Search Results 1-20 of 1748

  • Effect of aging on bone metabolism: the involvement of complemen t C1q

    Aonuma Fumiko , Higashi Sen , Tsuka Shintaro , Ohsumi Tomoko , Masaki Chihiro , Hosokawa Ryuji , Takeuchi Hiroshi

    … In this study, we examined whether C1q affects the differentiation of bone-forming osteoblasts and bone-resorbing osteoclasts, and investigated whether C1q could modify cellular signaling, including the Wnt/β-catenin pathway in these cells.<br><i>Methods:</i> … Differentiation of osteoclasts from mouse bone marrow cells was assessed using tartrate-resistant acid phosphatase staining. …

    Journal of Prosthodontic Research, 2021

    J-STAGE 

  • High-mobility group box 1 induces bone destruction associated with advanced oral squamous cancer via RAGE and TLR4

    Sakamoto Yumi , Okui Tatsuo , Yoneda Toshiyuki , Ryumon Shoji , Nakamura Tomoya , Kawai Hotaka , Kunisada Yuki , Ibaragi Soichiro , Masui Masanori , Ono Kisho , Obata Kyoichi , Shimo Tsuyoshi , Sasaki Akira

    Bone destruction of maxillary and mandibular bone by invasive oral squamous cell cancer (OSCC) raises various problems in the management of patients, resulting in poor outcomes and survival. However, …

    Biochemical and Biophysical Research Communications 531(3), 422-430, 2020-10-20

    IR 

  • Osteoclast Inhibitors for Bone Fracture Healing in Mice with High-Turnover Osteoporosis

    Miyazawa Ken , Torii Yasuyoshi , Tabuchi Masako , Mizuno Manami , Yoshizako Mamoru , Minamoto Chisato , Kawatani Makoto , Osada Hiroyuki , Maeda Hatsuhiko , Goto Shigemi

    Journal of hard tissue biology 29(4), 255-261, 2020-10

  • The fungal metabolite (+)-terrein abrogates osteoclast differentiation via suppression of the RANKL signaling pathway through NFATc1

    Nakagawa Saki , Omori Kazuhiro , Nakayama Masaaki , Mandai Hiroki , Yamamoto Satoshi , Kobayashi Hiroya , Sako Hidefumi , Sakaida Kyosuke , Yoshimura Hiroshi , Ishii Satoki , Ibaragi Soichiro , Hirai Kimito , Yamashiro Keisuke , Yamamoto Tadashi , Suga Seiji , Takashiba Shogo

    … Pathophysiological bone resorption is commonly associated with periodontal disease and involves the excessive resorption of bone matrix by activated osteoclasts. …

    International Immunopharmacology (83), 106429, 2020-06

    IR 

  • Iatrogenic risk of osteonecrosis of the jaw? Bone substitutes for dental implants: a warning from Japan

    Hibi Hideharu

    … Most of these materials are supplied as inorganic porous granules of calcium phosphate, which have characteristics that exceed the bone resorption ability of normal osteoclasts; …

    Nagoya Journal of Medical Science 82(1), 1-3, 2020-02

    IR  DOI  Ichushi Web 

  • The matrix vesicle cargo miR-125b accumulates in the bone matrix, inhibiting bone resorption in mice

    Minamizaki Tomoko , Nakao Yuko , Irie Yasumasa , Ahmed Faisal , Itoh Shota , Sarmin Nushrat , Yoshioka Hirotaka , Nobukiyo Asako , Fujimoto Chise , Niida Shumpei , Sotomaru Yusuke , Tanimoto Kotaro , Kozai Katsuyuki , Sugiyama Toshie , Bonnelye Edith , Takei Yuichiro , Yoshiko Yuji

    … Communication between osteoblasts and osteoclasts plays a key role in bone metabolism. … Bone formation and osteoblasts in Tg mice are normal, but the number of bone-resorbing osteoclasts is reduced, leading to higher trabecular bone mass. …

    Communications Biology (3), 30, 2020-01-16

    IR 

  • Effects of the linagliptin, dipeptidyl peptidase-4 inhibitor, on bone fragility induced by type 2 diabetes mellitus in obese mice

    Kanda Junkichi , Furukawa Megumi , Izumo Nobuo , Shimakura Taketoshi , Yamamoto Noriaki , Takahashi Hideaki E. , Wakabayashi Hiroyuki

    … Bone histomorphometric analysis revealed a reduced osteoid volume and osteoblast surface with an increase in the eroded surface and number of osteoclasts in T2DM mice. …

    Drug Discoveries & Therapeutics 14(5), 218-225, 2020

    J-STAGE 

  • Effects of Glucocorticoids on Diurnal Variations in Experimental Tooth Movement

    Kusafuka Sae , Kondo Hisataka , Hayashi Kaori , Hamamura Kazunori , Sato Takuma , Miyazawa Ken , Goto Shigemi , Togari Akifumi

    … Glucocorticoids induce a circadian rhythm in osteoclasts, causing a circadian rhythm in bone resorption. …

    Journal of Hard Tissue Biology 29(4), 231-238, 2020

    J-STAGE 

  • Osteoclast Inhibitors for Bone Fracture Healing in Mice with High-Turnover Osteoporosis

    Miyazawa Ken , Goto Shigemi , Torii Yasuyoshi , Tabuchi Masako , Mizuno Manami , Yoshizako Mamoru , Minamoto Chisato , Kawatani Makoto , Osada Hiroyuki , Maeda Hatsuhiko

    <p>The effectiveness of osteoclast inhibitors for high-turnover osteoporosis-related bone fracture is slightly unclear. This study aimed to examine the effectiveness of continuous administration …

    Journal of Hard Tissue Biology 29(4), 255-262, 2020

    J-STAGE 

  • Osteoclast Differentiation Is Suppressed by Increased <i>O</i>-GlcNAcylation Due to Thiamet G Treatment

    Takeuchi Tomoharu , Horimoto Yasuhiro , Oyama Midori , Nakatani Sachie , Kobata Kenji , Tamura Mayumi , Arata Yoichiro , Hatanaka Tomomi

    … <p>Osteoclasts are the only bone-resorbing cells in organisms and understanding their differentiation mechanism is crucial for the treatment of osteoporosis. …

    Biological and Pharmaceutical Bulletin 43(10), 1501-1505, 2020

    J-STAGE 

  • Resorption analysis of deproteinized cancellous bovine bone

    NARUKAWA Masayuki , SUZUKI Osamu , MAYAHARA Mitsuori , IMAMURA Eisaku , TAKAGI Yoshitoki , FUNAE Takashi , MAKINO Yuusuke , OHKI Retsu , NAKAMURA Masanori

    … Stoichiometric hydroxyapatite (HA) was not resorbed by osteoclasts while calcium-deficient and carbonate-rich apatite converted from octacalcium (OCP hydrolysate) was resorbed by osteoclasts. … At 12 weeks, osteoclasts were directly attached to both materials. … The ultrastructure of ruffled borders on DPBB was identical to osteoclasts resorbing normal bone while ruffled border on OCP hydrolysate showed irregular shape. …

    Dental Materials Journal 39(5), 760-765, 2020

    J-STAGE 

  • Effect of theobromine intake on proliferation and bone differentiation abilities of bone marrow-derived somatic stem cells  [in Japanese]

    Horimoto Yasuhiro , Nakatani Sachie , Saito Saika , Katakura Masanori , Sugimoto Naotoshi , Kobata Kenji

    … The proliferation ability, the ability of the MSCs to differentiate to osteoblasts and the ability of the HSCs to differentiate to osteoclasts were evaluated. …

    Functional Food Research 16(0), n/a, 2020

    J-STAGE 

  • Atriplex nummularia extract suppresses RANKL-activated osteoclastogenesis  [in Japanese]

    KO Tsui Ling , KUO Han Chun , YANG Jyh Ferng , CHANG Chi Chang , WANG Shih Wei , HOUNG Jer Yiing

    … This study investigates the effects of AN extract (ANE) on the formation of RANKL-activating osteoclasts from RAW264.7 macrophages. … Multinucleated osteoclasts were observed on differentiation day 4. … To measure TRAP activity, osteoclasts underwent lysis using 0.1% Triton X-100; … Bone resorption Assay, RAW264.7 cells or PBMCs were differentiated into osteoclasts for 7 days on Osteo Assay Surface Multiple Well Plate. …

    Annual Meeting of the Japanese Society of Toxicology 47.1(0), P-201, 2020

    J-STAGE 

  • Bone homeostasis and mechano-biology  [in Japanese]

    Nakashima Tomoki

    … Bone remodeling is stringently regulated by communication between bone component cells such as osteoclasts, osteoblasts and osteocytes. … During bone remodeling, resorption by osteoclasts precedes bone formation by osteoblasts. …

    Transactions of Japanese Society for Medical and Biological Engineering Annual58(Abstract), 178-178, 2020

    J-STAGE 

  • Detection of RANKL-producing cells and osteoclastic activation by the addition of exogenous RANKL in the regenerating scales of goldfish

    Yamamoto Tatsuki , Urata Makoto , Hattori Atsuhiko , Suzuki Nobuo , Ikegame Mika , Kawago Umi , Tabuchi Yoshiaki , Hirayama Jun , Sekiguchi Toshio , Furusawa Yukihiro , Yachiguchi Koji , Matsubara Hajime

    … <p>We have previously reported that microgravity promotes the activation of osteoclasts in cultured regenerating scales. …

    Biological Sciences in Space 34(0), 34-40, 2020

    J-STAGE 

  • How is Bone Homeostasis Maintained? Dynamic Regulatory Mechanism by Cells with Opposite Functions  [in Japanese]

    YARI Shinya , KIKUTA Junichi , ISHII Masaru

    … By means of this system, we succeeded in visualization of direct cell-cell contact between osteoclasts and osteoblasts. …

    Seibutsu Butsuri 60(4), 227-230, 2020

    J-STAGE 

  • Immunohistochemical Analysis of the Distribution of RANKL-Expressing Cells and the Expression of Osteoclast-Related Markers in Giant Cell Tumor of Bone

    Shibuya Isao , Takami Masamichi , Kawamoto Masashi , Karakawa Akiko , Nakamura Shigeru , Kamijo Ryutaro

    … <p>To clarify the mechanism underlying the regulation of osteoclast differentiation and activation in giant cell tumor of bone, we investigated the expression of osteoclast-related markers in osteoclasts, neoplastic cells, and osteoclast precursors comprising giant cell tumor of bone using immunohistochemical analysis, and analyzed the distribution of receptor activator of nuclear factor κ-B ligand (RANKL)-expressing cells. … mononuclear cells, large numbers of osteoclasts were observed. …

    Journal of Hard Tissue Biology 29(3), 137-146, 2020

    J-STAGE 

  • Pharmacological characteristics and clinical study results of romosozumab (EVENITY<sup>®</sup>; genetical recombination), a drug with novel mechanism of action to treat osteoporosis at high risk of fracture  [in Japanese]

    Hamaya Etsuro

    … Sclerostin is a glycoprotein that is secreted by osteocytes and that inhibits Wnt signaling in osteoblast lineage cells, leading to decreased bone formation by osteoblasts and increased bone resorption by osteoclasts. …

    Folia Pharmacologica Japonica 155(4), 258-267, 2020

    J-STAGE  Ichushi Web 

  • Inhibitory effect of omega-3 fatty acids on alveolar bone resorption and osteoclast differentiation

    Ozaki Yu , Tsukinoki Keiichi , Hamada Nobushiro , Minabe Masato , Morozumi Toshiya , Watanabe Kiyoko , Toyama Toshizo , Sasaki Haruka , Sato Takenori , Yamamoto Yuko , To Masahiro , Inaba Keitaro

    … Thirty-three days after beginning the experiment, bone marrow cells were sampled from the femoral bone of mice from each group and differentiated into osteoclasts; … infection on the number of osteoclasts (<i>P</i> … However, the fatty acid type affected the number of osteoclasts in mice (<i>P</i> …

    Journal of Oral Science 62(3), 298-302, 2020

    J-STAGE 

  • Crosstalk between bone remodeling and blood coagulation-anticoagulation system  [in Japanese]

    Akita Nobuyuki , Yoshida Kakunoshin , Suzuki Koji , Hayashi Tatsuya

    <p>骨リモデリングは,骨芽細胞と破骨細胞が相互に密接に関わる制御システムである.骨では,骨芽細胞による骨形成と破骨細胞による骨吸収が恒常的に行われており,この機能的に相反する性質を持つ細胞のバランスによって骨のホメオスタシスが保たれている.骨の基質蛋白質の一つであるオステオカルシンの合成にはビタミンKが必要とされる.同様に,血液凝固因子や凝固制御因子の一部についても,それらの蛋白質の …

    Japanese Journal of Thrombosis and Hemostasis 31(3), 316-324, 2020

    J-STAGE 

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