Search Results 1-20 of 76

  • 1 / 4
  • <b>Sensing and Catalytic Systems with Monoclonal Antibodies </b>  [in Japanese]

    YAMAGUCHI Hiroyasu

    … We have prepared monoclonal antibodies for various compounds such as optically active substances and transition-metal complexes. …

    Journal of the Society of Materials Engineering for Resources of Japan 29(1_2), 1-6, 2018

    J-STAGE 

  • Expectation to fermentation innovative drug development  [in Japanese]

    Hino Motohiro

    … In addition, the discovery of iPS cells has made regenerative medicine greatly attracted attention, and a paradigm shift of the innovative drug development technology is happening from small molecular to macromolecular substances and cells. …

    MEDCHEM NEWS 25(1), 22-27, 2015

    J-STAGE 

  • P-12 Study on the culture condition of enhancing hydrocarbon productivity of microalgae

    LIU Yifan , FURUHASHI Kenichi , HASEGAWA Fumio , KAIZU Yutaka , IMOU Kenji

    … Besides, microscopic observation of algae cultured at different stages showed that the high salinity medium reduced the thickness of the macromolecular substances covering the algae colony, which could explain the reason why brackish water medium was more effective in recovering hydrocarbons. …

    Proceedings of the Conference on Biomass Science 10(0), 71-72, 2015

    J-STAGE 

  • Effects of Repeated Intravenous Administration of Dextrans,Water-soluble Macromolecules, in Rats

    Kitazawa Ikue , Ito Shino , Kagawa Yusuke , Suehiro-Narita Miki , Hashizume Naoto , Minamisawa Yuka , Nii Aisuke , Kawakami Akio , Nakajima Shinichi

    … These results are considered useful in interpreting data from preclinical studies, in which DEXs or their derivatives are administered as test or control substances. …

    Journal of Toxicologic Pathology 27(3+4), 231-234, 2014

    J-STAGE  Ichushi Web 

  • Novel Diagnostic Method of Peritoneal Injury Using Dual Macromolecular Markers

    Hirata Haruna , Miyamoto Hirotaka , Shimokawa Kenta , Nakashima Mikiro , Nakayama Morio , Fumoto Shintaro , Nishida Koyo

    … Then, marker substances of various molecular weights (phenolsulfonphthalein, fluorescein isothiocyanate-dextran (FD)-10, FD-40, FD-70, FD-2000 or tetramethylrhodamine-dextran (RD)-10) were injected into the peritoneal cavity. … At 120 min after injection, the remaining amounts of all marker substances were significantly decreased in the MGO-treated rats compared with those in the vehicle-treated rats. …

    Biological and Pharmaceutical Bulletin 37(2), 262-267, 2014

    IR  J-STAGE  Ichushi Web 

  • Crystallization strategy for the glycoprotein-receptor complex between measles virus hemagglutinin and its cellular receptor SLAM.

    Hashiguchi Takao , Ose Toyoyuki , Kubota Marie , Maita Nobuo , Kamishikiryo Jun , Maenaka Katsumi , Yanagi Yusuke

    Measles virus (MV), one of the most contagious agents, infects immune cells using the signaling lymphocyte activation molecule (SLAM) on the cell surface. A complex of SLAM and the attachment protein, …

    福山大学薬学部研究年報 = Protein and peptide letters (31), 35-35, 2013-12-25

    IR 

  • Hypothesis:Apheresis Treatments Are Not Mere Removal of the Pathogenic Substances from Blood  [in Japanese]

    Agishi Tetsuzo

    … Apheresis treatments have been recognized as a modality of blood purification procedures, specifically beneficial for removal of the macromolecular pathogenic substances from blood. … However, recent reports which refer to the healthy conditions brought about by repeated plasma donations and prophylactic apheresis lead me to propose the hypothesis that apheresis treatments are not mere removal of the pathogenic substances from blood. …

    日本アフェレシス学会雑誌 32(2), 135-137, 2013

    NDL Digital Collections 

  • Pdz adaptors : Their regulation of epithelial transporters and involvement in human diseases

    Sugiura Tomoko , Shimizu Takuya , Kijima Ai , Minakata Sosuke , Kato Yukio

    … Homeostasis in the body is at least partially maintained by mechanisms that control membrane permeability, and thereby serve to control the uptake of essential substances (e.g., nutrients) and the efflux of unwanted substances (e.g., xenobiotics and metabolites) in epithelial cells. …

    Journal of Pharmaceutical Sciences 100(9), 3620-3635, 2011-09-01

    IR  Cited by (1)

  • Pdz adaptors: Their regulation of epithelial transporters and involvement in human diseases

    Sugiura Tomoko , Shimizu Takuya , Kijima Ai , Minakata Sosuke , Kato Yukio

    … 金沢大学医薬保健研究域薬学系Homeostasis in the body is at least partially maintained by mechanisms that control membrane permeability, and thereby serve to control the uptake of essential substances (e.g., nutrients) and the efflux of unwanted substances (e.g., xenobiotics and metabolites) in epithelial cells. …

    Journal of Pharmaceutical Sciences xx(xx), xxxx-xxxx, 2011-01-01

    IR 

  • Transepithelial Transport of Macromolecular Substances in IL-4 Treated Human Intestinal T84 Cell Monolayers

    MOCHIZUKI Tetsunosuke , SATSU Hideo , TOTSUKA Mamoru , SHIMIZU Makoto

    … Sodium azide (NaN<SUB>3</SUB>), which inhibits ATP synthesis of the cells, did not inhibit the increases in these substances. …

    Bioscience, Biotechnology, and Biochemistry 73(11), 2422-2426, 2009-11-23

    J-STAGE  Ichushi Web  References (19) Cited by (1)

  • Pyrolysis- and Chemical Degradation-GC/MS Analyses of Environmental Kerogen and Humic Substances and Their Applications to Geochemistry  [in Japanese]

    YAMAMOTO Shuichi , YOSHIOKA Hideyoshi , ISHIWATARI Ryoshi

    … A brown complex or refractory organic materials, which are often called humic substances and kerogen, are ubiquitous in aquatic and terrestrial environments. … The molecular characterization of these materials is difficult due to their insolubility and complex macromolecular nature. …

    BUNSEKI KAGAKU 56(2), 71-91, 2007-02-05

    J-STAGE  NDL Digital Collections  References (121) Cited by (3)

  • Clinical studies of pediatric malabsorption syndromes  [in Japanese]

    細山田 隆

    … An electron microscope analysis of the small bowel in 2 cases showed alterations:increased pinocytosis in microvillus membranes and lysosomes by endocytosis of undigested macromolecular substances. …

    Fukuoka acta medica 97(11), 322-350[含 英語文要旨], 2006-11-25

    IR  DOI  Ichushi Web 

  • Gene Delivery into Brain Capillary Endothelial Cells Using Antp-Modified DNA-Loaded Nanoparticles

    HUANG Rongqin , YANG Wuli , JIANG Chen , PEI Yuanying

    … The nanoparticles could protect themselves from the displacement of anionic substances and the digestion of DNase I. …

    Chemical and Pharmaceutical Bulletin 54(9), 1254-1258, 2006-09-01

    J-STAGE  Ichushi Web  References (11)

  • Measurement of Hydrophobic Macromolecular Solution with High Sensitivity Using Taste Sensor  [in Japanese]

    TAKAMATSU Ryuji , TOKO Kiyoshi

    … Environmental-hormone substances elute from a familiar vessel etc., as stated above. … The purpose of this study is to measure hydrophobic macromolecular solution with high sensitivity using taste sensor. …

    Research reports on information science and electrical engineering of Kyushu University 7(1), 59-64, 2002-03

    IR  DOI 

  • An autopsied case of multiple organ failure due to vespa mandarinia stings  [in Japanese]

    FUJIBAYASHI Tetsuo , YASUDA Yoshikazu , ISHIMOTO Masayuki , SUZUKI Hisato , FUKUDA Satoru , NAIKI Hironobu

    … We suggest that plasma exchange should be initiated as soon as possible, because hornet venom contains many kinds of cellulotoxic macromolecular substances. …

    Journal of the Japanese Society of Intensive Care Medicine 8(3), 171-176, 2001-07-01

    J-STAGE  Ichushi Web  References (7) Cited by (3)

  • The Formation of Cell Aggregates in Response to Heat Shock in Halobacterium halobium

    NAKAYAMA M. , Inoue Mika

    … On the synthesis of macromolecular substances, the protein synthesis is significantly stimulated by aggregated cells, but in free cells, RNA synthesis is more active than protein synthesis. …

    Memoirs of Osaka Kyoiku University Ser.3 Natural science and applied science 47(2), 257-262, 1999-01

    IR  Cited by (1)

  • MONITORING OF AFLATOXIN EXPOSURE BY BIOMARKERS

    MAKARANANDA Kittima , PENGPAN Urathida , SPISAKULTHONG Mukda , YOOVATHAWORN Krongtong , SRIWATANAKUL Kampon

    … However, the presence of substances that are presumably not AFs and which are inhibitory in the ELISA system has necessitated the development of purification techniques, usually based on adsorption onto Sep-Pak C18 cartridges and immunoaffinity chromatography. … Among the various possible biomarkers of AF exposure, the measurements of AF-DNA and-protein adducts are of major interest because they are direct products of damage to a critical cellular macromolecular target. …

    The Journal of Toxicological Sciences 23, 155-159, 1998-07-24

    J-STAGE  Ichushi Web  References (15) Cited by (1)

  • Development of Drug Delivery Systems for Macromolecular Drugs  [in Japanese]

    TAKAKURA Yoshinobu

    … With a rapid progress in biotechnology, a variety of endogenous macromolecular substances have become a novel class of therapeutic agents. … This review will focus on the development of delivery systems for macromolecular drugs. … Based on this information, we first developed macromolecular prodrugs as a delivery system for low molecular weight drugs. …

    Journal of the Pharmaceutical Society of Japan 116(7), 519-532, 1996-07-25

    References (56) Cited by (1)

  • Development of Drug Delivery Systems for Macromolecular Drugs

    TAKAKURA Yoshinobu

    … With a rapid progress in biotechnology, a variety of endogenous macromolecular substances have become a novel class of therapeutic agents. … This review will focus on the development of delivery systems for macromolecular drugs. … Based on this information, we first developed macromolecular prodrugs as a delivery system for low molecular weight drugs. …

    YAKUGAKU ZASSHI 116(7), 519-532, 1996

    J-STAGE 

  • Pharmacokinetic Analysis and Development of Delivery Systems of Macromolecular Drugs.  [in Japanese]

    TAKAKURA Yoshinobu

    … Various endogenous macromolecular substances have become a new class of therapeutic agents with recent progress in biotechnology. … For a successful use of the macromolecular drugs, optimal delivery systems should be developed. … In our laboratory, a series of pharmacokinetic studies have been carried out aiming at the development of delivery systems for macromolecular drugs. …

    Drug Metabolism and Pharmacokinetics 11(4), 436-442, 1996

    J-STAGE 

  • 1 / 4
Page Top