Search Results 1-20 of 532

  • Formation of neutrophil extracellular traps in mitochondrial DNA-deficient cells

    Takishita Yutaka , Yasuda Hiroyuki , Shimizu Mio , Matsuo Akane , Morita Akihiro , Tsutsumi Tomonari , Tsuchiya Masahiko , Sato Eisuke F.

    … <p>Neutrophil extracellular trap (NET) formation plays an important role in inflammatory diseases. … We generated mitochondrial DNA-deficient cells (ρ<sup>0</sup> …

    Journal of Clinical Biochemistry and Nutrition 66(1), 15-23, 2020


  • Mitochondria-targeting drugs for kidney diseases  [in Japanese]

    鈴木 健弘 , 阿部 高明

    腎臓内科・泌尿器科 = Nephrology & urology 10(2), 170-177, 2019-08

    Ichushi Web 

  • Mitochondria-targeting medicine for refractory kidney diseases  [in Japanese]

    山本 恵則 , 佐藤 有紀 , 柳田 素子

    腎臓内科・泌尿器科 = Nephrology & urology 9(5), 491-495, 2019-05

    Ichushi Web 

  • Concentration of mitochondrial DNA mutations by cytoplasmic transfer from platelets to cultured mouse cells

    石川 香 , 中田 和人 , Kaori ISHIKAWA , Kohei Kobayashi , Akihito Yamada , Moe Umehara , Toshihiko Oka , Kazuto NAKADA

    … Accumulation of mutations in mitochondrial DNA (mtDNA) is thought to be responsible for mitochondrial, and other, diseases and biological phenomena, such as diabetes, cancer, neurodegenerative diseases, and aging. … Abnormal respiratory complex formation and high stress on the mitochondrial protein quality control system appeared to be involved in these severe respiration defects. …

    PLOS ONE 14(3), e0213283, 2019-03


  • Positron Emission Tomography Imaging for Oxidative Stress in Mitochondrial and Neurodegenerative Diseases  [in Japanese]

    井川 正道 , 岡沢 秀彦 , 米田 誠

    Brain and nerve 71(2), 161-166, 2019-02

    Ichushi Web 

  • Deleteriousness of rare variants in patients with bipolar disorder assessed by biochemical analysis, computer prediction, <i>etc</i>.  [in Japanese]

    Kasahara Takaoki

    まれな変異とは,一般的にはその頻度が1%未満の変異を指し,その中に精神疾患の発症や病態に関連するものがあるだろうと考えて研究を行っている。しかし,そのような有害な変異が,なぜヒト集団に存在するのだろうか。本稿ではまず,分子生物学と分子進化学による説明と最近の大規模ゲノム解析のデータを見ながら議論する。また,有害とはどういうことか,どのように調べるのかについて解説し,筆者らが行った双極性障害における …

    Japanese Journal of Biological Psychiatry 30(1), 3-9, 2019


  • A Case of Leberʼs Hereditary Optic Neuropathy with m.4171C>A Mutation  [in Japanese]

    Hashiya Nozomu , Yamagami Akiko , Iwasa Mayumi , Inoue Kenji , Wakakura Masato , Matsumoto Tadashi , Yasumoto Ryoma , Sakurai Keizo , Ishikawa Hitoshi

    <p> レーベル遺伝性視神経症(Leber's hereditary optic neuropathy: LHON)はミトコンドリア遺伝子変異を呈する疾患であり,約90%がm.11778G>A,14484T>C,3460G>Aの変異を呈するが,約10%に希少変異が報告される.本症例は,20歳男性で典型的LHONの経過を示し,希少変異とされるm.4171C>A変異を呈した.この変異は本邦 …

    Neuro-Ophthalmology Japan 36(4), 421-428, 2019


  • A new insight into the apoptotic effect of nitidine chloride targeting Checkpoint kinase 2 in human cervical cancer <i>in vitro</i>

    Kwon Hye-Jeong , Kim Lee-Han , Ahn Chi-Hyun , Yang In-Hyoung , Hong Kyoung-Ok , Doo Hong Seong , Shin Ji-Ae , Cho Sung-Dae

    … We also found that NC significantly affected the p53/Bim signaling axis, which was accompanied by mitochondrial membrane depolarization and cytochrome c release from the mitochondria into the cytosol. …

    Journal of Clinical Biochemistry and Nutrition 65(3), 193-202, 2019


  • Ellagic acid promotes browning of white adipose tissues in high-fat diet-induced obesity in rats through suppressing white adipocyte maintaining genes

    Wang Lifeng , Yang Yining , Wei Yuanyuan , Ning Chao , Zhang Minfang , Fan Ping , Lei Dongyu , Du Jing , Gale Mengke , Ma Yitong

    mitochondrial biogenesis markers including TFAM in inguinal WAT (iWAT) when compared to their counterparts. … EA treatment significantly improved mitochondrial function, as measured by citrate synthase activity. … These findings suggest that EA could be a promising therapeutic avenue to treat metabolic diseases.</p> …

    Endocrine Journal 66(10), 923-936, 2019


  • Transmission electron microscopy of the benzbromarone-induced change in mitochondrial morphology in HepG2 cells

    Sato Tomoyuki , Takemura Akinori , Ikeyama Yugo , Sakamaki Yuriko , Mimata Ayako , Aoyagi Haruyo , Aizaki Hideki , Sekine Shuichi , Ito Kousei

    … <p>Drug-induced mitochondrial dysfunction can lead to severe adverse effects. … assay systems for assessing mitochondrial-related toxicity are required. … Current systems evaluate drug-induced mitochondrial dysfunction based on cell death. … To solve this problem, we attempted to measure morphological changes semi-quantitatively by transmission electron microscopy and to detect subtle changes in mitochondrial function. …

    Fundamental Toxicological Sciences 6(8), 281-286, 2019


  • Reactive Oxygen Species (ROS) Signaling: Regulatory Mechanisms and Pathophysiological Roles  [in Japanese]

    Hirata Yusuke

    … <p>Reactive oxygen species (ROS) are highly reactive molecules generated during mitochondrial respiration and under various environmental stresses, and cause damage to DNA, proteins, and lipids, which is linked to a wide variety of pathologies. … Dysregulation of ROS signaling causes cellular malfunctions, which are also linked to various diseases, such as cancer, neurodegeneration and inflammatory diseases. …

    YAKUGAKU ZASSHI 139(10), 1235-1241, 2019


  • Co-Administration of Curcumin and Artepillin C Induces Development of Brown-Like Adipocytes in Association with Local Norepinephrine Production by Alternatively Activated Macrophages in Mice

    NISHIKAWA Sho , KAMIYA Misa , AOYAMA Hiroki , YOSHIMURA Kazuki , MIYATA Ryo , KUMAZAWA Shigenori , TSUDA Takanori

    … Recent studies have shown that induction of brown-like adipocytes, also referred to as beige or brite cells, in white adipose tissue (WAT) results in the release of excess energy through mitochondrial heat production via uncoupling protein 1. … This has potential a therapeutic strategy for obesity and related diseases as well as classical brown adipocytes. …

    Journal of Nutritional Science and Vitaminology 65(4), 328-334, 2019


  • Qiliqiangxin Attenuates Oxidative Stress-Induced Mitochondrion-Dependent Apoptosis in Cardiomyocytes <i>via</i> PI3K/AKT/GSK3β Signaling Pathway

    Zhao Qifei , Li Hongrong , Chang Liping , Wei Cong , Yin Yujie , Bei Hongying , Wang Zhixin , Liang Junqing , Wu Yiling

    … Meanwhile, it further ameliorated mitochondrion-related apoptosis by inhibiting the mitochondrial fission, mitochondrial permeability transition pore (MPTP) opening, and mitochondrial membrane potential (MMP) decline in H9c2 cardiomyocytes induced by H<sub>2</sub>O<sub>2</sub>. …

    Biological and Pharmaceutical Bulletin 42(8), 1310-1321, 2019


  • A case of Pearson syndrome confirmed by mitochondrial genetic tests  [in Japanese]

    NODA Nozomi , MATSUMOTO Shinya , HOTTA Taeko

    <p>ミトコンドリアは全身の細胞に存在し,独自にミトコンドリアDNAを保持している。ミトコンドリアDNAの塩基置換,欠失,重複,コピー数の低下はミトコンドリア病を引き起こす原因になるとされている。ミトコンドリア病の症状は一概ではなく,遺伝子検査のみならず画像検査,組織学的検査,臨床所見などから総合的に判断される。今回,末梢血では通常検出しにくいとされるミトコンドリアDNAの欠失を検出し …

    Japanese Journal of Medical Technology 68(3), 596-601, 2019

    J-STAGE  Ichushi Web 

  • Reverse Genetic Studies on Mammalian Mitochondrial DNA with Pathogenic Mutations  [in Japanese]

    Nakada Kazuto

    <p> ミトコンドリアゲノム(mtDNA)に生じた特定の突然変異の病原性は,その変異型mtDNA分子種が組織や細胞に優位に蓄積した時にのみ,ミトコンドリア呼吸機能異常として誘導されることが知られている.近年,mtDNAに生じた病原性の欠失突然変異や点突然変異がミトコンドリア病,糖尿病,神経変性疾患,不妊症,がんなどの多様な病態群の原因だけでなく,老化にも寄与する可能性が示唆され,広く注 …

    Neuro-Ophthalmology Japan 36(2), 199-206, 2019


  • The role of tumor suppressor p53 in metabolism and energy regulation, and its implication in cancer and lifestyle-related diseases

    Hashimoto Naoko , Nagano Hidekazu , Tanaka Tomoaki

    … Related to energy metabolisms, it has been reported that p53 reduces glycolysis and enhances mitochondrial respiration. … p53 is also involved in the regulation of other cellular metabolism and energy production systems: amino acid metabolism, fatty acid metabolism, nucleic acid metabolism, anti-oxidation, mitochondrial quality control, and autophagy. …

    Endocrine Journal 66(6), 485-496, 2019


  • Evaluation of Naturally Occurring Compounds Regulating Brown/Beige Adipocyte Differentiation  [in Japanese]

    Hirai Takao , Takagi Michiyo , Nakashima Ken-ichi , Inoue Makoto

    … <p>Brown adipose tissue is a critical regulator of metabolic health, and contributes to thermogenesis by uncoupling oxidative phosphorylation through the action of mitochondrial uncoupling protein 1 (Ucp1). … Therefore, the development of brown/beige adipocytes may prevent obesity and metabolic diseases. …

    YAKUGAKU ZASSHI 139(6), 861-866, 2019


  • Developmental origins of renal disease  [in Japanese]

    Awazu Midori

    <p>生活習慣病,慢性腎臓病(CKD)をはじめとする種々の疾患の発症が,胎生期,周産期,乳幼児期の環境に影響されることが明らかになっている(Developmental Origins of Health and Disease,DOHaD 学説)。低出生体重(子宮内発育遅延,早産による)がマーカーとされているが,高出生体重もリスクである。DOHaD によるCKD 発症機序としてネフロン …

    Japanese journal of pediatric nephrology 32(1), 12-15, 2019

    J-STAGE  Ichushi Web 

  • Glycerol kinase 2 is essential for proper arrangement of crescent-like mitochondria to form the mitochondrial sheath during mouse spermatogenesis

    SHIMADA Keisuke , KATO Hirotaka , MIYATA Haruhiko , IKAWA Masahito

    … The mitochondrial sheath is composed of mitochondria that coil tightly around the midpiece of sperm flagellum. … Recently, disorganization of the mitochondrial sheath was reported in Glycerol kinase 2 (<i>Gk2</i>) disrupted mice. … To analyze the disorganization of the mitochondrial sheath further, we generated <i>Gk2</i>-deficient mice using the CRISPR/Cas9 system and observed sperm mitochondria in testis using a freeze-fracture method with scanning electron microscopy. …

    Journal of Reproduction and Development 65(2), 155-162, 2019


  • Autophagy in the Heart

    Yamaguchi Osamu

    … Hemodynamic stress and aging induce mitochondrial damage, leading to increased oxidative stress and decreased ATP production. … Complete digestion of mitochondrial DNA through mitophagy is important to avoid inflammatory responses that can induce heart failure. … Therefore, appropriate induction of autophagy could be a novel therapeutic target for cardiovascular diseases, including heart failure. …

    Circulation Journal 83(4), 697-704, 2019


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