Search Results 1-20 of 49

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  • Versatile whole-organ/body staining and imaging based on electrolyte-gel properties of biological tissues

    Susaki Etsuo A. , Shimizu Chika , Kuno Akihiro , Tainaka Kazuki , Li Xiang , Nishi Kengo , Morishima Ken , Ono Hiroaki , Ode Koji L. , Saeki Yuki , Miyamichi Kazunari , Isa Kaoru , Yokoyama Chihiro , Kitaura Hiroki , Ikemura Masako , Ushiku Tetsuo , Shimizu Yoshihiro , Saito Takashi , Saido Takaomi C. , Fukayama Masashi , Onoe Hirotaka , Touhara Kazushige , Isa Tadashi , Kakita Akiyoshi , Shibayama Mitsuhiro , Ueda Hiroki R.

    … This pipeline, named CUBIC-HistoVIsion, thus offers advanced opportunities for organ- and organism-scale histological analysis of multicellular systems. …

    Nature Communications (11), 2020-12

    IR 

  • Collective cell migration of Dictyostelium without cAMP oscillations at multicellular stages

    Hashimura Hidenori , Morimoto Yusuke V. , Yasui Masato , Ueda Masahiro

    … In Dictyostelium discoideum, a model organism for the study of collective cell migration, extracellular cyclic adenosine 3',5'-monophosphate (cAMP) acts as a diffusible chemical guidance cue for cell aggregation, which has been thought to be important in multicellular morphogenesis. …

    Communications Biology 2(34), 1-15, 2019-01-24

    IR 

  • Living Organisms under an Electron Microscope: the NanoSuit<sup>®</sup>

    Hariyama Takahiko , Takaku Yasuharu , Suzuki Chiaki , Takehara Sayuri , Hirakawa Satoshi , Suzuki Hiroshi , Kawasaki Hideya

    … A simple surface modification to extracellular substances (ECS) of the certain multicellular organisms by electron beams or plasmas can coat of thin polymer membrane made of ECS. … The "NanoSuit<sup>®</sup>" acts as a barrier to the passage of gases and liquids and thus protects the organism. … Based on this discovery, we invented the coating method by the "biomimetic ECS" composed of biocompatible substance for the organism which lack the natural ECS. …

    Journal of Photopolymer Science and Technology 32(2), 287-290, 2019

    J-STAGE 

  • Design and constructs of the single "All-in-One" type double conditional shRNA expression vectors for a spatio-temporal gene and/or cell targeting

    Oyamada Hideto , Kiuchi Yuji , Kudo Yoshiko , Ao Yoko , Okamoto Reiko , Aoyama Eri , Matsuoka Tomoyuki , Nakano Masahide , Tsuchiya Hiromichi , Oguchi Katsuji

    … <p>The functional identification of individual genes and/or cells in multicellular organism will give us invaluable pharmacological information for translational research into drug target discovery. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), PO3-11-15, 2018

    J-STAGE 

  • Genomic structure and evolution of the mating type locus in the green seaweed Ulva partita

    Yamazaki Tomokazu , Ichihara Kensuke , Suzuki Ryogo , Oshima Kenshiro , Miyamura Shinichi , Kuwano Kazuyoshi , Toyoda Atsushi , Suzuki Yutaka , Sugano Sumio , Hattori Masahira , Kawano Shigeyuki , 宮村 新一

    … We report the structure of the mating type (MT) locus and its evolutionary history in the green seaweed Ulva partita, which is a multicellular organism with an isomorphic haploid-diploid life cycle and mating type determination in the haploid phase. …

    Scientific Reports (7), 11679, 2017-09

    IR 

  • Verification of Tubular Structure Acquisition Principle in Multicellular Organism  [in Japanese]

    YAMATSUTA Eitaro , UESUGI Kaoru , MORISHIMA Keisuke

    <p>This paper proposes a concept of tubular organisms and a new image of hierarchy of living orgasms. Multi-cellular organisms must have obtained tubular structure to live effectively and effici …

    The Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec) 2017(0), 2A1-G03, 2017

    J-STAGE 

  • Heterogeneity of cellular circadian clocks in intact plants and its correction under light-dark cycles

    Muranaka Tomoaki , Oyama Tokitaka

    一つの体に無数の時計。アバウトでも整然と。－ウキクサ植物を用いて植物の概日時計の挙動を細胞レベルで解明－. 京都大学プレスリリース. 2016-07-21.

    Science Advances 2(7), 2016-07-15

    IR 

  • Extending the Use of Optogenetics Beyond Neuroscience

    Matsui Ko

    <p>光遺伝学は，開発当初から，主に脳神経細胞に適用されてきた．しかし，光遺伝学のアイディア自体は，どんな細胞の光制御にも応用可能であると考えられる．多種の細胞が形作るネットワーク間を，何らかの信号が行き交うことで，多細胞生物である我々は，ひとつの個体として，整合性のある活動を行っている．本稿では，脳内グリア細胞に光遺伝学を適用した例を紹介し，神経科学に限らず，システム生物学への光遺伝 …

    Nippon Laser Igakkaishi 36(4), 473-477, 2016

    J-STAGE  Ichushi Web 

  • Branchial Cilia and Sperm Flagella Recruit Distinct Axonemal Components

    Konno Alu , Shiba Kogiku , Cai Chunhua , Inaba Kazuo , 柴 小菊 , 稲葉 一男

    … They are functionally diverged to play cell-type-specific roles even in a multicellular organism. … Although their structural components are therefore believed to be common, few studies have investigated the molecular diversity of the protein components of the cilia and flagella in a single organism. …

    PLoS ONE 10(5), e0126005, 2015-05

    IR 

  • Preprophase band and division plane establishment  [in Japanese]

    Mineyuki Yoshinobu

    多細胞体制の生物の形づくりの研究には，細胞分裂面挿入位置が時間的・空間的にどのように制御されているのかを解明する必要がある．植物の細胞分裂面挿入位置は核分裂前に決定されており，その位置に分裂準備帯（preprophase band）が出現する．著者は長年様々なイメージング技術を使って分裂準備帯の研究を行って来た．本稿では，その成果を中心に分裂準備帯の形成と機能について解説する．

    PLANT MORPHOLOGY 27(1), 33-42, 2015

    J-STAGE 

  • An Alkylbenzoquinone Involved in Development of Cellular Slime Molds  [in Japanese]

    Takaya Yoshiaki , Oohata Akiko , Hotta Rie , Fujiwara Kenshu , Otani Risa , Uchiyama Yurika , Sakakibara Mizuki , Fukuda Eri , Niwa Masatake , Inoue Kei

    <p>細胞性粘菌は，土壌中のバクテリアを捕食し生活する微生物で，その生活環は増殖ステージと分化ステージよりなる．増殖ステージでは，単細胞の粘菌アメーバが増殖を繰り返す．一方，餌のバクテリアがなくなり飢餓状態になると，約10万個の細胞が引き寄せられ集合体を形成し，予定胞子細胞と予定柄細胞からなるslugとなった後，それぞれ胞子と柄となり子実体を形成する (Fig. 1)．このステージを分 …

    Symposium on the Chemistry of Natural Products, symposium papers 56(0), Oral33, 2014

    J-STAGE 

  • Comparison between Pearson Correlation Coefficient and Mutual Information as a Similarity Measure of Gene Expression Profiles  [in Japanese]

    HORYU Daisuke , HAYASHI Takeshi

    … The results showed that the better similarity measure is different depending on the purpose of the analysis or from which organism the data derived. … In the case of evaluating similarities among more than three genes, mutual information was a better similarity measure for the data derived from multicellular organisms, though Pearson correlation coefficient was a better similarity measure for the data derived from unicellular organisms. …

    Japanese Journal of Biometrics 33(2), 125-143, 2013-02-28

    J-STAGE  References (23)

  • Intercellular communication via septal pore in the multicellular microorganism Aspergillus oryzae  [in Japanese]

    MARUYAMA Jun-ichi

    糸状菌は，多数の細長い細胞が連なる菌糸の形態で生長する．隣接する細胞は隔壁で仕切られているが，隔壁孔と呼ばれる小さな穴を介して連絡をしている．この隔壁孔を介した細胞間連絡は，糸状菌の多細胞生物としての生育に重要な役割を果たしていると考えられるが，一方で，ある細胞が溶菌した際に，隔壁孔を介して連絡している隣の細胞も溶菌に巻き込まれるリスクを伴うシステムでもある．筆者らは，低浸透圧ショックにより麹菌& …

    JSM Mycotoxins 61(2), 53-58, 2011-07-31

    J-STAGE  JASI  References (8)

  • Illumination of vertebrate development by fluorescence live imaging

    IIMURA Tadahiro , SUGIYAMA Mayu , MAKINO Yuji , NAKANE Ayako , WATANABE Takashi , YAMAGUCHI Akira

    <p>個体発生は細胞の増殖や移動，機能分化が動的に協調して変遷していく過程である。分子生物学やゲノム科学の進展によって，脊椎動物の発生に関わる様々な共通ルールが明らかとなってきた。蛍光ライブイメージングは，4 次元での定量的な解析を可能にし，分子から細胞，組織，器官，個体までのより包括的な理解を助ける。これによって，発生・発達生物医学は，分子の階層的記述から，より動的に理解することが可 …

    Cytometry Research 20(3), 57-63, 2011-03-25

    J-STAGE  References (15) Cited by (1)

  • Molecular and Cellular Biological Studies for Deep-sea Multicellular Organisms under Atmospheric Pressure Condition  [in Japanese]

    小山 純弘

    極限環境生物学会誌 = Journal of Japanese Society for Extremophiles 9(2), 106-115, 2010-12

  • Survival strategy of filamentous fungi as multicellular organism : regulatory system of intercellular communication via septal pore  [in Japanese]

    MARUYAMA Jun-ichi

    Bioscience & industry 68(5), 341-345, 2010-09-01

    References (10)

  • Molecular and Cellular Biological Studies for Deep-sea Multicellular Organisms under Atmospheric Pressure Condition  [in Japanese]

    Koyama S

    Journal of Japanese Society for Extremophiles 9(2), 106-115, 2010

    J-STAGE 

  • Drosophila Genetic Resource and Stock Center; The National BioResource Project

    YAMAMOTO Masa-Toshi

    … DNA was the first among multicellular organisms to be cloned. … thus became the pioneering model organism for various fields of life science research into multicellular organisms. …

    Experimental Animals 59(2), 125-138, 2010

    J-STAGE  Ichushi Web 

  • Intercellular bridges for cell-cell communication

    Takayuki Kohno

    … In multicellular organism, intercellular communication is essential for maintenance of life activity. …

    Tumor Research = Tumor Research (45), 67-71, 2010

    IR  DOI 

  • Differentiation-inducing factor-1 and -2 function also as modulators for Dictyostelium chemotaxis  [in Japanese]

    KUWAYAMA H. , Kubohara Yuzuru , 桑山 秀一

    … BackgroundIn the early stages of development of the cellular slime mold Dictyostelium discoideum, chemotaxis toward cAMP plays a pivotal role in organizing discrete cells into a multicellular structure. … To our knowledge, this is the first report in any organism of physiologic modulators (small molecules) for chemotaxis having differentiation-inducing activity. …

    PLoS ONE 4(8), e6658, 2009-08-17

    IR  Cited by (1)

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