Search Results 1-20 of 535

  • Lifestyle modifications as a non-pharmacological therapy of hypertension  [in Japanese]

    土橋 卓也

    日本臨床 = Japanese journal of clinical medicine 78(2), 266-271, 2020-02

  • Pharmacological properties and clinical efficacy of rasagiline mesylate (Azilect<sup>®</sup>)  [in Japanese]

    Nagai Masahiro , Hattori Nobutaka

    <p>パーキンソン病は主に運動緩慢,振戦,強剛及び姿勢保持障害が運動症状として現れる神経変性疾患であり,病理学的特徴として黒質ドパミン作動性ニューロンの脱落による線条体ドパミン量の減少が挙げられる.パーキンソン病の治療は対症療法であるドパミン補充療法が中心となっており,モノアミン酸化酵素B(MAO-B)阻害薬を投与する治療では線条体でのドパミン代謝を阻害して脳内ドパミン濃度を増加させる …

    Folia Pharmacologica Japonica 155(3), 187-194, 2020

    J-STAGE 

  • Radiolabeled proteins for the development of biopharmaceuticals  [in Japanese]

    Harada Ryuichi , Morito Takahiro , Yanai Kazuhiko

    <p>ポジトロン断層撮影法(PET)による分子イメージングはポジトロン放出核種で標識された放射性薬剤(=PETプローブ)を,臨床的に薬理作用を示さない極微量(~数μg)で生体に投与し,薬剤から放出される消滅ガンマ線の分布を3次元に画像化する技術である.PETは標識化合物の薬物動態評価の他に標的分子に直接作用したか(target engagement:proof-of-mechanism …

    Folia Pharmacologica Japonica 155(3), 159-163, 2020

    J-STAGE 

  • Recommendations for VTE Prophylaxis in Medically Ill Patients

    Skeik Nedaa , Westergard Emily

    … Because many acutely ill medical patients have multiple comorbidities, the risk of major bleeding must be considered when choosing to implement pharmacological VTE prophylaxis. … Our paper reviews the current evidence and reasoning for appropriate selection of VTE prophylaxis in acutely medical ill patients, and highlights our own approach and recommendations.</p> …

    Annals of Vascular Diseases 13(1), 38-44, 2020

    J-STAGE 

  • Pathological mechanisms and novel therapeutic outlooks for sepsis-associated acute lung injury  [in Japanese]

    Hattori Yuichi , Hattori Kohshi , Matsuda Naoyuki

    … Given that sepsis can be regarded as a gene-related disorder, the potential usefulness of systemic delivery of decoy oligodeoxynucleotide against some transcription factors may be considered to be a promising novel therapeutic approach for treatment of acute lung injury in sepsis.</p> …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-S34-3, 2020

    J-STAGE 

  • Resolvins & Pro-Resolving Mediators with Novel Mechanisms in Infectious-Inflammation  [in Japanese]

    Serhan Charles N.

    … Using a systems approach with self-limited inflammatory infectious exudates to map tissue events, cell traffic and identification of protein and chemical mediators, we uncovered three structurally distinct families of potent omega-3 fatty acid-derived (EPA, DPA, DHA) novel endogenous mediators, named<b> …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-SL09, 2020

    J-STAGE 

  • A Chemical Approach to Controlling Cell Fate  [in Japanese]

    Ding Sheng

    <p>Recent advances in stem cell biology may make possible new approaches for the treatment of a number of diseases. A better understanding of molecular mechanisms that control stem cell fate as …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-SL10, 2020

    J-STAGE 

  • Analysis of contractile functions of human iPS-derived cardiomyocytes using motion field imaging  [in Japanese]

    Kurokawa Junko , Sakamoto Kazuho , Yamaguchi Masahiko

    … <p>Human iPS cell-derived cardiomyocyte (hiPSC-CM) is conceptually promising as an unlimited source of human cardiomyocytes for cardiac pharmacological assessment including pre-clinical safety testing. … In order to improve the accuracy of pharmacological assessment, we conducted a multidisciplinary approach for developing new methods to evaluate effects of drugs on contractile functions. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-S29-2, 2020

    J-STAGE 

  • High throughput screening in silico via computer models of induced-pluripotent stem cell derived cardiomyocytes  [in Japanese]

    Clancy Colleen E.

    … A major strength of this approach is that iPSC-CMs contain donor genetic information and therefore capture patient-specific genotype-phenotype relationships. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-S29-3, 2020

    J-STAGE 

  • Assessment of developmental neurotoxicity using human iPS cells  [in Japanese]

    Kazunobu Tsunemoto , Yamada Shigeru , Kanda Yasunari

    … </p><p>Because current developmental neurotoxicity (DNT) guideline (OECD TG426) requires a lot of animals and costs, it is necessary to establish more predictable approach using human iPS cells (hiPSCs). …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-P-374, 2020

    J-STAGE 

  • Development of Alveolar Epithelial Type II Cells from Human Induced Pluripotent Stem Cells  [in Japanese]

    Kayoko Tsuji , Kanda Yasunari

    … However, it is difficult to obtain human lung cells and culture the cells for a long-term period to explore the mechanistic approach for the adverse effects. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-P-369, 2020

    J-STAGE 

  • Voluntary wheel running improves cardiac dysfunction associated with cancer cachexia induced by human stomach cancer cell line 85As2  [in Japanese]

    Nonaka Miki , Ueno Susumu , Kakigi Ryo , Kurebayashi Nagomi , Murayama Takashi , Miyano Kanako , Terawaki Kiyoshi , Sakurai Takashi , Uezono Yasuhito

    … Additionally, VWR could improve cachexia-induced cardiac dysfunction, suggesting exercise on cardiac dysfunction in cancer patients with cachexia is a possible therapeutic approach.</p> …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-O-128, 2020

    J-STAGE 

  • Cognitive dysfunction in new animal model for schizophrenia with suppression of presynaptic protein Piccolo in the prefrontal cortex of mice is involved in disturbance of neuronal network in the perirhinal cortex  [in Japanese]

    Miyamoto Yoshiaki , Oketani Yuki , Hamatani Kohei , Muramatsu Shin-ichi , Nitta Atumi

    … Accordingly, improvement of disturbed PFC-PRC-vHIP network could be a therapeutic approach for cognitive dysfunction in schizophrenia.</p> …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-O-100, 2020

    J-STAGE 

  • Long interspersed element-1 retrotransposition induced by valproic acid depends on NR2A  [in Japanese]

    Okudaira Noriyuki

    … Overall, L1-RTP induced by valproic acid is a novel type of genomic instability, and analysis of this phenomenon might be a novel approach to elucidate the mechanism of substance-use disorders.</p><p></p> …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-P-252, 2020

    J-STAGE 

  • Safe opioid analgesics targeting nociceptin receptor in primates  [in Japanese]

    Kiguchi Norikazu , Ko Mei-Chuan

    … Given that the nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor agonists exert antinociception without producing nonpreferable effects at analgesic doses in nonhuman primates, we hypothesized that bifunctional NOP/MOP agonists may be a viable approach to generate safer opioid analgesics. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-S20-4, 2020

    J-STAGE 

  • Ubiquitin-proteasome drug development with SNIPER technology  [in Japanese]

    Naito Mikihiko

    … <p>Development of potent inhibitors against disease-related proteins, such as oncogenic kinases, is a promising approach for novel drug discovery. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-S21-4, 2020

    J-STAGE 

  • exploring mechanisms of renal fibrosis progression  [in Japanese]

    Nakano Daisuke

    … The sophisticated architecture of nephron made its physiology difficult to unravel and the variety for experimental approach for renal (patho)physiology is limited so far. … Another hand, from the pharmacological viewpoint, one of the biggest problem on the anti-renal fibrotic drug development is lacking the good animal model. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-S22-3, 2020

    J-STAGE 

  • Novel protein targets for 15-deoxy-Δ<sup>12,14</sup>-prostaglandin J<sub>2</sub> were identified in neuronal plasma membranes  [in Japanese]

    Yagami Tatsurou , Yamamoto Yasuhiro , Koma Hiromi

    … A proteomic approach with biotinylated 15d-PGJ<sub>2</sub> …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-P-194, 2020

    J-STAGE 

  • The analysis for βCTF mediated vesicular traffic impairment in Alzheimer disease  [in Japanese]

    Takasugi Nobumasa , Kaneshiro Nanaka , Komai Masato , Uehara Takashi

    … We analyzed the event induced by complex formation of TMEM30A and βCTF using biochemical approach.</p><p>[Results]</p><p>We found that βCTF accumulation caused the interaction between TMEM30A and βCTF, which resulted in endosomal characteristic change in SH-SY5Y(BACE1). …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-O-066, 2020

    J-STAGE 

  • Dynamics of neuron-induced astrocyte tiling and self-avoidance  [in Japanese]

    Hayashi Mariko , Sekino Yuko , Sato Kaoru

    … <p>An astrocyte makes thousands of finely branched processes to approach neurons. Each astrocyte expands processes to form an exclusive territory with limited penetration of processes from neighboring astrocytes. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-O-032, 2020

    J-STAGE 

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