CiNii Articles - osteoclast

1

Effect of aging on bone metabolism: the involvement of complemen t C1q

Aonuma Fumiko , Higashi Sen , Tsuka Shintaro , Ohsumi Tomoko , Masaki Chihiro , Hosokawa Ryuji , Takeuchi Hiroshi

… C1q, at 5-15 µg/mL promoted osteoclast fusion, whereas it did not affect the differentiation of osteoblasts. … On the other hand, a higher concentration of C1q (50 µg/mL) suppressed both bone morphogenetic protein-2-induced osteogenic differentiation and osteoclast formation. …

Journal of Prosthodontic Research, 2021

J-STAGE
2

Effects of metformin on the prevention of bisphosphonate-related osteonecrosis of the jaw-like lesions in rats

Nakagawa Tomohito , Hosokawa Ryuji , Tsuka Shintaro , Aonuma Fumiko , Nodai Tomotaka , Munemasa Takashi , Tamura Akiko , Mukaibo Taro , Kondo Yusuke , Masaki Chihiro

… Hematoxylin-eosin and tartrate-resistant acid phosphatase (TRAP) staining were performed to evaluate bone apoptosis and osteoclast number. Results: … TRAP staining presented increased osteoclast numbers in the ZD group when compared with that observed in the Control. Conclusions: …

Journal of Prosthodontic Research, 2021

J-STAGE
3

Pathophysiological aspect of osteoporosis [in Japanese]

竹内靖博

日本臨床 = Japanese journal of clinical medicine 78(12), 2005-2009, 2020-12
4

IL-33 and periodontitis [in Japanese]

大野建州

臨床免疫・アレルギー科 = Clinical immunology & allergology 74(5), 477-483, 2020-11
5

Rab11A Functions as a Negative Regulator of Osteoclastogenesis through Dictating Lysosome-Induced Proteolysis of c-fms and RANK Surface Receptors

Okusha Yuka , Tran Manh Tien , Itagaki Mami , Sogawa Chiharu , Eguchi Takanori , Okui Tatsuo , Kadowaki Tomoko , Sakai Eiko , Tsukuba Takayuki , Okamoto Kuniaki

… Osteoclast differentiation and activity are controlled by two essential cytokines, macrophage colony-stimulating factor (M-CSF) and the receptor activator of nuclear factor-kappa B ligand (RANKL). … Nevertheless, the regulatory role of Rab11A in osteoclast differentiation has been completely unknown. …

Cells 9(11), 2384, 2020-10-31

IR
6

Aging-Affected MSC Functions and Severity of Periodontal Tissue Destruction in a Ligature-Induced Mouse Periodontitis Model

Aung Kyaw Thu , Akiyama Kentaro , Kunitomo Masayoshi , Mun Aung Ye , Tosa Ikue , Nguyen Ha Thi Thu , Zhang Jiewen , Kohno Teisaku , Ono Mitsuaki , Hara Emilio Satoshi , Kuboki Takuo

… The results of micro computerized tomography (micro-CT) and histological analysis revealed a more severe bone loss associated with increased osteoclast activity in aged (50-week-old) mice compared to young (5-week-old) mice. …

International Journal of Molecular Sciences 21(21), 8103, 2020-10-30

IR
7

Osteoclast Inhibitors for Bone Fracture Healing in Mice with High-Turnover Osteoporosis

Miyazawa Ken , Torii Yasuyoshi , Tabuchi Masako , Mizuno Manami , Yoshizako Mamoru , Minamoto Chisato , Kawatani Makoto , Osada Hiroyuki , Maeda Hatsuhiko , Goto Shigemi

Journal of hard tissue biology 29(4), 255-261, 2020-10
8

Effects of Glucocorticoids on Diurnal Variations in Experimental Tooth Movement

Kusafuka Sae , Kondo Hisataka , Hayashi Kaori , Hamamura Kazunori , Sato Takuma , Miyazawa Ken , Goto Shigemi , Togari Akifumi

Journal of hard tissue biology 29(4), 231-237, 2020-10
9

BMP-2/beta-TCP Local Delivery for Bone Regeneration in MRONJ-Like Mouse Model

Mikai Akihiro , Ono Mitsuaki , Tosa Ikue , Ha Thi Thu Nguyen , Hara Emilio Satoshi , Nosho Shuji , Kimura-Ono Aya , Nawachi Kumiko , Takarada Takeshi , Kuboki Takuo , Oohashi Toshitaka

… Medication-related osteonecrosis of the jaw (MRONJ) is a severe pathological condition associated mainly with the long-term administration of bone resorption inhibitors, which are known to induce suppression of osteoclast activity and bone remodeling. … Bone Morphogenetic Protein (BMP)-2 is known to be a strong inducer of bone remodeling, by directly regulating osteoblast differentiation and osteoclast activity. …

International Journal of Molecular Sciences 21(19), 7028, 2020-09-24

IR
10

MicroRNA-548-3p overexpression inhibits proliferation, migration and invasion in osteoblast-like cells by targeting STAT1 and MAFB

Ramirez-Salazar Eric G. , Almeraya Erika V. , Lopez-Perez Tania V. , Patino Nelly , Salmeron Jorge , Velazquez-Cruz Rafael

The journal of biochemistry 168(3), 203-211, 2020-09
11

Identification of arthritis-associated osteoclast precursors in pannus [in Japanese]

長谷川哲雄 , 石井優

臨床免疫・アレルギー科 = Clinical immunology & allergology 74(3), 294-299, 2020-09

Ichushi Web
12

The recent studies using intravital bone imaging techniques [in Japanese]

森本彬人 , 菊田順一 , 石井優

臨床免疫・アレルギー科 = Clinical immunology & allergology 74(3), 288-293, 2020-09

Ichushi Web
13

Effect of theobromine intake on proliferation and bone differentiation abilities of bone marrow-derived somatic stem cells [in Japanese]

堀本泰弘 , 中谷祥恵 , 齋藤彩果 , 片倉賢紀 , 杉本直俊 , 古旗賢二

… Theobromine was detected only in the TBD group at the concentration of 18.9 ± 5.6 pg/mL.These results suggest that continuous intake of theobromine possibly increased the bone density by promoting the osteoblast proliferation and differentiation and suppressing the osteoclast differentiation. …

Functional Food Research (16), 57-64, 2020-08

IR
14

High Mobility Group Box 1 Expression in Oral Inflammation and Regeneration

Yamashiro Keisuke , Ideguchi Hidetaka , Aoyagi Hiroaki , Yoshihara-Hirata Chiaki , Hirai Anna , Suzuki-Kyoshima Risa , Zhang Yao , Wake Hidenori , Nishibori Masahiro , Yamamoto Tadashi , Takashiba Shogo

… This indicates that secreted HMGB1 regulates angiogenesis and bone remodeling by osteoclast and osteoblast activation and promotes bone healing in oral tissue repair. …

Frontiers in Immunology (11), 1461, 2020-07-14

IR
15

Expression and localisation of Rab44 in immune-related cells change during cell differentiation and stimulation

Tokuhisa Mitsuko , Kadowaki Tomoko , Ogawa Kohei , Yamaguchi Yu , Kido Mizuho A. , Gao Weiqi , Umeda Masahiro , Tsukuba Takayuki

… Our previous study showed that Rab44 negatively regulates osteoclast differentiation by modulating intracellular calcium levels; …

Scientific Reports 10(1), 10728, 2020-07-01

IR
16

Identification of arthritis-associated osteoclast precursor macrophages in pannus [in Japanese]

長谷川哲雄 , 石井優

整形・災害外科 63(8), 1069-1072, 2020-07

Ichushi Web
17

Identification of arthritis-associated osteoclast precursors in pannus [in Japanese]

長谷川哲雄 , 石井優

医学のあゆみ 273(10), 1023-1028, 2020-06-06

Ichushi Web
18

The fungal metabolite (+)-terrein abrogates osteoclast differentiation via suppression of the RANKL signaling pathway through NFATc1

Nakagawa Saki , Omori Kazuhiro , Nakayama Masaaki , Mandai Hiroki , Yamamoto Satoshi , Kobayashi Hiroya , Sako Hidefumi , Sakaida Kyosuke , Yoshimura Hiroshi , Ishii Satoki , Ibaragi Soichiro , Hirai Kimito , Yamashiro Keisuke , Yamamoto Tadashi , Suga Seiji , Takashiba Shogo

… Receptor activator of nuclear factor (NF)-κB ligand (RANKL) signaling pathways have been proposed as targets for inhibiting osteoclast differentiation and bone resorption. … In the present study, we showed that 10 µM synthetic (+)-terrein inhibited RANKL-induced osteoclast formation and bone resorption in a dose-dependent manner and without cytotoxicity. …

International Immunopharmacology (83), 106429, 2020-06

IR
19

The Roles of ROS Generation in RANKL-Induced Osteoclastogenesis : Suppressive Effects of Febuxostat

Ashtar Mohannad , Tenshin Hirofumi , Teramachi Jumpei , Bat-Erdene Ariunzaya , Hiasa Masahiro , Oda Asuka , Tanimoto Kotaro , Shimizu So , Higa Yoshiki , Harada Takeshi , Oura Masahiro , Sogabe Kimiko , Nakamura Shingen , Fujii Shiro , Sumitani Ryohei , Miki Hirokazu , Udaka Kengo , Takahashi Mamiko , Kagawa Kumiko , Endo Itsuro , Tanaka Eiji , Matsumoto Toshio , Abe Masahiro

… however, febuxostat inhibited the RANKL-induced ROS production and osteoclast (OC) formation. …

Cancers 12(4), 929, 2020-04-09

IR
20

Depressive effect of m-TOR inhibitor and CSF-1R inhibitor in jawbone invasion of oral cancer [in Japanese]

多田昌功 , 里見貴史 , 藤居泰行 , 古賀陽子 , 近津大地

東京医科大学雑誌 78(2), 189-197, 2020-04

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