Search Results 1-20 of 2818

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Synthesis of Non-canonical Amino Acids and Peptide Containing Them for Establishment of the Template for Drug Discovery

Inokuma Tsubasa

… Non-canonical amino acid derivatives are an attractive scaffold for novel drug candidates. …

Chemical and Pharmaceutical Bulletin 69(4), 303-313, 2021-04-01

IR
2

Construction of Unknotted and Knotted Symmetric Developable Bands

Johannes Schönke , Michael Grunwald , Eliot Fried

… Each band is formed by threading a flat rectangular strip through a scaffold made from identical circular cylinders and smoothly connecting its short ends. … The N cylinders in a scaffold are arranged with N-fold rotational symmetry. … The number of half twists in a band is equal to the number N of cylinders in its scaffold and each band inherits the symmetry of its scaffold. …

Symmetry 13(3), 431, 2021-03-07

IR
3

SPATIAL SETTING AND ITS APPEARANCE IN THE DYE FACTORY OF CHUSEN FROM THE VIEWPOINT OF CLOTH:Study on Interrelation between Thing, Architecture and City in Manufacturing Space of Local Industry [in Japanese]

YASUMORI Akio , FUKUZAWA Junya , TSUKAMOTO Takuya

… The two story building being the center among the seriate of one-story buildings, and the fabrics hung on the scaffold and the rods are exposed to the street and riverside. … The Ebaman dye factory (No. 3), which doesn't face a river, has a scaffold in the middle, and the manufacturing flow expands as the fabric comes and goes from one building to another. … The water tank and the scaffold are stacked as a unified form, and the scenery of the fabrics hanging from there makes the landmark. …

Journal of Architecture and Planning (Transactions of AIJ) (781), 1135-1145, 2021-03

J-STAGE AIJ
4

Effects of Alternatives in Training-Pruning Procedures of Fruit Trees on Light Environments in Orchards : Analytical Results Using Model Methods [in Japanese]

山本隆儀

… As the results of Experiment 1, the next cases may be effective for the improvement, namely, the increment of central angle of the primary scaffold branches (PSBs) being equal to "360 degree / number of the PSBs", the trunk being long, the first PSB emerging out of the south side of the crown, the PSBs branching with wide angles, the compound units of stems after secondary scaffold branches (units) being big in size, the units branching with narrow angles and the units rising horizontally at both sides of the PSB. …

山形大学紀要．農学 = Bulletin of the Yamagata Unibersity.Agricultural science 18(4), 287-320, 2021-02-26

IR
5

Cryopreserved human adipose-derived stromal vascular fraction maintains fracture healing potential via angiogenesis and osteogenesis in an immunodeficient rat model

Kamenaga Tomoyuki , Kuroda Yuichi , Nagai Kanto , Tsubosaka Masanori , Takashima Yoshinori , Kikuchi Kenichi , Fujita Masahiro , Ikuta Kemmei , Anjiki Kensuke , Maeda Toshihisa , Nakano Naoki , Takayama Koji , Hashimoto Shingo , Hayashi Shinya , Matsushita Takehiko , Niikura Takahiro , Kuroda Ryosuke , Matsumoto Tomoyuki

… Immediately after the creation of non-healing fracture, rats received local transplantation of F and C-SVFs suspended in phosphate-buffered saline (PBS) or the same volume of PBS without cells using the same scaffold as a control group. …

Stem Cell Research & Therapy 12(1), 110, 2021-02-04

IR
6

Dysregulation of erythropoiesis and altered erythroblastic NMDA receptor-mediated calcium influx in Lrfn2-deficient mice

Maekawa Ryuta , Muto Hideki , Hatayama Minoru , Aruga Jun

… LRFN2 encodes a synaptic adhesion-like molecule that physically interacts with N-methyl-D-aspartate (NMDA) receptor 1 and its scaffold proteins. …

PLOS ONE 16(1), e0245624, 2021-01-22

IR
7

New Application of Plant Cultivation Scaffold by the Porous Titanium [in Japanese]

小畠玲子 , 土井一矢 , 津賀一弘

チタン = Titanium Japan 69(1), 18-22, 2021-01
8

Teachers' Question in Science Lessons Discussion at Secondary Level of Bangladesh

Siddiquee Muhammad Nur-E-Alam , Kubota Kenichi

特集　久保田賢一名誉教授　定年退職記念

情報研究 = Journal of informatics : 関西大学総合情報学部紀要 (52), 25-36, 2021-01

IR
9

TNF receptor-associated factor 6 (TRAF6) plays crucial roles in multiple biological systems through polyubiquitination-mediated NF-κB activation

YAMAMOTO Mizuki , GOHDA Jin , AKIYAMA Taishin , INOUE Jun-ichiro

… This discovery led to the proposal of an entirely new signaling mechanism concept, wherein K63-ubiquitin chains act as a scaffold for the signaling complex to activate downstream kinases. …

Proceedings of the Japan Academy, Series B 97(4), 145-160, 2021

J-STAGE
10

Bioactive small molecules in calcium phosphate scaffold enhanced osteogenic differentiation of human induced pluripotent stem cells

SONG Bing , XU Huakun , FU Haijun , LIU Jianwei , REN Ke , WEIR Michael D. , SCHNEIDER Abraham , WANG Ping , SONG Yang , ZHAO Liang

… The objectives were to: (1) develop a novel injectable calcium phosphate cement (CPC)-SB431542 scaffold for dental/craniofacial bone engineering; … and (2) investigate cell proliferation and osteo-differentiation of hiPSC-derived mesenchymal stem cells (hiPSC-MSCs) on CPC-SB431542 scaffold. … In conclusion, hiPSC-MSCs on CPC scaffold containing SB431542 showed excellent osteo-differentiation and bone mineral synthesis for the first time. …

Dental Materials Journal, 2021

J-STAGE
11

Synthesis and Evaluation of a Novel Series of 2,7-Substituted-6-tetrazolyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Selective Peroxisome Proliferator-Activated Receptor γ Partial Agonists

Morishita Ko , Ito Yuma , Otake Kazuya , Takahashi Kenji , Yamamoto Megumi , Kitao Tatsuya , Ozawa Shin-ichiro , Hirono Shuichi , Shirahase Hiroaki

… In conclusion, 6-tetrazolyl-1,2,3,4-tetrahydroisoquinoline derivatives provide a novel scaffold for selective PPARγ partial agonists and 26v …

Chemical and Pharmaceutical Bulletin 69(4), 333-351, 2021

J-STAGE
12

Synthesis of Non-canonical Amino Acids and Peptide Containing Them for Establishment of the Template for Drug Discovery

Inokuma Tsubasa

… Non-canonical amino acid derivatives are an attractive scaffold for novel drug candidates. …

Chemical and Pharmaceutical Bulletin 69(4), 303-313, 2021

J-STAGE
13

Studies on Elastase and Elastase Inhibitor from Aspergillus flavus [in Japanese]

Nikai Toshiaki

… The X-ray analysis has revealed that the structure of this inhibitor was wedge shaped and composed of a binding loop and a scaffold protein core. …

YAKUGAKU ZASSHI 141(4), 527-540, 2021

J-STAGE
14

The effect of the polyglycolic acid/collagen composite nanofiber scaffold with fibroblast growth factor in wound healing

Terabe Yuta , Ichioka Shigeru , Sekiya Naomi

再生医療の分野は，創傷治癒でも有用な手段となりつつある．形成外科医は，臨床の場で人工真皮という足場を用いて，創傷治療を行なっている．既存の足場のみならず我々は，ポリグリコール酸を使用したナノファイバーの足場（PGA/collagen）を開発し，過去に動物実験でその効果を実証し報告している． また線維芽細胞成長因子（FGF）は，創傷治癒を促進させるシグナ …

Journal of Saitama Medical University 47(2), 75-81, 2021

J-STAGE
15

TRPC5 channel-Caveolin-1-eNOS signalplexes coordinate interplay between Ca2+ and NO signals in endothelial cells [in Japanese]

Sakaguchi Reiko , Hara Yuji , Mori Masayuki , Furukawa Tetsushi , Shimizu Shunichi , Inoue Ryuji , Mori Yasuo , Takahashi Nobuaki , Yoshida Takashi , Ogawa Nozomi , Ueda Yoshifumi , Hamano Satoshi , Yamaguchi Kaori , Sawamura Seishiro , Yamamoto Shinichiro

… influx and NO production, suggesting that caveolin-1 is the scaffold that enables TRPC5 and eNOS to assemble into the signaling complex. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 3-Y-G2-1, 2021

J-STAGE
16

p38 MAPK is directly inhibited by PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptor [in Japanese]

Uwada Junsuke

… Docking simulation indicated that the diaryl urea scaffold of PNU-120596 is important to form hydrogen bonds with p38α MAPK. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 2-P1-21, 2021

J-STAGE
17

Influence of Surface Modification Ratio on Tensile Strength of Hybrid-interface-controlled HAp/PLA Composite Materials

TANAKA Mototsugu , OKE Junichiro , TAKAHASHI Tomoyuki , KIMPARA Isao

The aim of this paper is to investigate the influence of the surface modification ratio on the tensile strength of the hybrid-interface-controlled HAp/PLA composite materials. Here, pectin and chitosa …

Materials System 38(0), 31-35, 2021

J-STAGE
18

c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1 (JSAP1) attenuates curcumin-induced cell death differently from its family member, JNK-associated leucine zipper protein (JLP)

Gunarta I Ketut , Yoshioka Katsuji , Yuliana Dewi , Erdenebaatar Purev , Kishi Yuhei , Boldbaatar Jambaldorj , Suzuki Ryusuke , Odongoo Ravdandorj , Davaakhuu Gantulga , Hohjoh Hirohiko

… We previously reported that the mitogen-activated protein kinase (MAPK) scaffold protein c-Jun NH2-terminal kinase (JNK)-associated leucine zipper protein (JLP) reduces curcumin-induced cell death by modulating p38 MAPK and autophagy through the regulation of lysosome positioning. …

Drug Discoveries & Therapeutics, 2021

J-STAGE
19

Investigations of Chirality Effects on Undifferentiated State of Mesenchymal Stem Cells Using Soft Nanofibrous Oligopeptide Hydrogels

YOSHITOMI Toru , ZHENG Hangyu , YOSHIMOTO Keitaro

… This indicates that d-form peptide materials might be useful as scaffold materials for regenerative medicine using stem cells. …

Analytical Sciences 37(3), 539-543, 2021

J-STAGE
20

Digital assisted soft tissue sculpturing (DASS) technique for immediate loading pink free complete arch implant prosthesis

Pozzi Alessandro , Arcuri Lorenzo , S. Block Michael , K. Moy Peter

… To introduce a digitally assisted technique to achieve the ideal soft and bone tissue interface for anatomic-driven pink free implant supported fixed prosthesis, and prefabricate an interim prosthesis to be used the day of the surgery as a prosthetic scaffold to condition the healing. … The interim prosthesis is used as a prosthetic scaffold to guide the soft and bone tissue surgical sculpturing and regeneration. Conclusions: …

Journal of Prosthodontic Research 65(1), 119-124, 2021

J-STAGE

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