Search Results 1-20 of 1708

  • Influence of Polluted Sea Water in the Red Sea on the Osteoclasts and Osteoblasts of Goldfish, Carassius auratus

    ZANATY I. Mohamed , NASSAR F. Hossam , MAHMOUD M. Hamada , ABDEL–GAWAD Kh. Fagr , SATO Masayuki , YACHIGUCHI Koji , SHIMIZU Nobuaki , HAYAKAWA Kazuichi , HATTORI Atsuhiko , MUKAI Koki , SHIMASAKI Yohei , OSHIMA Yuji , SUZUKI Nobuo

    … To analyze the influences of environmental pollutants and bioactive substances on fish bone metabolism, we have developed an original in vitro bioassay using goldfish scales that have osteoclasts, osteoblasts, and bone matrix. … We used tartrate–resistant acid phosphatase (TRAP) for osteoclasts and alkaline phosphatase (ALP) for osteoblasts as respective markers. …

    九州大学大学院農学研究院紀要 64(2), 287-291, 2019-09-02

    IR 

  • Suppression of Osteoclast Differentiation with Intermittent MechanicalStress in RAW264.7 Cells  [in Japanese]

    加藤 結香 , 吉村 善隆 , 上村 光太郎 , 南川 元 , 鈴木 邦明 , 飯田 順一郎

    骨改造において機械的刺激が重要な役割を果たしていることが明らかとなっているが,破骨細胞の分化誘導系に対し機械的刺激を直接作用させた報告は我々の研究のみである.これまで我々は周期的および持続的な機械的刺激による破骨細胞分化の抑制に関して報告してきた.本研究では,可撤式矯正装置の間歇的な使用による組織変化を想定して,間歇的な機械的刺激を加えた場合の破骨細胞分化への影響について検討した.RAW 264. …

    北海道歯学雑誌 40(1), 5-12, 2019-09

    IR 

  • Elucidation of osteoporosis prevention mechanism by citrus limonoid

    君羅 好史

    Impact is published under a CC-BY Creative Commons licence.

    Impact 2019(6), 12-14, 2019-06

    IR 

  • Feature Article: Altered morpho-functional features of bones in autoimmune disease-prone BXSB/MpJ-Yaa mice

    Namba Takashi , Ichii Osamu , Nakamura Teppei , Masum Md Abdul , Otani Yuki , Otsuka-Kanazawa Saori , Elewa Yaser Hosny Ali , Kon Yasuhiro

    … Histologically, osteoclasts and osteoblasts showed increased and decreased tendencies, respectively, in BXSB/MpJ-Yaa during the early stage, and osteoclasts and bone area significantly increased and decreased, respectively, compared with BXSB/MpJ at later stages. …

    Experimental biology and medicine 244(5), 333-343, 2019-04

    IR 

  • 4-Hydroxyderricin inhibits osteoclast formation and accelerates osteoblast differentiation

    宮崎 均 , 吉田 滋樹 , Hiromi Hagiwara , Kyoko Nakata , Hitoshi MIYAZAKI , Sanae Maehashi , Yuki Komiyama , Rieko Aida , Shigeki YOSHIDA , Daichi Kokubu , Keitaro Hagiwara , Kaoru Yoshida

    … The present study was designed to evaluate the effects of 4-HD on bone formation and maintenance by using cultured osteoclasts and osteoblasts. … This compound inhibited the formation of multinucleated osteoclasts from mouse splenic cells, and we identified a molecular pathway of osteoclast differentiation mediated by 4-HD, which led to inhibition of the expression of receptor activator of nuclear factor-κB ligand and macrophage-colony stimulating factor in ST2 cells. …

    Cytotechnology 71(1), 15-22, 2019-02

    IR 

  • IL-1β enhances cell adhesion through laminin 5 and β4 integrin in gingival epithelial cells

    Mezawa Masaru , Tsuruya Yuto , Yamazaki-Takai Mizuho , Takai Hideki , Nakayama Yohei , McCulloch Christopher A. , Ogata Yorimasa

    … IL-1β induces bone resorption by activating osteoclasts; …

    Journal of Oral Science, 2019

    J-STAGE 

  • Carbonate apatite bone replacement: learn from the bone

    ISHIKAWA Kunio

    … Compared to sintered HAp, which is not resorbed by osteoclasts, CO<sub>3</sub>Ap is resorbed by osteoclasts. …

    Journal of the Ceramic Society of Japan 127(9), 595-601, 2019

    J-STAGE 

  • A novel device to prevent osteoporosis by promoting bone metabolism using a newly developed double-loading stimulation with vibration and shaking

    YAO Runhong , NISHII Kazuhiro , KITO Takumi , TERANISHI Toshio , SUGIYAMA Tomohisa , SAKAI Kazuyoshi , MATSUBARA Mamoru , YAMADA Kouji

    … These results suggest that stimulation activated osteoblasts and osteoclasts, thereby leading to highly active bone remodeling. …

    Okajimas Folia Anatomica Japonica 96(1), 13-21, 2019

    J-STAGE 

  • HSP90 inhibitors diminish PDGF-BB-induced migration of osteoblasts via suppression of p44/p42 MAP kinase

    KAWABATA Tetsu , OTSUKA Takanobu , KOZAWA Osamu , TOKUDA Haruhiko , FUJITA Kazuhiko , MATSUSHIMA-NISHIWAKI Rie , SAKAI Go , TACHI Junko , HIOKI Tomoyuki , KIM Woo , IIDA Hiroki

    … <p>Migration of osteoblasts to the sites resorbed by osteoclasts is an essential step in bone remodeling. …

    Biomedical Research 40(4), 169-178, 2019

    J-STAGE 

  • Tumor Necrosis Factor-α Produced by Osteoclasts Might Induce Intractable Pain in a Rat Spinal Metastasis Model of Breast Cancer

    Mazaki Ai , Ohtori Seiji , Yamauchi Kazuyo , Orita Sumihisa , Inage Kazuhide , Suzuki Miyako , Abe Kohki , Shiga Yasuhiro , Inoue Masahiro , Norimoto Masaki , Umimura Tomotaka

    … It is well known that cancer cells produce these cytokines, but whether osteoclasts produce them as well remains unclear. … We hypothesize that osteoclasts produce these cytokines; … Tartrate-resistant acid phosphatase (TRAP) staining was performed to reconfirm that osteoclasts increase in vertebrae with spinal metastasis. …

    Spine Surgery and Related Research 3(3), 261-266, 2019

    J-STAGE 

  • Effect of serine protease trypsin on the interaction of RANKL and RANK

    SHINTANI Tsuguo , DOMAE Eisuke , YOSHIKAWA Yoshihiro , KAMADA Aiko , IKEO Takashi

    … Because osteoclasts differentiate from monocyte/macrophage lineage cells, the enzymatic activity might also affect osteoclast differentiation. … In this study we examined the effect of trypsin on the ability of the mouse macrophage cell line RAW264.7 to differentiate into osteoclasts. … We found that trypsin treatment of RAW264.7 cells lowers their ability to differentiate into osteoclasts in response to RANKL. …

    Journal of Osaka Dental University 53(1), 9-14, 2019

    J-STAGE 

  • Microglia express GPNMB in the brains of Alzheimer's disease and Nasu-Hakola disease

    Satoh Jun-ichi , Kino Yoshihiro , Yanaizu Motoaki , Ishida Tsuyoshi , Saito Yuko

    … TREM2 and DAP12 constitute a receptor/adaptor signaling complex expressed exclusively on osteoclasts, dendritic cells, macrophages, and microglia. …

    Intractable & Rare Diseases Research 8(2), 120-128, 2019

    J-STAGE 

  • A preliminary study on the mechanism of skeletal abnormalities in Turner syndrome using inducing pluripotent stem cells (iPS)-based disease models

    Cui Xiaoxiao , Cui Yazhou , Shi Liang , Luan Jing , Zhou Xiaoyan , Han Jinxiang

    … In this study, we used pluripotent stem cells (iPSCs) derived from a Turner syndrome patient and a health control to induce functional osteoblasts and osteoclasts, in order to compare their difference in these two differentiation. …

    Intractable & Rare Diseases Research 8(2), 113-119, 2019

    J-STAGE 

  • Vacuolar-type ATPase: A proton pump to lysosomal trafficking

    FUTAI Masamitsu , SUN-WADA Ge-Hong , WADA Yoh , MATSUMOTO Naomi , NAKANISHI-MATSUI Mayumi

    … The mammalian counterpart is found ubiquitously in endomembrane organelles and the plasma membrane of specialized cells such as osteoclasts. …

    Proceedings of the Japan Academy, Series B 95(6), 261-277, 2019

    J-STAGE 

  • The effect of mesenchymal stem cells on osteoclast precursor cell differentiation

    Abe Takaharu , Sumi Keisuke , Kunimatsu Ryo , Oki Nanae , Tsuka Yuji , Nakajima Kengo , Ando Kazuyo , Tanimoto Kotaro

    … Bone regeneration is achieved via the interaction of osteoblasts and osteoclasts. … However, the influence of MSCs on osteoclasts is unknown. … The numbers of osteoclasts after addition of soluble receptor activator of nuclear factor kappa B (NF-κB) ligand (sRANKL) were also compared. … The differentiation of RAW264 cells into mature osteoclasts following addition of sRANKL was significantly inhibited by co-culture with MSCs. …

    Journal of Oral Science 61(1), 30-35, 2019

    J-STAGE 

  • Molecular biological and histological effects of Er:YAG laser irradiation on tooth movement

    Tsuka Yuji , Kunimatsu Ryo , Gunji Hidemi , Nakajima Kengo , Hiraki Tomoka , Nakatani Ayaka , Tanimoto Kotaro

    … These results suggest that a fiberotomy-like procedure using an Er:YAG laser stimulates osteoclasts and osteoblasts and may promote bone metabolism in the context of experimental tooth movement.</p> …

    Journal of Oral Science 61(1), 67-72, 2019

    J-STAGE 

  • Pathogenesis of Cancer-associated Bone Pain  [in Japanese]

    Hiasa Masahiro

    … Inhibitors of osteoclasts including bisphosphonates and denosumab incompletely reduce bone pain, indicating that not only osteoclast-dependent but also osteoclast-independent mechanisms are operant. …

    Journal of Oral Health and Biosciences 31(2), 92-96, 2019

    IR  J-STAGE 

  • Calcium, Phosphorus and Oxygen Around Implant at Early Osseointegration in Hyperlipidemic Rats

    Liu Qibo , Wang Zhifeng , Dong Xiaofei , Wang Hui , Lan Jing

    … Histological results revealed less osteoblasts and trabecular bone, but more osteoclasts and trabecular space in experimental group than those in control group. …

    Journal of Hard Tissue Biology 28(1), 57-62, 2019

    J-STAGE 

  • Anabolic action of teriparatide to osteoporotic patients  [in Japanese]

    Hasegawa Tomoka , Miyamoto Yukina , Yamamoto Tomomaya , Amizuka Norio

    <p>骨粗鬆症治療薬の副甲状腺ホルモン(PTH)製剤として,遺伝子組み換え型ヒトPTH[1-34]であるテリパラチドが用いられている.我が国においては,連日製剤と週1回製剤の2種類が存在しており,そのどちらも骨量を増加させ,また,骨折率を低下させることが報告されている.一般的にPTHを持続投与すると骨吸収を誘導するのに対して,PTH間歇投与では骨量増加につながることが知られている.その …

    Folia Pharmacologica Japonica 153(1), 16-21, 2019

    J-STAGE  Ichushi Web 

  • A Novel Oral Anti-osteoporosis Drug with Osteogenesis-promoting Effects <i>via</i> Osteoblast Differentiation  [in Japanese]

    Kitao Tatsuya , Ito Yuma , Fukui Masaki , Yamamoto Megumi , Shoji Yoshimichi , Takeda Shigemitsu , Shirahase Hiroaki

    … On the other hand, KY-273 did not clearly exert differentiation effects in osteoclasts, chondrocytes, adipocytes, or myoblasts. …

    YAKUGAKU ZASSHI 139(1), 19-25, 2019

    J-STAGE  Ichushi Web 

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