Search Results 1-20 of 1751

  • A Novel RNA Synthesis Inhibitor, STK160830, Has Negligible DNA-Intercalating Activity for Triggering A p53 Response, and Can Inhibit p53-Dependent Apoptosis

    Morita Akinori , Ochi Shintaro , Satoh Hidetoshi , Ujita Shohei , Matsushita Yosuke , Tada Kasumi , Toyoda Mihiro , Nishiyama Yuichi , Mizuno Kosuke , Deguchi Yuichi , Suzuki Keiji , Tanaka Yoshimasa , Ueda Hiroshi , Inaba Toshiya , Hosoi Yoshio , Aoki Shin

    … RNA synthesis inhibitors and protein synthesis inhibitors are useful for investigating whether biological events with unknown mechanisms require transcription or translation; … however, the dependence of RNA synthesis has been difficult to verify because many RNA synthesis inhibitors cause adverse events that trigger a p53 response. …

    Life 11(10), 1087, 2021-10-15


  • New metal complexes derived from diacetylmonoxime-n(4)antipyrinylthiosemicarbazone: Synthesis, characterization and evaluation of antitumor activity against Ehrlich solid tumors induced in mice  [in Japanese]

    , , , , ,

    … The volumes of the formed solid tumors, the alanine transaminase, aspartate transaminase, albumin concentration in the serum, as well as the levels of Ki67 and p53 proteins in tumor and liver tissues were detected. … All the tested complexes, especially complex 5, possessed proliferative inhibition manifested as the reduction of the tumor volume, Alanine aminotransferase & Aspartate aminotransferase activity, and the level of the Ki67 protein. …

    Arabian Journal of Chemistry 14(3), 102993, 2021-03-31


  • Overexpressed tumor protein p53 and the impaired function in aggressively growing calcifying odontogenic cyst: a case report  [in Japanese]

    Ohiro Yoichi , Kakuguchi Wataru , Kuribayashi Kazuyo , Kitamura Tetsuya , Tei Kanchu

    北海道歯学雑誌 41(2), 143-146, 2021-03-15

    IR  Ichushi Web 

  • 53BP1 expression as a biomarker to differentiate thyroid follicular tumors

    Sato Ayako , Matsuda Katsuya , Motoyama Takahiro , Mussazhanova Zhanna , Otsubo Ryota , Kondo Hisayoshi , Akazawa Yuko , Higuchi Miyoko , Suzuki Ayana , Hirokawa Mitsuyoshi , Miyauchi Akira , Nagayasu Takeshi , Nakashima Masahiro

    … We have previously reported that the expression of p53-binding protein 1 (53BP1) in nuclear foci (NF), a marker reflecting DNA damage response (DDR), detected using immunofluorescence (IF) is useful to estimate the malignant potency of diverse cancers. …

    Endocrine Connections 10(3), 309-315, 2021-03


  • Application of liquid-based cytology in diagnosis of oral precancerous lesion.  [in Japanese]

    金子 裕康 , 中尾 寿奈 , 江原 道子 , 永山 元彦 , 住友 伸一郎

    … これまで坂野らは4-nitroquinoline 1-oxide(4NQO)を用いたラット舌発がん実験により、heterogeneous nuclear ribonucleic protein K(hnRNP K)の検索を行ってきた。 … 今回、ラット舌発がんモデルを用いて細胞診と組織診を比較し診断の精度について検討し、さらにhnRNP Kとp53の免疫組織化学的染色や、mRNA発現量比較検討への応用による診断精度向上の可能性についても検討した。 …

    岐阜歯科学会雑誌 = The Journal of Gifu Dental Society 47(3), 115-125, 2021-02


  • Identification of the Myogenetic Oligodeoxynucleotides (myoDNs) That Promote Differentiation of Skeletal Muscle Myoblasts by Targeting Nucleolin

    Shinji Sayaka , Umezawa Koji , Nihashi Yuma , Nakamura Shunichi , Shimosato Takeshi , Takaya Tomohide

    … We further identified nucleolin as an iSN04-binding protein. … Results showed that iSN04 antagonizes nucleolin, increases the levels of p53 protein translationally suppressed by nucleolin, and eventually induces myotube formation by modulating the expression of genes involved in myogenic differentiation and cell cycle arrest. …



  • Different effects of p53 protein overexpression on the survival of gastric cancer patients according to Lauren histologic classification : a retrospective study

    Kim Ki Wook , Kim Nayoung , Choi Yonghoon , Kim Won Seok , Yoon Hyuk , Shin Cheol Min , Park Young Soo , Lee Dong Ho , Park Young Suk , Ahn Sang-Hoon , Park Do Joong , Kim Hyung-Ho , Lee Hye Seung , Kim Ji-Won , Kim Jin Won , Lee Keun-Wook , Chang Won , Park Ji Hoon , Lee Yoon Jin , Lee Kyoung Ho , Kim Young Hoon

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 24(4), 844-857, 2021

    Ichushi Web 

  • Dipeptidyl peptidase-4 inhibition prevents lung injury in mice under chronic stress via the modulation of oxidative stress and inflammation

    Zhang Shengming , Li Ping , Xin Minglong , Jin Xianglan , Zhao Longguo , Nan Yongshan , Cheng Xian Wu

    … and gp91<sup>phox</sup>), inflammation (monocyte chemoattractant protein-1, vascular cell adhesion molecule-1, and intracellular adhesion molecule-1), apoptosis (caspase-3, -8, -9), senescence (p16<sup>INK4A</sup>, p21, and p53) and proteolysis (matrix metalloproteinase-2 to -9, cathepsin S/K, and tissue inhibitor of matrix metalloproteinase-1 and -2), and reduced levels of eNOS, Sirt1, and Bcl-2 proteins; …

    Experimental Animals 70(4), 541-552, 2021


  • A Case of Primary Acinic Cell Carcinoma of the Breast  [in Japanese]

    YATABE Yusuke , OSANAI Takayuki , NAKAGAWA Tsuyoshi , TAKIGUCHI Noriaki , BHUNCHET Ekapot

    … 有するやや好酸性な異形細胞が,小型腺管状や小胞巣状の浸潤性増殖パターンを呈していた.免疫組織学的検査では,p63およびCD10陽性筋上皮との二相性は見られず,浸潤が認められた.S-100,α1-AT,唾液腺アミラーゼ,p53,CEA,EMA,GCDFP-15が陽性,Mammaglobin,ER,PgR,HER2が陰性,Ki67は最大21%陽性であり,AcCCと診断した.術後化学療法は行わずに経過観察中であるが,術後4年7カ月の時点で無再発生存中である.</p> …

    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) 82(4), 684-689, 2021

    J-STAGE  Ichushi Web 

  • Discovery and Verification of Key Liver Cancer Genes and Alternative Splicing Events Based on Second-Generation Sequencing Data Analysis

    Cui Mengqi , Yu Zhenxiang , Li Yuxin , Huang Yanxin , Bai Miao , Zheng Lihua , Bao Yongli , Sun Luguo , Yu Chunlei , Sun Ying , Song Zhenbo , Wang Guannan

    … was found to be a key variant that influenced cell proliferation through the p53 cell cycle pathway through cell viability and proliferation assays, and <i>MT1E-203</i> …

    Biological and Pharmaceutical Bulletin 44(10), 1433-1444, 2021


  • Identification and characterization of Bombyx mori homologs of Bonus, Mdm2, Rad6, Sce, and Synoviolin

    Justine Bennette H. Millado , Hamajima Rina , Sugiura Waka , Makino Shizuka , Kobayashi Michihiro , Ikeda Motoko

    … <p> The tumor suppressor protein p53 serves as a crucial mediator of apoptosis induction and is negatively regulated by various upstream cellular factors through post-translational modifications, including ubiquitination. … with E2 ubiquitin conjugating enzyme activity, which negatively regulate p53 levels and contribute to p53-mediated apoptosis induction in <i>Drosophila melanogaster</i> … homologs, Bm-p53 (<i>B. …

    Journal of Insect Biotechnology and Sericology 90(2), 2_021-2_032, 2021


  • Elaboration of Non-naturally Occurring Helical Tripeptides as p53–MDM2/MDMX Interaction Inhibitors

    Su Aoze , Ohwada Tomohiko , Tabata Yuko , Aoki Kiyono , Sada Akane , Ohki Rieko , Nagatoishi Satoru , Tsumoto Kouhei , Wang Siyuan , Otani Yuko

    … <p>Proteinprotein interactions (PPIs) are often mediated by helical, strand and/or coil secondary structures at the interface regions. … amide bonds can block the p53–MDM2/MDMX α-helix–helix interaction, which plays a role in regulating p53 function. … Biological activity assay in human osteosarcoma cell line SJSA-1, which has wild-type p53 and amplification of the <i>Mdm2</i> …

    Chemical and Pharmaceutical Bulletin 69(7), 681-692, 2021


  • <i>miR-4270</i> Modulates the Irradiation-Sensitivity of Nasopharyngeal Carcinoma Cells through Modulation of p53 <i>in Vivo</i>

    Hao Wenwei , Zhu Yongping , Wang Haowei , Guo Ying

    … (the gene of the tumor suppressor protein p53) with the normal nasopharyngeal epithelial cells as a control. … RT-PCR detected the RNA expression and Western blot examined the protein expression of p53. … Additionally, p53 increased cell sensitivity to irradiation and modulated by <i>miR-4270</i> …

    The Tohoku Journal of Experimental Medicine 254(2), 63-70, 2021


  • A case of malignant peripheral nerve sheath tumor of the mandibular gingiva  [in Japanese]

    MAKISHI Shoko , MATAYOSHI Akira , MIYAMOTO Sho , HIRANO Husahiro , NAKASONE Toshiyuki , NAKAMURA Hiroyuki

    … Immunohistochemical staining showed positive results for S-100 protein, p53, and vimentin, but negative results for pan-cytokeratin (AE1 / AE3), Melan A, and desmin. …

    Japanese Journal of Oral and Maxillofacial Surgery 67(3), 194-199, 2021

    J-STAGE  Ichushi Web 

  • Involvement of TRPM8 Channel in Radiation-Induced DNA Damage Repair Mechanism Contributing to Radioresistance of B16 Melanoma

    Nomura Daichi , Abe Ryo , Tsukimoto Mitsutoshi

    … Here, we show that a TRPM8 channel inhibitor suppresses the DNA damage response (phosphorylated histone variant H2AX-p53-binding protein 1 (γH2AX-53BP1) focus formation) and colony formation of B16 melanoma cells. … Phosphorylation of ataxia telangiectasia mutated and p53, which both contribute to the DNA damage response was also suppressed after γ-irradiation. …

    Biological and Pharmaceutical Bulletin 44(5), 642-652, 2021


  • The Potential as New Treatment Agent of Urolithin-A Metabolized from Ellagic Acid by Gut Microbiota in Cancer


    … Urolithin-A was reported to regulate p53 protein, <i>caspase 3</i>, <i>caspase 7</i>, <i>AKT</i>, aromatase and <i>PARP</i> …

    Juntendo Medical Journal 67(2), 131-139, 2021


  • Molecular pathogenesis of autism spectrum disorder with abnormal chromatin remodeling  [in Japanese]

    Katayama Yuta

    … CHD8 is a member of the chromodomain helicase DNA-binding (CHD) family of proteins and functions as an ATP-dependent chromatin-remodeling factor in regulation of the expression of many genes including those for b-catenin and p53.</p><p>We showed that mice heterozygous for <i>Chd8 </i>mutations manifest ASD-like behavioural characteristics including increased anxiety, persistence tendency, and altered social behaviour. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 3-S27-2, 2021


  • Involvement of CD73 and A2B Receptor in Radiation-Induced DNA Damage Response and Cell Migration in Human Glioblastoma A172 Cells

    Kitabatake Kazuki , Kaji Toshiyuki , Tsukimoto Mitsutoshi

    … To investigate DDR, we evaluated ataxia telangiectasia mutated (ATM) activation and focus formation of histone H2A isoform γ (γH2AX) and p53-binding protein 1 (53BP1) in the nucleus of A172 cells after γ-irradiation. …

    Biological and Pharmaceutical Bulletin 44(2), 197-210, 2021


  • CCN3 (NOV) Drives Degradative Changes in Aging Articular Cartilage

    Kuwahara Miho , Kadoya Koichi , Kondo Sei , Fu Shanqi , Miyake Yoshiko , Ogo Ayako , Ono Mitsuaki , Furumatsu Takayuki , Nakata Eiji , Sasaki Takako , Minagi Shogo , Takigawa Masaharu , Kubota Satoshi , Hattori Takako

    … During aging, the expression of Ccn3 mRNA in mouse primary chondrocytes from knee cartilage increased and showed a positive correlation with p21 and p53 mRNA. … Increased accumulation of CCN3 protein was confirmed. … Artificial senescence induced by H2O2 caused a dose-dependent increase in Ccn3 gene and CCN3 protein expression, along with enhanced expression of p21 and p53 mRNA and proteins, as well as SA-beta gal activity. …

    International Journal of Molecular Sciences 21(20), 7556, 2020-10-13


  • Elimination of MYCN-Amplified Neuroblastoma Cells by Telomerase-Targeted Oncolytic Virus via MYCN Suppression

    Tanimoto Terutaka , Tazawa Hiroshi , Ieda Takeshi , Nouso Hiroshi , Tani Morimichi , Oyama Takanori , Urata Yasuo , Kagawa Shunsuke , Noda Takuo , Fujiwara Toshiyoshi

    … For targeting hTERT-activated tumors, we developed two oncolytic adenoviruses, OBP-301 and tumor suppressor p53-armed OBP-702, in which the hTERT promoter drives expression of the viral E1 gene for tumor-specific virus replication. … Virus-mediated activation of E2F1 protein suppressed MYCN expression. … Thus, these hTERT-driven oncolytic adenoviruses are promising antitumor agents for eliminating MYCN-amplified NB cells via E2F1-mediated suppression of MYCN protein. …

    Molecular Therapy - Oncolytics (18), 14-23, 2020-09-25


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