CiNii Articles

1

Feasibility studies of radioiodinated pyridyl benzofuran derivatives as potential SPECT imaging agents for prion deposits in the brain

Fuchigami Takeshi , Kawasaki Masao , Watanabe Hiroyuki , Nakagaki Takehiro , Nishi Kodai , Sano Kazunori , Atarashi Ryuichiro , Nakaie Mari , Yoshida Sakura , Ono Masahiro , Nishida Noriyuki , Nakayama Morio

… Introduction: Prion diseases are fatal neurodegenerative disorders caused by the deposition of abnormal prion protein aggregates (PrPSc) in the central nervous system. … Methods: In vitro binding assays of IPBF derivatives were carried out in the recombinant mouse prion protein (rMoPrP) …

Nuclear Medicine and Biology (90-91), 41-48, 2020-09-15

IR
2

Update on Iatrogenic Creutzfeldt-Jakob Disease [in Japanese]

小林篤史

Brain and nerve 72(4), 437-443, 2020-04

Ichushi Web
3

Development and structural determination of an anti-PrPC aptamer that blocks pathological conformational conversion of prion protein

Mashima Tsukasa , Lee Joon-Hwa , Kamatari Yuji O. , Hayashi Tomohiko , Nagata Takashi , Nishikawa Fumiko , Nishikawa Satoshi , Kinoshita Masahiro , Kuwata Kazuo , Katahira Masato

… 2020-03-19.Prion diseases comprise a fatal neuropathy caused by the conversion of prion protein from a cellular (PrPC) to a pathological (PrPSc) isoform. … Except for some antibodies, R24 exhibited the lowest recorded IC50 and the highest anti-prion activity. … The quadruplex structure of either R24 or R12-A-R12 is unimolecular, and therefore the structure could be stably formed when they are administered to a prion-infected cell culture. …

Scientific Reports (10), 2020-03-18

IR
4

A rare challenge in general surgery: double surgical procedure for large and small bowel obstruction in a patient with Gerstmann-Sträussler-Scheinker syndrome

Costanzi Andrea , Monteleone Michela , Berardi Valter , Miranda Angelo , Mari Giulio , Maggioni Dario

… Gerstmann-Sträussler-Scheinker syndrome (GSS) is a rare, infectious syndrome related to a mutation in the prion protein gene. …

Intractable & Rare Diseases Research, 2020

J-STAGE
5

Phasing Biology Reveals the Role of Prion Protein [in Japanese]

Nishinami Suguru , Shiraki Kentaro

… Prion is a misfolded protein that has a unique propagation system by the change of the tertiary structure. … The concept of prion is conserved among various species, such as bacteria, yeast, anaspidea, sheep, and human. … Here we summarize the researches of prion proteins about the function of the cellular prion or the dysfunction triggering neurotoxicity. …

Butsuri 75(4), 192-200, 2020

J-STAGE
6

Identification of a chemical chaperone for preventing protein aggregation and proteotoxicity under endoplasmic reticulum stress [in Japanese]

Kitakaze Keisuke , Yoshida Suguru , Hosoya Takamitsu , Oyadomari Seiichi , Taniuchi Shusuke , Kawano Eri , Hamada Yoshimasa , Miyake Masato , Oyadomari Miho , Kojima Hirotatsu , Kosako Hidetaka , Kuribara Tomoko

… Furthermore, compound X significantly prevented cell death caused by chemically induced ER stress and by an aggression-prone mutant prion protein. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-YIA-48, 2020

J-STAGE
7

Cell-based HTS identifies a chemical chaperone for preventing ER protein aggregation and proteotoxicity

Kitakaze Keisuke , Taniuchi Shusuke , Kawano Eri , Hamada Yoshimasa , Miyake Masato , Oyadomari Miho , Kojima Hirotatsu , Kosako Hidetaka , Kuribara Tomoko , Yoshida Suguru , Hosoya Takamitsu , Oyadomari Seiichi

… Finally, IBT21 prevented cell death caused by chemically induced ER stress and by a proteotoxin, an aggression-prone prion protein. …

eLife (8), e43302, 2019-12-17

IR
8

Postmortem Quantitative Analysis of Prion Seeding Activity in the Digestive System

Satoh Katsuya , Fuse Takayuki , Nonaka Toshiaki , Dong Trong , Takao Masaki , Nakagaki Takehiro , Ishibashi Daisuke , Taguchi Yuzuru , Mihara Ban , Iwasaki Yasushi , Yoshida Mari , Nishida Noriyuki

… Human prion diseases are neurodegenerative disorders caused by prion protein. … Therefore, we reanalyzed autopsy samples collected from patients with sporadic and genetic human prion diseases and found that seeding activity exists in almost all digestive organs. …

Molecules 24(24), 4601, 2019-12-16

IR
9

Prion-like properties of α-synuclein [in Japanese]

医学のあゆみ 271(7), 668-670, 2019-11-16

Ichushi Web
10

The Propagation Hypothesis of Prion-like Protein Aggregates in Neurodegenerative Diseases [in Japanese]

野中隆

Brain and nerve 71(11), 1209-1214, 2019-11

Ichushi Web
11

Neuropathology of Amyotrophic Lateral Sclerosis [in Japanese]

吉田眞理

Brain and nerve 71(11), 1152-1168, 2019-11

Ichushi Web
12

Animal models of Prion-like propagation of tau [in Japanese]

細川雅人

Dementia Japan : 日本認知症学会誌 33(3), 306-317, 2019-09
13

A Novel Combination of Prion Strain Co-Occurrence in Patients with Sporadic Creutzfeldt-Jakob Disease

Kobayashi Atsushi , Iwasaki Yasushi , Takao Masaki , Saito Yuko , Iwaki Toru , Qi Zechen , Torimoto Ryouta , Shimazaki Taishi , Munesue Yoshiko , Isoda Norikazu , Sawa Hirofumi , Aoshima Keisuke , Kimura Takashi , Kondo Hinako , Mohri Shirou , Kitamoto Tetsuyuki

The American Journal of Pathology 189(6), 1276-1283, 2019-06

IR
14

Tracking and clarifying differential traits of classical- and atypical L-type bovine spongiform encephalopathy prions after transmission from cattle to cynomolgus monkeys

Hagiwara Ken'ichi , Sato Yuko , Yamakawa Yoshio , Hara Hideyuki , Tobiume Minoru , Okemoto-Nakamura Yuko , Sata Tetsutaro , Horiuchi Motohiro , Shibata Hiroaki , Ono Fumiko

… Classical- (C-) and atypical L-type bovine spongiform encephalopathy (BSE) prions cause different pathological phenotypes in cattle brains, and the disease-associated forms of each prion protein (PrPSc) has a dissimilar biochemical signature. … However, when isolated from infected brains, the two prion proteins (PrPSc) have similar biochemical signatures (i.e., electrophoretic mobility, glycoforms, and resistance to proteinase K). …

PLOS ONE 14(5), e0216807, 2019-05-16

IR
15

A domain responsible for spontaneous conversion of bank vole prion protein

Kobayashi Atsushi , Matsuura Yuichi , Takeuchi Atsuko , Yamada Masahito , Miyoshi Ichiro , Mohri Shirou , Kitamoto Tetsuyuki

Brain pathology 29(2), 155-163, 2019-03

IR
16

Ganglioside Synthase Knockout Reduces Prion Disease Incubation Time in Mouse Models

Kobayashi Atsushi , Qi Zechen , Shimazaki Taishi , Munesue Yoshiko , Miyamoto Tomomi , Isoda Norikazu , Sawa Hirofumi , Aoshima Keisuke , Kimura Takashi , Mohri Shirou , Kitamoto Tetsuyuki , Yamashita Tadashi , Miyoshi Ichiro

The American Journal of Pathology 189(3), 677-686, 2019-03

IR
17

Type I interferon protects neurons from prions in in vivo models

Ishibashi Daisuke , Homma Takujiro , Nakagaki Takehiro , Fuse Takayuki , Sano Kazunori , Satoh Katsuya , Mori Tsuyoshi , Atarashi Ryuichiro , Nishida Noriyuki

… Infectious prions comprising abnormal prion protein, which is produced by structural conversion of normal prion protein, are responsible for transmissible spongiform encephalopathies including Creutzfeldt-Jakob disease in humans. … Although we previously reported that interferon regulatory factor 3 (IRF3) was likely to be involved in the pathogenesis of prion diseases, suggesting the protective role of host innate immune responses mediated by IRF3 signalling, this remained to be clarified. …

Brain 142(4), 1035-1050, 2019-02-07

IR
18

Prion-like propagation of intracellular protein aggregates [in Japanese]

野中隆

Dementia Japan : 日本認知症学会誌 33(1), 39-45, 2019-01

Ichushi Web
19

A PRNP-Disrupted Human Neuroblastoma Cell Line and Its Stable Transformants Expressing Prion Protein Variants

Okemoto-Nakamura Yuko , Tanida Isei , Yamaji Toshiyuki , Hanada Kentaro , Hagiwara Ken'ichi

… A key event in prion diseases is the conformational conversion of a cellular normal form of the prion protein (PrPC) to disease-associated conformers (PrPSc). … Polymorphisms or mutations in the human prion protein gene (PRNP) are associated with acquired or hereditary human prion diseases. …

BPB Reports 2(5), 73-79, 2019

J-STAGE
20

18. Transmission of Prion and Prion-like Proteins in Prion Diseases and Neurodegenerative Diseases [in Japanese]

Yamada Masahito , Hamaguchi Tsuyoshi

Nihon Naika Gakkai Zasshi 108(9), 1979-1984, 2019

J-STAGE Ichushi Web

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