Search Results 1-20 of 5164

  • COVID-19 and the Political Economy of the "September School Year Start" in Japan: Overlooked Victims and Foregone Revenues  [in Japanese]

    ARAKI Satoshi , AIZAWA Shinichi , OKAMOTO Naoya

    … In response to the COVID-19 pandemic, a"September School Year Start"has become a central topic of discussion in Japan. … Although the primary focus of this article is on a September Start and its consequences, the said approach with close attention to scientific evidence rather than abstract notions is now required for the effective education policy-making and beyond. …

    社会情報研究 = Journal of Information and Communication 2(2), 25-34, 2021-03-26

    IR  DOI 

  • Tracing the Memory of Mizuhiki in Modern and Contemporary Japan  [in Japanese]

    矢島 由佳 , Yajima Yoshika , ヤジマ ヨシカ


    デザイン理論 (77), 37-51, 2021-01-31


  • Crizotinib for recurring non-small-cell lung cancer with EML4-ALK fusion genes previously treated with alectinib: A phase II trial

    Harada Daijiro , Isozaki Hideko , Kozuki Toshiyuki , Yokoyama Toshihide , Yoshioka Hiroshige , Bessho Akihiro , Hosokawa Shinobu , Takata Ichiro , Takigawa Nagio , Hotta Katsuyuki , Kiura Katsuyuki , Okayama Lung Cancer Study Group

    … The objective response rate was the primary outcome of interest. … </br>Results</br>Nine (100%) patients achieved a partial response with alectinib therapy with a median treatment duration of 6.7 months. … The overall response rate was 33.3% (90% confidence interval [CI]: 9.8–65.5 and 95% CI: 7.5–70.1), which did not reach the predefined criteria of 50%. …

    Thoracic Cancer 12(5), 643-649, 2021-01-20


  • Current status of diarrhea and colitis caused by immune checkpoint inhibitors in our hospital  [in Japanese]

    MIYAOKA Youichi , FUJISHIRO Hirofumi , KOHGE Naruaki , YAMAMOTO Tomohiko , ONUMA Hideyuki , KODAMA Yasuhide , SUEMITSU Shinsuke , FUJIWARA Aya , Tsukano Kosuke , OGAWA Sayaka , YAMANOUCHI Satoshi , TANAKA Masaki , MIYAKE Tatsuya

    【背景・目的】免疫チェックポイント阻害薬(ICI)には免疫関連有害事象(irAE)が認め られることがあり,特に下痢や大腸炎は発生頻度が高い.今回,当院におけるICIによる下痢・大腸 炎の現状について後方視的に検討した.【対象・方法】2014年7月1日から2019年6月30日までの 期間に当院で新規導入したICI症例98例(重複例5例)を対象とし,主要評価項目として下痢・大 腸炎発症の頻度,副次評 …

    Medical Journal of Shimane Prefectural Central Hospital 45(0), 13-18, 2021


  • Genome-wide analysis of DNA methylation identifies apoptosis-related gene UQCRH in renal cancer  [in Japanese]

    Shogo Ehata , Miyakuni Kosuke , Nishida Jun , Miyazono Kohei

    … Pre-treatment of advanced ccRCC with 5-aza-deoxycytidine attenuated a formation of a primary tumor through the induction apoptosis. … Silencing of UQCRH attenuated the cytochrome c release in response to apoptotic stimuli and resulted in enhancement of primary tumor formation in vivo, implying the tumor-suppressive role of UQCRH. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 2-P2-42, 2021


  • Role of MrgprA3-expressing primary sensory neurons in itch responses in atopic dermatitis model mice  [in Japanese]

    Fujii Masanori , Fujii Kyoko , Miyagawa Ryosuke , Tanaka Satoshi

    … Mas-related G protein-coupled receptor A3 (MrgprA3) has attracted attention as a marker of primary sensory neurons that specifically transmit itch signals, but it is still unclear whether MrgprA3-expressing neurons are involved in itch in AD. … Our results suggest that the MrgprA3-expressing primary sensory neurons should mediate acute itch response induced by allergen challenge in AD mice.</p> …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 1-O-B1-2, 2021


  • Implication of glutamine-glutamate metabolic change in astrocyte via cGAMP transmitted by metastatic cancer cells  [in Japanese]

    Sato Hiromi , Hatakeyama Hiroto , Hisaka Akihiro , Okawa Toya , Hara Kurumi , Goto Kyoko , Kikuchi Moe , Tanaka Hiroki , Shirane Daiki , Yamakawa Takuma , Akita Hidetaka

    … cGAMP is a selective ligand of STING that introduces an innate immune response, although the role for astrocyte is not yet well understood. … In this study, we aimed to grasp the metabolome shift in detail, especially focused on glutamine (Gln)-glutamate (Glu) axis in astrocyte because of its physiological impact.</p><p>The ssPalm-cGAMP complex (cGAMP) or only ssPalm complex (empty) was added to the primary cultured astrocytes. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 1-O-B3-5, 2021


  • 術後臓器不全の分類  [in Japanese]

    井上 茂亮

    … 手術侵襲は,高サイトカイン血症に代表される全身性炎症反応SIRS (systemic inflammatory response syndrome) を引き起こすだけでなく, 抗炎症反応であるCARS (compensatory anti‐inflammatory response syndrome)を誘導し, 局所の臓器障害がドミノ倒しのように多臓器不全へと進行する. … 多臓器不全を, 1) 局所臓器不全か遠隔臓器不全か, 2) PrimaryかSecondaryか, で考えると, 4つのカテゴリーに分類される. …

    The Japanese Journal of SURGICAL METABOLISM and NUTRITION 55(1), 6-10, 2021


  • Temporal Course of Vascular Response After Fluoropolymer Paclitaxel-Eluting Stent Implantation for Femoropopliteal Artery Lesions

    Tomoi Yusuke , Kuramitsu Shoichi , Shinozaki Tomohiro , Hiramori Seiichi , Soga Yoshimitsu , Ando Kenji

    … <p><b><i>Background:</i></b>Limited data are available regarding the vascular response after fluoropolymer paclitaxel-eluting stent (FP-PES) implantation. …

    Circulation Journal, 2021


  • Glycyrrhizin ameliorates melanoma cell extravasation into mouse lungs by regulating signal transduction through HMGB1 and its receptors

    Hiramoto Keiichi , Yamate Yurika , Goto Kenji , Ohnishi Shiho , Morita Akihiro , Yoshikawa Nobuji , Kawanishi Shosuke

    … Furthermore, glycyrrhizin ameliorated the lung tissue expression of high mobility group box-1 protein (HMGB1), receptor for advanced glycation end products (RAGE), Toll-like receptor (TLR)-4, RAS, extracellular signal-related kinase, NF-κB, myeloid differentiation primary response 88, IκB kinase complex, epithelial-mesenchymal transition markers, and vascular endothelial growth factor-A. …

    Journal of Clinical Biochemistry and Nutrition, 2021


  • Direct Impact of Motor Cortical Stimulation on the Blood Oxygen-level Dependent Response in Rats

    Xin Zonghao , Abe Yoshifumi , Liu Shuang , Tanaka Kenji F. , Hosomi Koichi , Saitoh Youichi , Sekino Masaki

    … The purpose of the present study was to investigate the blood oxygen-level dependent (BOLD) response in the brain during MCS.</p><p>Methods: We inserted a bipolar tungsten electrode into the primary motor cortex (M1) of adult male Wistar rats. …

    Magnetic Resonance in Medical Sciences 20(1), 83-90, 2021


  • Rapid Response System for In-Hospital Large Vessel Occlusion: A Case–Control Study

    Fujiwara Satoru , Ohara Nobuyuki , Imamura Hirotoshi , Seo Ryutaro , Nagata Kazuma , Shimizu Hayato , Kawamoto Michi , Kohara Nobuo , Sakai Nobuyuki

    … This study aimed to evaluate the time-saving effects of rapid response system (RRS) for the management of in-hospital LVO.</p><p><b>Methods:</b> … The primary outcome was time from detection to the first assessment by stroke team and to initial CT. … RRS has the potential to shorten response time efficiently in the management of in-hospital LVO. …

    Journal of Neuroendovascular Therapy, 2021


  • Utility of core-needle biopsy as a primary diagnostic method for detecting aggressive B-cell lymphoma in the intensive care unit  [in Japanese]

    NAMIKI Hiroya , HIROOKA Shinichi , MASUOKA Hidekazu , SADAOKA Shunichi , NISHIWAKI Kaichi , YANO Shingo , ITO Yuta , MATSUZAWA Haruka , ENOKI Keitaro , MOTOHASHI Kenji , HATTORI Daiki , TANOUE Susumu , SUZUKI Kazuhito , KATORI Mitsuji

    … After chemotherapy was initiated, the patient showed complete response, suggesting that CNB can be performed immediately and safely even on a critically ill patient.</p> …

    Rinsho Ketsueki 62(1), 55-57, 2021


  • Cooccurrence of classic Hodgkin lymphoma and multiple myeloma  [in Japanese]

    ANDOH Shohei , YOKOYAMA Kazuaki , UCHIDA Sanshiro , MAKIYAMA Junya , KAWAMATA Toyotaka , YASUI Hiroshi , OTA Yasunori , IMAI Yoichi , TOJO Arinobu

    … <p>古典的Hodgkinリンパ腫(CHL)を多発性骨髄腫(MM)治療後のsecondary primary malignancyとして生じる例があるが,未治療例に両者を同時合併することは稀である。 …

    Rinsho Ketsueki 62(1), 14-19, 2021


  • Transient Receptor Potential Melastatin 3 Is Functionally Expressed in Oligodendrocyte Precursor Cells and Is Upregulated in Ischemic Demyelinated Lesions

    Ohashi Kana , Shibasaki Koji , Nakazawa Hayaki , Kunimasa Ryotaro , Nagayasu Kazuki , Shirakawa Hisashi , Kaneko Shuji

    … however, these cells also secrete cytokines and elicit both protective and deleterious effects in response to brain injury. … expression was detected in primary cultured rat OPCs and was increased by treatment with tumor necrosis factor α (TNFα). …

    Biological and Pharmaceutical Bulletin 44(2), 181-187, 2021


  • Early Vascular Response to Ultrathin Biodegradable Polymer Sirolimus-Eluting Stents for the Treatment of ST-Elevation Myocardial Infarction After Plaque Rupture

    Oishi Yosuke , Tsukamoto Shigeto , Matsumoto Hidenari , Mori Hiroyoshi , Arai Ken , Nomura Kosuke , Sato Syunya , Yamamoto Myong Hwa , Kosaki Ryota , Wakabayashi Kohei , Sakai Rikuo , Tsujita Hiroaki , Arai Taito , Suzuki Hiroshi , Ochiai Masahiko , Shinke Toshiro , Ogura Kunihiro , Matsukawa Naoki , Tanaka Hideaki , Masaki Ryota , Sakai Koshiro , Sekimoto Teruo , Kondo Seita

    … <p>Recent clinical studies suggest that newer-generation drug-eluting stents that combine ultrathin struts and nanocoating (biodegradable polymer sirolimus-eluting stents, BP-SES) could improve long-term clinical outcomes in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). …

    International Heart Journal 62(1), 42-49, 2021



    ISHIHARA Tadashi , MOTOYUI Shojiro , KISHIKI Shoichi , OKI Yusuke

    … In past researches, response spectrum methods have been proposed to analyze three-dimensional piping. … It seems useful to obtain basic knowledge for the practical design of SS by studying both effects with a simple typical model.</p><p> In this paper, seismic responses due to both effects are studied for SS modeled as light-weight bending beams fixed to the upper and lower floors in a multistory building through response history analysis.</p><p> <b>2. …

    Journal of Structural and Construction Engineering (Transactions of AIJ) 86(779), 43-51, 2021


  • Impact of the COVID-19 Pandemic on Door-to-Balloon Time for Primary Percutaneous Coronary Intervention ― Results From the Singapore Western STEMI Network ―

    Chew Nicholas WS , Tam Howen , Quek Lit-Sin , Sia Winnie CH , Saw Kalyar Win , Tung Benjamin Wei-Liang , Ng Zan Zhe-Yan , Ambhore Anand , Tay Edgar Lik-Wui , Chan Koo-Hui , Lee Chi-Hang , Sia Ching-Hui , Loh Joshua Ping-Yun , Low Adrian Fatt-Hoe , Chan Mark Yan-Yee , Yeo Tiong-Cheng , Tan Huay-Cheem , Loh Poay-Huan , Wee Hwee-Lin , Benedict Loh Jia-Da , Rastogi Saurabh , Kojodjojo Pipin , Chor Wei Ping Daniel , Leong Benjamin Sieu-Hon , Koh Brandon Chi-Ping

    … <p><b><i>Background:</i></b>Little is known about the effect of the coronavirus disease 2019 (COVID-19) pandemic and the outbreak response measures on door-to-balloon time (D2B). …

    Circulation Journal 85(2), 139-149, 2021


  • Diagnosis of meningeal melanomatosis in a dog using magnetic resonance imaging and cerebrospinal fluid findings

    WU Chih-Ching , HUANG Wei-Hsiang , LIAO Pei-Wen , CHANG Ya-Pei

    … Based on histopathologic findings, a positive response against Melan-A, and no melanoma identified outside the central nervous system, primary meningeal melanomatosis was diagnosed.</p> …

    Journal of Veterinary Medical Science 83(1), 94-99, 2021


  • Variability of salivary metabolite levels in patients with Sjögren's syndrome

    Herrala Maria , Kullaa Arja M. , Mikkonen Jopi J. W. , Pesonen Paula , Lappalainen Reijo , Tjäderhane Leo , Niemelä Raija K. , Seitsalo Hubertus , Salo Tuula , Myllymaa Sami

    … To investigate inter- and intra-individual variation in the levels and outputs (concentration multiplied by salivary flow rate) of salivary metabolites in patients with primary Sjögren's syndrome (pSS).</p><p><b>Methods:</b> … In spite of considerable intra- and inter-individual variation, levels and outputs of specific metabolites in patients with pSS differ from those in controls, and may be potentially applicable as new biological markers for monitoring of the response to treatment.</p> …

    Journal of Oral Science 63(1), 22-26, 2021


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