Search Results 1-20 of 409

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Peripheral administration of SB223412, a selective neurokinin-3 receptor antagonist, suppresses pulsatile luteinizing hormone secretion by acting on the gonadotropin-releasing hormone pulse generator in estrogen-treated ovariectomized female goats

SASAKI Takuya , TSUKAMURA Hiroko , MAEDA Kei-ichiro , MATSUDA Fuko , MORITA Yasuhiro , MATSUYAMA Shuichi , OHKURA Satoshi , SONODA Tomoya , TATEBAYASHI Ryoki , KITAGAWA Yuri , OISHI Shinya , YAMAMOTO Koki , FUJII Nobutaka , INOUE Naoko , UENOYAMA Yoshihisa

… Accumulating evidence suggests that KNDy neurons located in the hypothalamic arcuate nucleus (ARC), which are reported to express kisspeptin, neurokinin B, and dynorphin A, are indispensable for the gonadotropin-releasing hormone (GnRH) pulse generation that results in rhythmic GnRH secretion. …

Journal of Reproduction and Development 66(4), 351-357, 2020

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2

GnRH(1-5), a metabolite of gonadotropin-releasing hormone, enhances luteinizing hormone release via activation of kisspeptin neurons in female rats

Ieda Nahoko , Inoue Naoko , Uenoyama Yoshihisa , Tsukamura Hiroko , Assadullah , Minabe Shiori , Ikegami Kana , Watanabe Youki , Sugimoto Yusuke , Sugimoto Arisa , Kawai Narumi , Ishii Hirotaka

… Accumulating evidence suggests that kisspeptin neurons in the arcuate nucleus (ARC), which coexpress neurokinin B and dynorphin, are involved in gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH) pulse generation, while the anteroventral periventricular nucleus (AVPV) kisspeptin neurons are responsible for GnRH/LH surge generation. …

Endocrine Journal 67(4), 409-418, 2020

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3

Identification of the molecule required for transmission of IL-31–induced itch sensation in the spinal cord [in Japanese]

Sakata Daiji , Fukui Yoshinori

… By analyzing a mouse model for atopic dermatitis, we found that the expression of Tac2, which encodes neurokinin B (NKB), markedly increased in the DRG neurons in response to IL-31. … NKB transmits the signal through neurokinin 3 receptor (NK3R), a G protein-coupled tachykinin receptor. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-O-045, 2020

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Scaffold hopping of fused piperidine-type NK3 receptor antagonists to reduce environmental impact

Yamamoto Koki , Inuki Shinsuke , Ohno Hiroaki , Oishi Shinya

… Neurokinin-3 receptor (NK3R) plays a pivotal role in the release of gonadotropin-releasing hormone in the hypothalamus–pituitary–gonadal (HPG) axis. …

Bioorganic and Medicinal Chemistry 27(10), 2019-2026, 2019-05-15

IR
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Possible involvement of tachykinin neurokinin-1 receptors on nociceptive behaviors induced by intrathecally administered cholecystokinin-8 [in Japanese]

Hayashi Takafumi , Katsuyama Soh , Suzuki Tsuneyoshi , Sakurada Shinobu

… The tachykinin neurokinin-1 (NK1) receptor antagonists, CP-99,994 and sendide, inhibited CCK-8 (10 pmol)-induced behavioral response in a dose-dependent manner. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 2-P-033, 2019

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6

Hypothalamic Kisspeptin Expression in Hyperandrogenic Female Rats and Aging Rats

Iwata Kinuyo , Kunimura Yuyu , Ozawa Hitoshi

Hypothalamic kisspeptin neurons stimulate gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) release. Kisspeptin neurons in the anteroventral periventricular nucleus (AVPV) of …

ACTA HISTOCHEMICA ET CYTOCHEMICA 52(5), 85-91, 2019

J-STAGE Ichushi Web
7

The efficacy of a newly developed neurokinin 3 receptor agonist B21-750 on luteinizing hormone secretion in cycling goats

RAHAYU Larasati Puji , ENDO Natsumi , KUWAI Shinji , OISHI Shinya , TANAKA Tomomi

 This study aimed to investigate the efficacy of a newly developed NK3 receptor agonist (B21-750) on the secretion of luteinizing hormone (LH) in association with ovarian steroid hormones dur …

Journal of Reproduction and Development 65(5), 481-484, 2019

J-STAGE Ichushi Web
8

Ad libitum feeding triggers puberty onset associated with increases in arcuate Kiss1 and Pdyn expression in growth-retarded rats

MAJARUNE Sutisa , Nima Pelden , SUGIMOTO Arisa , NAGAE Mayuko , INOUE Naoko , TSUKAMURA Hiroko , UENOYAMA Yoshihisa

… (neurokinin B gene) and Pdyn …

Journal of Reproduction and Development 65(5), 397-406, 2019

J-STAGE Ichushi Web
9

Clinical Pharmacology Research for Promoting Individualized Cancer Chemotherapy [in Japanese]

Watanabe Hiroyuki , Uchida Mayako , Masuda Satohiro

… Guidelines on the management of chemotherapy-induced nausea and vomiting recommend aprepitant, a selective neurokinin-1 (NK-1) receptor antagonist, 5-hydroxytryptamine 3 (5-HT3) receptor antagonists, and dexamethasone as prophylactic antiemetics. …

YAKUGAKU ZASSHI 139(6), 901-909, 2019

J-STAGE Ichushi Web
10

Clinical Research Practice Tips - From Pharmacist's "notice" to Research Realization - [in Japanese]

Suzuki Kenichi , Yamamoto Nobuyuki

2012年「Cisplatinを含む高度催吐性化学療法施行時の嘔吐に対するグラニセトロン（以下GRA) 1 mgとパロノセトロン（以下PALO) 0.75 mgの二重盲検ランダム化比較試験：TRIPLE study」を実施した。これは全国から842例を集めて実施した第Ⅲ相試験であり、日本癌治療学会から推奨されている3剤併用標準制吐療法において、セロトニン受容体拮抗薬(5-HT3RA)の中ではどの薬 …

Applied Therapeutics 11(0), 37-45, 2019

J-STAGE Ichushi Web
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Allopregnanolone suppresses mechanical allodynia and internalization of neurokinin-1 receptors at the spinal dorsal horn in a rat postoperative pain model

Fujita Masahide , Fukuda Taeko , Sato Yasuhiro , Takasusuki Toshifumi , 田中誠 , 福田妙子 , 田中誠

BackgroundTo identify a new strategy for postoperative pain management, we investigated the analgesic effects of allopregnanolone (Allo) in an incisional pain model, and also assessed its effects on t …

The Korean Journal of Pain 31(1), 10-15, 2018-01

IR
12

Overview of Recent Progress in Neuropharmacology of Lower Urinary Tract Function

Yoshimura Naoki

… Although they are still in preclinical stages, pharmacological modulation of urothelial-afferent interactions targeting purinergic, muscarinic/nicotinic cholinergic and neurokinin receptors has been investigated. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), SY65-1, 2018

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13

Effects of histamine H4 receptor antagonist on the chemotherapy-induced anorexia in mice

Yamamoto Kouichi , Okui Rikuya , Yamatodani Atsushi

… receptor antagonists, neurokinin NK1receptor antagonists, and corticosteroids are used. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), PO3-5-9, 2018

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14

Therapeutic effects of an NK1 receptor antagonist on mechanical hypersensitivity and bone loss in partial sciatic nerve ligated mice

Kodama Daisuke , Ohi Yoshiaki , Haji Akira

Background: Patients with neuropathic pain frequently express osteoporosis. It has been thought that reduction of mechanical loading causes a lower bone mass in neuropathic …

Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), PO2-2-23, 2018

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15

The effect of diet control on puberty onset and immunoreactivity of kisspeptin and neurokinin B in female rats

Kim Eunyoung , Chung Min Jae , Chung Yoonyoung , Jun Yonghyun

… Kisspeptin is an essential factor for the regulation of sexual maturation and is co-expressed with neurokinin B in neurons in the hypothalamic arcuate nucleus. … Therefore, in this study, we examined the immunoreactivity pattern of the kisspeptin/kiss1-receptor (KISS1R) and neurokinin B/neurokinin3-receptor (R). … We examined kisspeptin/Kiss1-receptor and neurokinin B/neurokinin3-receptor immunoreactivity (IR) in the arcuate nucleus of the pups. …

Endocrine Journal 65(12), 1177-1185, 2018

J-STAGE Ichushi Web
16

Increase in arcuate Kiss1 and Pdyn expressions may trigger the puberty onset in female rats [in Japanese]

MAJARUNE Sutisa , NIMA Pelden , INOUE Naoko , TSUKAMURA Hiroko , UENOYAMA Yoshihisa

… To clarify the mechanism underlying the puberty onset, the present study examined the effects of food restriction and subsequent relief from the restriction on Kiss1 (kisspeptin gene), Tac3 (neurokinin B gene) and Pdyn (Dynorphine A gene) expressions in the arcuate nucleus (ARC) and puberty onset in rats, because the ARC kisspeptin neurons are considered to be responsible for GnRH/gonadotropin pulse generation. …

The Journal of Reproduction and Development Supplement 111(0), OR2-23-OR2-23, 2018

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17

Oral administration of selective neurokinin B receptor antagonist suppresses pulsatile LH secretion in female goats [in Japanese]

SASAKI Takuya , MAEDA Kei-Ichiro , MATSUDA Fuko , OHKURA Satoshi , SONODA Tomoya , OISHI Sinya , FUJII Nobutaka , MORITA Yasuhiro , MATSUYAMA Shuichi , INOUE Naoko , UENOYAMA Yoshihisa , TSUKAMURA Hiroko

【目的】近年，ニホンジカによる農作物への被害が深刻化しており，その個体数を制御することは農業被害を軽減するために重要である。反芻動物を含む哺乳類の性腺機能維持に不可欠な性腺刺激ホルモン放出ホルモン（GnRH）のパルス状分泌は，視床下部弓状核に局在するGnRHパルス発生機構（GnRHパルスジェネレーター）により制御される。視床下部弓状核に局在し，キスペプチン，ニューロキニンB（NK …

The Journal of Reproduction and Development Supplement 111(0), P-5-P-5, 2018

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18

Cytokines mediate sperm-cumulus cell interaction in the mouse [in Japanese]

TANII Ichiro , ARADATE Tadashi

… 我々はこれらの遺伝子産物の中でサイトカインに絞り込んで解析を進め， Neurokinin A（NKA）とCCL2の作用に関して研究成果を得た。 …

The Journal of Reproduction and Development Supplement 111(0), P-24-P-24, 2018

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19

Etiology and pathology of prolonged cough [in Japanese]

Watanabe Naoto

 咳嗽は生体防御反応であり, その経路には生理的反応と病的反応がある. 生理的咳嗽は知覚神経終末 (咳受容体) に過剰な刺激が加わったときに湿性あるいは乾性咳嗽として出現する. 病的反応としては咳感受性亢進ないし低下の状態があり, これら咳受容体を介する機序は, 機械的または化学的に刺激されるほかに, 気道炎症によってC線維の受容体が刺激され, サブスタンスP (SP), ニュー …

Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology 32(2), 197-204, 2018

J-STAGE Ichushi Web
20

Neurokinin B receptor agonist and Dynorphin receptor antagonist stimulated luteinizing hormone secretion in fasted male rodents

Matsuzaki Toshiya , Kato Takeshi , Kuwahara Akira , Irahara Minoru , Tungalagsuvd Altankhuu , Munkhzaya Munkhsaikhan , Iwasa Takeshi , Yano Kiyohito , Mayila Yiliyasi , Tokui Takako , Yanagihara Rie , Matsui Sumika

… Kisspeptin/neurokinin B (NKB)/dynorphin (Dyn) (KNDy) neuron in hypothalamic arcuate nucleus plays a key role in GnRH/LH pulsatile secretion. … We aimed to determine whether stimulation of NKB/neurokinin 3 receptor (NK3R) signaling and inhibition of Dyn/kappa-opioid receptor (KOR) signaling recover LH secretion that is suppressed by acute fasting in male rats. …

Endocrine Journal 65(4), 485-492, 2018

J-STAGE Ichushi Web

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