Search Results 1-20 of 1887

  • Concepts of Evolutionary Theory and Biogeography : Through a Comparison of Darwin and Wallace

    野尻 亘

    … "Geographicalisolation" was taken to be important as a principal component of this speciation and researchinto the migration and diffusion of living things was conducted. … Darwin initially considered the impact of a geographical barrierwith regards to speciation however he came to stress the mechanism of fortuitous transport as the cause of this diffusion and geographical distribution. …

    桃山学院大学総合研究所紀要 = ST. ANDREW'S UNIVERSITY BULLETIN OF THE RESEARCH INSTITUTE 46(3), 129-154, 2021-03-22


  • The Establishment of the Japanese Housing System in Japan : Prewar to Postwar Housing Policy  [in Japanese]

    村上 あかね

    … Industrialization and migration tometropolitan areas and munitions factory districts since World War Icaused serious housing problems. … During the last four decades, the Japanese housing system hasbeen under pressure to adapt to market mechanism. …

    桃山学院大学社会学論集 = ST.ANDREW'S UNIVERSITY SOCIOLOGICAL REVIEW 54(2), 91-118, 2021-02-22


  • Extracellular vesicles shed from gastric cancer mediate protumor macrophage differentiation

    Ito Atene , Kagawa Shunsuke , Sakamoto Shuichi , Kuwada Kazuya , Kajioka Hiroki , Yoshimoto Masashi , Kikuchi Satoru , Kuroda Shinji , Yoshida Ryuichi , Tazawa Hiroshi , Fujiwara Toshiyoshi

    … However, the mechanism by which macrophages differentiate into tumor-associated macrophages in the peritoneal cavity is not well understood. …

    BMC Cancer 21(1), 102, 2021-01-28


  • The time-dependent evolutionary rate of mitochondrial DNA in small mammals inferred from biogeographic calibration points with reference to the late Quaternary environmental changes in the Japanese archipelago


    … However, the mechanism of the nucleotide substitution rate of mtDNA remains unclear. … The global sea level fluctuation and migration to islands help to specify the calibration points. …

    Anthropological Science, 2021


  • Anticancer effect of <i>Dictyostelium</i> differentiation-inducing factor-1 through AMPK-mediated inhibition of mTORC1 signaling pathway  [in Japanese]

    Sasaguri Toshiyuki , Tetsuo Fumi , Arioka Masaki , Miura Koichi

    … <p>We reported that <i>Dictyostelium</i>-derived differentiation-inducing factor-1 (DIF-1) inhibits proliferation and motility (migration and infiltration) of several cancer cells, although the mechanism is not sufficiently clarified. … In our recent study, we investigated whether DIF-1 can inhibit the tumor growth and metastasis of triple-negative breast cancer (TNBC) with regard to the mechanism of action. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 3-S28-4, 2021


  • The anti-alcoholism drug disulfiram produces anxiolytic effects in mice.  [in Japanese]

    Yoshifumi Nagayama , Okano Kotaro , Omata Tomoki , Takahashi Hideyo , Matsushima Kouji , Saitoh Akiyoshi , Yamada Daisuke , Terashima Yuya , Makino Kosyo , Takahashi Yoshino , Sano Yoshitake , Toda Etsuko , Ohashi Misaki , Yoshioka Toshinori

    … <p>Recent study has demonstrated that anti-alcoholism drug disulfiram (DSF) inhibits chemokine receptor-mediated migration signals. … We proposed that DSF could be an effective novel anxiolytic drug without the coordination disorder found in diazepam, and that the monoamine content changes in amygdala may be involved in its underlying mechanism.</p> …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 2-P1-32, 2021


  • Emodin suppresses the migration and invasion of melanoma cells

    Liu Chi , Zhou Yiqun , Zhao Haiguang , Liu Tianyi , Chen Liang , Wang Wanchen , Qin Dengke , Jia Chuanlong , Yuan Mingjie , Wang Heng , Guo Yu , Zhu Jingjing

    … However, the inhibitory effect of emodin on the migration and invasion of melanoma cells and its underlying mechanism are still unclear. … In the study, we observed the impercipient effects of emodin in B16F10 and A375 melanoma cells with strong metastatic abilities, focusing on the functions and mechanisms of migration and invasion of B16F10 and A375 melanoma cells. …

    Biological and Pharmaceutical Bulletin, 2021


  • Interface Formation Mechanism of Cemented Carbide Dipped in Molten Cast Iron  [in Japanese]

    Shibata Akihiro , Takemura Mamoru , Matsumuro Mitsuaki , Kitsudo Tadashi

    … It is important to understand the melting mechanism to clarify the interface formation mechanism, and subsequently control the interface structure. … The purpose of this study is to clarify the interface formation mechanism from the microstructural change of cemented carbide dipped in molten cast iron. … These are thought to be due to liquid phase migration occurring in the molten binder phase and decreased WC solubility due to the increase in Fe concentration. …

    Journal of Japan Foundry Engineering Society 93(2), 67-73, 2021


  • Development of Grain Growth Promotion Technique of Ni-Based Superalloy IN713 Fabricated by Metal Injection Molding

    Hibino Shinya , Fujimitsu Kazushige , Okada Ryutaro , Nomura Yoshimichi , Igashira Kenichiroh

    … The creep deformation mechanism of IN713C-MIM materials is revealed that grain boundary diffusion creep was dominant as the stress exponent was determined as n = 2.72. … In the examinations aiming to reduce carbides on grain boundary, which inhibited grain boundary migration, the carbon content of IN713LC-MIM-sintered material could be suppressed to C = 0.05%. …

    MATERIALS TRANSACTIONS 62(3), 436-441, 2021


  • Silencing long non-coding RNAs nicotinamide nucleotide transhydrogenase antisense RNA 1 inhibited papillary thyroid cancer cell proliferation, migration and invasion and promoted apoptosis <i>via</i> targeting miR-199a-5p

    Wang DongLiang , Zheng Ying

    … <p>The increasing incidence of papillary thyroid cancer (PTC) has attracted many researchers to investigate the mechanism underlying PTC progression. … This study explored the growth and apoptosis of PTC cells based on an lncRNA regulatory mechanism. … The viability, clone formation, migration, invasion and apoptosis of TPC-1 and IHH-4 cells were examined by CCK-8, colony formation, wound-healing, transwell, and flow cytometry assays, respectively. …

    Endocrine Journal, 2021


  • Transient Receptor Potential Melastatin 3 Is Functionally Expressed in Oligodendrocyte Precursor Cells and Is Upregulated in Ischemic Demyelinated Lesions

    Ohashi Kana , Shibasaki Koji , Nakazawa Hayaki , Kunimasa Ryotaro , Nagayasu Kazuki , Shirakawa Hisashi , Kaneko Shuji

    … The mechanism regulating the behaviors of OPCs in physiological and pathological conditions must be elucidated to control these cells and to treat demyelinating diseases. … Stimulation of TRPM3 with PS (50 µM) did not affect the differentiation or migration of OPCs. …

    Biological and Pharmaceutical Bulletin 44(2), 181-187, 2021


  • Migration Behavior of Components in Converter Slag during Smelting Reduction Process Using Aluminum Dross

    Shen Xiang , Chen Min , Zheng Xiaorui

    … <p>In order to efficiently recycle valuable element from the molten converter slag and enhance utilization ratio and added value of the slag, a novel aluminothermic smelting reduction process using aluminum dross as reductant was investigated from component migration and reduction kinetics, meanwhile the reduction mechanism of smelting reduction process of molten converter slag using aluminum dross was discussed. …

    ISIJ International 61(1), 49-54, 2021


  • Retrograde ERK activation waves drive base-to-apex multicellular flow in murine cochlear duct morphogenesis

    Ishii Mamoru , Tateya Tomoko , Matsuda Michiyuki , Hirashima Tsuyoshi

    … Here, we show that extracellular signal-regulated kinase (ERK) activation waves control collective cell migration during the murine cochlear duct development using deep tissue live-cell imaging, Förster resonance energy transfer (FRET)-based quantitation, and mathematical modeling. … Our findings propose a regulatory mechanism to coordinate the multicellular behaviors underlying the duct elongation during development. …

    eLife (10), 2021


  • Hypocenter distribution and focal mechanism of earthquakes off the coast of Kiire, Kagoshima Bay obtained from seismic observation in 2017 : Remarkable seismic activity along the faults that associated with the formation of Kagoshima Rift  [in Japanese]

    平野 舟一郎 , 八木原 寛 , 仲谷 幸浩 , 後藤 和彦

    … Therefore, to investigate the detailed hypocenter distribution and focal mechanism of the remarkable M5-class event and its sequence is essential for understanding the crustal background stress and faulting process.Since 2005, Nansei-Toko Observatory for Earthquakes and Volcanoes (NOEV), Kagoshima University have installed five onshore offline seismic stations around Kagoshima Bay, which consist of 2-Hz velocity sensors and data loggers. …

    鹿児島大学理学部紀要 = Reports of the Faculty of Science, Kagoshima University (53), 32-44, 2020-12-31


  • 4. Material Science and Radiation Effects

    CO4-28 Defect Characterization of Ion-Irradiated GdBa2Cu3O7−δ Superconducting Tapes Probed by a Slow Positron Beam /T. Ozaki et al.(31159) [175]

    KURNS Progress Report (2019), 148-176, 2020-08


  • Oncolytic Virus-Mediated Targeting of the ERK Signaling Pathway Inhibits Invasive Propensity in Human Pancreatic Cancer

    Koujima Takeshi , Tazawa Hiroshi , Ieda Takeshi , Araki Hiroyuki , Fushimi Takuro , Shoji Ryohei , Kuroda Shinji , Kikuchi Satoru , Yoshida Ryuichi , Umeda Yuzo , Teraishi Fuminori , Urata Yasuo , Mizuguchi Hiroyuki , Fujiwara Toshiyoshi

    … however, the mechanism of PDAC cell invasion remains to be elucidated. … ERK1/2 inhibitor or small interfering RNA (siRNA) treatment significantly reduced the migration and invasion of PDAC cells, suggesting that the ERK signaling pathway is associated with the invasiveness of PDAC cells. … OBP-702 infection suppressed ERK signaling and inhibited PDAC cell migration and invasion more efficiently than OBP-301. …

    Molecular Therapy - Oncolytics (17), 107-117, 2020-06-26


  • Tug-of-war between actomyosin-driven antagonistic forces determines the positioning symmetry in cell-sized confinement

    Sakamoto Ryota , Tanabe Masatoshi , Hiraiwa Tetsuya , Suzuki Kazuya , Ishiwata Shin'ichi , Maeda Yusuke T. , Miyazaki Makito

    細胞内構造の配置対称性が決まる仕組みを解明 --人工細胞と物理学からメカニズムに迫る--. 京都大学プレスリリース. 2020-06-15.The tug-of-war at the heart of cellular symmetry. 京都大学プレスリリース. 2020-06-26.

    Nature Communications (11), 2020-06-15


  • Induction of CEMIP in Chondrocytes by Inflammatory Cytokines: Underlying Mechanisms and Potential Involvement in Osteoarthritis

    Ohtsuki Takashi , Hatipoglu Omer F. , Asano Keiichi , Inagaki Junko , Nishida Keiichiro , Hirohata Satoshi

    … Cell migration-inducing hyaluronidase 1 (CEMIP), also known as hyaluronan (HA)-binding protein involved in HA depolymerization (HYBID), was recently reported as an HA depolymerization-related molecule expressed in the cartilage of patients with OA. … However, the underlying mechanism of CEMIP regulation is not well understood. … In conclusion, we clarified the regulatory mechanism of CEMIP in chondrocytes by inflammatory cytokines and suggested the potential involvement in osteoarthritis development. …

    International Journal of Molecular Sciences 21(9), 3140, 2020-04-29


  • microRNA-875-5p plays critical role for mesenchymal condensation in epithelial-mesenchymal interaction during tooth development

    Funada Keita , Yoshizaki Keigo , MIyazaki Kanako , Han Xue , Yuta Tomomi , Tian Tian , Mizuta Kanji , Fu Yao , Iwamoto Tsutomu , Yamada Aya , Takahashi Ichiro , Fukumoto Satoshi

    … To identify the molecular mechanism of this interaction, we explored the specific transcriptional start sites (TSSs) of tooth organs using cap analysis of gene expression (CAGE). … To assess the role of miR875-5p in dental mesenchyme, we transfected mimic miR875-5p into mouse dental pulp (mDP) cells, which showed that cell migration toward dental epithelial cells was significantly induced by miR875-5p via the PDGF signaling pathway. …

    Scientific Reports (10), 4918, 2020-03-18



    QI Yingtao , SAIO Naoko

    … The purpose of this paper is to obtain knowledge of traditional culture inheritance and sustainable planning for maintaining habitation originality by analyzing the relationship between "old village" and "new village" and residents' living situation.</p><p> In chapter two, we clarified the transition of the residence maintenance mechanism on policies, plans and projects of living area, production area and faith area. …

    Journal of Architecture and Planning (Transactions of AIJ) (768), 297-306, 2020-02


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