Search Results 1-20 of 152

  • Potential involvement of the mitochondrial unfolded protein response in depressive-like symptoms in mice  [in Japanese]

    Kambe Yuki , Miyata Atsuro

    … <p>Many evidences strongly suggest that a mitochondrial deficit is implicated in major depression. … A mitochondrial deficit leads to mitochondrial stress responses, including the mitochondrial unfolded protein response (UPRmt), which is associated with certain brain disorders such as spastic paraplegia and Parkinson's disease. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-S33-1, 2020

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  • The protective effect of a novel radical scavenger, NSP-116 on cerebral ischemia injury  [in Japanese]

    Imai Takahiko , Iwata Sena , Daisuke Miyo , Nakamura Shinsuke , Shimazawa Masamitsu , Hara Hideaki

    … patient outcome with stroke, recanalization of occlusion vessels is an effective therapy. However, recanalization induces oxidative stress via oxygen over-supply, which leads to neuronal damage as ischemia reperfusion injury (IRI). NSP-116 is a novel radical scavenger, and our previous study showed that NSP-116 suppressed oxidative stress. Therefore, we speculated that NSP-116 could ameliorate IRI damage. The purpose of this study is to investigate the effect of NSP-116 on IRI.</p><p>We established the IRI mouse model by using …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 2-P-040, 2019

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  • A method for evaluation of both aerobic and anaerobic capacities of middle- and long- distance runners  [in Japanese]

    Mitsuka Takaya , Tsuji Toshiki , Nabekura Yoshiharu

    … An individual's anaerobic capacity is evaluated in terms of the maximal accumulated oxygen deficit in the supramaximal test. … The mean accumulated oxygen deficit in the maximal test was 30.6 ± 10.0 mlO2/kg, and the mean maximal accumulated oxygen deficit in the supramaximal test was 55.7 ± 16.1 mlO2/kg. …

    Taiikugaku kenkyu (Japan Journal of Physical Education, Health and Sport Sciences) 64(1), 59-66, 2019

    IR  J-STAGE  Ichushi Web 

  • Molecular mechanism responsible for the neurotropic effects of cognition enhancer Noopept

    Vakhitova Yulia V. , Zainullina Liana F. , Ivanova Tatyana V. , Ostrovskaya Rita U. , Gudasheva Tatyana A. , Seredenin Sergey B.

    … Hypoxia-inducible growth factor-1 (HIF-1) is the master regulator of cellular and tissue adaptive responses to low oxygen. … Over the past few years, HIF-1 has emerged as a viable target to counteract neurodegeneration, ischemia and cognition deficit in some neurological and neurodegenerative diseases. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), PO4-1-3, 2018

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  • Microglial apoptosis is involved in neuronal cell death after ischemic stroke

    Wang Hong-Wen , Chang Alice Y. W.

    … Our previous study showed that ischemic stroke induced neuronal death and caused a neurological deficit in vivo. … Neuronal, microglial and astrocytes cell lines (CATH.a, BV-2, and C6, respectively) were treated with oxygen-glucose deprivation (OGD) serving as an in vitro model of ischemic stroke. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), PO2-1-32, 2018

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  • Hemoglobin-related molecules injure blood-brain barrier via iron accumulation

    Imai Takahiko , Iwata Sena , Hirayama Tasuku , Nagasawa Hideko , Nakamura Shinsuke , Shimazawa Masamitsu , Hara Hideaki

    … </p><p><b>Results</b></p><p>HRMs induced cell death approximately 10 % via increasing reactive oxygen species production by 3 to 10 folds in both cells, and increased the intracellular Fe<sup>2+</sup> … <i>In vivo study</i>, the hemin injection caused neuronal deficit, and aggravated BBB permeability more than 10 times compared with Sham group at 3 days after injection. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), PO2-1-87, 2018

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  • Chronic intermittent hypoxia aggravates neurocognitive decline in an animal model of Alzheimer's disease

    Du Lida , O Chun Kwan , Geng Linting , Xu Linhao , Ke Ya , Yung Wing Ho

    … <p>Aims: Alzheimer's disease (AD), characterized by progressive cognitive deficit, is a major neurodegenerative disease that affects tens of millions of patients worldwide. … Methods: 3xTg-AD transgenic mice were treated by changing environmental oxygen levels between 10% to 21% for 8 hours per day for 4 weeks to mimic OSA-associated CIH. … Control AD mice were exposed to normal oxygen level. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), PO1-1-47, 2018

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  • Relationships between longitudinal changes in physiological capacities and running performance in 800-m runners

    Tanji Fumiya , Nabekura Yoshiharu

    … Three running tests on a treadmill were conducted to determine aerobic (maximal oxygen uptake [VO<sub>2</sub>max], lactate threshold [LT] and running economy [RE]) and anaerobic (maximal accumulated oxygen deficit [MAOD] and maximal blood lactate accumulation [LAmax]) energy metabolism capacities in July and November. …

    The Japan Journal of Coaching Studies 32(1), 79-88, 2018

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  • Validity of a newly developed method to predict accumulated oxygen deficit

    SHIRAI Yusuke , MURATA Munenori , NABEKURA Yoshiharu

    … <p>Rowers transfer power output (PO) to the handle with the movement of their body toward back and forth which is defined as internal work, however, accumulated oxygen deficit (AOD) is estimated from only PO. … This study aimed to investigate the validity of a newly proposed method, which estimates oxygen demand from PO and internal work, by comparing the relationships between AOD and blood lactate related parameters. …

    Human Performance Measurement 15(0), 1-13, 2018

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  • Relationship between 800-m Running Performance and Aerobic and Anaerobic Energy Metabolism Capacities in Well-Trained Middle-Distance Runners

    Tanji Fumiya , Tsuji Toshiki , Shimazu Wataru , Nabekura Yoshiharu

    … Participants underwent three running tests on a treadmill to assess aerobic (maximal oxygen uptake [VO<sub>2</sub>max], lactate threshold intensity [LTI], and running economy [RE]) and anaerobic (maximal accumulated oxygen deficit [MAOD] and maximal accumulation blood lactate concentration [ΔbLa]) energy metabolism capacities. …

    International Journal of Sport and Health Science 16(0), 70-76, 2018

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  • Estimation of accumulated oxygen deficit from accumulated blood lactate concentration during supramaximal running in middle-distance runners

    Tanji Fumiya , Tsuji Toshiki , Shimazu Wataru , Nabekura Yoshiharu

    … <p>The maximal accumulated oxygen deficit (MAOD), which is the gold standard for anaerobic energy metabolism capacity, requires multiple tests for evaluation that impose a heavy load on subjects. … The maximal accumulated blood lactate (ΔbLa) concentration is also a measure of anaerobic energy metabolism capacity, and is related to the accumulated oxygen deficit (AOD). …

    The Journal of Physical Fitness and Sports Medicine 6(5), 359-363, 2017

    J-STAGE  Ichushi Web 

  • Umbilical Cord MSCs Reverse D-Galactose-Induced Hepatic Mitochondrial Dysfunction <i>via</i> Activation of Nrf2/HO-1 Pathway

    Yan Weihong , Li Dong , Chen Tong , Tian Guiying , Zhou Panpan , Ju Xiuli

    … Mitochondria isolated from the liver of D-Gal models exhibited decreased antioxidant capacity as well as compromised bioenergetics functions, as shown by a loss of mitochondrial membrane potential, elevation of reactive oxygen species (ROS) production, reduction of mitochondrial respiration complexes and ATP decrement. … In conclusion, the attenuating effects of UC-MSCs on hepatic damage partially rely on normalizing mitochondrial function and preventing a state of energetic deficit <i>via</i> …

    Biological and Pharmaceutical Bulletin 40(8), 1174-1182, 2017

    J-STAGE  Ichushi Web 

  • Associations of peak oxygen uptake with its decrease time and exercise intensity

    Tajima Akihiko

    International journal of analytical bio-science 4(2), 28-31, 2016-06

    Ichushi Web 

  • Surgical Strategies and Technical Tips for Performing Extracranial-Intracranial Bypass for Occlusive Cerebrovascular Disease  [in Japanese]

    OTANI Naoki , WADA Kojiro , INAKA Yasufumi , NISHIDA Sho , TANOUE Shunsuke , KUMAGAI Kohsuke , FUJII Kazuya , TOYOOKA Terushige , MORI Kentaro

    … Hyperbaric oxygen therapy was performed for wound problems. … None of the patients had permanent deficit. …

    Surgery for Cerebral Stroke 44(6), 417-424, 2016

    J-STAGE  Ichushi Web 

  • Administration of General Anesthesia for a Patient with Angelman Syndrome during Tooth Extraction  [in Japanese]

    KANO Keita , MURAYAMA Takafumi , HIRAKAWA Hiroshi , SATO Yoko , YAMAMOTO Toshiro , KANAMURA Narisato , AKIYAMA Shigehisa , MORISAKI Ichijiro

    … The clinical features of AS are characterized by mental retardation, seizures, frequent paroxysms of laughter, ataxia, and characteristic faces (small head, large tongue and large lower jaw) due to a partial deficit on the paired chromosome 15 (q11-q13). … Anesthesia was induced with propofol and rocronium, and was maintained with oxygen and propofol. …

    Journal of the Japanese Society for Disability and Oral Health 37(4), 414-418, 2016

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  • Perioperative General Anesthetic Management for a Patient with Congenital Myotonic Dystrophy Accompanied by Mental Retardation and Attention Deficit Hyperactivity Disorder  [in Japanese]

    ODA Aya , YOSHIDA Keita , MUKAI Tomohiro , UNO Tamayo , YOSHINAKA Taiga , MUKAI Akari , YOSHIDA Mitsuhiro , IRIFUNE Masahiro

    … We report here the perioperative general anesthetic management of a patient with congenital myotonic dystrophy accompanied by mental retardation and attention deficit hyperactivity disorder, a combination which we anticipated would further complicate the anesthetic management.<br>The patient had previously undergone mandible movement surgery. … by transient apnea was observed at the time of sleeping, so oxygen administration via a nasal cannula was necessary until the next morning. …

    Journal of the Japanese Society for Disability and Oral Health 37(1), 48-53, 2016

    J-STAGE  Ichushi Web 

  • The effects of instructions provided on the working memory while performing a task(The second report)A study involving elderly people  [in Japanese]

    杉原 勝美 , 西田 斉二 , 田丸 佳希 , Katsumi Sugihara , Saiji Nishida , Yoshiki Tamaru

    … We developed a hypothesis that aggravated attention deficit of the elderly, a probable cause of the above-mentioned difficulty, is influenced by their inactive working memory functions. …

    四條畷学園大学リハビリテーション学部紀要 (12), 15-22, 2016

    IR  Ichushi Web 

  • Nitrogen isotope ratios of nitrate and N* anomalies in the subtropical South Pacific

    Yoshikawa Chisato , Makabe Akiko , Shiozaki Takuhei , Toyoda Sakae , Yoshida Osamu , Furuya Ken , Yoshida Naohiro

    … The relationships among math formula concentrations, N* values, δ^<15>N- NO^-_3 values, and oxygen and nitrite concentrations suggest that a few samples east of 90°W were from suboxic and nitrite-accumulated conditions and were possibly affected by in situ water column denitrification. …

    Geochemistry, Geophysics, Geosystems 16(5), 1439-1448, 2015-05

    IR 

  • Skin Flap Monitoring Using Tissue Oximeter OXY-2<sup>®</sup>  [in Japanese]

    MATSUSUE Takeo , TAKAMI Shoji

    … is a device that transmits two wavelengths of near-infrared rays to a depth of 10 mm just below the sensor and detects some of the reflected scattering light in order to measure the tissue oxygen saturation ( StO<sub>2</sub> … The greatest advantages of the tissue oximeter are that measurement of tissue oxygen saturation is possible at any site of the local living body such as the finger, as well as the trunk and the skin flap at which StO<sub>2</sub> …

    Journal of Japanese Society of Reconstructive Microsurgery 28(1), 8-15, 2015

    J-STAGE  Ichushi Web 

  • TEMPORAL AND SPATIAL CHARACTERISTICS OF OXYGEN DEFICIT WATER IN LAKE SUWA  [in Japanese]

    KIMURA Masashi , TOYOTA Masashi , MIYABARA Yuichi

    Oxygen deficit water near the bottom of Lake Suwa has often been measured during the summer since the 1990’s. … In this study, continuous field measurements of dissolved oxygen near the bottom at several points were conducted in order to understand the temporal and spatial characteristics of the oxygen deficit water in detail. …

    Journal of Japan Society of Civil Engineers, Ser. B1 (Hydraulic Engineering) 71(4), I_769-I_774, 2015

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