Search Results 1-20 of 2210

  • Effect of dietary soy protein on skeletal muscle atrophy  [in Japanese]

    橋本 理恵 , 寺尾 純二 , 二川 健

    甲南女子大学研究紀要. Ⅱ = Konan Women's University studies. Ⅱ (14), 85-90, 2020-03-18

    IR 

  • Exploration of locomotive syndrome for bone and muscle from the countermeasures of musculoskeletal changes in astronauts  [in Japanese]

    志波 直人 , 松瀬 博夫 , 大本 将之 , 橋田 竜騎 , 田川 善彦

    整形外科 = Orthopedic surgery 71(3), 251-257, 2020-03

    Ichushi Web 

  • TAK-242, a specific inhibitor of Toll-like receptor 4 signalling, prevents endotoxemia-induced skeletal muscle wasting in mice

    Ono Yuko , Maejima Yuko , Saito Masafumi , Sakamoto Kazuho , Horita Shoichiro , Shimomura Kenju , Inoue Shigeaki , Kotani Joji

    … Systemic inflammatory responses induced by endotoxemia induce severe involuntary loss of skeletal muscle, termed muscle wasting, which adversely affects the survival and functional outcomes of these patients. … Currently, no drugs are available for the treatment of endotoxemia-induced skeletal muscle wasting. …

    Scientific Reports (10), 694, 2020-01-20

    IR 

  • Specificity of the swallowing muscles and sarcopenia  [in Japanese]

    藤島 一郎 , 梅﨑 俊郎 , 杉山 庸一郎

    嚥下医学 : 日本嚥下医学会学会誌 = Deglutition : the official journal of the Society of Swallowing and Dysphagia of Japan 9(1), 7-11, 2020

    Ichushi Web 

  • A case of dropped head syndrome that developed immediately after cervical laminoplasty in an elderly patient  [in Japanese]

    Honda Eiichiro , Tanaka Tatsuya , Shojima Hirotaka , Tsunoda Keiji

    <p>首下がり症候群は以前より筋側索硬化症,重症筋無力症,パーキンソン病など多様な疾患が関与していることは知られているが,長寿化に伴い,高齢者での頚髄症の手術も数多く行われるようになった.今回高齢者の後方椎弓形成術を行った直後より高度な首下がり現象が起こり神経学的には改善しているものの,日常生活でこれが新たな障害として発現した例を経験した.今回この1例から術前に首下がり現象を発現する要 …

    Journal of Spine Research 11(7), 974-979, 2020

    J-STAGE 

  • Associations between Paraspinal Muscle Morphology, Disc Degeneration, and Clinical Features in Patients with Lumbar Spinal Stenosis

    Miki Takahiro , Fujita Naoki , Takashima Hiroyuki , Takebayashi Tsuneo

    … <p><b>Objective: </b>The purpose of this study was to examine the relationships between intervertebral disc degeneration in the lumbar spine, paraspinal muscle morphology, and clinical features in patients with lumbar spinal stenosis (LSS).</p><p><b>Methods: </b>A total of 52 patients with LSS participated in this study. …

    Progress in Rehabilitation Medicine 5(0), n/a, 2020

    J-STAGE 

  • Castration-Induced Pelvic Floor Muscle Specific Atrophy and the Effect of Voluntary Wheel-Running Exercise  [in Japanese]

    YOSHIOKA Kiyoshi , MATSUMOTO Tomohiro , NAKAMURA Kodai , TSUCHIYA Yoshifumi , SEKO Daiki , KITAJIMA Yasuo , SAWADA Yuichiro , ONO Yusuke

    <p>【目的】アンドロゲン低下による球海綿体筋・肛門挙筋の筋萎縮に対する自走運動の効果を検証し,併せて,アンドロゲン低下による筋萎縮が他の骨盤底の筋にも共通する特徴であるかを検証する。【方法】3 ヵ月齢雄性マウスを対象とし,去勢術を施す群,去勢術後に自走ケージで飼育する群,偽手術群に無作為に分けた。手術から8 週間後に,後肢筋および骨盤底筋の重量,筋線維直径を測定した。【結果】後肢筋の …

    Physical Therapy Japan, 2020

    J-STAGE 

  • PROGRESS OF MOTOR FUNCTIONS IN PATIENTS POST HEMATOPOIETIC STEM CELL TRANSPLANTATION  [in Japanese]

    HOSAKA Yutaro , SAITOH Bungo , YOSHIKAWA Akira , YANAGISAWA Kouji , HATTORI Norimichi , NAKAMAKI Tsuyoshi , SEKIYA Noboru

    本研究の目的は,造血幹細胞移植(以下,移植)を受けた血液疾患患者の無菌室入室直前(以下,移植前),移植後に造血幹細胞が生着した直後(以下,生着後),および退院時における運動機能(筋力,持久力,バランス機能,柔軟性,活動性)の経時的変化を明らかにすることである.データ収集は,診療録を用いて後方視的に行われた.対象は,血液疾患と診断され同種移植を受けた60症例のうち自宅退院に至った41症例(年齢の中央 …

    Journal of The Showa University Society 80(2), 169-180, 2020

    IR  J-STAGE 

  • A case of Emery-Dreifuss muscular dystrophy with slight joint contracture  [in Japanese]

    M.D. Fujii Shintaro , M.D. Eguchi Katsuki , M.D. Sato Chika , M.D. Saito Yoshihiko , M.D. Indrawati Luh Ari , M.D. Ph.D. Shirai Shinichi , M.D. Ph.D. Nishino Ichizo , M.D. Ph.D. Yabe Ichiro

    <p>症例は42歳,男性.2度の冠動脈塞栓症の既往があり,筋疾患の精査目的に当科紹介となった.40歳頃から筋力低下を自覚し,肩甲周囲,上腕,下腿の筋萎縮を認めた.筋生検標本の免疫染色でエメリン蛋白の完全欠損を認め,遺伝子検査でemerin(<i>EMD</i>)遺伝子に病原性変異を確認しEmery-Dreifuss型筋ジストロフィー(Emery-Dreifuss …

    Rinsho Shinkeigaku, 2020

    J-STAGE 

  • KLF5 regulates chicken skeletal muscle atrophy via the canonical Wnt/β-catenin signaling pathway

    ZHANG Dong-Hao , YIN Hua-Dong , LI Jing-Jing , WANG Yan , YANG Chao-Wu , JIANG Xiao-Song , DU Hua-Rui , LIU Yi-Ping

    … <p>Recent studies in mice suggested that KLF5 (Kruppel like factor 5), a zinc-finger transcription factor, plays an important role in skeletal muscle development and regeneration. … As an important factor in the process of muscle development, KLF5 participates in the regulation of the cell cycle, cell survival, and cell dryness under different environmental conditions, but it is not clear whether KLF5 participates in muscle atrophy. …

    Experimental Animals, 2020

    J-STAGE 

  • Roles of satellite cells and/or myonuclei in the regulation of morphological properties of anti-gravitational skeletal muscle in response to mechanical stress

    Ohira Takashi , Kawano Fuminori , Ozaki Yusaku , Fukuda Shunya , Goto Katsumasa , Ohira Yoshinobu

    … <p>It is well-reported that the morphological properties of skeletal muscles or muscle fibers, which are influenced by the level of protein synthesis and/or degradation, are regulated in response to mechanical load. …

    Biological Sciences in Space 34(0), 1-11, 2020

    J-STAGE 

  • Role of skeletal muscle homeostasis of functional food material  [in Japanese]

    Yamazawa Toshiko , Yamada Shizuo

    <p>高齢者の筋力低下の原因には,加齢に伴う筋減弱を特徴とする病態(サルコペニア)や,あるいは神経支配が消失することによる筋萎縮が知られている.しかしこれらの詳細なメカニズムは不明で病態マーカーもなく,病態類似性について解明されていない点が多い.一方で近年,機能性健康食品が注目されてきている.しかしながら,機能性食品素材には,作用機序が解明されていないものが多くある.機能性食品素材のポ …

    Folia Pharmacologica Japonica 155(4), 236-240, 2020

    J-STAGE 

  • Perioperative physical and nutritional therapy for tongue cancer-induced malnutrition and muscle atrophy: A case report

    TANAKA Kohei , KASHIWAGI Hirohiko , TOGAWA Takeshi , YAMADA Tomoki

    … <p>Malnutrition is a common complication in patients with tongue cancer who experience dysphagia and can steadily lead to skeletal muscle atrophy. … Additionally, skeletal muscle loss commonly occurs in patients after invasive surgery. … Therefore, patients with tongue cancer are at high risk of skeletal muscle atrophy during the perioperative phase of treatment. …

    Physical Therapy Research 23(1), 87-91, 2020

    J-STAGE 

  • A case of motor and sensory polyneuropathy and respiratory failure with novel heterozygous mutation of the senataxin gene  [in Japanese]

    M.D. Ph.D. Kitao Ruriko , M.D. Ph.D. Honma Yutaka , M.D. Ph.D. Hashiguchi Akihiro , M.D. Ph.D. Mizoguchi Kouichi , M.D. Ph.D. Takashima Hiroshi , M.D. Ph.D. Komori Tetsuo

    <p>症例は29歳男性である.2歳半で独歩を獲得したが,筋力低下が進行し12歳時に歩行不能となった.20歳時に呼吸不全を合併した.診察では,顔面を含めた遠位筋優位の筋力低下と筋萎縮,脊椎側弯,四肢末梢優位の感覚障害を認めた.神経伝導検査では,複合筋活動電位の低下と運動神経伝導速度低下を認め,感覚神経電位は誘発不能であった.遺伝子解析でセナタキシン遺伝子(<i>SETX< …

    Rinsho Shinkeigaku, 2020

    J-STAGE 

  • The Aging of Skeletal Muscle and Potential Therapeutic Effects of Extracts from Edible and Inedible Plants

    Majeda Alfarafisa Nayla , Kitaguchi Kohji , Yabe Tomio

    … As humans age, they are likely to experience skeletal muscle weakness and atrophy; … This article reviews information on bioactive plant compounds which may affect skeletal muscle health, particularly with respect to therapeutic approaches to sarcopenia. …

    Reviews in Agricultural Science 8(0), 70-88, 2020

    J-STAGE 

  • Differential protective effects of <i>Radix astragali</i>, herbal medicine, on immobilization-induced atrophy of slow-twitch and fast-twitch muscles

    NOZAKI Risa , HUNG Yung-Li , TAKAGI Kana , NAKANO Daiki , FUJII Takako , KAWANISHI Noriaki , OKAMOTO Takeshi , MACHIDA Shuichi

    … prevented atrophy in both slow- and fast-twitch muscles following cast immobilization. … 0.05) in soleus and plantaris muscle-to-body weight ratios by 74.3% and 70.5%, respectively, compared with those in the CON group. … significantly reversed (+35.5%) the weight reduction observed in soleus muscle, but not in the plantaris muscle, compared with that in the IM group. … mRNA expression only in the soleus muscle during cast immobilization. …

    Biomedical Research 41(3), 139-148, 2020

    J-STAGE 

  • Reduction of stearoyl-CoA desaturase (SCD) contributes muscle atrophy through the excess endoplasmic reticulum stress in chronic kidney disease

    Niida Yuki , Nikawa Takeshi , Yamamoto Hironori , Miyazaki Makoto , Taketani Yutaka , Masuda Masashi , Adachi Yuichiro , Yoshizawa Aika , Ohminami Hirokazu , Mori Yuki , Ohnishi Kohta , Yamanaka-Okumura Hisami , Uchida Takayuki

    … <p>Skeletal muscle atrophy is associated with mortality and poor prognosis in patients with chronic kidney disease (CKD). … However, underlying mechanism by which CKD causes muscle atrophy has not been completely understood. …

    Journal of Clinical Biochemistry and Nutrition, 2020

    J-STAGE 

  • A Case of Mitochondrial Diabetes Mellitus Diagnosed by Development of Cognitive Decline  [in Japanese]

    Kikuchi Akira , Okamoto Yuji , Hashiguchi Hiroshi , Yoshishige Koichi , Taniguchi Takaki , Deguchi Takahisa , Takashima Hiroshi , Nishio Yoshihiko

    <p>64歳女性.X-24年巣状糸球体硬化症,X-11年糖尿病の診断と加療を受け,X-4年にはインスリン治療が開始された.X-2年10月頃からは物忘れが激しくなり,血糖コントロール悪化の原因と考えられ,神経内科を受診した.上肢巧緻運動障害と高次脳機能障害の存在を指摘され,X年8月に精査入院した.頭部MRIでは両側大脳皮質病変,大脳・脳幹・小脳の萎縮を,左上腕二頭筋の筋生検でragged …

    Journal of the Japan Diabetes Society 63(5), 344-349, 2020

    J-STAGE 

  • Selective muscular atrophy in a family with hereditary myopathy with early respiratory failure  [in Japanese]

    Aoki Reika , Kokubun Norito , Komagamine Tomoko , Ishii Yuko , Nishino Ichizo , Hirata Koichi

    <p>Hereditary myopathy with early respiratory failure(HMERF)はtitin遺伝子(TTN)の変異によって生じ,早期からの呼吸不全を特徴とする筋原線維性ミオパチーである.われわれは,HMERFの一家系3症例の臨床像ならびに特徴的な罹患筋分布を報告する.兄妹および父親の間で重症度は著しく異なっていたが,3症例とも既報告と同様に半腱様 …

    Rinsho Shinkeigaku 60(5), 334-339, 2020

    J-STAGE 

  • Muscle atrophy in critically ill patients : a review of its cause, evaluation, and prevention

    Nakanishi Nobuto , Takashima Takuya , Oto Jun

    … Critically ill patients exhibit prominent muscle atrophy, which occurs rapidly after ICU admission and leads to poor clinical outcomes. … The extent of atrophy differs among muscles as follows: upper limb: 0.7%–2.4% per day, lower limb: 1.2%–3.0% per day, and diaphragm 1.1%–10.9% per day. … This atrophy is caused by numerous risk factors such as inflammation, immobilization, nutrition, hyperglycemia, medication, and mechanical ventilation. …

    The Journal of Medical Investigation 67(1.2), 1-10, 2020

    IR  J-STAGE 

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