Search Results 1-20 of 1236

  • Modification of synaptic-input clustering by intrinsic excitability plasticity on cerebellar Purkinje cell dendrites

    Ohtsuki Gen

    … Here, I performed simultaneous voltage-clamp recordings from the soma and dendrites of single cerebellar Purkinje neurons in male Sprague-Dawley rats and analyzed the relationship between spontaneous excitatory postsynaptic currents (EPSCs) on both sides. … These properties of dendrites may confer branch-specific computational power to neurons. …

    Journal of Neuroscience 40(2), 267-282, 2020-01-08

    IR 

  • Expressive Numbers of Two or More Hidden Layer ReLU Neural Networks

    Inoue Kenta

    … However, existing works on expressive numbers mainly target single hidden layer neural networks, and little is known about those with two or more hidden layers. … This result shows the expressive number of two hidden layer neural networks is in O(a_1a_2) where a_1 and a_2 are the numbers of each hidden layer's neurons. …

    International Journal of Networking and Computing 10(2), 293-307, 2020

    J-STAGE 

  • The role of Robo1 in the formation of the cerebral cortex  [in Japanese]

    Gonda Yuko , Hanashima Carina

    … Over recent years, the roles of Robo1 in the developing neocortex has been examined using molecular and genetic approaches, highlighting its importance in the differentiation of cortical neurons and the formation of the cerebral cortical circuit. …

    Japanese Journal of Biological Psychiatry 31(2), 98-105, 2020

    J-STAGE 

  • Dynamics of Stimulus Selectivity in Inferotemporal Neurons

    Dai Lulin , Okamura Jun-ya , Wang Gang

    … In each phase, single cell responses to images (4 objects × 4 views; …

    Advanced Biomedical Engineering 9(0), 93-99, 2020

    J-STAGE 

  • Social defeat stress increased interfaces between microglia and neurons in the medial prefrontal cortex of mice  [in Japanese]

    Nagai Midori , Nagai Hirotaka , Furuyashiki Tomoyuki

    … <p>Animal studies using various stress models have shown that excessive environmental stress induces depression-like behaviors with concomitant dendritic atrophy of neurons especially in the medial prefrontal cortex (mPFC) and the hippocampus. … Recent progresses have revealed that inflammatory responses in the brain and periphery are critical inducers of dendritic atrophy of the neurons. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-P-171, 2020

    J-STAGE 

  • Analysis of ultrastructural alterations in the mouse medial prefrontal cortex toward the understanding of pathophysiology of social stress-induced depressive-like behaviors  [in Japanese]

    Nagai Hirotaka , Furuyashiki Tomoyuki

    … <p>Animal studies using various stress models have shown that excessive environmental stress induces depressive-like behaviors with concomitant atrophic changes of neurons especially in the medial prefrontal cortex (mPFC) and in the hippocampus. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-YIA-03, 2020

    J-STAGE 

  • Specificities in dendritic branching pattern and spine density along the dorso-ventral axis of the hippocampus  [in Japanese]

    Mika Hojo , Deguchi Mai , Nomura Yutaka , Takeuchi Chiaki , Ishikawa Miho , Sawano Toshinori , Nakatani Jin , Tanaka Hidekazu

    … Visualization of single neurons by microinjection of Lucifer Yellow revealed that the branching patterns of GC dendrites are distinct between dorsal and ventral DGs; …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-LBS-20, 2020

    J-STAGE 

  • Multiscale Ca<sup>2+</sup> imaging for brain function analysis  [in Japanese]

    Osanai Makoto

    … <p>Central nervous system has a hierarchical organization from neurons to huge complex network, and each hierarchy can process and can hold the information. … For in vivo local circuit imaging with single cell resolution, we have developed ultra-thin florescence endoscope imaging system. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-S07-2, 2020

    J-STAGE 

  • Phosphorylation of Collapsin Response Mediator Protein 1 by Semaphorin 3A-Fyn signaling regulates basal dendritic growth and arborization  [in Japanese]

    Jitsuki-Takahashi Aoi , Kawashima Takeshi , Jitsuki Susumu , Goshima Yoshio , Nakamura Fumio

    … A dominant negative mutant of CRMP1 Y504F, substitution of tyrosine 504 to phenylalanine (F), suppressed Sema3A-induced growth cone collapse of chick E8 DRG neurons. … Fyn -/- </i>single-homozygous mice as well as<i> … CRMP1 Y504F or CRMP1 WT with tdTomato was transfected in the mice cortical layer V neurons at E15 by <i>in utero </i>electroporation. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-P-008, 2020

    J-STAGE 

  • Characterization of lysosomal proteins Progranulin and Prosaposin and their interactions in Alzheimer's disease and aged brains: increased levels correlate with neuropathology.

    Mendsaikhan Anarmaa , TOOYAMA Ikuo , BELLIER Jean-Pierre , SERRANO Geidy E , SUE Lucia I , LUE Lih-Fen , BEARCH Thomas G , WALKER Douglas Gordon , 遠山 育夫

    … A single mutation in the human GRN gene resulting in reduced PGRN expression causes types of frontotemporal lobar degeneration resulting in frontotemporal dementia. … Immunohistochemistry showed PGRN expression in cortical neurons, microglia, cerebral vessels and amyloid beta (Aβ) plaques, while PSAP expression was mainly detected in neurons and Aβ plaques, and to a limited extent in astrocytes. …

    Acta Neuropathologica Communications 7(1), 215, 2019-12-21

    IR 

  • CD38, CD157, and RAGE as Molecular Determinants for Social Behavior

    Tanaka Yukie , Higashida Haruhiro , Hashii Minako , Matsukawa Shigeru , Higuchi Yoshihiro , Gabata Ryosuke , Tsubomoto Makoto , Seishima Noriko , Teramachi Mitsuyo , Kamijima Taiki , Hattori Tsuyoshi , Hori Osamu , Tsuji Chiharu , Cherepanov Stanislav M. , Shabalova Anna A. , Gerasimenko Maria , Minami Kana , Yokoyama Shigeru , Munesue Sei-ichi , Harashima Ai

    Single-nucleotide polymorphisms of the CD38 and CD157/BST1 genes are associated with multiple neurological and psychiatric conditions, including autism spectrum disorder, Parkinson's disease, and schizophrenia. … OT is axo-dendritically secreted into the brain from OT-containing neurons and causes activation of OT receptors mainly on hypothalamic neurons. …

    Cells 9(1), 62-1-16, 2019-12

    IR 

  • Voltage imaging with ANNINE dyes and two-photon microscopy of Purkinje dendrites in awake mice

    Christopher J. Roome , Bernd Kuhn

    … It promises to resolve neuronal activity 10 to 100-times faster than calcium imaging and to report not only supra but also subthreshold activity on a single cell or even subcellular level. … We used this method to study supra and subthreshold dendritic voltage changes in Purkinje neurons of awake mice. …

    Neuroscience Research (152), 15-24, 2019-11-20

    IR 

  • Chromatin Environment and Cellular Context Specify Compensatory Activity of Paralogous MEF2 Transcription Factors

    山田 朋子 , Shahriyar P. Majidi , Naveen C. Reddy , Michael J. Moore , Hao Chen , Tomoko YAMADA , Milena M. Andzelm , Timothy J. Cherry , Linda S. Hu , Michael E. Greenberg , Azad Bonni

    … Using single and double conditional knockout of myocyte enhancer factor 2 (MEF2) family TFs in granule neurons of the mouse cerebellum, we find that MEF2A and MEF2D play functionally redundant roles in cerebellar-dependent motor learning. … Although both TFs are highly expressed in granule neurons, transcriptomic analyses show MEF2D is the predominant genomic regulator of gene expression in vivo. …

    Cell Reports 29(7), 2001-2015.e5, 2019-11

    IR 

  • Mice deficient in protein tyrosine phosphatase receptor type Z (PTPRZ) show reduced responsivity to methamphetamine despite an enhanced response to novelty

    Fujikawa Akihiro , Noda Yukihiro , Yamamoto Hideko , Tanga Naomi , Sakaguchi Gaku , Hattori Satoko , Song Wen-Jie , Sora Ichiro , Nabeshima Toshitaka , Katsuura Goro , Noda Masaharu

    Single-cell RT-PCR revealed that the majority of midbrain DA neurons expressed PTPRZ. …

    PLoS ONE 14(8), e0221205, 2019-08-20

    IR 

  • Primer to Voltage Imaging With ANNINE Dyes and Two-Photon Microscopy

    Bernd Kuhn , Christopher J. Roome

    … ANNINE-6 and ANNINE-6plus are voltage-sensitive dyes that when combined with two-photon microscopy are ideal for recording of neuronal voltages in vivo, in both bulk loaded tissue and the dendrites of single neurons. … Alternatively, if ANNINE-6plus is applied internally, supra and sub threshold voltage changes can be recorded from dendrites of single neurons in awake animals. …

    Frontiers in Cellular Neuroscience (13), 321, 2019-07-16

    IR 

  • Orchestrated ensemble activities constitute a hippocampal memory engram

    Khaled Ghandour , Noriaki Ohkawa , Chi Chung Alan Fung , Hirotaka Asai , Yoshito Saitoh , Takashi Takekawa , Reiko Okubo-Suzuki , Shingo Soya , Hirofumi Nishizono , Mina Matsuo , Makoto Osanai , Masaaki Sato , Masamichi Ohkura , Junichi Nakai , Yasunori Hayashi , Takeshi Sakurai , Takashi Kitamura , Tomoki Fukai , Kaoru Inokuchi , Tomoki Fukai , Kaoru Inokuchi

    … The brain stores and recalls memories through a set of neurons, termed engram cells. … Within a single engram population, we detected several sub-ensembles composed of neurons collectively activated during learning. …

    Nature communications 10(1), 2637, 2019-06

    IR 

  • Distributions of different types of nociceptive neurons in thalamic mediodorsal nuclei of anesthetized rats

    Lu Pen-Li , Tsai Meng-Li , Jaw Fu-Shan , Yen Chen-Tung

    The journal of physiological sciences 69(2), 387-397, 2019-03

    Ichushi Web 

  • Rab33a and Rab33ba mediate the outgrowth of forebrain commissural axons

    Huang Liguo , Urasak Akihiro , Inagaki Naoyuki

    … Rab33a promotes axon outgrowth of cultured rat hippocampal neurons by mediating the anterograde axonal transport of Golgi-derived vesicles and the concomitant exocytosis of these vesicles at the growth cone. … They are expressed in the developing brain, including in neurons of the telencephalic dorsorostral cluster and the diencephalic ventrorostral cluster, which project axons to form the anterior and postoptic commissures, respectively. …

    2019-02-12

    IR 

  • Micropatterning of Extracellular Matrix for Single Neuron Culture on a Microporous SiN Membrane  [in Japanese]

    NAKAMA Ayaka , YASUDA Takashi

    Neurons cultured on the plate adhered to the laminin-modified regions and elongated their axons inside the regions. …

    The Proceedings of the Symposium on Micro-Nano Science and Technology 2019.10(0), 19am3PN325, 2019

    J-STAGE 

  • Cortico-thalamic reciprocal circuit working for trigeminal sensory processing  [in Japanese]

    Furuta Takahiro

    … <p>Primary sensory cortexes provide massive descending axons to the thalamus to modulate sensory responsiveness of thalamic relay neurons. … The impact of the corticothalamic pathways on the firing mode and sensory gain of thalamic neurons has only been extensively examined in anesthetized animals, but has yet to be established in the awake state. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 3-YS-1, 2019

    J-STAGE 

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