Search Results 1-20 of 3376

  • Advances in Diagnosis and Treatment of Diabetic Retinopathy  [in Japanese]

    久冨 智朗

    … With anti-VEGF treatment, macula edema has been improved in the short term, but the pathology and molecular mechanism of retinal degeneration remain unknown. … In Japan, outcomes of diabetic retinopathy treatment have improved due to recent remarkable progression of Ophthalmic imaging techniques such as optical coherence tomography (OCT), Minimally Invasive Vitrectomy Surgery (MIVS), and membrane staining adjuvant such as Brilliant Blue G during ocular surgery. …

    福岡醫學雜誌 111(1), 13-19, 2020-03-25

    IR 

  • Dynamic actin-mediated nano-scale clustering of CD44 regulates its meso-scale organization at the plasma membrane

    Parijat Sil , Nicolas Mateos , Sangeeta Nath , Sonja Buschow , Carlo Manzo , Kenichi G. N. Suzuki , Takahiro Fujiwara , Akihiro Kusumi , Maria F. Garcia-Parajo , Satyajit Mayor

    … While spatial organization and diffusion studies of membrane proteins are usually conducted separately, here we combine observations of organization and diffusion by using high spatio-temporal resolution imaging on living cells to reveal a hierarchical organization of CD44. …

    Molecular Biology of the Cell 31(7), 561-579, 2020-03-19

    IR 

  • Tree of motility – A proposed history of motility systems in the tree of life

    Makoto Miyata , Robert C. Robinson , Taro Q. P. Uyeda , Yoshihiro Fukumori , Shun‐ichi Fukushima , Shin Haruta , Michio Homma , Kazuo Inaba , Masahiro Ito , Chikara Kaito , Kentaro Kato , Tsuyoshi Kenri , Yoshiaki Kinosita , Seiji Kojima , Tohru Minamino , Hiroyuki Mori , Shuichi Nakamura , Daisuke Nakane , Koji Nakayama , Masayoshi Nishiyama , Satoshi Shibata , Katsuya Shimabukuro , Masatada Tamakoshi , Azuma Taoka , Yosuke Tashiro , Isil Tulum , Hirofumi Wada , Ken‐ichi Wakabayashi

    … However, many organisms exhibit surprisingly diverse motilities, and advances in genomics, molecular biology and imaging have showed that those motilities have inherently independent mechanisms. …

    Genes to Cells 25(1), 6-21, 2020-01-19

    IR 

  • Tree of motility : A proposed history of motility systems in the tree of life

    Miyata Makoto , Robinson Robert C. , Uyeda Taro Q. P. , Fukumori Yoshihiro , Fukushima Shun-ichi , Haruta Shin , Homma Michio , Inaba Kazuo , Ito Masahiro , Kaito Chikara , Kato Kentaro , Kenri Tsuyoshi , Kinosita Yoshiaki , Kojima Seiji , Minamino Tohru , Mori Hiroyuki , Nakamura Shuichi , Nakane Daisuke , Nakayama Koji , Nishiyama Masayoshi , Shibata Satoshi , Shimabukuro Katsuya , Tamakoshi Masatada , Taoka Azuma , Tashiro Yosuke , Tulum Isil , Wada Hirofumi , Wakabayashi Ken-ichi

    新学術領域「運動マシナリー」では、これまでにあまり研究されてこなかった種類の運動能にスポットを当て、それらのメカニズムの多くを原子レベルに迫る解像度で明らかにしました。その集大成として、全ての運動能の俯瞰を行いました。その結果、運動能が18種類に分類できること、それらの発生と進化が細菌の細胞壁(ペプチドグリカン層)の形成と消失、アーキア(古細菌)から真核生物にいたる膜ダイナミクスの獲得、細胞の巨大 …

    Genes to Cells 25(1), 6-21, 2020-01

    IR 

  • Development of Molecular Imaging Probe for Dual NIR/MR Imaging

    Doan Thi Kim Dung , Umezawa Masakazu , Nigoghossian Karina , Yeroslavsky Gil , Okubo Kyohei , Kamimura Masao , Yamaguchi Masayuki , Fujii Hirofumi , Soga Kohei

    Journal of photopolymer science and technology 33(1), 117-122, 2020

  • Association between the Symptomatic Appearance of Dural Arteriovenous Fistula and Trigeminal Ganglion Radiofrequency Thermocoagulation

    Revilla-Pacheco Francisco , Antón-Alonso Arantxa , Rodríguez-Salgado Pamela , Rubalcava-Ortega Johnatan , Manrique-Guzmán Salvador , Herrada-Pineda Tenoch

    <p>Fluoroscopy-guided radiofrequency thermocoagulation of the trigeminal ganglion is an alternative treatment for symptomatic trigeminal neuralgia. The most common complications of the procedure …

    NMC Case Report Journal, 2020

    J-STAGE 

  • Fragile X associated neuropsychiatric disorders in a male without FXTAS

    Cabal-Herrera Ana María , Saldarriaga-Gil Wilmar , Salcedo-Arellano Maria Jimena , Hagerman Randi J

    … A detailed medical history was collected and complete physical, neurological and psychiatric evaluations were performed in addition to molecular and neuroradiological studies. … Brain imaging revealed white matter lesions in the periventricular region and mild cerebral atrophy. …

    Intractable & Rare Diseases Research 9(2), 113-118, 2020

    J-STAGE 

  • Visualization of mechanical stress-mediated Ca<sup>2+</sup> signaling in the gut using intravital imaging

    AIHARA Yoshiko , FUKUDA Yota , TAKIZAWA Akiyoshi , OSAKABE Naomi , AIDA Tomomi , TANAKA Khoichi , YOSHIKAWA Soichiro , KARASUYAMA Hajime , ADACHI Takahiro

    … x, y, z, time, and Ca<sup>2+</sup>) intravital imaging system for investigating lymphoid tissues and enteric epithelial cell responses. … These data indicate that the present intravital imaging system can be used to visualize mechanosensory Ca<sup>2+</sup> …

    Bioscience of Microbiota, Food and Health, 2020

    J-STAGE 

  • Evaluation of Triboluminescent Rare Earth Complexes by the Drop-Tower System  [in Japanese]

    HASEGAWA Miki , OHMAGARI Hitomi

    <p>希土類イオンは,その本来の電子状態から非常に色純度の高い発光を示す.一般に,光励起による希土類イオンの発光は,吸光係数の高い有機配位子を用いた分子エネルギー移動によるアンテナ効果によって促される.最近,トリボルミネッセンスを示す希土類錯体が頻繁に発見されている.しかし,この原理にはいくつかの仮説があり,光励起による発光に対し,トリボルミネッセンスは不明瞭な点が多い.そこで,結晶を …

    NIHON GAZO GAKKAISHI (Journal of the Imaging Society of Japan) 59(3), 325-329, 2020

    J-STAGE 

  • Organic Long-persistent Luminescence from Photoinduced Charge-separated State  [in Japanese]

    KABE Ryota

    <p>蓄光材料は光エネルギーを吸収し,長時間にわたる発光を示す.既存の蓄光材料は全て無機材料で構成されるのに対し,我々は有機材料のみで構成される有機蓄光システムを見出した.有機蓄光システムは電子ドナー材料とアクセプター材料から構成され,励起状態ではなく電荷分離状態にエネルギーを蓄積する.レアメタルを必要としない,溶液から成膜可能,柔軟性と透明性の両立が可能など従来の無機材料では実現が難 …

    NIHON GAZO GAKKAISHI (Journal of the Imaging Society of Japan) 59(3), 316-324, 2020

    J-STAGE 

  • Computer Simulation Techniques and Applications for Soft Crystals  [in Japanese]

    NAKAYAMA Naofumi , OBATA Shigeaki , GOTO Hitoshi

    <p>穏やかな外部刺激に応答し,その形状,色,発光等の物性が変化する 「ソフトクリスタル」の相転移過程を解析するための計算機シミュレーション技法とその応用事例を紹介する.結晶の構造パラメーター (非対称単位内分子構造,空間群,格子定数) に依存するポテンシャルエネルギーは,分子内と分子間に働く相互作用を分子力学に基づく結晶力場で定義される結晶エネルギーという熱力学的な状態量で評価される …

    NIHON GAZO GAKKAISHI (Journal of the Imaging Society of Japan) 59(3), 308-315, 2020

    J-STAGE 

  • The Nationwide Survey on Avoidance of Targeted Radionuclide Therapy in Patients with Limited Activities of Daily Living and Those Undergoing Hemodialysis  [in Japanese]

    MORI Hiroshi , KINUYA Seigo , INAKI Anri , KAYANO Daiki , WAKABAYASHI Hiroshi , HOSONO Makoto , HIGASHI Tatsuya , ORIUCHI Noboru , ABE Koichiro , UCHIYAMA Mayuki

    <p>放射性同位元素 (radioisotope: RI) を用いた内用療法(核医学治療)は放射線治療病室内で施行され,放射線治療病室から退室するためには,公衆被ばくの防護の観点から各核種に定められ た退出基準を満たす必要がある.放射線治療病室内で大量投与を行う際には,数日間の入院生活が 求められる.そのため,日常生活動作が自立していない患者や血液透析を行っている患者では内用 療 …

    KAKUIGAKU 57(1), 39-46, 2020

    J-STAGE 

  • Study of Hybrid Type Two-dimensional Electrochemical Sensor  [in Japanese]

    Maejima Kazuma , Hasegawa Yuki , Uchida Hidekazu

    … <p>In the field of life science such as drug discovery, technological innovation of molecular evolution is required. …

    IEEJ Transactions on Sensors and Micromachines 140(6), 144-149, 2020

    J-STAGE 

  • Visualization of Cell Attached Nanointerface using Metal Nanoparticle Sheet  [in Japanese]

    Masuda Shihomi , Tamada Kaoru

    … This imaging technique can be applied even for live–cell imaging under a total internal reflection fluorescence (TIRF) microscope. … This non–scanning–type, high–resolution imaging method will be an effective tool for monitoring interfacial phenomena including molecular level of rapid reaction or various cellular and molecular dynamics. …

    MEMBRANE 45(3), 115-120, 2020

    J-STAGE 

  • Optical Coherence Tomography-Guided Percutaneous Coronary Intervention With Low-Molecular-Weight Dextran ― Effect on Renal Function ―

    Kurogi Kazumasa , Kaikita Koichi , Tsujita Kenichi , Ishii Masanobu , Sakamoto Kenji , Komaki Soichi , Kusaka Hiroaki , Yamamoto Nobuyasu , Takashio Seiji , Arima Yuichiro , Yamamoto Eiichiro

    … Low-molecular-weight dextran (LMWD) has been used for OCT image acquisition instead of contrast media. … This study compared the effects of OCT-guided PCI using LMWD on renal function and clinical outcomes to those of intravascular ultrasound (IVUS)-guided PCI.</p><p><b><i>Methods and Results:</i></b>In all, 1,183 consecutive patients who underwent intracoronary imaging-guided PCI were enrolled in this single-center, retrospective, observational study. …

    Circulation Journal 84(6), 917-925, 2020

    J-STAGE 

  • Portal Vein Thrombosis Associated with Trousseau Syndrome due to Urinary Bladder Squamous Cell Carcinoma in a Liver Cirrhosis Patient

    Kimura Naruhiro , Terai Shuji , Tsuchiya Atsunori , Oda Chiyumi , Kimura Atsushi , Hosaka Kazunori , Tominaga Kentaro , Hayashi Kazunao , Abé Tatsuya , Umezu Hajime

    … Magnetic resonance imaging revealed multiple small acute cerebral infarctions and, on CT, a 30-mm bladder tumour; …

    Internal Medicine, 2020

    J-STAGE 

  • Monte Carlo Simulator for Diffusion-weighted Imaging Sequences

    Tachibana Yasuhiko , Duval Tanguy , Obata Takayuki

    … <p>We developed a Monte Carlo simulator for diffusion-weighted imaging sequences which displays the motion of water molecules and computes the dynamic phase dispersion due to the applied motion probing gradients. …

    Magnetic Resonance in Medical Sciences, 2020

    J-STAGE 

  • The Endocytic Mechanism and Cytotoxicity of Boron-containing Vesicles

    Wang Dan , Meng Yue , Wang Xuelei , Xia Guimin , Zhang Qiang

    … The data would provide reference information and guidance for BCVs' multifunctional application serving as a boron delivery agent for BNCT, a hydrophilic and/or hydrophobic drug carrier and a diagnostic imaging fluorescent probe.</p> …

    Chemical and Pharmaceutical Bulletin, 2020

    J-STAGE 

  • Long-term sustained complete response with off-therapy to sorafenib in advanced hepatocellular carcinoma: a case report  [in Japanese]

    Koujima Takeshi , Endo Yoshikatsu , Yamamoto Takeharu , Tada Toshifumi , Morii Kazuhiko , Nakamura Shinichiro , Kai Kyohei

    <p>症例は77歳,女性.C型慢性肝炎による肝細胞癌で,経皮的ラジオ波焼灼療法(S3)を施行した.1年後に総肝動脈幹リンパ節の孤立性転移再発を認め,外科的切除を施行し,病理学的にも肝細胞癌リンパ節転移と診断された.しかし術後7カ月で肝門部リンパ節再発,脾門部リンパ節再発が認められたためソラフェニブ導入となった.投与開始後8カ月で完全寛解(CR)となった.段階的減量を経ても明らかな再発が …

    Kanzo 61(5), 255-261, 2020

    J-STAGE 

  • Construction and Scanning Probe Microscopy Imaging of Two-dimensional Nanomaterials

    Kunitake Masashi , Uemura Shinobu

    … <p>Several fabrication technologies for molecular level ultra-thin films, from organic to organic–inorganic hybrids, are introduced using the surface imaging technology of scanning probe microscopy (SPM). …

    Chemistry Letters 49(5), 565-573, 2020

    J-STAGE 

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