Search Results 1-20 of 7299

  • Real-Time Fluorescence Image-Guided Oncolytic Virotherapy for Precise Cancer Treatment

    Yano Shuya , Tazawa Hiroshi , Kishimoto Hiroyuki , Kagawa Shunsuke , Fujiwara Toshiyoshi , Hoffman Robert M.

    … We generated three types of telomerase-specific replication-competent oncolytic adenovirus: OBP-301; …

    International Journal of Molecular Sciences 22(2), 879, 2021-01-17

    IR 

  • The S. pombe CDK5 Orthologue Pef1 Cooperates with Three Cyclins, Clg1, Pas1 and Psl1, to Promote Pre-Meiotic DNA Replication

    Matsuda Shinya , Kikkawa Ushio , Nakashima Akio

    … Meiotic chromosomal segregation occurs when DNA replication is completed during the pre-meiotic S phase. … Here, we show that Schizosaccharomyces pombe Pef1, an orthologue of mammalian cyclin-dependent kinase 5 (CDK5), is required to promote pre-meiotic DNA replication. … Deletion of pef1 also suppressed the expression of DNA replication factors and the phosphorylation of Cdc2 Tyr-15. …

    Biomolecules 11(1), 89, 2021-01

    IR 

  • Qualitative Assessment of End-of-life Care Simulation in Nursing University Students Using a Review Sheet: Replication Report for University B  [in Japanese]

    Inumaru Anri , Tamaki Tomoko , Yokoi Yumie , Fujii Makoto , Tsujikawa Mayumi

    <p>【目的】単一施設(A大学)で評価を行ってきた終末期ケアシミュレーションを,異なる教育環境(B大学)の看護大学生に実施し,振返りを通して評価する.【方法】終末期ケアシミュレーション実施後,参加者に振返り用紙への自由な回答を求め,内容分析を行った.【結果】参加者は12名であった.振返り内容は,13個のカテゴリー:看護に関する自己の理解,看護に関する自己の肯定的見通しの実感,コミュニケ …

    Palliative Care Research 16(1), 59-66, 2021

    J-STAGE 

  • Immunohistochemical evaluation of hepatic progenitor cells in different types of feline liver diseases

    ABOU MONSEF Yanad , KUTSAL Osman

    … Regeneration of the liver through hepatocellular replication and proliferation of progenitor cell compartment were comparatively evaluated. …

    Journal of Veterinary Medical Science, 2021

    J-STAGE 

  • Characterization of JC Polyomavirus Derived from COS-IMRb Cells

    Nukuzuma Souichi , Nukuzuma Chiyoko , Kameoka Masanori , Sugiura Shigeki , Nakamichi Kazuo , Tasaki Takafumi , Hidaka Koushi , Takegami Tsutomu

    … The JCPyV derived from COS-IMRb cells were characterized by analyzing the viral replication, amount of virus by hemagglutination (HA), production of viral protein 1 (VP1), and structure of the NCCR. …

    Japanese Journal of Infectious Diseases 74(1), 48-53, 2021

    J-STAGE 

  • Thyroid complications of SARS and coronavirus disease 2019 (COVID-19)

    Speer Gábor , Somogyi Péter

    … Angiotensin-converting enzyme 2 is a membrane-bound enzyme, which is also expressed in the thyroid gland and the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) uses it for docking, entering as well as replication. …

    Endocrine Journal, 2021

    J-STAGE 

  • Anti-Influenza virus effects of <i>Enterococcus faecalis</i> KH2 and <i>Lactobacillus plantarum</i> SNK12 RNA

    WATANABE Takumi , HAYASHI Kyoko , KAN Tatsuhiko , OHWAKI Makoto , KAWAHARA Toshio

    … SNK12 (SNK) in IFV-infected mice suppressed viral replication and stimulated production of virus-specific antibodies. …

    Bioscience of Microbiota, Food and Health 40(1), 43-49, 2021

    J-STAGE 

  • Single-Cell Transcriptome Analysis Dissects the Replicating Process of Pancreatic Beta Cells in Partial Pancreatectomy Model

    Tatsuoka Hisato , Sakamoto Satoko , Yabe Daisuke , Kabai Ryotaro , Kato Unyanee , Okumura Tatsuya , Botagarova Ainur , Tokumoto Shinsuke , Usui Ryota , Ogura Masahito , Nagashima Kazuaki , Mukai Eri , Fujitani Yoshio , Watanabe Akira , Inagaki Nobuya

    膵臓ベータ細胞の増殖プロセスを時系列解析 --糖尿病の新規治療開発に期待--. 京都大学プレスリリース. 2020-12-24.

    iScience 23(12), 2020-12-18

    IR 

  • Deletion of the GAPDH gene contributes to genome stability in Saccharomyces cerevisiae

    Hanasaki Miki , Yaku Keisuke , Yamauchi Motohiro , Nakagawa Takashi , Masumoto Hiroshi

    … cells by suppressing the replication fork instability that leads to both DNA deletions among repeats. … We focused on quinolinic acid (QUIN), a metabolic intermediate in the de novo nicotinamide adenine dinucleotide (NAD+) synthesis pathway, which accumulated in the tdh2 deletion cells and was a candidate metabolite to suppress DNA replication fork instability. … In addition, qpt1 deletion could suppress replication fork slippage between direct repeats. …

    Scientific Reports 10(1), 21146, 2020-12-03

    IR 

  • Establishment of Neurospora crassa as a model organism for fungal virology

    Honda Shinji , Eusebio-Cope Ana , Miyashita Shuhei , Yokoyama Ayumi , Aulia Annisa , Shahi Sabitree , Kondo Hideki , Suzuki Nobuhiro

    … crassa supports the replication of these viruses as well as some viruses from other fungi. … This allowed us to examine viral replication and RNAi-mediated antiviral responses in this organism. … We show that viral infection upregulates the transcription of RNAi components, and that Dicer proteins (DCL-1, DCL-2) and an Argonaute (QDE-2) participate in suppression of viral replication. …

    Nature Communications 11(1), 5627, 2020-11-06

    IR 

  • Multiplexed tat-Targeting CRISPR-Cas9 Protects T Cells from Acute HIV-1 Infection with Inhibition of Viral Escape

    Ophinni Youdiil , Miki Sayaka , Hayashi Yoshitake , Kameoka Masanori

    … Multiplexed tat gRNAs inhibited acute viral replication in the 2nd round of infection, abolished cell-associated transmission to unprotected T cells, and maintained protection through 45 days, post-infection (dpi) after a higher dose of HIV-1 infection. …

    Viruses 12(11), 1223, 2020-11

    IR 

  • IDENTIFICATION OF HOST PROTEINS THAT REGULATE HIV REPLICATION  [in Japanese]

    宮川 敬

    ヒト免疫不全ウイルス(HIV)は,後天性免疫不全症候群(AIDS)の病原ウイルスである.HIVは免疫系をさまざまな手段で回避し,CD 4 陽性T細胞やマクロファージなどに感染すると自身のゲノムを宿主の染色体へ組み込む.そして大量のウイルスを細胞膜から出芽させ,細胞死を誘発しながら次々と感染を拡げていく.この一連の過程には宿主,つまりヒトのタンパク質が深く関わっている.自己増殖能のないウイルスが,感 …

    横浜医学 = Yokohama Medical Journal 71(4), 603-607, 2020-10-30

    IR 

  • Simulation-based Optimum Models for Type-I(a) and Type-I(b) IUPAC Classified Adsorption Isotherms

    Md. Matiar Rahman , Pal Animesh , Bidyut Baran Saha

    … To boost the calculation of the performance parameters, the replication of experimental data and the rigorous study of adsorption heat transformation (AHT) method, optimum adsorption isotherms model must be identified. …

    Proceedings of International Exchange and Innovation Conference on Engineering & Sciences (IEICES) (6), 14-19, 2020-10-22

    IR  DOI 

  • The Doubling of Time and AR Museum Apps  [in Japanese]

    富田 英典

    電子メディアによって電子メディアによってふたつの場所が重なっている。Paddy Scannell (1996) やShaun Moores (2004,2012, 2017) は、それをDoubling of Place と呼んだ。時間も電子メディアによって重なっている。ここでは、それをDoubling of Time と呼ぶ。本論文は、ミュージアム公式ARアプリを取り上げながらDoubling …

    関西大学社会学部紀要 = Bulletin of the Faculty of Sociology, Kansai University 52(1), 57-80, 2020-10

    IR 

  • Alcohol abrogates human norovirus infectivity in a pH-dependent manner

    Sato Shintaro , Matsumoto Naomi , Hisaie Kota , Uematsu Satoshi

    研究グループは、自ら確立したヒトiPS細胞株由来腸管上皮細胞を用いたヒトノロウイルス増殖系を用いて、pHを酸性、もしくはアルカリ性に傾けた消毒用アルコールに、ヒトノロウイルスをほぼ完全に不活化しうる効果があることを確認しました。pHの調整には食品添加物として用いられるクエン酸(市販のレモン果汁でも可)や重曹を用いることができるため、今回の研究成果は、抗ヒトノロウイルス活性を持つ手指消毒薬の開発、検 …

    SCIENTIFIC REPORTS (10), 15878, 2020-09-28

    IR 

  • Elimination of MYCN-Amplified Neuroblastoma Cells by Telomerase-Targeted Oncolytic Virus via MYCN Suppression

    Tanimoto Terutaka , Tazawa Hiroshi , Ieda Takeshi , Nouso Hiroshi , Tani Morimichi , Oyama Takanori , Urata Yasuo , Kagawa Shunsuke , Noda Takuo , Fujiwara Toshiyoshi

    … For targeting hTERT-activated tumors, we developed two oncolytic adenoviruses, OBP-301 and tumor suppressor p53-armed OBP-702, in which the hTERT promoter drives expression of the viral E1 gene for tumor-specific virus replication. …

    Molecular Therapy - Oncolytics (18), 14-23, 2020-09-25

    IR 

  • Boosting Replication and Penetration of Oncolytic Adenovirus by Paclitaxel Eradicate Peritoneal Metastasis of Gastric Cancer

    Ishikawa Wataru , Kikuchi Satoru , Ogawa Toshihiro , Tabuchi Motoyasu , Tazawa Hiroshi , Kuroda Shinji , Noma Kazuhiro , Nishizaki Masahiko , Kagawa Shunsuke , Urata Yasuo , Fujiwara Toshiyoshi

    … PTX enhanced the antitumor effect of OBP-401 due to enhanced viral replication in cancer cells. …

    Molecular Therapy - Oncolytics (18), 262-271, 2020-09-25

    IR 

  • APC/CCdh1 is required for the termination of chromosomal passenger complex activity upon mitotic exit

    Tsunematsu Takaaki , Arakaki Rieko , Kawai Hidehiko , Ruppert Jan , Tsuneyama Koichi , Ishimaru Naozumi , Earnshaw William C. , Pagano Michele , Kudo Yasusei

    … Indeed, Cdh1 depletion sustains an Aurora B activity with stable levels of borealin and Aurora B throughout the cell cycle, and causes reduced efficiency of DNA replication after release from serum starvation. … Notably, inhibition of Aurora B kinase activity improves the efficiency of DNA replication in Cdh1-depleted cells. … We thus propose that APC/CCdh1 terminates CPC activity upon mitotic exit and thereby contributes to proper control of DNA replication. …

    Journal of Cell Science 133(18), jcs251314, 2020-09-15

    IR 

  • A Modified Replication of a Resilience Program Comprised of Individual and Group Activities : Examination of Program Validity  [in Japanese]

    上野 雄己 , 平野 真理

    教育心理学研究 = The Japanese journal of educational psychology 68(3), 322-331, 2020-09

  • RTEL1 DNA helicase : a key factor in the maintenance of genome stability  [in Japanese]

    宮脇 由梨奈 , 中村 有里彩 , 長澤 知樹 , 水崎 彰治 , 倉岡 功 , 竹立 新人 , Miyawaki Yurina , Nakamura Arisa , Nagasawa Tomoki , Mizusaki Shoji , Kuraoka Isao , Takedachi Arato

    福岡大学理学集報 = Fukuoka University science reports 50(2), 127-134, 2020-09

    IR 

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