Search Results 1-20 of 712

  • Immunohistochemical study for the expression of leukocyte adhesion molecules, and FGF23 and ACE2 in P. gingivalis LPS-induced diabetic nephropathy

    Kajiwara Koichiro , Sawa Yoshihiko , Fujita Takahiro , Tamaoki Sachio

    … Objective</br>The present study aims to examine the expression of leukocyte adhesion molecules and renal metabolic factors in diabetic mouse kidneys with periodontal pathogen Pg-LPS-induced nephropathy.</br>Background</br>We recently reported that the glomerular endothelium expresses toll-like receptor (TLR)2 and TLR4 in diabetic environments and TLR2/4 ligand Porphyromonas (P.) gingivalis lipopolysaccharides (Pg-LPS) induce nephropathy in diabetic mice. …

    BMC Nephrology 22(1), 3, 2021-01-06

    IR 

  • Periodontal Regenerative Therapy with Recombinant Human Fibroblast Growth Factor-2 and Deproteinized Bovine Bone Mineral in Patient with Chronic Periodontitis: An 18-month Follow-up Report

    Bizenjima Takahiro , Irokawa Daisuke , Tanaka Kobun , Saito Atsushi , Tomita Sachiyo

    … <p>This report describes a case of generalized chronic periodontitis requiring periodontal regenerative therapy. … Based on a clinical diagnosis of moderate chronic periodontitis, initial periodontal therapy consisting of plaque control and scaling and root planing was performed. … Occlusal adjustment of premature contact sites was performed after inflammation was suppressed. … Surgical periodontal therapy was subsequently performed at selected sites. …

    The Bulletin of Tokyo Dental College, 2021

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  • A Case Report: Endodontic-periodontal Disease Due to Root Malformation  [in Japanese]

    Motoki OKAMOTO , Yoshifumi KINOMOTO , Nanako KURIKI , Keigo SAWADA , Yusuke TAKAHASHI , Shinya MURAKAMI , Mikako HAYASHI

    <p> 目的 : 歯内-歯周疾患は日常臨床で頻繁に遭遇する病態であり, 臨床症状として歯根破折・穿孔・セメント質剝離などと類似した症状を呈しうるため, 鑑別診断が重要である. 今回, 複数の歯科医院において, 歯根破折のため抜歯が必要と診断された上顎中切歯に対して, 根の形態異常に由来した歯内-歯周疾患との診断の下, 歯内療法および歯周組織再生療法を実施することで良好な治癒が得られたの …

    The Japanese Journal of Conservative Dentistry 64(2), 171-180, 2021

    J-STAGE 

  • Analysis of Systemic Markers Relating to Bleeding on Probing in Patients with Cardiovascular Disease  [in Japanese]

    Norio AOYAMA , Keitetsu KURE , Toshiya FUJII , Sayuri KIDA , Masahiro TAKASE , Shuntaro SUGIHARA , Daichi MONDEN , Masato MINABE

    <p> 目的 : 歯周病は罹患率の高い感染症であり, プロービング時の出血 (BOP) は局所の炎症程度を表す指標として歯周病検査に導入されている. 歯周病と全身の関連が示されているが, 主な歯周病指標として歯周ポケット深さやクリニカルアタッチメントレベルなど歯周組織破壊の程度が用いられ, BOPと全身の関係についての報告は少ない. 以上のことから本研究の目的は, BOPと関連のある全 …

    The Japanese Journal of Conservative Dentistry 64(2), 163-170, 2021

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  • TRPV1 and TRPA1 are cooperatively involved in the tooth movement-related pain.  [in Japanese]

    Adachi Kazunori , Yugawa Misato

    … <p>Electrical stimulation to periodontal ligament induces the jaw-opening reflex. … Recently, the conjugational function of TRPV1 and TRPA1 to inflammation has been reported, and both receptors are widely present in peripheral nervous systems. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 3-P1-04, 2021

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  • A Case of Mandibular Prognathism with Generalized Aggressive Periodontitis and Crowding

    Ishii Takenobu , Goto Hiroaki , Watanabe Akira , Yamamoto Shigeki , Onodera Hiroko , Yoshida Shuji , Nishii Yasushi

    … Initial periodontal examination revealed deep periodontal pockets and extensive inflammation. … Therefore, it was necessary to adopt an interdisciplinary approach involving surgical, orthodontic, and periodontal treatment. … Prior to commencement of orthodontic treatment, plaque control, scaling, and root planing of all teeth were performed by a periodontist to suppress inflammation and reduce probing depth. …

    The Bulletin of Tokyo Dental College 62(1), 27-39, 2021

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  • The Initial Periodontal Therapy for Chronic Periodontitis with Gingival Hyperplasia in a Diabetic Patient : A Case Report  [in Japanese]

    Takeshi KIKUCHI , Akio MITANI

    … 辺縁歯肉の腫脹が消失した後に, う蝕治療と補綴治療を行い, プラークリテンションファクターを除去した.</p><p> 成績 : 歯周ポケット炎症表面積 (Periodontal Inflamed Surface Area : PISA) 値は, 初診時2,291.0mm<sup>2</sup>から最新SPT時91.4mm<sup>2</sup>と低下した. …

    The Japanese Journal of Conservative Dentistry 64(1), 74-81, 2021

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  • The Relationship between Colorectal Cancer and Gut Microbiota: New Trends in Colorectal Cancer Research into <i>Fusobacterium nucleatum</i>  [in Japanese]

    YOSHIHARA Tsutomu , NAKAJIMA Atsushi , NOGAMI Asako , TAKATSU Tomohiro , MISAWA Noboru , ASHIKARI Keiichi , MATSUURA Tetsuya , FUYUKI Akiko , OKUBO Hidenori , HIGURASHI Takuma

    <p>大腸癌と関連する腸内細菌の研究は,<i>Fusobacterium (F.) nucleatum</i>が発癌や癌の進行に大きな役割を担っている可能性を指摘されてから,短い間に多くの研究報告がみられるようになった.<i>F. nucleatum</i>は炎症を惹起することで発癌や癌の進行に関与し,免疫機構からの回避,癌遺伝子や癌抑制 …

    Journal of Intestinal Microbiology 35(1), 1-11, 2021

    J-STAGE  Ichushi Web 

  • A case report of long-term clinical outcomes in esthetic rehabilitation of discolored maxillary and mandibular anterior teeth with porcelain laminate veneers  [in Japanese]

    Soejima Masakazu

    <p><b>症例の概要</b>:37歳,女性,永久歯萌出時からコンプレックスであった上下前歯部の変色による審美不良を主訴に来院した.術前検査でアンテリアガイダンスの喪失を認めたため咬合調整と抜歯を行った後, 最終補綴装置としてポーセレンラミネートベニアを装着した.</p><p><b>考察</b>:補綴装置装着後10 …

    Annals of Japan Prosthodontic Society 13(1), 62-65, 2021

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  • Lipopolysaccharide and High Concentrations of Glucose Enhances Zoledronate-induced Increase in RANKL/OPG Ratio by Upregulating PGE<sub>2</sub> Production in Osteoblasts

    Nagasaki Maki , Tonogi Morio , Nakai Kumiko , Tanaka Hideki , Ozaki Manami , Kato Kengo , Koshi Ryosuke , Maeno Masao , Nishikubo Shuichi , Kawato Takayuki

    … <p>Preexisting diseases, such as diabetes and chronic inflammation in periodontal tissue, are risk factors associated with bisphosphonate-related osteonecrosis of the jaw. …

    Journal of Hard Tissue Biology 30(1), 37-44, 2021

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  • Periodontal disease and Alzheimer's disease : associations and evidence  [in Japanese]

    松下 健二

    日本歯科医師会雑誌 73(9), 715-723, 2020-12

    Ichushi Web 

  • Involvement of Fusobacterium Species in Oral Cancer Progression : A Literature Review Including Other Types of Cancer

    Fujiwara Natsumi , Kitamura Naoya , Yoshida Kaya , Yamamoto Tetsuya , Ozaki Kazumi , Kudo Yasusei

    … Chronic inflammation caused by infections has been suggested to be one of the most important cause of cancers. … nucleatum is a well-known oral bacterium involved in formation of typical dental plaque on human teeth and causing periodontal diseases. …

    International Journal of Molecular Sciences 21(17), 6207, 2020-08-27

    IR 

  • High Mobility Group Box 1 Expression in Oral Inflammation and Regeneration

    Yamashiro Keisuke , Ideguchi Hidetaka , Aoyagi Hiroaki , Yoshihara-Hirata Chiaki , Hirai Anna , Suzuki-Kyoshima Risa , Zhang Yao , Wake Hidenori , Nishibori Masahiro , Yamamoto Tadashi , Takashiba Shogo

    … HMGB1 mediates various mechanisms such as inflammation, cell migration, proliferation, and differentiation. … In the oral cavity, high levels of HMGB1 have been detected in the gingival tissue from periodontitis and peri-implantitis patients, and it has been shown that secreted HMGB1 induces pro-inflammatory cytokine expression, such as interleukin (IL)-1 beta, IL-6, and tumor necrosis factor (TNF)-alpha, which prolong inflammation. …

    Frontiers in Immunology (11), 1461, 2020-07-14

    IR 

  • Linking oral diseases with stroke and dementia –RAMESSES study  [in Japanese]

    Ihara Masafumi , Saito Satoshi , Hattori Yorito , Hosoki Satoshi , Yamamoto Yumi , Tonomura Shuichi

    … In many epidemiological studies, the relationship of stroke with oral diseases such as dental caries and periodontal disease, so–called "brain-oral association", has been reported. … is presumed to attach to exposed collagen in areas of disrupted blood–brain barrier, induce inflammation, block platelet accumulation, and subsequently induce microbleeds and ICH. …

    Neurological Therapeutics 37(3), 379-384, 2020

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  • Antibacterial, anti-inflammatory, and anti-osteoclastogenic activities of <i>Colocasia antiquorum</i> var. <i>esculenta</i>: Potential applications in preventing and treating periodontal diseases

    MOON Seong-Hee , JI Sang Hee , SON Ju-Lee , SHIN Seong-Jin , OH Seunghan , KIM Seong Hwan , BAE Ji-Myung

    … gingivalis</i>) growth, inflammation, and osteoclastogenesis. …

    Dental Materials Journal 39(6), 1096-1102, 2020

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  • Pathophysiologic Consideration for a Patient with Aggressive Periodontitis Suggesting a Relationship between Periodontal Inflammation and Infertility  [in Japanese]

    Kazuhiro OMORI , Takayuki KONO , Hiroya KOBAYASHI , Hideo ARAI , Tadashi YAMAMOTO , Shogo TAKASHIBA

    <p> 緒言 : 歯周病原細菌の感染と歯周組織の炎症が, 妊娠に影響を与える可能性が報告されている. 今回, 不妊治療の経過が思わしくない侵襲性歯周炎患者に感染源除去の観点から専門的歯周治療を行い, 自然妊娠から正常出産にいたった症例の経過をふまえ病態を考察する.</p><p> 症例 : 33歳, 女性, 既婚 (不妊治療中). 2016年9月, 26の動揺およ …

    The Japanese Journal of Conservative Dentistry 63(5), 451-460, 2020

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  • Periodontal bacteria induce innate immune response, resulting in induction of the chronic inflammation and the mucosal barrier dysfunction  [in Japanese]

    Tada Hiroyuki

    … <p> Periodontal disease is one of the major diseases afflicting human beings and is caused by a bacterial infection leading to gingival inflammation, periodontal tissue destruction, alveolar bone loss, and eventually to tooth loss. … Chronic periodontitis is one of the major periodontal diseases, and the periodontal pathogen <i>Porphyromonas gingivalis</i> …

    Endotoxin and Innate Immunity 23(0), 7-11, 2020

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  • Case report of comprehensive treatment of a generalized chronic periodontitis patient with skeletal mandibular prognathism  [in Japanese]

    Ishida Naoyuki , Masuda Yoshiko , Yoshinari Nobuo , Yamaguchi Masato , Takada Masaki , Kagami Hideaki , Yamada Kazuhiro , Ishioka Yasuaki , Uehara Ryuichi , Ozaki Yuki , Ishihara Yuichi

    … 現在初診より13年が経過,歯周病安定期治療(Supportive periodontal therapy:SPT)へ移行してから6年経過しているが,良好に歯周組織と咬合の安定が維持されている。 …

    Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) 62(3), 168-181, 2020

    J-STAGE  Ichushi Web 

  • Analysis of patient's understanding of dental related words at Kyushu Dental University Hospital  [in Japanese]

    Usui Michihiko , Onizuka Satoru , Kasai Shingo , Sano Kotaro , Hanatani Tomoya , Konoo Tetsuro , Nakashima Keisuke

    <p>歯科医療従事者間で日常使用される歯科専門用語は,患者にとって難解なものも多い。医療面接の際に,患者に理解されない専門用語を使用することは,不十分な医療コミュニケーションの原因となり,良好な歯科医師・患者関係を構築する足枷となる可能性がある。本研究では,我々の使用する歯科専門用語を患者がどの程度理解しているか調査し,2006年に実施した前回調査と比較した。九州歯科大学附属病院に来院 …

    Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) 62(3), 136-146, 2020

    J-STAGE  Ichushi Web 

  • Relationship between Obesity Indicators and Gingival Inflammation in Middle-aged Japanese Men

    Suzuki Seitaro , Onose Yuki , Yoshino Koichi , Takayanagi Atsushi , Kamijo Hideyuki , Sugihara Naoki

    … The purpose of this study was to investigate the relationship among the waist-to-height ratio (WHtR) and the body mass index (BMI) as obesity indicators and gingival inflammation as determined by bleeding on probing (BOP). …

    The Bulletin of Tokyo Dental College 61(3), 153-160, 2020

    J-STAGE 

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