravascular Large B-cell Lymphoma Diagnosed by Detection of the <i>MYD88</i> Gene Mutation  [in Japanese]

    ARIMATSU Tomoyuki , MIYAMOTO Kana , OGAWA Shinichi , ITOH Takayoshi

    症例は76歳女性。X年1月初めから断続的に発熱あり。徐々に食欲が低下してきたため,2月末に入院。身体所見上,局所感染徴候はなし。血液検査ではWBC 4,940/μl,Hb 7.9g/dl,Plt 10.4万/μl。他,LDH 315U/l,CRP 12.43mg/dl,可溶性IL-2R 10,200U/ml。画像上,軽度の肝脾腫を認めたため血液疾患を疑われ骨髄検査を施行。しかし,病理結果は異型リン …

    JOURNAL OF THE JAPANESE ASSOCIATION OF RURAL MEDICINE 67(5), 585, 2019

    J-STAGE  Ichushi Web 

  • Bortezomib therapy for patients with LPL/WM  [in Japanese]

    遠山 和博 , 黒川 峰夫

    血液内科 = Hematology 77(5), 683-687, 2018-11

    Ichushi Web 

  • Diagnosis and Treatment for Waldenstrom's Macroglobulinemia/Lymphoplasmacytic Lymphoma  [in Japanese]

    関口 直宏

    最新醫學 = The medical frontline 73(11), 1436-1440, 2018-11

    Ichushi Web 

  • AL amyloidosis with non-amyloid forming monoclonal immunoglobulin deposition; a case mimicking AHL amyloidosis

    長田 道夫 , Shun Manabe , Chihiro Iwasaki , Michiyasu Hatano , Fuyuki Kametani , Masahide Yazaki , Kosaku Nitta , Michio NAGATA

    … However, both techniques do not biochemically differentiate immunoglobulins that formed amyloid fibrils from non-responsible immunoglobulins.Case presentationWe herein report a case of 67-year-old female patient with renal amyloidosis due to lymphoplasmacytic lymphoma secreting monoclonal immunoglobulin M (IgM)-kappa. …

    BMC nephrology (19), 337, 2018-11

    IR 

  • Lymphoplasmacytic rhinitis  [in Japanese]

    藤原 亜紀

    SA medicine : Journal of small animal medicine 24(1), 14-17, 2018

  • Neutrophil infiltrations compared between types 1 and 2 autoimmune pancreatitis  [in Japanese]

    Mitsuyama Toshiyuki , Satoi Sohei , Mizuno Nobumasa , Notohara Kenji , Shimosegawa Tooru , Zamboni Giuseppe , Frulloni Luca , Okazaki Kazuichi , Uchida Kazushige , Sumimoto Kimi , Fukui Yuri , Ikeura Tsukasa , Fukui Toshiro , Nishio Akiyoshi , Shikata Nobuaki , Uemura Yoshiko

    <p>【背景】自己免疫性膵炎(Autoimmune pancreatitis; AIP)はわが国から提唱された疾患概念である.2011年に国際コンセンサス診断基準が作成されIgG4の関与するものを1型自己免疫性膵炎,好中球病変が主体とするものを2型自己免疫性膵炎と分類することとなった.2型自己免疫性膵炎の組織像として,好中球が膵管内腔や上皮に集簇し,管腔の破壊や閉塞をきたすことが特徴的 …

    The Journal of Kansai Medical University 69(0), 7-18, 2018

    J-STAGE  Ichushi Web 

  • Significance of oncogenic <i>MYD88</i> and <i>CD79B</i> mutations in B-cell lymphomas  [in Japanese]

    Maekawa Fumiyo , Ohno Hitoshi , Hayashida Masahiko , Sakamoto Shinichi , Maegawa Takako , Takeoka Kayo , Fukutsuka Katsuhiro , Kishimori Chiyuki , Nakagawa Miho , Honjo Gen

    <p><i>MYD88</i> と<i>CD79B</i> はNF-κB シグナル伝達経路関連因子をコードする遺伝子で,その遺伝子変異によってNF-κB経路が恒常的に活性化されリンパ腫発症に至ると考えられている.今回我々は,B 細胞リンパ腫の各カテゴリーにおける<i>MYD88</i><sup>L265 …

    Tenri Medical Bulletin 21(2), 81-89, 2018

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  • Acute neurological deterioration after rituximab and R–CHOP therapy for anti–MAG neuropathy  [in Japanese]

    Eguchi Katsuki , Tsuzaka Kazuhumi , Yabe Ichiro , Sasaki Hidenao

    <p>症例は74歳の男性.4年の経過で四肢の感覚障害,歩行時のふらつきが徐々に進行していた.他院神経内科にて精査の結果,リンパ形質細胞性リンパ腫に伴う抗myelin–associated glycoprotein(MAG)抗体陽性ニューロパチーと診断され当院に紹介された.化学療法(R–CHOP療法)を1コース施行後,weekly rituximabを4コース施行された.R–CHOP開始 …

    Neurological Therapeutics 35(3), 356-360, 2018

    J-STAGE  Ichushi Web 

  • Acute Kidney Injury by Renal Hemosiderosis Secondary to Primary Cold Agglutinin Disease Associated with an Excessive Alcohol Intake

    Imafuku Aya , Fujii Takeshi , Ohashi Kenichi , Ubara Yoshifumi , Yamamoto Go , Takemura Koji , Hasegawa Eiko , Sawa Naoki , Kawada Masahiro , Sekine Akinari , Hoshino Junichi , Takaichi Kenmei

    … We encountered a patient with CAD caused by lymphoplasmacytic lymphoma who developed AKI secondary to renal hemosiderosis after an excessive alcohol intake. …

    Internal Medicine 57(22), 3261-3265, 2018

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  • Successful Transcatheter Diagnosis and Medical Treatment of Right Atrial Involvement in IgG4-related Disease:A Case Report and Review of the Literature

    Yano Toshiyuki , Miki Takayuki , Suzuki Chisako , Takahashi Hiroki , Ishibashi-Ueda Hatsue , Miura Tetsuji , Yamamoto Motohisa , Mochizuki Atsushi , Ogawa Toshifumi , Nagano Nobutaka , Fujito Takefumi , Nishida Junichi , Nagahara Daigo , Abe Koki

    … <p>IgG4-related disease (IgG4-RD) is a fibro-inflammatory disorder characterized by lymphoplasmacytic infiltration of numerous IgG4-positive plasma cells, leading to fibrous thickening in the affected tissue. …

    International Heart Journal 59(5), 1155-1160, 2018

    J-STAGE  Ichushi Web 

  • Immunoglobulin G Subclass 4-Related Lymphoplasmacytic Thoracic Aortitis in a Patient with Acute Type A Aortic Dissection

    Uchida Tetsuro , Hamasaki Azumi , Kuroda Yoshinori , Sadahiro Mitsuaki , Tamazawa Nobuyuki , Ohe Rintaro , Yamakawa Mitsunori

    <p>Immunoglobulin G subclass 4-related disease (IgG4-RD) is a recently recognized systemic inflammatory disease characterized by an elevated serum IgG4 level and an IgG4-positive lymphocyte infi …

    Annals of Thoracic and Cardiovascular Surgery 24(4), 208-210, 2018

    J-STAGE  Ichushi Web 

  • Successful Transcatheter Diagnosis and Medical Treatment of Right Atrial Involvement in IgG4-related Disease:A Case Report and Review of the Literature

    Yano Toshiyuki , Miki Takayuki , Suzuki Chisako , Takahashi Hiroki , Ishibashi-Ueda Hatsue , Miura Tetsuji , Yamamoto Motohisa , Mochizuki Atsushi , Ogawa Toshifumi , Nagano Nobutaka , Fujito Takefumi , Nishida Junichi , Nagahara Daigo , Abe Koki

    … <p>IgG4-related disease (IgG4-RD) is a fibro-inflammatory disorder characterized by lymphoplasmacytic infiltration of numerous IgG4-positive plasma cells, leading to fibrous thickening in the affected tissue. …

    International Heart Journal, 2018

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