Search Results 1-20 of 1103

  • Neural regulation of hematopoiesis  [in Japanese]

    淺田 騰 , 片山 義雄

    臨床免疫・アレルギー科 = Clinical immunology & allergology 74(2), 110-116, 2020-08

  • Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson's disease

    Doi Daisuke , Magotani Hiroaki , Kikuchi Tetsuhiro , Ikeda Megumi , Hiramatsu Satoe , Yoshida Kenji , Amano Naoki , Nomura Masaki , Umekage Masafumi , Morizane Asuka , Takahashi Jun

    臨床用iPS細胞を用いたパーキンソン病治療の非臨床研究を実施 --ヒトiPS細胞由来のドパミン神経前駆細胞の安全性と有効性を確認--. 京都大学プレスリリース. 2020-07-20.

    Nature Communications (11), 2020-07-06

    IR 

  • Bone Marrow Mesenchymal Stem Cells Transplantation on Acute Spinal Cord Injury

    Song Hua , Suo Shiqi , Ning Chao , Zhang Yang , Mu Weidong , Chen Song

    Journal of hard tissue biology 29(2), 91-97, 2020-04

  • Modeling of early neural development in vitro by direct neurosphere formation culture of chimpanzee induced pluripotent stem cells

    Kitajima Ryunosuke , Nakai Risako , Imamura Takuya , Kameda Tomonori , Kozuka Daiki , Hirai Hirohisa , Ito Haruka , Imai Hiroo , Imamura Masanori

    iPS細胞を使ってチンパンジーの初期神経発生を誘導 --ヒト脳進化の解明に向けたiPS細胞研究に道--. 京都大学プレスリリース. 2020-03-17.

    Stem Cell Research (44), 2020-04

    IR 

  • Stage-dependent differential gene expression profiles of cranial neural crest-like cells derived from mouse-induced pluripotent stem cells.

    Odashima A , Onodera S , Saito A , Ogihara Y , Ichinohe T , Azuma T

    Medical molecular morphology 53(1), 28-41, 2020-03

    IR 

  • Early Maternal and Social Deprivation Expands Neural Stem Cell Population Size and Reduces Hippocampus/Amygdala-Dependent Fear Memory.

    DAUN Kenny Anak , FUCHIGAMI Takahiro , KOYAMA Natsu , MARUTA Noriko , IKENAKA Kazuhiro , HITOSHI Seiji , 渕上 孝裕 , 小山 なつ , 等 誠司

    … Early life stress can exert detrimental or beneficial effects on neural development and postnatal behavior depending on the timing, duration, strength, and ability to control the stressors. … In this study, we utilized a maternal and social deprivation (MSD) model to investigate the effects of early life stress on neural stem cells (NSCs) and neurogenesis in the adult brain. …

    Frontiers in neuroscience, 2020-01-29

    IR 

  • Metabolic Regulation of Cardiac Differentiation and Maturation in Pluripotent Stem Cells: A Lesson from Heart Development

    Morita Yuika , Tohyama Shugo

    … <p>The heart, one of the more complex organs, is composed from a number of differentiated cells. … In general, researchers consider that the cardiac cells are derived from the same origin as mesodermal cells, except neural crest cells. …

    JMA Journal 3(3), 193-200, 2020

    J-STAGE 

  • Methyl-CpG binding domain protein 3: a new diagnostic marker and potential therapeutic target of melanoma

    Ishibashi Takayuki , Makino Takamitsu , Fukushima Satoshi , Kita Kanako , Ihn Hironobu , Kajihara Ikko , Mizuhashi Satoru , Kuriyama Haruka , Kimura Toshihiro , Kanemaru Hisashi , Makino Katsunari , Miyashita Azusa , Aoi Jun

    … MBD3 facilitates the initiation of neural stem cell reprogramming. … Melanoma originates in melanocytes derived from neural crest stem cells; … MBD3 knockdown had no effect on the proliferation of melanoma cells (A375 and A2058 cells). …

    BioScience Trends, 2020

    J-STAGE 

  • Fate specification of neural stem cells regulated by MeCP2 through miRNA processing  [in Japanese]

    NAKASHIMA Kinichi

    <p> Rett症候群 (RTT) は広汎性神経発達障害の1種であり、主にmethyl-CpG binding protein 2(MECP2)遺伝子変異によって発症する。我々は以前に、MeCP2がDrosha複合体と会合し、特定のmiRNA(miR-199a)のプロセシングを促進することで、ニューロンの機能を制御すること発見した。今回我々は、このMeCP2/miR199a経路が神経幹 …

    Annual Meeting of the Japanese Society of Toxicology 47.1(0), S29-1, 2020

    J-STAGE 

  • Potential application of postnatal and adult neurogenesis in the olfactory bulb to test developmental neurotoxicity  [in Japanese]

    IMAYOSHI Itaru

    <p>従来、ニューロンの産生は発生期においてしか行われないと考えられていたが、ヒトを含めた哺乳類の成体の脳においても神経幹細胞が存在し、ニューロンの新生が一生涯続いている事が解ってきた。新生ニューロンが既存の神経回路に組み込まれる様式と、高次脳機能との関係についても、解明が進んでいる。本公演では、マウス生後脳・成体脳の嗅球におけるニューロン新生について最新の知見を紹介するとともに、毒性 …

    Annual Meeting of the Japanese Society of Toxicology 47.1(0), S17-5, 2020

    J-STAGE 

  • Influences of diazepam exposure during pregnancy on neural development  [in Japanese]

    KUWAHARA Misaki , KITAOKA Satoshi , KOYAMA Yuya , KAINUMA Reo , NEGISHI Keita , OCHIAI Wataru

    … The second trimester is a period in which the division of neural stem cells and the differentiation into neurons and astrocytes occur actively in the cerebral cortex region of the fetus, and the effect of OZ on neurogenesis is feared. …

    Annual Meeting of the Japanese Society of Toxicology 47.1(0), P-51S, 2020

    J-STAGE 

  • Early-life exposure to low levels of permethrin exerts impairments in learning and memory with the effects on neuronal and glial population in adult male mice  [in Japanese]

    SAITO Hirokatsu , HARA Kenshiro , TOMINAGA Takashi , NAKASHIMA Kinichi , KITAJIMA Satoshi , KANNO Jun , TANEMURA Kentaro

    … Immunohistochemical analysis revealed an increase in doublecortin- (an immature neuron marker) positive cells in the hippocampal dentate gyrus in the permethrin exposure group compared with the control group. … These results suggest that exposure to permethrin at low levels in early life affects the formation of the neural circuit base and behavior after maturation. …

    Annual Meeting of the Japanese Society of Toxicology 47.1(0), P-59E, 2020

    J-STAGE 

  • Historic Overview of Genetic Engineering Technologies for Human Gene Therapy

    TAMURA Ryota , TODA Masahiro

    … Although a variety of methods have also been performed for the treatment of malignant gliomas, it has been difficult to target invasive glioma cells. … To overcome this problem, immortalized neural stem cell (NSC) and a nonlytic, amphotropic retroviral replicating vector (RRV) have attracted attention for gene delivery to invasive glioma. …

    Neurologia medico-chirurgica, 2020

    J-STAGE 

  • Strong demands for the new preclinical assessment system of the CNS adverse effects  [in Japanese]

    Takahashi Kanako , Sato Kaoru

    … 観性を排除し,客観性を向上させるアルゴリズムを開発した.これらのプロトコルは,日本製薬工業組合を母体として始まったヒトiPS細胞応用安全性評価コンソーシアム(Consortium for Safety Assessment using Human iPS Cells:CSAHi)において,複数施設による再現性も確認されている.さらに,国際コンソーシアムInternational Life Sciences Institute(ILSI):Health and Environmental Sciences Institute(HESI)HESI NeuTox MEA sub teamにおいて,共通化合物 …

    Folia Pharmacologica Japonica 155(5), 295-298, 2020

    J-STAGE 

  • Quality Improvement of Embryonic Bodies on Integrated Spheroid Culture Chip by Using 3DCNN  [in Japanese]

    Suda Shuya , Aoyama Chihiro , Ikeuchi Masashi

    <p>幹細胞から各種細胞への分化誘導において,形成する胚様体の大きさが,その後の分化の方向性や効率を決定づける大きな要因であることが明らかとなってきた.高い再現性で分化誘導を行うには,大量の胚様体を均一に形成することに加えて,最終的な胚様体の大きさを,早期に定量的に予測し,選別することが非常に重要である.本発表は,我々が開発してきた,大量の胚様体を一度に培養できるマイクロプレート「TA …

    Transactions of Japanese Society for Medical and Biological Engineering Annual58(Abstract), 364-364, 2020

    J-STAGE 

  • Change in Electrical Activity of Hippocampal Neuronal Network by the Presence of Immature Neurons  [in Japanese]

    Moriya Fumika , Shimba Kenta , Kotani Kiyoshi , Jimbo Yasuhiko

    <p>記憶や学習を担う海馬では、成体の脳内で神経幹細胞が神経細胞へと分化する現象である成体神経新生が起きている。認知機能の低下をもたらす加齢や糖尿病、アルツハイマー病等において異常な成体神経新生が確認されることから、海馬での成体神経新生と学習・記憶には関連があり、脳内に存在し続ける未熟神経細胞が学習・記憶に重要な役割を担うと考えられている。詳細なメカニズムの解明は、成体神経新生に起因す …

    Transactions of Japanese Society for Medical and Biological Engineering Annual58(Abstract), 354-354, 2020

    J-STAGE 

  • Automatic Cell discrimination by Imaging Flow Cytometry and Machine Learning  [in Japanese]

    Matsuoka Yoshikazu

    … Particularly, deep learning represented by a Convolutional Neural Network has enabled high-accuracy image recognition compared with conventional machine learning methods. … We describe a strategy to obtain training image datasets of cells using highthroughput imaging fl ow cytometry. … Particularly, deep learning represented by a Convolutional Neural Network has enabled high-accuracy image recognition compared with conventional machine learning methods. …

    Cytometry Research 30(1), 15, 2020

    J-STAGE 

  • Genome Engineering Evolves Brain Tumor Modeling

    KOGA Tomoyuki , CHEN Clark C. , FURNARI Frank B.

    … Pertaining to brain tumors, neural progenitor cells derived from human induced pluripotent stem cells (iPSCs) engineered with different combinations of genetic driver mutations observed in distinct molecular subtypes of glioblastomas, the most common form of primary brain cancer in adults, give rise to brain tumors when engrafted orthotopically in mice. …

    Neurologia medico-chirurgica 60(7), 329-336, 2020

    J-STAGE 

  • Artificial intelligence (AI) and hematological diseases: establishment of a peripheral blood convolutional neural network (CNN)-based digital morphology analysis system  [in Japanese]

    OHSAKA Akimichi

    <p>塗抹標本の血液形態検査は,血液疾患を診断する上で必須の臨床検査である。日本において,血液形態検査は,臨床検査技師がガラススライドに塗沫標本を作成し,メイギムザ染色を行って鏡検する検査法が現在でも続けられている。この方法はgold standardとされているが,多大な労力と臨床検査技師の継続的トレーニングを必要とし,検査者による精度のバラツキも避けられない。人工知能(AI)技術, …

    Rinsho Ketsueki 61(5), 564-569, 2020

    J-STAGE  Ichushi Web 

  • L-Theanine Attenuates Isoflurane-Induced Injury in Neural Stem Cells and Cognitive Impairment in Neonatal Mice

    Chen Yong , Lian Fang , Lu Qiang , Peng Shengliang , Li Jiahao , Huang Song , Du Xiaohong

    … The present study was designed to investigate whether L-theanine could attenuate isoflurane-induced damage in neural stem cells and cognitive impairment in young mice, and to discuss the role of protein kinase B (Akt)–glycogen synthase kinase 3β (GSK-3β) signaling pathway in this process. …

    Biological and Pharmaceutical Bulletin 43(6), 938-945, 2020

    J-STAGE 

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