Search Results 1-20 of 393

  • A Molecular Assembly Machine Working under a Quasi-Steady State pH Gradient

    Nawa-Okita Erika , Nakao Yuki , Yamamoto Daigo , Shioi Akihisa

    … <p>Biological functions are maintained by various types of molecular motors driven at several pico-newtons, where the driving force is obtained from a chemical potential difference within the microscale. … This study demonstrates that they can be regarded as a molecular assembly machine. …

    Bulletin of the Chemical Society of Japan 93(4), 604-610, 2020


  • A reconfigurable spin filter based on a molecular motor  [in Japanese]

    SUDA Masayuki , YAMAMOTO Hiroshi

    <p>電子がカイラルな分子を通過すると,スピン偏極が生じるという現象(CISS)を利用して,新たなスピン偏極電流源を作製した.このデバイスで我々が用いたのは分子モータと呼ばれる可動性の分子で,光と熱によって1方向に内部回転を行う.この回転が4ステップに分割されたカイラリティ反転を伴うため,モータ分子の薄膜を内蔵したスピンバルブに対して光を照射したり熱を加えたりすることによって,電流のス …

    Oyo Buturi 89(4), 203-207, 2020


  • Molecular Mechanisms of Melanogenic Enzyme Transport and Melanosome Transport: Development of New Cosmetics That Inhibit Transport Machineries  [in Japanese]

    Fukuda Mitsunori

    … To prevent undesirable melanin deposition, it is important to understand the molecular mechanisms of formation, maturation, and transport of melanosomes, specialized organelles that synthesize and store melanin in melanocytes. …


    J-STAGE  Ichushi Web 

  • Titin folding powers muscle contraction  [in Japanese]

    Fernández Julio M.

    … <p>By combining springs with motors and chemical switches biological systems can achieve great scales of mechanical power amplification, for example when jumping or launching a projectile. … However, the molecular mechanisms of how this is achieved remain unknown. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 2-SL05, 2019


  • Measuring Dissipation of Molecular Motor Kinesin  [in Japanese]

    ARIGA Takayuki , TOMISHIGE Michio , MIZUNO Daisuke

    … <p>Molecular motors are nonequilibrium open systems that convert chemical energy to mechanical work. …

    Seibutsu Butsuri 59(6), 300-304, 2019

    J-STAGE  Ichushi Web 

  • Biomimetic and Technomimetic Single Molecular Machines

    Kammerer Claire , Erbland Guillaume , Gisbert Yohan , Nishino Toshio , Yasuhara Kazuma , Rapenne Gwénaël

    … <p>This highlight review describes our contribution to the field of biomimetic and technomimetic molecular machines specially designed to be studied as single molecules on surfaces. … Prototypes of molecular wheels, vehicles, gears and motors will be described from their design to the study of their controlled motions using ultra-high-vacuum low-temperature scanning tunneling microscopes (UHV-LT-STM).</p> …

    Chemistry Letters 48(4), 299-308, 2019


  • Arcsine Laws in Stochastic Thermodynamics

    Andre C. Barato , Édgar Roldán , Ignacio A. Martínez , Simone Pigolotti

    … These results apply to, inter alia, molecular motors, quantum dots, and colloidal systems. …

    Physical Review Letters 121(9), 090601, 2018-08-28


  • ZMYND10 functions in a chaperone relay during axonemal dynein assembly

    Mali Girish R , Yeyati Patricia L , Mizuno Seiya , Dodd Daniel O , Tennant Peter A , Keighren Margaret A , zur Lage Petra , Shoemark Amelia , Garcia-Munoz Amaya , Shimada Atsuko , Takeda Hiroyuki , Edlich Frank , Takahashi Satoru , von Kreigsheim Alex , Jarman Andrew P , Mill Pleasantine , 水野 聖哉 , 高橋 智

    Molecular chaperones promote the folding and macromolecular assembly of a diverse set of 'client' proteins. … Our study indicates that primary ciliary dyskinesia (PCD), caused by mutations in dynein assembly factors disrupting cytoplasmic pre-assembly of axonemal dynein motors, should be considered a cell-type specific protein-misfolding disease. …

    eLife (7), e34389, 2018-06


  • Light-induced propulsion of a giant liposome driven by peptide nanofibre growth

    Inaba Hiroshi , Uemura Akihito , Morishita Kazushi , Kohiki Taiki , Shigenaga Akira , Otaka Akira , Matsuura Kazunori

    … Light-driven nano/micromotors are attracting much attention, not only as molecular devices but also as components of bioinspired robots. … Despite the development of various motors, it remains challenging to mimic natural systems to create artificial motors propelled by fibre formation. … These results showed that chemical design of the light-induced peptide nanofibre formation is a useful approach to fabricating bioinspired motors with controllable motility. …

    Scientific Reports (8), 6243, 2018-04-19


  • Structural Basis of Multiple Functions of Kinesin Superfamily Proteins  [in Japanese]

    Nitta Ryo

    <p>キネシンスーパーファミリータンパク質は,微小管上を一方向性に動く分子モーターである.その機能は,細胞内物質輸送に留まらず,染色体分裂の牽引,左右軸の決定,シグナル伝達の制御,線毛の長さの調節など多岐に渡っている.私はこれまで,X線結晶構造解析法やクライオ電子顕微鏡構造解析法を用いて,キネシンの多彩な機能を支える分子構造基盤を明らかにして来た.本解説では,微小管のプラス端方向へ順行 …

    KENBIKYO 53(2), 85-91, 2018


  • Mechanism of how molecular motors work revealed by forced rotation  [in Japanese]

    Hasekura Yuichi , Sasaki Kazuo

    Meeting Abstracts of the Physical Society of Japan 73.1(0), 2970-2970, 2018


  • Long-time simulation for the correlation of traveling direction of a filament driven by molecular motors  [in Japanese]

    Shinagawa Ryota , Sasaki Kazuo

    Meeting Abstracts of the Physical Society of Japan 73.1(0), 2696-2696, 2018


  • Fabrication of bio-actuators with molecular motors by stereolithography

    WANG Yingzhe , MINAKATA Kazuyuki , HIRATSUKA Yuichi , UESUGI Kaoru , MORISHIMA Keisuke

    … <p>On the basis of our previous design, a fabrication system of bio-actuators with molecular motors was set up and tested. … With stereolithography technology, a UV scanning system was built to fabricate artificial substrate from PEG-based hydrogels and artificial muscles from molecular motors in micro channels. …

    The Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec) 2018(0), 2A2-L13, 2018


  • Fabrication of Stacked Rotary Actuator Using Bio-molecular Motor  [in Japanese]

    MINAKATA Kazuyuki , HIRATSUKA Yuichi , UESUGI Kaoru , MORISHIMA Keisuke

    … <p>In this paper, we propose a stacked rotary actuator, which is a high power actuator driven by molecular motors. … By stacking rotation units driven by molecular motors, the number of molecular motors working cooperatively increases and we expect to realize a high power actuator. … In order to fabricate rotation units, it is necessary to control the orientation of the molecular motor. …

    The Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec) 2018(0), 1P1-K11, 2018


  • Cytoskeletal control of nuclear migration in neurons and non-neuronal cells

    KENGAKU Mineko

    … <p>Cell migration is a complex molecular event that requires translocation of a large, stiff nucleus, oftentimes through interstitial pores of submicron size in tissues. … In many cases, the microtubule motors dynein and kinesin directly interact with the nucleus via the LINC complex and steer directional nuclear movement, while actomyosin contractility and its global flow exert forces to deform and move the nucleus. …

    Proceedings of the Japan Academy, Series B 94(9), 337-349, 2018

    J-STAGE  Ichushi Web 

  • Driving and photo-regulation of myosin-actin motors at molecular and macroscopic levels by photo-responsive high energy molecules

    Menezes Halley M. , Islam Md. Jahirul , Takahashi Masayuki , Tamaoki Nobuyuki

    Organic & biomolecular chemistry 15(42), 8894-8903, 2017-11-14

  • Osmotic mechanism of the loop extrusion process

    Yamamoto Tetsuya , Schiessel Helmut

    … The loop extrusion theory assumes that protein factors, such as cohesin rings, act as molecular motors that extrude chromatin loops. …

    Physical Review E 96(3), 030402(R)-030402(R), 2017-09-22


  • Ciliary entry of KIF17 is dependent on its binding to the IFT-B complex via IFT46-IFT56 as well as on its nuclear localization signal

    Funabashi Teruki , Katoh Yohei , Michisaka Saki , Terada Masaya , Sugawa Maho , Nakayama Kazuhisa

    … Anterograde and retrograde ciliary protein trafficking are mediated by the IFT-B and IFT-A complexes in concert with kinesin-2 and dynein-2 motors, respectively. …

    Molecular Biology of the Cell 28(5), 624-633, 2017-03-01


  • Preparation of Biomolecular Robot  [in Japanese]

    SUZUKI Ryuhei , Kabir Arif Md. Rashedul , SADA Kazuki , KAKUGO Akira


    Oleoscience 17(2), 49-53, 2017


  • curvature of trajectory of a filament driven by molecular motors studied by simulation  [in Japanese]

    Shinagawa Ryota , Sasaki Kazuo

    <p>複数のタンパク質フィラメントはガラス基板上に散布された分子モーターに駆動されることで,渦構造を形成する.この現象は自己駆動体集団の秩序形成の例として注目されている.渦構造を形成するためには単独のフィラメントが軌跡の曲率を維持しようとする性質が重要である.本講演ではフィラメントの動きをシミュレーションを用いて再現した結果から,軌跡の曲率に関する時間相関を解析し,得られた結果を報告す …

    Meeting Abstracts of the Physical Society of Japan 72.1(0), 3157-3157, 2017


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