Search Results 1-20 of 522

  • Role of O-linked N-acetylglucosamine in the homeostasis of metabolic organs, and its potential links with diabetes and its complications.

    MORINO Katsutaro , MAEGAWA Hiroshi , 森野 勝太郎 , 前川 聡

    … Recent studies using genetically manipulated mouse models have shown the pivotal role of O-linked N-acetylglucosamine modification (O-GlcNAcylation) in the metabolism of multiple organs. …

    Journal of diabetes investigation, 2020-07-12


  • Reduced Tumorigenicity of Mouse ES Cells and the Augmented Anti-Tumor Therapeutic Effects under Parg Deficiency

    Sonoda Yuki , Sasaki Yuka , Gunji Akemi , Shirai Hidenori , Araki Tomonori , Imamichi Shoji , Onodera Takae , Rydén Anna-Margareta , Watanabe Masatoshi , Itami Jun , Honda Takuya , Ashizawa Kazuto , Nakao Kazuhiko , Masutani Mitsuko

    … PolyADP-ribosylation is a post-translational modification of proteins, and poly(ADP-ribose) (PAR) polymerase (PARP) family proteins synthesize PAR using NAD as a substrate. …

    Cancers 12(4), 1056, 2020-04-24


  • Novel Insights Into N-Glycan Fucosylation and Core Xylosylation in C. reinhardtii

    Oltmanns Anne , Hoepfner Lara , Scholz Martin , Zinzius Karen , Schulze Stefan , Hippler Michael

    Chlamydomonas reinhardtii (C. reinhardtii) N-glycans carry plant typical beta 1,2-core xylose, alpha 1,3-fucose residues, as well as plant atypical terminal beta 1,4-xylose and methylated mannoses. In …

    Frontiers in Plant Science (10), 1686, 2020-01-15


  • A Novel Treatment for Arrhythmias via the Control of the Degradation of Ion Channel Proteins

    Miake Junichiro

    … <p>Although there are many reports on the regulation of ion channel expression in transcription and translation, few drugs have been studied to influence post-translational modification of ion channel proteins. …

    Yonago Acta Medica 63(3), 146-153, 2020


  • Analysis of protein post-translational modifications using electrophoresis  [in Japanese]

    Kimura Yayoi

    <p>タンパク質の翻訳後修飾(PTM)は,タンパク質の多様性の創出に寄与し,様々な生物学的プロセスの調節において重要な役割を果たしている.そのため,タンパク質の機能を理解するためにはPTM解析が重要になる.本稿では,著者らのタンパク質PTM解析に関する3つのトピックについて紹介した.1. 2-DEや質量分析を用いて酵母プロテアソーム構成サブユニットのN末端修飾を同定すると共に,変異体解 …

    Electrophoresis Letters 64(1), 1-6, 2020


  • Expression and Post-translational Modification of Heat Shock Protein 27 (HSP27) in Cancer


    <p>熱ショックや低酸素,高酸素,紫外線暴露,栄養不足など様々な刺激により発現誘導される熱ショックタンパク質27(HSP27)は,細胞の恒常性を維持し,細胞の生存を促進するため,分子シャペロンおよび抗アポトーシスタンパク質として機能する.HSP27のリン酸化や糖化など翻訳後修飾やオリゴマー化などの動的変化により,細胞は生理学的機能の変化に適応し,損傷に対する保護応答を開始する.HSP2 …

    Thermal Medicine 36(1), 1-24, 2020

    J-STAGE  Ichushi Web 

  • Stop the "Vicious Cycle" induced by Glycative Stress.

    Yonei Yoshikazu , Yagi Masayuki , Takabe Wakako

    … Glycative stress causes post-translational modifications of protein at the molecular level and increases the risks of various aging-related diseases, such as diabetic complications. … Lysine and arginine in amino acid sequence of insulin are susceptible to carbonyl modification and are resistant against the enzyme reaction to insulin from proinsulin. …

    Glycative Stress Research 7(1), 13-21, 2020


  • The class III histone deacetylase SIRT1-mediated post-translational modification of Ca<sup>2+</sup>-activated K<sup>+</sup> channel K<sub>Ca</sub>3.1 in cancer cells  [in Japanese]

    Ohya Susumu , Kajikuri Junko , Kito Hiroaki , Endo Kyoko

    … Histone deacetylases (HDACs) post-translationally regulate the expression and activity of a number of proteins that play a crucial role in cancer development and progeression. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-O-088, 2020


  • <i>O</i>-GlcNAcylation-mediated degradation of FBXL2 stabilizes FOXM1 oncogenic transcription factor to promote cancer progression  [in Japanese]

    Moriwaki Kazumasa , Ueda Yasuhiro , Higuchi Kazuhide , Asahi Michio

    … <p><i>O</i>-GlcNAcylation is a dynamic and reversible post-translational modification of cytonuclear molecules and critical for intracellular signaling. … The modification is regulated by only two enzymes, OGT and OGA, which add and remove a glucose metabolite, UDP-GlcNAc, respectively. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-O-009, 2020


  • Efficient Synthesis of Marine Alkaloid Ageladine A and its Structural Modification for Exploring New Biological Activity  [in Japanese]

    Iwata Takayuki , Fukase Koichi , Nakao Yoichi , Tanaka Katsunori

    … In addition, structural modification of natural products has been simultaneously received much attention because these modified natural products would show not only enhanced activity and selectivity, but possibly also an entirely distinct bioactivity from those of the parent natural products. … We describe herein a series of study on structual modification of ageladine A for exploring new biological activity. …

    Journal of Synthetic Organic Chemistry, Japan 78(1), 51-59, 2020


  • Glycoproteins and Glycoenzymes in Periodontal Bacteria  [in Japanese]

    村上 幸孝

    蛋白質の多くは、「第3の生命鎖」と呼ばれる糖鎖による翻訳後修飾を受けて、糖蛋白質として機能している。これまでの長い間、糖蛋白質の存在は真核生物のみに限られ、原核生物である細菌にはありえないと信じられてきた。ところが、ようやく近年になって、細菌においても糖蛋白質が発見されてきた。当初はCampylobacter属やNeisseria属で研究が始められ、そしてBacteroides属やその他の属にも拡 …

    岐阜歯科学会雑誌 = The Journal of Gifu Dental Society 46(2), 73-85, 2019-11

    IR  Ichushi Web 

  • Chemical Control of Mammalian Circadian Behavior through Dual Inhibition of Casein Kinase Iα and δ

    Lee Jae Wook , Hirota Tsuyoshi , Ono Daisuke , Honma Sato , Honma Ken-ichi , Park Keunwan , Kay Steve A.


    Journal of Medicinal Chemistry 62(4), 1989-1998, 2019-02-28


  • Crystallization of Pearl Biomineralization Protein in Microgravity Environments

    NAKAE Setsu , SHIONYU Masafumi , OGAWA Tomohisa , SHIRAI Tsuyoshi

    … Additionally, the N-terminal residues of PPL3 isoforms were found in pyroglutamate form in the high-resolution electron densities, which was partly explained by the post-translational modification implied from the discrepancy between amino acid and gene sequences of PPL3 isoforms. …

    International journal of microgravity science and application 36(1), 360105, 2019


  • Novel regulatory mechanism of gene expression by nitric oxide  [in Japanese]

    Uehara Takashi

    … </p><p>Protein <i>S</i>-nitrosylation is an NO-dependent reversible post-translational modification of cysteine that regulates both protein structure and function in bacteria, plants, and mammals. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 3-S21-1, 2019


  • <i>O</i>-GlcNAcylation stabilizes FOXM1 protein via suppression of its poly-ubiquitination  [in Japanese]

    Moriwaki Kazumasa , Ueda Yasuhiro , Higuchi Kazuhide , Asahi Michio

    … <p><i>O</i>-GlcNAcylation is a post-translational modifications regulating dynamic intracellular signaling by two enzymes, OGT and OGA, which add and remove the modification, respectively. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 1-P-094, 2019


  • KANPHOS (Kinase-Associated Phospho-Signaling) Platform - A comprehensive database for kinase-associated neural phosphorylation signaling  [in Japanese]

    Kuroda Keisuke , Nagai Taku , Amano Mutsuki , Yoshimoto Junichiro , Kannon Takayuki , Nishioka Tomoki , Usui Shiro , Kaibuchi Kozo

    … <p>Protein phosphorylation is a major and essential post-translational modification in eukaryotic cells that plays a critical role in various cellular processes. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 1-P-132, 2019


  • Inhibitory mechanisms of glucosamine on the activation of transcription factor NF-κB in synovial cells  [in Japanese]

    Someya Akimasa , Sakamoto Koji , Nagaoka Isao

     グルコサミンは,関節の痛みや違和感などの症状を緩和することを期待し,サプリメントとして使用されている.そして,このような関節症状の緩和にはグルコサミンの抗炎症作用が関与していると考えられている.われわれは,グルコサミンが関節滑膜細胞からの炎症性サイトカインの産生を抑制すること,そして,その抑制には <i>O </i>-N-アセチルグルコサミン( <i&g …

    Functional Food Research 15(0), 67-71, 2019

    J-STAGE  Ichushi Web 

  • Perspective of the regulatory and functional roles of nasal nitric oxide in chronic rhinosinusitis

    Takemoto Kota , Takeno Sachio , Ohtani Atsuko , Takahara Daisuke , Nishida Manabu , Ishino Takashi

    <p>一酸化窒素(NO)は気道防御における恒常性の維持と同時に,炎症性メディエーターとしても機能している。ヒト鼻副鼻腔は生理的に重要なNO産生の場であると同時に,呼気中NO(FeNO)濃度の変化が副鼻腔炎における病態診断や治療効果判定に役立つ可能性を有している。また好酸球性気道炎症のバイオマーカーとしても近年注目を集めている。生体におけるNO産生は3種類のNO合成酵素(NOS)isof …

    Journal of Japan Society of Immunology & Allergology in Otolaryngology 37(4), 233-239, 2019

    J-STAGE  Ichushi Web 

  • Development and Application of Phos-tag Technology for Phosphoproteomics  [in Japanese]

    Kinoshita Eiji

    <p>Phos-tagは,中性の水溶液中においてリン酸モノエステルジアニオンを選択的に捕捉する機能性分子である.Phos-tagのリン酸モノエステルジアニオンに対する親和性は,生体中に存在する他のアニオン,たとえば,カルボン酸アニオンに対するそれよりも1万倍以上大きい.これまでに筆者らは,Phos-tagを基盤としたリン酸化プロテオミクスに有用な技術を開発し,実用化している.本稿では, …

    Proteome Letters 4(2), 49-60, 2019


  • Emerging Function of Cardiac Macrophages Ushers in a New Era for the Electrophysiology of the Heart

    Sugita Junichi , Fujiu Katsuhito

    … In mammalian hearts, Cx43, Cx40, Cx45, and Cx30.2 are expressed and regulated by post-translational modification. …

    Circulation Reports 1(12), 558-563, 2019


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