Search Results 1-20 of 412

  • Combination of host immune metabolic biomarkers for the PD-1 blockade cancer immunotherapy

    Hatae Ryusuke , Chamoto Kenji , Kim Young Hak , Sonomura Kazuhiro , Taneishi Kei , Kawaguchi Shuji , Yoshida Hironori , Ozasa Hiroaki , Sakamori Yuichi , Akrami Maryam , Fagarasan Sidonia , Masuda Izuru , Okuno Yasushi , Matsuda Fumihiko , Hirai Toyohiro , Honjo Tasuku

    … Current clinical biomarkers for the programmed cell death 1 (PD-1) blockade therapy are insufficient because they rely only on the tumor properties, such as programmed cell death ligand 1 expression frequency and tumor mutation burden. … We investigated levels of plasma metabolites and T cell properties, including energy metabolism markers, in the blood of patients with non-small cell lung cancer before and after treatment with nivolumab (n = 55). …

    JCI Insight 5(2), 2020-01-30


  • Next-generation Antibody-drug Conjugates (ADCs): Exploring New Frontiers with Chemical Approaches  [in Japanese]

    Anami Yasuaki , Tsuchikama Kyoji

    … They are expected to revolutionize current cancer treatment strategies and regimens. … In this paper we describe branched linkers, efficient conjugation methods for constructing homogeneous branched ADCs, and a novel tripeptide linker that retains responsiveness to enzymatic drug release and stability in both mouse and human plasma. …

    Journal of Synthetic Organic Chemistry, Japan 78(5), 503-515, 2020


  • Possibility for Dose Optimization of Pazopanib from Its Plasma Concentration in Japanese Patients with Cancer

    Tanaka Hiroyuki , Hiraga Hiroaki , Takekuma Yoh , Harabayashi Toru , Nagamori Satoshi , Endo Masayuki , Sugawara Mitsuru

    … Forty patients who received pazopanib for renal cancer or soft-tissue sarcoma at the Hokkaido Cancer Center were evaluated prospectively. … for pazopanib was calculated based on the measured values from the plasma samples. … However, therapeutic drug monitoring is necessary during pazopanib therapy.</p> …

    Biological and Pharmaceutical Bulletin 43(5), 762-766, 2020


  • Ability of plasma-activated acetated Ringer's solution to induce A549 cell injury is enhanced by a pre-treatment with histone deacetylase inhibitors

    Adachi Tetsuo , Matsuda Yumiko , Ishii Rika , Kamiya Tetsuro , Hara Hirokazu

    … <p>Non-thermal plasma (NTP) is applicable to living cells and has emerged as a novel technology for cancer therapy. … NTP affect cells not only by direct irradiation, but also by an indirect treatment with previously prepared plasma-activated liquid. …

    Journal of Clinical Biochemistry and Nutrition, 2020


  • A Case of IgG4-Related Pharyngeal Ulcer  [in Japanese]

    Ishida Masayuki , Fujisaka Michiro , Shojaku Hideo , Abe Hideharu , Maeda Chihiro , Takii Koji , Oi Yutaro , Ito Shinsuke , Nakanishi Akihito , Tachino Hirohiko , Takakura Hiromasa

    … <p>IgG4-related disease (IgG4-RD) is a multi-organ disease characterized by elevated serum IgG4 concentrations, tissue infiltration by IgG4-positive plasma cells, and hypertrophic lesions with fibrosis. … Various organs can be involved, including the salivary glands, thyroid, pancreas, bile duct, retroperitoneum, etc.</p><p>A 71-year-old man who had received radiation therapy for laryngeal cancer presented to us with swallowing difficulty, dyspnea and anemia. …

    Practica Oto-Rhino-Laryngologica 113(3), 167-173, 2020


  • A study of the relationship between the pineal, immune mechanisms and cancer : a historical survey(1)Immunocytes in the pineal region and the relationship between the pineal and cancer  [in Japanese]

    加地 隆 , 加地 眸

    … Pineal and cancer, and pineal roles in body's defense mechanisms: 1) Following a paper on pineal size increase in cancer autopsy cases in 1967, papers showing similar or decrease results were reported. … 2) At the first international meeting on the pineal gland and cancer in 1977, the pineal was recognized as one of the neuroendocrine factors that should be studied in relation to oncogenic processes, and thereafter the research activity was accelerated. …

    弘前医療福祉大学紀要 10(1), 1-13, 2019-03-28

    IR  Ichushi Web 

  • Molecular mechanisms of non-thermal plasma-induced effects in cancer cells

    Tanaka Hiromasa , Mizuno Masaaki , Ishikawa Kenji , Toyokuni Shinya , Kajiyama Hiroaki , Kikkawa Fumitaka , Hori Masaru

    Plasma is the fourth state of matter with higher energy than gas; … non-thermal plasma (NTP) is currently available. … As NTP is useful in sterilization, promoting wound healing and cancer treatments, the molecular mechanisms of plasma-induced effects in living cells and microorganisms are of significant interest in plasma medicine with medical-engineering collaboration. …

    Biological Chemistry 400(1), 87-91, 2019-01


  • Involvement of ALOX in resistance or sensitivity of cancer treatment via plasma membrane oxidation state.  [in Japanese]

    Tomita Kazuo , Takemura Motohiko , Nishiyama Nobuyoshi , Fukumoto Manabu , Nishitani Yoshihiro , Kurimasa Akihiro , Sato Tomoaki , Kuwahara Yoshikazu , Igarashi Kento , Takashi Yuko , Nagasawa Taisuke , Nabika Hideki , Tanaka Koh-ichi , Kitaknaka Junichi , Kitanaka Nobue

    … <p>Although radiation therapy is one of the choices to treat cancers and is an excellent local treatment method, existence of radiation resistant cell is a major problem. … We investigated the relationships between resistant mechanism to hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) and plasma membrane state in CRR cells. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 2-O-12, 2019


  • A specific PET tracer for L-type amino acid transporter 1 (LAT1) differentiates the function of transporter in tumors from that in inflammatory lesions  [in Japanese]

    Wiriyasermkul Pattama , Watabe Tadashi , Kongpracha Pornparn , Tanaka Yoko , Moriyama Satomi , Naka Sadahiro , Hatazawa Jun , Kanai Yoshikatsu , Nagamori Shushi

    … <p>LAT1 (SLC7A9) is a large-neutral amino acid transporter that forms heterodimer with CD98hc to function at the plasma membrane. … LAT1 is a target for cancer diagnosis and therapy due to its important roles on cancer cell growth. … PET imaging using FDG is a common cancer diagnosis. … LAT1 formed complex with CD98hc at the plasma membrane in tumors. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 1-P-107, 2019


  • Rapid measurement of plasma concentration of a molecular targeted agent, imatinib, with diamond sensor.  [in Japanese]

    Sawamura Seishiro , Razvina Olga , Ogata Genki , Watanabe Kota , Asai Kai , Hanawa Ai , Einaga Yasuaki , Hibino Hiroshi

    … Therefore, it is difficult to expect the effects of the therapy. … Optimization of the administration protocol for individual patients requires immediate determination of plasma level of the compounds at clinical site. … We examined guinea-pig plasma containing imatinib at different concentrations. … The methodology described here may contribute to advances in pharmacotherapies for cancer.</p> …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 1-P-131, 2019



    CHINO Akiko

    … <p>Radiation therapy is increasingly the first choice of treatment for pelvic malignancies such as prostate cancer and uterine cancer. … We propose the following classification of RP in order to systematically perform treatment with argon plasma coagulation (APC): Type A, localized telangiectasia; …

    GASTROENTEROLOGICAL ENDOSCOPY 61(10), 2379-2387, 2019

    J-STAGE  Ichushi Web 

  • Current management and emerging treatment strategies for multiple myeloma

    LEI Matthew , KIM E. Bridget , BRANAGAN Andrew , LOU Uvette , ZEMEL Melanie , RAJE Noopur

    … <p>Multiple myeloma is a malignant plasma cell neoplasm that is incurable despite significant progress in treatment over the past several decades. … The current strategy for newly diagnosed myeloma involves induction, consolidation, and maintenance therapy. …

    Rinsho Ketsueki 60(9), 1243-1256, 2019

    J-STAGE  Ichushi Web 

  • Recurrent ataxia and respiratory failure with probable paraneoplastic syndrome responsive to plasma exchange therapy  [in Japanese]

    Kondo Toshiyuki , Igari Ryosuke , Sato Hiroyasu , Iseki Chifumi , Ishizawa Kenichi , Suzuki Kyoko

    … Steroid pulse therapy and plasma exchange (PE) were performed. … In response to the therapy, all these symptoms were relieved, and NPPV and tube feeding were withdrawn. … Although paraneoplastic neurological syndrome associated with prostatic cancer is rare, immunotherapy could be a therapeutic choice to relive symptoms.</p> …

    Rinsho Shinkeigaku 59(6), 339-344, 2019

    J-STAGE  Ichushi Web 

  • Toward Personalized Cancer Therapy with Oral Molecular-targeted Agents  [in Japanese]

    Yamaguchi Hiroaki , Takasaki Shinya , Kikuchi Masafumi , Kawasaki Yoshihide , Arai Yoichi , Mano Nariyasu

    … <p>Oral molecular-targeted agents are used clinically for the treatment of various types of cancer. … We examined the relationship between the plasma concentration of drugs and clinical findings, such as side effects and treatment effects, at our hospital. …

    YAKUGAKU ZASSHI 139(6), 911-915, 2019

    J-STAGE  Ichushi Web 

  • Gemcitabine-induced thrombotic microangiopathy requiring hemodialysis: Two case reports  [in Japanese]

    Koshino Akihiko , Ochi Masahiko , Kobayashi Taku , Shiraishi Shiori , Kamikawa Yasutaka , Nose Chikako , Kawabata Masahiko

    … <p>Case 1: Gemcitabine was administered to a male of over 70 years of age due to the postoperative recurrence of pancreatic cancer. … The gemcitabine was stopped, and treatment with steroid pulse therapy, plasma exchange, and hemodialysis was started. …

    Nihon Toseki Igakkai Zasshi 52(3), 191-197, 2019

    J-STAGE  Ichushi Web 

  • A Low Crizotinib Concentration in the Cerebrospinal Fluid Causes Ineffective Treatment of Anaplastic Lymphoma Kinase-positive Non-small Cell Lung Cancer with Carcinomatous Meningitis

    Okimoto Tamio , Tsubata Yukari , Hotta Takamasa , Hamaguchi Megumi , Nakao Mika , Hamaguchi Shun-ichi , Hamada Akinobu , Isobe Takeshi

    … His cancer recurred with brain metastases and carcinomatous meningitis. … We started whole-brain radiation therapy (WBRT) and subsequently administered crizotinib. … The concentration of crizotinib on day 15 in the plasma was 158 ng/mL, and that in the spinal fluid was 4.32 ng/mL. … WBRT may elevate the CSF/plasma crizotinib concentration ratio; …

    Internal Medicine 58(5), 703-705, 2019



    関井 洋輔 , 吉永 光宏 , 中川 勝弘 , 岸川 英史 , 岡 一雅 , 西村 憲二

    … Combined androgen blockade therapy was started, and PSA levels began to decrease gradually. … The plasma cortisol level was not reduced by either the 1 mg or 8 mg dexamethasone suppression test, and the plasma cortisol and ACTHlevels did not respond to the corticotropin-releasing hormone test. … Combined androgen blockade therapy was continued, and inhibitors of adrenocortical synthesis were also administered. …

    泌尿器科紀要 = Acta urologica Japonica 64(4), 175-179, 2018-04

    IR  DOI  Ichushi Web 

  • Palbociclib in combination with letrozole as first-line treatment for advanced breast cancer: A Japanese phase II study

    Masuda Norikazu , Nishimura Reiki , Takahashi Masato , Inoue Kenichi , Ohno Shinji , Iwata Hiroji , Mori Yuko , Hashigaki Satoshi , Muramatsu Yasuaki , Nagasawa Takashi , Umeyama Yoshiko , Toi Masakazu

    … This single‐arm, open‐label, phase II study in 42 Japanese postmenopausal patients with estrogen receptor‐positive/human epidermal growth factor receptor 2‐negative (ER+/HER2−) advanced breast cancer evaluated the efficacy, safety, and pharmacokinetics of first‐line palbociclib (125 mg once daily, 3 weeks on/1 week off) coadministered with letrozole (2.5 mg once daily). …

    Cancer Science 109(3), 803-813, 2018-03-03

    IR  Ichushi Web 

  • Epigenetic Regulation of Pharmacokinetic-related Genes in Human Tissues  [in Japanese]

    Hirota Takeshi

    … The ATP-binding cassette transporter family member breast cancer resistance protein (BCRP) is one of the most important intestinal efflux transporters involved in the intestinal absorption or permeability of drugs. … These results suggest that circulating intestine-derived exosomal miR-328 in plasma has potential as a possible biomarker for estimating BCRP function in human intestines. …

    YAKUGAKU ZASSHI 138(11), 1391-1396, 2018

    J-STAGE  Ichushi Web 


    Okamura-Shiki Ikue , Matsuyama Nobuki , Yasui Kazuta , Hirayama Fumiya , Ikeda Takashi

    … In this study, we attempted to elucidate the source of the sIgE using the patient's plasma and whole blood obtained during the 2-year period encompassing the entire BMT course. …

    Japanese Journal of Transfusion and Cell Therapy 64(5), 649-654, 2018

    J-STAGE  Ichushi Web 

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