CiNii Articles - scrapie

1

Development and structural determination of an anti-PrPC aptamer that blocks pathological conformational conversion of prion protein

Mashima Tsukasa , Lee Joon-Hwa , Kamatari Yuji O. , Hayashi Tomohiko , Nagata Takashi , Nishikawa Fumiko , Nishikawa Satoshi , Kinoshita Masahiro , Kuwata Kazuo , Katahira Masato

… The 50% inhibitory concentration for the formation of PrPSc (IC50) of R24 in scrapie-infected cell lines was ca. …

Scientific Reports (10), 2020-03-18

IR
2

SCRG1 induces chemotaxis to CCL19 by enhancing the expression of CCR7 in macrophage-like Raw264.7 cells [in Japanese]

AIHARA Keiko

… In this study, MSC-derived cytokine-like peptide, scrapie responsive gene 1 （SCRG1）, was investigated for paracrine activity in macrophages. …

Dental Journal of Iwate Medical University 45(1), 35-45, 2020

IR J-STAGE
3

First case of atypical scrapie in a goat in Japan

MATSUURA Yuichi , MIYAZAWA Kohtaro , IMAMURA Morikazu , YOKOYAMA Takashi , IWAMARU Yoshifumi

… Atypical scrapie in goats has only been reported in European countries. … The present study reports the identification of the first case of atypical scrapie in goats in Japan. … Western blot analysis showed a multiplex proteinase K-resistant prion protein (PrP-res) band pattern with a band <15 kDa that was clearly distinguishable from the triplet PrP-res band pattern observed in classical scrapie cases. …

Journal of Veterinary Medical Science 81(7), 986-989, 2019

J-STAGE Ichushi Web
4

Prion Protein Devoid of the Octapeptide Repeat Region Delays BSE Pathogenesis in Mice

Hara Hideyuki , Miyata Hironori , Das Nandita Rani , Chida Junji , Yoshimochi Tatenobu , Uchiyama Keiji , Watanabe Hitomi , Kondoh Gen , Yokoyama Takashi , Sakaguchi Suehiro

… Conformational conversion of the cellular isoform of prion protein PrPC, into the abnormally folded, amyloidogenic isoform, PrPSc, is a key pathogenic event in prion diseases including Creutzfeldt-Jakob disease in humans and scrapie and bovine spongiform encephalopathy (BSE) in animals. …

Journal of Virology 92(1), e01368-17, 2017-10-18

IR
5

Selective propagation of mouse-passaged scrapie prions with long incubation period from a mixed prion population using GT1-7 cells

宮澤光太郎 , 舛甚賢太郎 , 岡田洋之 , 松浦裕一 , 横山隆

PLoS ONE = PLoS ONE 12(6), e0179317, 2017-06-21

IR
6

Prion pathogenesis is unaltered in the absence of SIRPα-mediated "don't-eat-me" signaling

Nuvolone Mario , Paolucci Marta , Sorce Silvia , Kana Veronika , Moos Rita , Matozaki Takashi , Aguzzi Adriano

… To study the involvement of SIRPα in prion pathogenesis in vivo, mice expressing a truncated SIRPα protein unable to inhibit phagocytosis were inoculated with rodent-adapted scrapie prions of the 22L strain. …

PLoS ONE 12(5), e0177876, 2017-05-17

IR
7

Scrapie prion strain analysis based on the ovine prion protein expressing cell lines [in Japanese]

宮澤光太郎

農研機構研究報告動物衛生研究部門 = Bulletin of the NARO, National Institute of Animal Health (123), 75-79, 2017-03-31

IR DOI
8

Short Neuropathology Report : Immunohistochemistry of abnormal prion protein PrP[Sc] in an autopsy case of sporadic type MM1 + 2 Creutzfeldt-Jakob disease (CJD)

Konishi Yoshihiro , Ijiri Tamami , Watanabe Ken , Nishimura Hirotake

鳥取臨床科学研究会誌 9(2), 176-189, 2017
9

Transmission of atypical scrapie to homozygous ARQ sheep

OKADA Hiroyuki , MIYAZAWA Kohtaro , IMAMURA Morikazu , IWAMARU Yoshifumi , MASUJIN Kentaro , MATSUURA Yuichi , YOKOYAMA Takashi

The journal of veterinary medical science 78(10), 1619-1624, 2016-10
10

Scrapie prion strain analysis based on the ovine prion protein expressing cell lines [in Japanese]

宮澤光太郎

農研機構研究報告. 動物衛生研究部門 = Bulletin of the NARO (123), 75-79, 2016

Ichushi Web
11

Identification of the first case of atypical scrapie in Japan

IMAMURA Morikazu , MIYAZAWA Kohtaro , IWAMARU Yoshifumi , MATSUURA Yuichi , YOKOYAMA Takashi , OKADA Hiroyuki

… A Corriedale ewe was confirmed as the first atypical scrapie case during an active surveillance program for transmissible spongiform encephalopathies in small ruminants in Japan. … Based on these results, this case was conclusively diagnosed as atypical scrapie with encephalitic listeriosis. …

Journal of Veterinary Medical Science 78(12), 1915-1919, 2016

J-STAGE Ichushi Web
12

Transmission of atypical scrapie to homozygous ARQ sheep

OKADA Hiroyuki , MIYAZAWA Kohtaro , IMAMURA Morikazu , IWAMARU Yoshifumi , MASUJIN Kentaro , MATSUURA Yuichi , YOKOYAMA Takashi

… (AL141RQ) prion protein (PrP) genotype were exposed intracerebrally to brain pools prepared using four field cases of atypical scrapie from the United Kingdom. … Our results indicate that atypical scrapie is transmissible to AL141RQ sheep, but these animals act as clinically silent carriers with long incubation times. …

Journal of Veterinary Medical Science 78(10), 1619-1624, 2016

J-STAGE Ichushi Web
13

RT-QuIC Assays in Humans … and Animals.

Collins Steven , Sarros Shannon

… The phenotypic spectrum is broad and includes Creutzfeldt-Jakob disease (CJD) and its variant zoonotic form (vCJD) in humans, while in animals, scrapie of sheep and goats, bovine spongiform encephalopathy and chronic wasting disease of deer, elk and moose are naturally occurring forms. …

Food Safety 4(4), 115-120, 2016

J-STAGE Ichushi Web
14

Scrapie in Swine: a Diagnostic Challenge

Greenlee Justin J. , Kunkle Robert A. , Smith Jodi D. , Greenlee M. Heather West

… Swine are thought to have a robust species barrier when exposed to the naturally occurring prion diseases of other species, but the susceptibility of swine to the agent of sheep scrapie has not been thoroughly tested. …

Food Safety 4(4), 110-114, 2016

J-STAGE Ichushi Web
15

Prion Diseases in Animals and Zoonotic Potential

Torres Juan Maria , Marin-Moreno Alba , Andreoletti Olivier , Espinosa Juan-Carlos , Beringue Vincent , Aguilar Patricia , Fernandez-Borges Natalia

… However, homozygous 129V mice are resistant to all tested BSE derived prions independently of the originating species, suggesting a higher transmission barrier for 129V-PrP variant.Transmission data also revealed that several scrapie prions propagate in HuPrP-Tg mice with efficiency comparable to that of cattle BSE. …

Food Safety 4(4), 105-109, 2016

J-STAGE Ichushi Web
16

Basic study of prion disease [in Japanese]

八谷如美 , Naomi Hachiya

東京医科大学雑誌 72(1), 12-18, 2014-01

IR Ichushi Web
17

Heterogeneity of Abnormal Prion Protein (PrPSc) in Murine Scrapie Prions Determined by PrPSc-Specific Monoclonal Antibodies

USHIKI-KAKU Yuko , SHIMIZU Yoshihisa , TABETA Naoko , IWAMARU Yoshifumi , OGAWA-GOTO Kiyoko , HATTORI Shunji , YOKOYAMA Takashi

In prion diseases, abnormal prion protein (PrPSc) is considered as the main component of the infectious agent. Delineation of PrPSc conformation is expect …

Journal of Veterinary Medical Science 76(2), 285-288, 2014

J-STAGE Ichushi Web
18

Therapeutic effect of peripheral administration of an anti-prion protein antibody on mice infected with prions

Ohsawa Natsuo , Song Chang-Hyun , Suzuki Akio [他]

Microbiology and immunology 57(4), 288-297, 2013-04

Ichushi Web
19

Intestinal Transmission of Prions and Role of Exosomes in Enterocytes

Ano Yasuhisa , Sakudo Akikazu , Uraki Ryuta , Kono Juri , Yukawa Masayoshi , Onodera Takashi

… Infectious prion diseases include Kuru and its variant, Creutzfeldt-Jakob disease, in humans, scrapie in sheep, and bovine spongiform encephalopathy in cattle. …

Food Safety 1(1), 2013005-2013005, 2013

J-STAGE Ichushi Web
20

Experimental Chronic Wasting Disease in Wild Type VM Mice

LEE Yoon-Hee , CHO In-Soo , BALACHANDRAN Aru , SOHN Hyun-Joo , KIM Min-Jeong , KIM Hyo-Jin , PARK Kyung-Je , LEE Won-Yong , YUN Eun-Im , TARK Dong-Seob , CHOI Young-Pyo

Chronic wasting disease (CWD) is a naturally occurring prion disease in North American deer (Odocoileus species), Rocky mountain elk (Cervus elaphus nelsoni) and …

Journal of Veterinary Medical Science 75(8), 1107-1110, 2013

J-STAGE Ichushi Web

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