Search Results 1-20 of 475

  • Liquid Biopsy Targeting Monocarboxylate Transporter 1 on the Surface Membrane of Tumor-Derived Extracellular Vesicles from Synovial Sarcoma

    Yokoo Suguru , Fujiwara Tomohiro , Yoshida Aki , Uotani Koji , Morita Takuya , Kiyono Masahiro , Hasei Joe , Nakata Eiji , Kunisada Toshiyuki , Iwata Shintaro , Yonemoto Tsukasa , Ueda Koji , Ozaki Toshifumi

    … Simple Summary Synovial sarcoma (SS) is associated with a high risk of recurrence and poor prognosis, and no biomarker useful in monitoring tumor burden exists. … Patients with MCT1 expression on the plasma membrane have significantly worse overall survival than those with nuclear expression. … Immunohistochemistry revealed that MCT1 was positive in 96.7% of SS specimens and its expression on the cytoplasm/plasma membrane was significantly associated with worse overall survival (p = 0.002). …

    Cancers 13(8), 1823, 2021-04-11

    IR 

  • Identification and Validation of Combination Plasma Biomarker of Afamin, Fibronectin and Sex Hormone-Binding Globulin to Predict Pre-eclampsia

    Uchida Yasuo , Kinoshita Kengo , Yaegashi Nobuo , Yamamoto Masayuki , Terasaki Tetsuya , Sugawara Junichi , Higuchi Tomoya , Shirota Matsuyuki , Kagami Satoshi , Saigusa Daisuke , Koshiba Seizo , Yasuda Jun , Tamiya Gen , Kuriyama Shinichi

    … <p>The purpose of the present study was to identify a plasma protein biomarker able to predict pre-eclampsia (PE). …

    Biological and Pharmaceutical Bulletin 44(6), 804-815, 2021

    J-STAGE 

  • Health examination results and work environment factors affecting urinary 8-hydroxy-2′-deoxyguanosine levels

    Watanabe Sintaroo , Li Yun-Shan , Kawasaki Yuya , Ootsuyama Yuko , Kawai Kazuaki

    … On the other hand, the urinary 8-OHdG level was negatively associated with high plasma LDL-cholesterol levels in non-smokers and anemia.</p><p><b>Conclusion</b>: According to the results, anemia decreased the oxidative stress, regardless of smoking status, while leanness or high blood sugar increased the oxidative stress in smokers, and the presence of plasma cholesterol contributed to the lower oxidative stress in non-smokers. …

    Journal of Occupational Health 63(1), n/a, 2021

    J-STAGE 

  • Comparison of N-terminal pro-atrial natriuretic peptide and three cardiac biomarkers for discriminatory ability of clinical stage in dogs with myxomatous mitral valve disease

    OGAWA Mizuki , MIYAKAWA Hirosumi , HSU Huai-Hsun , MIYAGAWA Yuichi , TAKEMURA Naoyuki , HORI Yasutomo , KANNO Nobuyuki , IWASA Naoki , TOYOFUKU Takeshi , ISAYAMA Noriko , YOSHIKAWA Akane , AKABANE Ryota , SAKATANI Atsushi

    … <p>Plasma N-terminal pro-atrial natriuretic peptide (NT-proANP) concentration increases with progression of myxomatous mitral valve disease (MMVD) in dogs. … This multicentre, prospective study compared plasma NT-proANP, N-terminal pro-brain natriuretic peptide (NT-proBNP), ANP, and cardiac troponin I (cTnI) concentrations in dogs with MMVD for their characteristics and discriminatory ability to detect cardiac dilatation and congestive heart failure (CHF). …

    Journal of Veterinary Medical Science 83(4), 705-715, 2021

    J-STAGE 

  • Current status and prospects of phenotype analysis of drug transporters using endogenous metabolites  [in Japanese]

    Kusuhara Hiroyuki

    … demonstration that they are substrates of drug transporters, the fact that pharmacokinetic parameters of a set of endogenous substrates of the drug transporters, such as area under the plasma concentration-time curve (AUC), or renal clearance (CL<sub>R</sub>), are significantly associated with altered activities of the drug transporters supported that such endogenous substrates serve as clinical biomarker for the transporters. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 2-S23-2, 2021

    J-STAGE 

  • Feasibility of canstatin, a cleaved product of type IV collagen α2 chain, as a novel biomarker and therapeutic target in cardiac diseases  [in Japanese]

    Okada Muneyoshi

    Plasma canstatin concentration was decreased in monocrotaline-induced pulmonary hypertensive rat which was negatively correlated with the increase of right ventricular weight. … These findings may contribute to the development of innovative drug and biomarker targeting canstatin for cardiac diseases.</p> …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 2-S21-3, 2021

    J-STAGE 

  • Quantitative evaluation of <i>PTPN22</i> copy number variation by digital droplet PCR and association with type 2 diabetes risk

    Li Jiajun , Wang Yue , Zheng Xiao , Sheng Jie , Guo Hui , Long Wenlin , Xu Yao

    … CNV with fasting plasma glucose and glycated hemoglobin were demonstrated in T2D patients. … Statistical association analysis investigated that the T2D individuals carrying CN gain showed higher plasma glucose and lower insulin levels than those carrying CN normal and loss at 60 min/120 min/180 min during an OGTT test. … CNV may be a promising biomarker for predicting T2D risk, or a clinical target for T2D diagnosis and therapy.</p> …

    Endocrine Journal 68(2), 153-162, 2021

    J-STAGE 

  • JF1/B6F1 <i>Ngly1</i><sup>−/−</sup> mouse as an isogenic animal model of NGLY1 deficiency

    ASAHINA Makoto , FUJINAWA Reiko , FUJIHIRA Haruhiko , MASAHARA-NEGISHI Yuki , ANDOU Tomohiro , TOZAWA Ryuichi , SUZUKI Tadashi

    … mice showed increased levels of plasma and urinary aspartylglycosamine, a potential biomarker for NGLY1 deficiency. …

    Proceedings of the Japan Academy, Series B 97(2), 89-102, 2021

    J-STAGE 

  • Increased Circulating Cathepsin L in Patients with Coronary Artery Disease

    Yu Chenglin , Wan Ying , Xu Wenhu , Jin Xiongjie , Zhang Shengming , Xin Minglong , Jiang Haiying , Cheng Xianwu

    … This study investigated the hypothesis that plasma CatL is associated with the prevalence of coronary artery disease (CAD). … Plasma CatL and high-sensitive C-reactive protein (hs-CRP) and high-density lipoprotein cholesterol were measured. … The patients with CAD had significantly higher plasma CatL levels compared to the controls (1.4 ± 0.4 versus 0.4 ± 0.2 ng/mL, <i>P</i> …

    International Heart Journal 62(1), 9-15, 2021

    J-STAGE 

  • Plasma miR223 is a possible biomarker for diagnosing patients with severe atopic dermatitis

    Yasuike Risa , Tamagawa-Mineoka Risa , Nakamura Naomi , Masuda Koji , Katoh Norito

    Allergology International 70(1), 153-155, 2021

    J-STAGE 

  • Plasma biomarker for cerebral amyloid deposition using mass spectrometry  [in Japanese]

    金子 直樹

    臨床放射線 65(11), 1199-1205, 2020-10

  • Black Soybean Improves Vascular Function and Blood Pressure: A Randomized, Placebo Controlled, Crossover Trial in Humans

    Yamashita Yoko , Nakamura Asuka , Nanba Fumio , Saito Shizuka , Toda Toshiya , Nakagawa Junichi , Ashida Hitoshi

    … Body composition, vascular function, biomarkers for oxidative stress, and polyphenol contents in the urine and the plasma were measured. … Moreover, nitric oxide levels in plasma and urine were increased, while an oxidative stress biomarker, 8-hydroxy-2'-deoxyguanosine level, in the plasma was decreased accompanied by an increase in the concentration of polyphenols derived from black soybean in plasma and urine. …

    Nutrients 12(9), 2755, 2020-09

    IR 

  • Plasma vasohibin-1 and vasohibin-2 are useful biomarkers in patients with esophageal squamous cell carcinoma

    Yamamoto Miho , Ozawa Soji , Ninomiya Yamato , Koyanagi Kazuo , Oguma Junya , Kazuno Akihito , Hara Hitoshi , Yatabe Kentaro , Kajiwara Hiroshi , Nakamura Naoya , Sato Yasufumi

    Esophagus : official journal of the Japan Esophageal Society 17(3), 289-297, 2020-07

    Ichushi Web 

  • Proteomic profiling of HTLV-1 carriers and ATL patients reveals sTNFR2 as a novel diagnostic biomarker for acute ATL

    Guerrero Carmina Louise Hugo , Yamashita Yoshiko , Miyara Megumi , Imaizumi Naoki , Kato Megumi , Sakihama Shugo , Hayashi Masaki , Miyagi Takashi , Karimata Kaori , Uchihara Junnosuke , Ohshiro Kazuiku , Todoroki Junpei , Nakachi Sawako , Morishima Satoko , Karube Kennosuke , Tanaka Yuetsu , Masuzaki Hiroaki , Fukushima Takuya

    … In this study, we analyzed blood plasma profiles of asymptomatic HTLV-1 carriers (ACs); … Through SOMAscan, expression levels of 1305 plasma proteins were analyzed in 85 samples (AC, n = 40; … Quantification of sTNFR2 in 102 plasma samples (AC, n = 30; … No correlation between sIL-2 and sTNFR2 levels in acute ATL was found, suggesting the possibility of sTNFR2 as an independent biomarker. …

    Blood Advances 4(6), 1062-1071, 2020-03-24

    IR 

  • Study of glycosylation of prostate-specific antigen secreted by cancer tissue-originated spheroids reveals new candidates for prostate cancer detection

    Ideo Hiroko , Kondo Jumpei , Nomura Taisei , Nonomura Norio , Inoue Masahiro , Amano Junko

    … Prostate-specific antigen (PSA) is the most frequently used biomarker for the screening of prostate cancer. … The glycan profile of PSA from CTOS was determined by comparing with PSA from normal seminal plasma and cancer cell lines (LNCaP and 22Rv1) using lectin chromatography and mass spectrometry. … PSA from CTOS was mostly sialylated and the content of Wisteria floribunda agglutinin reactive glycan (LacdiNAc) was similar to that of PSA derived from seminal plasma and 22Rv1. …

    Scientific Reports (10), 2020-02-17

    IR 

  • A New Serum Biomarker Set to Detect Mild Cognitive Impairment and Alzheimer's Disease by Peptidome Technology

    Abe Koji , Shang Jingwei , Shi Xiaowen , Yamashita Toru , Hishikawa Nozomi , Takemoto Mami , Morihara Ryuta , Nakano Yumiko , Ohta Yasuyuki , Deguchi Kentaro , Ikeda Masaki , Ikeda Yoshio , Okamoto Koichi , Shoji Mikio , Takatama Masamitsu , Kojo Motohisa , Kuroda Takeshi , Ono Kenjiro , Kimura Noriyuki , Matsubara Etsuro , Osakada Yosuke , Wakutani Yosuke , Takao Yoshiki , Higashi Yasuto , Asada Kyoichi , Senga Takehito , Lee Lyang-Ja , Tanaka Kenji

    … blood sample is more feasible and plausible than CSF or radiological biomarkers for screening potential AD, measurements of serum amyloid- β (Aβ), plasma tau, and serum antibodies for Aβ1 - 42 are not yet well established.</br>Objective:</br>We aimed to identify a new serum biomarker to detect mild cognitive impairment (MCI) and AD in comparison to cognitively healthy control by a new peptidome technology.</br>Methods:</br>With only 1.5μl of serum, we examined a new target plate "BLOTCHIP®" …

    Journal of Alzheimer's Disease 73(1), 217-227, 2020-01-07

    IR 

  • Discovery of Levodopa Prodrug ONO-2160  [in Japanese]

    Kokubo Masaya , Kinoshita Atsushi , Kodera Yasuyo , Koyanagi Takashi , Maruyama Toru

    <p>パーキンソン病治療薬として上市されているレボドパは、脳内にドパミンを補充する薬剤として広く用いられており、最も治療効果の高い薬剤である。しかしながら、レボドパは血漿中での代謝により血中半減期が短く、頻回投与が必要であることが課題である。筆者らは、レボドパの動態的課題を克服するため、レボドパのプロドラッグ化に着想し研究を行った。700以上のレボドパプロドラッグを合成し、イヌでの動態 …

    MEDCHEM NEWS 30(3), 126-132, 2020

    J-STAGE 

  • Plasma phosphorykated–tau as a blood–based biomarker for Alzheimer's disease quantified with ultra–sensitive digital ELISA  [in Japanese]

    Tokuda Takahiko

    … In this context, we have developed a novel ultrasensitive immunoassay using an ultrasensitive digital array technology (Simoa system, Quanterix) to quantify plasma tau phosphorylated at threonine 181 (p–tau181) in 2017.</p><p>In the first cohort composed of 20 AD patients and 15 age–matched controls, the plasma levels of p–tau181 were significantly higher in the AD patients than those in the controls. …

    Neurological Therapeutics 37(3), 335-338, 2020

    J-STAGE 

  • Metabolic Groups Related to Blood Vitamin Levels and Inflammatory Biomarkers in Brazilian Children and Adolescents

    ALMADA Maria Olímpia Ribeiro do Vale , BARROS Tamiris Trevisan de , CAMELO-JUNIOR José Simon , MOCO Sofia , KAPUT Jim , MONTEIRO Jacqueline Pontes , ALMEIDA Ane Cristina Fayão , UED Fábio da Veiga , MATHIAS Mariana Giaretta , COELHO-LANDELL Carolina de Almeida , SALOMÃO Roberta Garcia , TOFFANO Roseli Borges Donegá , CAMARNEIRO Joyce Moraes , HILLESHEIM Elaine

    … were (i) to determine whether different metabolic profiles of B-vitamins and vitamin A in Brazilian children and adolescents were positively or negatively related to homocysteine and omega-3 fatty acids using k-means clustering analysis, (ii) compare nutrient intakes and metabolites between the different metabolic profiles, (iii) evaluate if the statistically significant metabolites found between the metabolic groups, can predict the variation of leukotriene A4 hydrolase (LTA4H) levels, a biomarker of low-grade inflammation, in the total studied …

    Journal of Nutritional Science and Vitaminology 66(6), 515-525, 2020

    J-STAGE 

  • Low-Dose Ethanol Has Impacts on Plasma Levels of Metabolites Relating to Chronic Disease Risk in SAMP8 mice

    FU Churan , YANG Yongshou , KUMRUNGSEE Thanutchaporn , KIMOTO Akiko , IZU Hanae , KATO Norihisa

    … This study examined plasma metabolites in senescence-accelerated mice 8 (SAMP8) given low-dose ethanol, and compared them with aging progress and skeletal muscle strength. … Plasma metabolites of control, 1% and 2% ethanol groups were analyzed by capillary electrophoresis–time-of-flight mass spectrometry (CE-TOF/MS). …

    Journal of Nutritional Science and Vitaminology 66(6), 553-560, 2020

    J-STAGE 

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