Search Results 1-20 of 1599

  • Oral Administration of Fucoidan Can Exert Anti-Allergic Activity after Allergen Sensitization by Enhancement of Galectin-9 Secretion in Blood

    Mizuno Masashi , Sakaguchi Kana , Sakane Iwao

    … The purpose of this study is to elucidate its mechanism using ovalbumin (OVA) induced anaphylaxis model mice (BALB/c, Female, 5-week-old) and mast cell line (RBL-2H3 cells). … Oral administration of fucoidan after sensitization with OVA/Al(OH)(3) inhibited reduction of rectal temperature induced by activation of mast cells. … Fucoidan increased galectin-9 mRNA expression only in colonic epithelial cells. …

    Biomolecules 10(2), 258, 2020-02

    IR 

  • Effects of denture adhesives and mouth moisturizers to human oral fibroblast and human keratinocyte cells using direct and indirect cell culture systems

    YAMADA Mao , TAKASE Kazuma , SUEHIRO Fumio , NISHIMURA Masahiro , MURATA Hiroshi

    … examinations with human fibroblast and epithelial cells. … Denture adhesives (Faston, Poligrip Powder, New Poligrip Free, Tafugurippu Kurimu, Polident Adhesive, Tafugurippu Tomei) and mouth moisturizers (Concool Mouth Gel, Biotene Oral Balance Gel) were subjected to live and dead detection and pH level determination. …

    Dental Materials Journal 39(4), 571-576, 2020

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  • Effect of HGF/c-Met pathway in oral squamous cell carcinoma on EMT and metastatic potential

    KIMURA Kazutaka , OHNISHI Yuichi , OKAMURA Tomoharu , TOMINAGA Kazuya , NAKAJIMA Masahiro

    … <p>Oral squamous cell carcinoma (OSCC) is characterized by highly invasive tumor cells. … Hepatocyte growth factor (HGF) signaling plays an important role in the induction of epithelial-mesenchymal transition (EMT), a process that converts immotile epithelial cells into motile mesenchymal cells and is involved in cancer metastasis by promoting tumor cell scattering. …

    Journal of Osaka Dental University 54(1), 135-144, 2020

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  • A case of papillary squamous cell carcinoma of the mandibular gingiva  [in Japanese]

    ARIMOTO Satomi , HASEGAWA Takumi , MATSUMOTO Kousuke , SHIGEOKA Manabu , MINAMIKAWA Tsutomu , KOMORI Takahide

    … <p>Papillary squamous cell carcinoma (PSCC) is a rare variant of squamous cell carcinoma with only a few documented cases in the oral cavity. … Microscopically, the tumor showed exophytic papillary proliferation with fibrovascular cores and consisted of atypical squamous epithelial cells. …

    Japanese Journal of Oral and Maxillofacial Surgery 66(5), 219-223, 2020

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  • 第565回大阪歯科学会例会  [in Japanese]

    <p>1. 金山愛加, 笹部倫代, 山本眸, 片岡宏介, 土居貴士, 河村佳穂里, 小柳圭代, 三宅達郎. ヒト口腔内細菌及び真菌に対する歯木ニーム抽出液の抗・殺菌能評価.</p><p>2. 板並悠香, 梶貢三子, 永久景那, 貴島真佐子, 糸田昌隆. 介護施設入所者の口腔インプラント治療に関する口腔衛生状況および咀嚼・嚥下機能の把握.</p>< …

    Shikaigaku 83(1), 23-33, 2020

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  • Taurocholic acid lowers the inflammatory response of gingival fibroblasts, epithelial cells, and macrophages

    Talebian Reza , Hashem Othman , Gruber Reinhard

    … Considering the epidemiologic linkage of periodontal disease to liver disease, the question arises about the possible effect of elevated TCA levels on periodontal cells. … To answer this question, gingival fibroblasts and human oral squamous cell carcinoma cell line (HSC-2) were pretreated with interleukine1β (IL1β) and tumor necrosis factorα (TNFα) in the presence and absence of TCA. …

    Journal of Oral Science 62(3), 335-339, 2020

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  • Conditioned Media from Human Dental Pulp Stem Cells Prevent Radiation-induced Skin Injury

    KAWARABAYASHI Keita , KANO Fumiya , HASHIMOTO Noboru , HIBI Hideharu , IWAMOTO Tsutomu , YAMAMOTO Akihito

    … Stem cells from human exfoliated deciduous teeth (SHEDs) can regenerate various tissues.In this study, we investigated the impact of SHED-conditioned medium (SHED-CM) on radiation-induced skin injury. … Histological examination revealed that SHED-CM treatment inhibited radiation-induced dermal thickness and epithelial hyperplasia. …

    Journal of Oral Health and Biosciences 33(1), 1-7, 2020

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  • Analysis of the Influence of <i>Porphyromonas gingivalis</i> on the Human Oral Mucosa with a Three-dimensional Construct Model  [in Japanese]

    Takanori RYU , Kunitoshi UCHIDA , Kazuhiko OKAMURA , Mitsutoki HATTA , Jun YAMAZAKI , Ryuji SAKAGAMI

    <p> 目的 : 口腔粘膜上皮細胞は, 細菌および細菌から産生されるさまざまな毒素からの曝露に対して重要なバリアとして機能している. 歯周病原細菌である<i>Porphyromonas gingivalis</i> (<i>P.</i> <i>g.</i>) は, 上皮組織におけるバリア機能の破綻を生じさせることに …

    The Japanese Journal of Conservative Dentistry 63(2), 144-155, 2020

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  • Cyclophosphamide Promotes Arrested Development of the Dental Root in Mice

    Matsuo Satoru , Toda-Nakamura Masako , Oka Kyoko , Kajiya Hiroshi , Ogata Kayoko , Ishii Hanako , Ozaki Masao , Ohno Jun

    … In cell culture experiments, the Hertwig's epithelial root sheath cell line (HERS01a) was cultured with or without CPA. … At high doses of CPA, HERS01a cells showed decreases in E-cadherin expression, while N-cadherin expression was upregulated, indicating that this cadherin switch may promote an epithelial-to-mesenchymal transition (EMT)-like phenomenon. …

    Journal of Hard Tissue Biology 29(2), 63-70, 2020

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  • Mushroom <i>Sparassis crispa</i> (Hanabiratake) Fermented with Lactic Acid Bacteria Significantly Enhances Innate Immunity of Mice

    Nishioka Junji , Hiramoto Keiichi , Suzuki Koji

    … studies using mice, oral administration of SC or SCL enhanced the accumulation of macrophages, neutrophils, natural killer (NK) cells, and C–C chemokine receptor type 2- or phospho-Syk-expressing cells in the jejunum epithelial villi and spleen, with significantly higher cell numbers in the SCL group than in the SC group. …

    Biological and Pharmaceutical Bulletin 43(4), 629-638, 2020

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  • Histamine receptor antagonists inhibited proton regulators in oral cancer cell lines Introduction  [in Japanese]

    Ogasawara Masahito , Kon Masashi , Yamada Hiroyuki , Tamura Haruki , Yamada Arisa

    … <p>Tumor cells including oral squamous epithelial cells are reported to express histamine receptors . …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-P-234, 2020

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  • Anti-biofilm Property of Sulfated Vizantin Against <i>Streptococcus mutans</i>:—Influence of Sucrose Included in Growth Media and Expression Analysis of Genes Related to Biofilm Formation—  [in Japanese]

    Shoji TAKENAKA , Taisuke HASEGAWA , Masataka ODA , Naoki TAKAHASHI , Toshihito ISONO , Naoto OHKURA , Hirofumi YAMAMOTO , Koichi TABETA , Yuichiro NOIRI

    <p> 目的 : 機能性糖脂質ビザンチン (Viz-S) は, <i>Streptococcus mutans</i>バイオフィルムを易剝離性に変化させることで抗バイオフィルム作用を示す. 本研究では, 培養条件のうち, スクロース濃度を変化させたときの<i>S. mutans</i>の抗バイオフィルム効果, 各種バイオフィルム形成関連遺 …

    The Japanese Journal of Conservative Dentistry 63(1), 61-72, 2020

    J-STAGE  Ichushi Web 

  • Influence of One-year Moderate Exercise Training on Oral Local Immune Function and Growth-inhibitory Effect on Streptococcus Mutans

    USUI Tatsuya , TSUJI Shintaro , NAGAI Nobuhito , TAKEYASU Chie , ORITA Keisuke

    口腔は外気にたえず曝露されていることから,細菌やウイルスなどの病原微生物が侵入しやすく,第一線の防御機構として唾液免疫成分の働きが重要となる.特に上気道感染症の予防において重要な役割を担っているのがHuman-β-defensin-2 (HBD-2)であり,気道上皮細胞や唾液腺から分泌され抗菌活動に貢献している.我々はこれまで一過性または慢性的な運動ストレスに伴い抗菌性ペプチド群の発現が抑制され, …

    The Journal of Education and Health Science 65(3), 185-191, 2020

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  • Changes in Function of Liver and Intestinal Barrier during Ulcerative Colitis Induced Sodium Dextran Sulfate in Rat  [in Japanese]

    熊谷 茉歩 , 石井 敬 , 森本 かおり , 富田 幹雄

    … expression levels of major ATP-binding cassette transporters such as P-glycoprotein(P-gp)and CYP metabolic enzymes in the liver and small and large intestines during ulcerative colitis(UC).In addition, we examined the involvement of tight junctions(TJ)such as intestinal epithelial cells with barrier functions by measuring membrane resistance(Rm),relative activity of P-gp evaluated by a P-gp substrate, and rhodamine 123(Rho123)permeability in the presence or absence of a specific P-gp inhibitor, …

    東北医科薬科大学研究誌 = Journal of tohoku Medical and Pharmaceutical university (66), 45-54, 2019-12

    IR 

  • CD163(+) macrophages infiltration correlates with the immunosuppressive cytokine interleukin 10 expression in tongue leukoplakia

    Shigeoka Manabu , Koma Yu-ichiro , Nishio Mari , Komori Takahide , Yokozaki Hiroshi

    … Objective Accumulating evidence suggests that macrophages are involved in the immunoediting of oral squamous cell carcinoma but the role of macrophages in oral carcinogenesis is unclear. … We aimed to clarify the role of macrophages in oral leukoplakia, which is the most common oral potentially malignant disorder from immunotolerance viewpoint. …

    Clinical and Experimental Dental Research 5(6), 627-637, 2019-12

    IR 

  • Anti-inflammatory effects of olanexidine gluconate on oral epithelial cells

    Nii Takuya , Yumoto Hiromichi , Hirota Katsuhiko , Miyake Yoichiro

    … This study aimed to evaluate the antiinflammatory effect of OLG on oral epithelial cells.Methods: We examined if OLG could inhibit the inflammatory responses caused by Porphyromonas gingivalis (P. …

    BMC Oral Health (19), 239, 2019-11-08

    IR 

  • Immunohistochemistry of YAP and dNp63 and survival analysis of patients bearing precancerous lesion and oral squamous cell carcinoma

    Ono Sawako , Nakano Keisuke , Takabatake Kiyofumi , Kawai Hotaka , Nagatsuka Hitoshi

    … However, the role of YAP and Delta Np63 expression in carcinogenesis and progression of oral squamous cell carcinoma (OSCC) has been unknown. … </br>Methods: We performed immunohistochemical analyses in whole tissue samples to investigate YAP and Delta Np63 expression in normal oral mucosa, epithelial hyperplasia, oral epithelial dysplasia (OED; …

    International Journal of Medical Sciences 16(5), 766-773, 2019-05-28

    IR 

  • Notch Signaling Affects Oral Neoplasm Cell Differentiation and Acquisition of Tumor-Specific Characteristics

    Nakano Keisuke , Takabatake Kiyofumi , Kawai Hotaka , Yoshida Saori , Maeda Hatsuhiko , Kawakami Toshiyuki , Nagatsuka Hitoshi

    … Histopathological findings of oral neoplasm cell differentiation and metaplasia suggest that tumor cells induce their own dedifferentiation and re-differentiation and may lead to the formation of tumor-specific histological features. … In our previous study, immunohistochemistry was used to examine Notch expression using cases of odontogenic tumors and pleomorphic adenoma as oral neoplasms. …

    International Journal of Molecular Sciences 20(8), 1973, 2019-04-23

    IR 

  • Diverticular Pouch of the Buccal Mucosa: A Rare Case Report

    KIKUTA SHOGO , IWANAGA JOE , KOGA MAKOTO , KUSUKAWA JINGO

    … Diverticular pouch in the oral cavity is a rare disease, and its etiology is unclear. … Histopathological examination after excisional biopsy showed that the epithelial cells lining the pouch were continuous with the mucous membrane and a diagnosis was made of diverticular pouch of the buccal mucosa. …

    The Kurume Medical Journal 66(1), 81-84, 2019

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  • A Case of Plasmacytosis Successfully Treated with Corticosteroids  [in Japanese]

    MURAMATSU Kentarou , SHIBAHARA Takahiko , OHNO Keisuke , KATOU Hiroshi , YOSHIDA Shuzi , WATANABE Akira , YAMAMOTO Nobuharu , TAKANO Masayuki , CHUJO Takatoshi , MATSUZAKA Kenichi

    開口部形質細胞症は口腔内,外陰部などの身体開口部に発生する慢性炎症性疾患で,粘膜の発赤,びらん,浮腫性変化を伴い,病理組織学的には上皮の菲薄化と形質細胞の浸潤を認める比較的稀な疾患である。<br>今回我々は,診断・治療に苦慮したものの,副腎皮質ステロイド薬内服が奏功した開口部形質細胞症の1例を経験したのでその概要を報告する。

    Journal of Japanese Society of Oral Medicine 25(2), 51-56, 2019

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