Search Results 1-20 of 107

  • RNF152 Negatively Regulates mTOR Signalling and Blocks Cell Proliferation in the Floor Plate

    Kadoya Minori , Sasai Noriaki

    … The neural tube is composed of a number of neural progenitors and postmitotic neurons distributed in a quantitatively and spatially precise manner. … The floor plate, located in the ventral-most region of the neural tube, has a lot of unique characteristics, including a low cell proliferation rate. …



  • JAK/STAT guarantees robust neural stem cell differentiation by shutting off biological noise

    Tanaka Yoshitaro , Yasugi Tetsuo , Nagayama Masaharu , Sato Makoto , Ei Shin-Ichiro

    Scientific reports (8), 12484, 2018-08-20

  • Differentiating cells mechanically limit the interkinetic nuclear migration of progenitor cells to secure apical cytogenesis

    Watanabe Yuto , Kawaue Takumi , Miyata Takaki

    … Although most epithelia, including early embryonic neuroepithelia (≤100 µm thick), undergo IKNM over the entire apicobasal extent, more apicobasally elongated (300 µm) neural progenitor cells (radial glial cells) in the mid-embryonic mouse cerebral wall move their nuclei only within its apical (100 µm) compartment, leaving the remaining basal region nucleus-free (fiber-like). …

    Development 145(14), dev162883, 2018-07-17


  • Origin and initiation mechanisms of neuroblastoma

    Tsubota Shoma , Kadomatsu Kenji

    … In this review article, we summarize the current knowledge about normal development of putative neuroblastoma sources, namely sympathoadrenal lineage of neural crest cells and Schwann cell precursors that were recently identified as the source of adrenal chromaffin cells. …

    Cell and Tissue Research 372(2), 211-221, 2018-05


  • Collective Behavior of Cells and Topological Defects  [in Japanese]

    KAWAGUCHI Kyogo , KAGEYAMA Ryoichiro , SANO Masaki

    … Here we show that mouse neural progenitor cells cultured on dish present features of an active nematic system, resembling the patterns of liquid crystal but with the cells rapidly gliding and stochastically switching its velocity. …

    Seibutsu Butsuri 58(3), 134-138, 2018

    J-STAGE  Ichushi Web 

  • Evolutionary mechanisms that generate morphology and neural-circuit diversity of the cerebellum

    Hibi Masahiko , Matsuda Koji , Takeuchi Miki , Shimizu Takashi , Murakami Yasunori

    … These cerebellar neurons are generated from neuronal progenitors or neural stem cells by mechanisms that are conserved among vertebrates. … However, vertebrate cerebella are widely diverse with respect to their gross morphology and neural circuits. …

    Development, Growth and Differentiation 59(4), 228-243, 2017-05

    IR  Ichushi Web 

  • SOX10-Nano-Lantern Reporter Human iPS Cells; A Versatile Tool for Neural Crest Research

    Horikiri Tomoko , Ohi Hiromi , Shibata Mitsuaki , Ikeya Makoto , Ueno Morio , Sotozono Chie , Kinoshita Shigeru , Sato Takahiko

    … The neural crest is a source to produce multipotent neural crest stem cells that have a potential to differentiate into diverse cell types. … The transcription factor SOX10 is expressed through early neural crest progenitors and stem cells in vertebrates. …

    PLOS ONE 12(1), 2017-01-20


  • Molecular Mechanism Underlying Abnormal Differentiation of Neural Progenitor Cells in the Developing Down Syndrome Brain  [in Japanese]

    Kurabayashi Nobuhiro , Sanada Kamon

    … Similar to abnormalities seen in DS brains, mouse models of DS show deficits in brain development, and neural progenitor cells that give rise to neurons and glia show dysregulation in their differentiation. … and <i>DSCR1</i>, contributes to suppressed neuronal differentiation of progenitors in the Ts1Cje mouse model of DS. … contributes to elevated potential of Ts1Cje progenitors to differentiate into astrocytes and enhanced astrogliogenesis in the Ts1Cje neocortex. …

    YAKUGAKU ZASSHI 137(7), 795-800, 2017

    J-STAGE  Ichushi Web 

  • Differences and similarities between human and chimpanzee neural progenitors during cerebral cortex development

    Mora-Bermúdez Felipe , Badsha Farhath , Kanton Sabina , Camp J Gray , Vernot Benjamin , Köhler Kathrin , Voigt Birger , Okita Keisuke , Maricic Tomislav , He Zhisong , Lachmann Robert , Pääbo Svante , Treutlein Barbara , Huttner Wieland B

    … This expansion is thought to primarily reflect differences in proliferation versus differentiation of neural progenitors during cortical development. … Notably, however, live imaging of apical progenitor mitosis uncovered a lengthening of prometaphase-metaphase in humans compared to chimpanzees that is specific to proliferating progenitors and not observed in non-neural cells. …

    eLife (5), 2016-09-26


  • An essential role of SVZ progenitors in cortical folding in gyrencephalic mammals

    Toda Tomohisa , Shinmyo Yohei , Dinh Duong Tung Anh , Masuda Kosuke , Kawasaki Hiroshi

    … Although it has been proposed that increased neural progenitors in the subventricular zone (SVZ) are responsible for making cortical folds, their roles in cortical folding are still largely unclear, mainly because genetic methods for gyrencephalic mammals had been poorly available. … Here, by taking an advantage of our newly developed in utero electroporation technique for the gyrencephalic brain of ferrets, we investigated the role of SVZ progenitors in cortical folding. …

    Scientific Reports (6), 29578, 2016-07-12


  • Induction of Excess Centrosomes in Neural Progenitor Cells during the Development of Radiation-Induced Microcephaly

    Shimada Mikio , Matsuzaki Fumio , Kato Akihiro , Kobayashi Junya , Matsumoto Tomohiro , Komatsu Kenshi

    … In this study, we showed that ionizing radiation induces apoptosis in the neural progenitors of the mouse cerebral cortex, and that the surviving progenitor cells subsequently develop a considerable amount of supernumerary centrosomes. …

    PLOS ONE 11(7), 2016-07-01


  • OVOL2 Maintains the Transcriptional Program of Human Corneal Epithelium by Suppressing Epithelial-to-Mesenchymal Transition.

    Kitazawa Koji , Hikichi Takafusa , Nakamura Takahiro , Mitsunaga Kanae , Tanaka Azusa , Nakamura Masahiro , Yamakawa Tatsuya , Furukawa Shiori , Takasaka Mieko , Goshima Naoki , Watanabe Akira , Okita Keisuke , Kawasaki Satoshi , Ueno Morio , Kinoshita Shigeru , Masui Shinji

    … Moreover, neuroectoderm derivatives were found to express mesenchymal genes, and OVOL2 alone could induce the transcriptional program of CECs in neural progenitors by repressing these genes while activating epithelial genes. …

    Cell reports (15), 2016-04-28


  • Neural Progenitors Adopt Specific Identities by Directly Repressing All Alternative Progenitor Transcriptional Programs

    Kutejova Eva , Sasai Noriaki , Shah Ankita , Gouti Mina , Briscoe James

    … In the vertebrate neural tube, a morphogen-induced transcriptional network produces multiple molecularly distinct progenitor domains, each generating different neuronal subtypes. … Combined with targeted perturbations of the network, this revealed a mechanism in which a progenitor identity is installed by active repression of the entire transcriptional programs of other neural progenitor fates. …



  • Oscillatory control of Delta-like1 in cell interactions regulates dynamic gene expression and tissue morphogenesis

    Shimojo Hiromi , Isomura Akihiro , Ohtsuka Toshiyuki , Kori Hiroshi , Miyachi Hitoshi , Kageyama Ryoichiro

    … Here, we developed a live-imaging system and found that Dll1 protein expression oscillated in neural progenitors and presomitic mesoderm cells. … In the developing brain, steady Dll1 expression inhibited proliferation of neural progenitors and accelerated neurogenesis, whereas optogenetic induction of Dll1 oscillation efficiently maintained neural progenitors. …

    Genes & Development (30), 102-116, 2016-01-01


  • Making pituitary hormone-producing cells in a dish [Review]

    Suga Hidetaka

    … Pluripotent stem cells, such as embryonic stem (ES) cells and induced pluripotent stem (iPS) cells, differentiate into neuroectodermal progenitors when cultured as floating aggregates under serum-free conditions. … Recent results have shown that strict removal of exogenous patterning factors during the early differentiation period induces rostral hypothalamic-like progenitors from mouse ES cells. …

    Endocrine Journal 63(8), 669-680, 2016


  • Cell therapy using induced pluripotent stem cells for Parkinson's disease  [in Japanese]

    Morizane Asuka

    … We are preparing a clinical trial that involves the transplantation of dopaminergic neural progenitors differentiated from iPSCs. …

    Neurological Therapeutics 33(2), 177-181, 2016

    J-STAGE  Ichushi Web 

  • 1D31 Profiling and Significance of Mechanical Factors in the Developing Brain Tissue : To Uncover Novel Regulatory Mechanisms for Neural Stem Cell Differentiation  [in Japanese]

    KOSODO Yoichi

    … During brain development, neural stem cells define specific niches within different cortical layers to control their cellular environment. … My previous work revealing the role of a physical crowding effect on interkinetic nuclear migration, an oscillation of nuclear positions of neural progenitors associated with the cell-cycle, led us to investigate the intimate physical interactions between cells and the surrounding tissue. …

    The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2016.28(0), _1D31-1_-_1D31-4_, 2016


  • Identification of neurexophilin 3 as a novel supportive factor for survival of induced pluripotent stem cell-derived dopaminergic progenitors

    Nishimura Kaneyasu , Murayama Shigeo , Takahashi Jun

    … When we injected mouse iPSC-derived neural cells along withNXPH3 into themouse striatum, the ratio of tyrosine hydroxylasepositive DA neurons per graft volume was higher at 8 weeks compared with cell injections that excluded NXPH3. …

    Stem Cells Translational Medicine 4(8), 932-944, 2015-08


  • Oncogenic <i>Lmo3</i> cooperates with <i>Hen2</i> to induce hydrocephalus in mice

    Isogai Eriko , Fushiki Shinji , Nagase Hiroki , Wakabayashi Yuichi , Okumura Kazuhiro , Saito Megumi , Yoshizawa Yasuhiro , Itoh Kyoko , Tando So , Ohira Miki , Haraguchi Seiki , Nakagawara Akira

    … promoter, which is expressed in the central nervous system and neural crest of the sympathoadrenal lineage from which neuroblastoma develops. … expression level was decreased in ventricular zone progenitors. …

    Experimental Animals 64(4), 407-414, 2015

    J-STAGE  Ichushi Web 

  • Induction of Hypothalamic Neurons from Pluripotent Stem Cells

    NAGASAKI Hiroshi , KODANI Yu , SUGA Hidetaka

    … Hypothalamic progenitor cells arise from the retina and anterior neural fold homeobox (Rax)<sup>+</sup> … In the pluripotent stem cells, rostrodorsal hypothalamus-like progenitors expressing retina and anterior neural fold homeobox are generated from floating aggregates in serum-free conditions with minimized exogenous patterning signaling. … progenitors generate Otp<sup>+</sup> …

    Interdisciplinary Information Sciences 21(3), 261-266, 2015

    IR  J-STAGE 

Page Top