Nomura Yuhta
,
Seki Hikaru
,
Suzuki Tomonori
,
Ohyama Kiyoshi
,
Mizutani Masaharu
,
Kaku Tomomi
,
Tamura Keita
,
Ono Eiichiro
,
Horikawa Manabu
,
Sudo Hiroshi
,
Hayashi Hiroaki
,
Saito Kazuki
,
Muranaka Toshiya
… The natural variant showed loss of specificity for UDP-glucuronic acid and resulted in the production of an alternative saponin, glucoglycyrrhizin. … Our findings demonstrate the functional specialization of UGT73P12 for glycyrrhizin biosynthesis during divergent evolution, and provide mechanistic insights into UDP-sugar selectivity for the rational engineering of sweet triterpenoid saponins. …
IR