Search Results 1-20 of 221

  • Sanguinarine Rapidly Relaxes Rat Airway Smooth Muscle Cells Dependent on TAS2R Signaling

    Luo Mingzhi , Yu Peili , Ni Kai , Jin Yang , Liu Lei , Li Jingjing , Pan Yan , Deng Linhong

    … Here, cell stiffness, traction force, calcium signaling, cAMP levels, and the mRNA expression were evaluated by using optical magnetic twisting cytometry, traction force microscopy, Fluo-4/AM labeling, ELISA, and qRT-PCR, respectively. …

    Biological and Pharmaceutical Bulletin, 2020


  • Time-resolved Conformational Analysis during GPCR-Gs Coupling  [in Japanese]

    Du Yang , Asuru Awuri , Chance Mark R. , Lodowski David T. , Kobilka Brian K. , Chung Ka Young , Duc Nguyen Minh , Rasmussen Søren G.F. , Hilger Daniel , Kubiak Xavier , Wang Liwen , Bohon Jennifer , Kim Hee Ryung , Wegrecki Marcin

    … To understand the precise signaling mechanism, studies have investigated the structural mechanism of signaling proteins using various biochemical and/or biophysical techniques such as X-ray crystallography, nuclear magnetic resonance (NMR), electron microscopy, and electron paramagnetic resonance. … In addition to these techniques, surface labeling mass spectrometry has been successfully used for conformational analysis of signaling proteins. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-S28-3, 2020


  • Hemangioblastoma of the Cerebellopontine Angle Evaluated with Pseudocontinuous Arterial Spin Labeling

    Kishi Seiya , Maeda Masayuki , Kogue Ryota , Umino Maki , Matsubara Toshio , Sakuma Hajime

    … We report a case of hemangioblastoma of the CPA evaluated by pseudocontinuous arterial spin labeling (pCASL). …

    Magnetic Resonance in Medical Sciences, 2020


  • Simple Identification of Cerebrospinal Fluid Turbulent Motion Using a Dynamic Improved Motion-sensitized Driven-equilibrium Steady-state Free Precession Method Applied to Various Types of Cerebrospinal Fluid Motion Disturbance

    ATSUMI Hideki , HORIE Tomohiko , KAJIHARA Nao , SUNAGA Azusa , SAKAKIBARA Yumetaro , MATSUMAE Mitsunori

    … We therefore investigated the usefulness of a dynamic improved motion-sensitized driven-equilibrium steady-state free precession (Dynamic iMSDE SSFP) sequence of magnetic resonance imaging that is superior for ascertaining turbulent motions in healthy volunteers and patients. …

    Neurologia medico-chirurgica 60(1), 30-36, 2020


  • Anaplastic glioneuronal tumor with <i>KIAA1549/BRAF</i> fusion

    Liu Liqiong , Narayan Prithvi , Xiong Jay , Xiong Zhenggang

    Magnetic resonance imaging showed a large mixed cystic and solid mass in the left frontal lobe of cerebrum. … Histologic analysis demonstrated a neoplasm with pseudopapillary growth pattern, focal necrosis, microcalcification, and brisk mitotic activity with a high Ki67 labeling index of focally up to 20%. …

    Intractable & Rare Diseases Research 8(4), 279-282, 2019


  • Intracranial 3D and 4D MR Angiography Using Arterial Spin Labeling: Technical Considerations

    Suzuki Yuriko , Fujima Noriyuki , van Osch Matthias J.P.

    … <p>In the 1980's some of the earliest studies of arterial spin labeling (ASL) MRI have demonstrated its ability to generate MR angiography (MRA) images. … not only focusing on the basic sequences based upon pulsed ASL or pseudo-continuous ASL, but also including more recent labeling approaches, such as vessel-selective labeling, velocity-selective ASL, vessel-encoded ASL and time-encoded ASL. …

    Magnetic Resonance in Medical Sciences, 2019


  • Prediction of Hypoxia in Brain Tumors Using a Multivariate Model Built from MR Imaging and <sup>18</sup>F-Fluorodeoxyglucose Accumulation Data

    Shimizu Yukie , Kudo Kohsuke , Kameda Hiroyuki , Harada Taisuke , Fujima Noriyuki , Toyonaga Takuya , Tha Khin Khin , Shirato Hiroki

    … MRI scans were performed using a 3T scanner, and dynamic contrast-enhanced (DCE) perfusion and arterial spin labeling images were obtained. …

    Magnetic Resonance in Medical Sciences, 2019


  • Impact of <i>b</i>-Value Sampling Scheme on Brain IVIM Parameter Estimation in Healthy Subjects

    Chabert Stéren , Verdu Jorge , Huerta Gamaliel , Montalba Cristian , Cox Pablo , Riveros Rodrigo , Uribe Sergio , Salas Rodrigo , Veloz Alejandro

    … Analysis was undertaken in ROI defined using in the Automated Anatomical Labeling atlas, and parameters distributions were compared in a total of 832 ROI.</p><p>Results: Maps with fewer speckles were obtained with the 'optimized' distribution. …

    Magnetic Resonance in Medical Sciences, 2019


  • Detection and Labeling of Lumbar Vertebral Body Using CNN in X-Ray Image  [in Japanese]

    TAKADA Masahiro , KINOSHITA Akira , KAWABATA Shigenori

    <p>脊磁計とは,無侵襲に脊髄からの磁場を計測し,得られた磁場から脊髄周辺の電流分布を推定して可視化する装置である.電流分布の推定のためには低線量単純X線画像から脊髄領域を指定する必要があるが,脊髄領域の指定は医師の手により行われているため,電流分布の推定までの処理を自動化できず,検査の高コスト化を招いている.そこで,低線量単純X線画像上の脊髄領域の自動抽出を目的とし,3つのステップ: …

    Medical Imaging Technology 37(4), 194-203, 2019

    J-STAGE  Ichushi Web 

  • Electrical measurement and quantification of different cell types by electro chemical impedance spectroscopy  [in Japanese]

    浅川 瑞光 , 野中 拓 , 川嶋 大介 , 水谷 武臣 , 小原 弘道 , 菅原 路子 , 武居 昌宏

    … Although fluorescent labeling and magnetic labeling of cells have been used for cell separation, invasive label-free methods are required from the point of view of cell damage. …

    The Proceedings of Conference of Kanto Branch 2019.25(0), 18A14, 2019


  • Second harmonic generation polarization microscopy as a tool for protein structure analysis

    Kaneshiro Junichi , Okada Yasushi , Shima Tomohiro , Tsujii Mika , Imada Katsumi , Ichimura Taro , Watanabe Tomonobu M.

    … Moreover, nuclear magnetic resonance or Förster resonance energy transfer can measure structural dynamics. … These results illustrate the potential of this method for protein structure analysis in physiological solutions at room temperature without any labeling.</p> …

    Biophysics and Physicobiology 16(0), 147-157, 2019


  • Free Breathing Multiple Post Labeling Delay Renal Perfusion Imaging [Presidential Award Proceedings]  [in Japanese]

    TAKEI Naoyuki , ISHIDA Shota , KANAMOTO Masayuki , MATTA Yuki , KOSAKA Nobuyuki , KIMURA Hirohiko , KABASAWA Hiroyuki

    … Pseudocontinous arterial spin labeling (pCASL) renal perfusion imaging is typically restricted to a single post-label delay (PLD) time. … The feasibility study explores the application of Hadamard encoding to renal perfusion imaging where spin labeling is affected by pulsatile flow, and demonstrated that a cardiac-triggered scan provided stable perfusion images achieving arterial transit time-corrected renal blood flow with seven PLD acquisitions.</p> …

    Japanese Journal of Magnetic Resonance in Medicine 39(2), 60-62, 2019

    J-STAGE  Ichushi Web 

  • Three-dimensional Pseudo-continuous Arterial Spin-labeling Using Turbo-spin Echo with Pseudo-steady State Readout: A Comparison with Other Major Readout Methods

    Aoike Suzuko , Sugimori Hiroyuki , Fujima Noriyuki , Suzuki Yuriko , Shimizu Yukie , Suwa Akira , Ishizaka Kinya , Kudo Kohsuke

    … <p>We evaluated 3D pseudo-continuous arterial spin labeling (pCASL) using turbo spin echo with a pseudo-steady-state (PSS) readout in comparison with the other major readout methods of 3D spiral and 2D echo-planar imaging (EPI). …

    Magnetic Resonance in Medical Sciences 18(2), 170-177, 2019


  • Deep Sylvian Meningioma without Dural Attachment – A Case Report

    Yamagishi Masayuki , Tokimura Hiroshi , Bohara Manoj , Komasaku Soichiro , Yamada Masahiko , Kawahara Dan , Sadamura Yuko , Mori Masanao , Nishimuta Yosuke , Ishii Takeshi

    Magnetic resonance imaging showed that the lesion was isointense on T<sub>1</sub>- and T<sub>2</sub>-weighted images (WI), with homogenous enhancement on post-gadolinium T<sub>1</sub>WI. … Histopathological examination of the lesion revealed both meningothelial and fibroblastic features, thereby suggesting the diagnosis of transitional meningioma (WHO grade I), with Ki-67 labeling index of 6.9%. …

    NMC Case Report Journal 6(2), 51-55, 2019

    J-STAGE  Ichushi Web 

  • The Accuracy of Low Magnetic Field MRI in Brain Volume Measurement; Atlas-Based Analysis


    … High magnetic field magnetic resonance imaging (MRI) has an advantage in evaluating brain volume due to its high signal-to-noise ratio (SNR). … However, many facilities only have low magnetic field MRI. … The brain was segmented to 116 regions of interest (ROIs) as listed in Automated Anatomical Labeling atlas. …

    Juntendo Medical Journal 64(Suppl.1), 71-71, 2018


  • Water Diffusion in the Brain of Chronic Hypoperfusion Model Mice: A Study Considering the Effect of Blood Flow

    Urushihata Takuya , Ito Hiroshi , Obata Takayuki , Takuwa Hiroyuki , Seki Chie , Tachibana Yasuhiko , Takahashi Manami , Kershaw Jeff , Takado Yuhei , Aoki Ichio , Higuchi Makoto

    … Thus, we used DTI to evaluate DWI signal changes in the brains of chronic hypoperfusion model mice at 4 weeks after UCCAO while monitoring the possible influence of CBF change using arterial spin-labeling (ASL) MRI.</p><p>Results: Simple <i>t</i>-tests indicated that there were significant differences in CBF between the control and occluded sides of the brain, but there was no significant difference for the mean diffusivity (MD) or fractional anisotropy (FA). …

    Magnetic Resonance in Medical Sciences 17(4), 318-324, 2018

    J-STAGE  Ichushi Web 

  • Diagnostic Performance of Arterial Spin Labeling for Grading Nonenhancing Astrocytic Tumors

    Khashbat Delgerdalai , Nagahiro Shinji , Harada Masafumi , Abe Takashi , Ganbold Mungunbagana , Iwamoto Seiji , Uyama Naoto , Irahara Saho , Otomi Youichi , Kageji Teruyoshi

    … <p>Purpose: We evaluated the utility of arterial spin labeling (ASL) imaging of tumor blood flow (TBF) for grading non-enhancing astrocytic tumors.</p><p>Materials and Methods: Thirteen non-enhancing astrocytomas were divided into high-grade (<i>n</i> … Both ASL and conventional sequences were acquired using the same magnetic resonance machine. …

    Magnetic Resonance in Medical Sciences 17(4), 277-282, 2018

    J-STAGE  Ichushi Web 

  • Cerebral circulation measurement with <sup>15</sup>O-PET: as a tool for validating newly-developed methods  [in Japanese]

    Ibaraki Masanobu

    <p>酸素15 標識ガスおよび標識水を用いたPET 測定(<sup>15</sup>O-PET)により,脳血流量(CBF)を含む主要な脳循環パラメータが高精度に,しかも1 回の検査で取得可能である.脳血管障害の病態評価における臨床的有用性が広く知られているが,近年では他モダリティによる脳循環測定法開発の評価ツールとしての役割も大きくなってきた.CT またはMR …

    Cerebral Blood Flow and Metabolism (Japanese journal of cerebral blood flow and metabolism) 30(1), 53-58, 2018

    J-STAGE  Ichushi Web 

  • Development of the MRI Flow Phantom System Focused on Low Speed Flows in Fluid Machinery

    Hosotani Kazunori , Uehara Shota , Ishihara Toru , Ono Atsushi , Takeuchi Kazuhiro , Hashiguchi Yusuke

    … <p>At present, magnetic resonance imaging (MRI), which is one of the noninvasive diagnostic imaging techniques for medical use, has been applied to industrial product inspection. … In this article, the test results of double cylindrical pipe flow, elbow pipe flow, cylindrical valve flow, and jet pump flow, which are often seen in fluid machines, are tested using the 2D time-spatial labeling inversion pulse (Time-SLIP) method, which can track a labeled water mass and visualize it using two-dimensional images. …

    Journal of Robotics and Mechatronics 30(4), 650-659, 2018


  • Anatomical and Functional Network in Visual Perception  [in Japanese]

    Sawamura Hiromasa

    網膜から入力した視覚情報はボトムアップ方式に情報が送られ段階的・階層的情報処理を受けると同時に,高次視覚領域からの注意や記憶といったトップダウン式の修飾も受ける.このような視覚認知のNetworkの解明には解剖学的および機能的な神経構造基盤の知見の双方を積み上げていく必要がある.<br>本稿では,①解剖学的神経構造基盤の例として,マカクザルを実験動物として,狂犬病ウイルスをトレーサーと …

    Neuro-Ophthalmology Japan 35(2), 159-166, 2018

    J-STAGE  Ichushi Web 

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