Search Results 1-20 of 159

  • Molecular Basis for Allosteric Inhibition of GTP-Bound H-Ras Protein by a Small-Molecule Compound Carrying a Naphthalene Ring

    Matsumoto Shigeyuki , Hiraga Toshiki , Hayashi Yuki , Yoshikawa Yoko , Tsuda Chiemi , Araki Mitsugu , Neya Masahiro , Shima Fumi , Kataoka Tohru

    … The ras oncogene products (H-Ras, K-Ras, and N-Ras) have been regarded as some of the most promising targets for anticancer drug discovery because their activating mutations are frequently found in human cancers. …

    Biochemistry 57(36), 5350-5358, 2018-09-11


  • Molecular pathology of oral carcinoma.  [in Japanese]

    進藤 正信 , 樋田 京子

    口腔癌における遺伝子異常について検索を行った。その結果、がん抑制遺伝子p53 の変異・欠失が70%以上の症例でみられることや、ets がん遺伝子群転写因子E1AF が細胞外基質分解酵素の活性亢進をもたらすこと、テロメラーゼ活性化により口腔癌の発症・悪性化に関与していることを明らかにした。AU-richelement(ARE)をもつmRNA は生理的状態ではエキソゾーム内で素早く分解されるが、がん細 …

    天使大学紀要 18(2), 1-14, 2018-03-30

    IR  Ichushi Web 

  • Cell density-dependent increase in tyrosine-monophosphorylated ERK2 in MDCK Cells expressing active ras or raf

    Kawabata Noriyuki , Matsuda Michiyuki

    … The extracellular signal-regulated kinase (ERK) is one of the principal hub proteins that transmit growth signals from upstream oncogene products including Ras and BRaf to downstream effector proteins. …

    PLOS ONE 11(12), 2016-12-09


  • Development of molecular targeted anti-cancer drugs based on the information on a novel crystal structure of the ras oncogene products  [in Japanese]

    島 扶美 , 熊坂 崇 , 松本 篤幸 [他]

    放射光 : 日本放射光学会誌 27(1), 3-9, 2014-01

  • Single Point Mutation Analysis Using Magnetic Beads Coated with Streptavidin  [in Japanese]

    Hashimoto Masahiko , Fujita Taku , Tsukagoshi Kazuhiko

    正常型DNAから微量の変異DNAを識別する有力な手法の一つとして,ポリメラーゼ連鎖反応(PCR)/リガーゼ検出反応(LDR)が知られている.本研究で行ったPCR/LDRアッセイでは,3'末端においてターゲットシークエンスの一塩基の差異をアレル特異的に認識し、3'末端がビオチン化された共通プライマーとライゲートする識別プライマーの5'末端が,異なる蛍光色素(ROX, HEX, TET, TAMRA) …

    The science and engineering review of Doshisha University 53(2), 59-66, 2012-07

    IR  DOI 

  • Evaluation of Cancer Toxicity of Arsenic  [in Japanese]

    加藤 昌志 , 筑摩 拓人 , 吉川 史花 , 山羽 穂奈美 , 鈴木 裕揮 , 兼松 繭梨 , 田巻 満里恵 , 田中 麻美 , 山下 真紀 , 中村 功一 , 中川 薫 , 堀 創二朗 , 清水 進吾

    … c-RET proto-oncogene encodes a receptor-type tyrosine kinase. … Mutations of the c-RET proto-oncogene are associated with the development of multiple endocrine neoplasia type 2A (MEN2A) and papillary thyroid carcinoma (PTC). … In this study, the biological effects of arsenic on the activities of c-RET proto-oncogene and RET oncogene (RET-MEN2A and RET-PTC1) products were examined. …

    総合工学 (24), 31-35, 2012-03


  • Altered expression of hepatic metabolic enzyme genes, immune-related genes, oncogene and apoptotic genes in patients with trichloroethylene-induced allergic disorder  [in Japanese]

    XU Xinyun , MAO Jiyan , MAO Kanlang

    … Trichloroethylene (TCE) is one of the common organic solvents that are used in cleaning or degreasing of metal products and electronic products. … oncogene. …

    Annual Meeting of the Japanese Society of Toxicology 39.2(0), AP-102, 2012


  • Nature of Cancer Explored from the Perspective of the Functional Evolution of Proto-oncogenes  [in Japanese]

    Watari Akihiro

    …   The products of proto-oncogene play critical roles in the development or maintenance of multicellular societies in animals <i>via</i> … consequently, we isolated a Pak gene ortholog, which encodes a serine/threonine kinase as a ‘primitive oncogene’. …

    YAKUGAKU ZASSHI 132(10), 1165-1170, 2012


  • Immunohistochemical Mapping of TRK-Fused Gene Products in the Rat Brainstem

    Takeuchi Shigeko , Masuda Chiaki , Maebayashi Hisae , Tooyama Ikuo

    The <i>TRK</i>-fused gene (<i>TFG</i> in human, <i>Tfg</i> in rat) was originally identified in human papillary thyroid cancer as a chimeric form of the <i>NT …



  • Expression and Localization of TRK-Fused Gene Products in the Rat Brain and Retina

    Maebayashi Hisae , Takeuchi Shigako , Masuda Chiaki , Makino Satoshi , Fukui Kenji , Kimura Hiroshi , Tooyama Ikuo

    … gene products and examined the localization of TFG in the rat brain and retina. …



  • Viral-mediated stabilization of AU-rich element containing mRNA contributes to cell transformation

    Kuroshima Takeshi , Aoyagi Mariko , Yasuda Motoaki , Kitamura Tetsuya , Jehung Jumond P. , Ishikawa Makoto , Kitagawa Yoshimasa , Totsuka Yasunori , Shindoh Masanobu , Higashino Fumihiro

    … E4orf6 is one of the oncogene products of adenovirus and it also plays an important role for transportation of cellular and viral mRNA during the late phase of virus infection. …

    Oncogene 30(26), 2912-2920, 2011-06-30

    IR  Cited by (1)

  • The sequential changes of carcinoma cuniculatum: a case report with 11-year follow-up

    Sun Yan , Kuyama Kayo , Fukumoto Masahiko , Nishimura Hitoshi , Burkhardt Arne , Yamamoto Hirotsugu

    … gene products (P53, P63). … This is the first report to describe a case of long-term follow-up of CC in which the expression modes of oncogene products were analyzed. …

    Oral Medicine & Pathology 15(4), 113-116, 2011


  • Promotion of direct reprogramming by transformation-deficient Myc


    形質転換活性を欠損したMycによるリプログラミング促進効果:L-Mycを用いた効率的なiPS細胞の樹立. 京都大学プレスリリース. 2010-07-27.

    Proceedings of the National Academy of Sciences 107(32), 14152-14157, 2010-07-26

    IR  Cited by (6)

  • Retinoblastoma : Current Status of Genetic Diagnosis for Clinical Application  [in Japanese]

    Ushiama Mineko , Sugano Kokichi , Suzuki Shigenobu , Sakamoto Hiromi , Yoshida Teruhiko

    小児悪性腫瘍の網膜芽細胞腫には両眼性と片眼性があり,生殖細胞系列の遺伝学的検査として染色体検査あるいはFISH 検査が保険適応となっている.国立がん研究センター中央病院には全国の約半数の患者が受診することより遺伝子診断の必要性が高く,1998 年に遺伝相談外来が開設されてから,発端者88 症例,血縁者74 例について<i>RB1</i>遺伝子の解析を実施した.1)genom …

    JOURNAL OF FAMILIAL TUMORS 10(2), 65-70, 2010

    J-STAGE  Ichushi Web 

  • Ubiquitin-mediated control of oncogene and tumor suppressor gene products

    KITAGAWA Kyoko , KOTAKE Yojiro , KITAGAWA Masatoshi

    Cancer science 100(8), 1374-1381, 2009-08-10

    Ichushi Web  References (81)

  • A Novel Mutation (D631del) of the RET Gene Was Associated with MEN2A in a Chinese Pedigree


    … Germline mutations in the RET proto-oncogene (RET gene) are well documented as the genetic causes of multiple endocrine neoplasia type 2A (MEN2A). … The PCR products were subjected to sequencing directly, or cloned into pGEM-T plasmids and sequenced. …

    Endocrine Journal 56(1), 99-104, 2009-02-01

    J-STAGE  References (24)

  • Chemoprevention of colorectal cancer : experimental and clinical aspects

    Takayama Tetsuji , Goji Takahiro , Taniguchi Tatsuya , Inoue Atsushi

    … These agents are largely classified into three categories : 1) Signal transduction modulators including epidermal growth factor (EGF) receptor inhibitors, anti-vascular endothelial growth factor (VEGF) antibodies, and inhibitors of oncogene products. …

    The journal of medical investigation : JMI 56(1-2), 1-5, 2009-02


  • The absence of significant mutational events of the p53 gene in the only two salivary gland tumors possessing radiation-related development risks, mucoepidermoid carcinoma and Warthin tumor

    Abé Mayumi , Cheng Jun , Maruyama Satoshi , Yamazaki Manabu , Kobayashi Takanori , Al-Eryani Kamal , Shahidul Ahsan M. , Tsuneki Masayuki , Syafriadi Mei , Saku Takashi

    … gene, an important proto-oncogene whose mutation has been related to radiation, was analyzed by DNA sequencing and immunohistochemistry in 37 cases of mucoepidermoid carcinoma collected from Niigata and Nagasaki and in 33 cases of Warthin tumor collected from Niigata. … gene products were heavily demonstrated in most of the tumor cell nuclei of mucoepidermoid carcinomas but not in Warthin tumors. …

    Oral Medicine & Pathology 13(4), 151-158, 2009


  • Chemoprevention of colorectal cancer-experimental and clinical aspects-

    Takayama Tetsuji , Goji Takahiro , Taniguchi Tatsuya , Inoue Atsushi

    … These agents are largely classified into three categories: 1) Signal transduction modulators including epidermal growth factor (EGF) receptor inhibitors, anti-vascular endothelial growth factor (VEGF) antibodies, and inhibitors of oncogene products. …

    The Journal of Medical Investigation 56(1,2), 1-5, 2009


  • Molecular targeting therapy for bladder cancer  [in Japanese]

    東 治人 , 勝岡 洋治

    … The major molecular targets in cancer therapy include oncogene products, growth factors and their receptors, signal-transducing molecules, hormone receptors, cell cycle-related proteins, telomerase-related molecules, apoptosis-related molecules, angiogenesis-related molecules, anticancer drug resistance/sensitivity factors, transcription factors, and molecules related to infiltration and metastasis. …

    Acta urologica Japonica 54(1), 67-75, 2008-01

    IR  Ichushi Web 

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