Search Results 1-20 of 61

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Juzentaihoto Suppresses Muscle Atrophy and Decreased Motor Function in SAMP8 Mice

Morita Yasuyo , Ishida Tomoaki , Morisawa Shumpei , Jobu Kohei , Ou Yangran , Fujita Hiroko , Hanazaki Kazuhiro , Miyamura Mitsuhiko

… Conversely, sirtuin 1 (Sirt1) is known to regulate the expression of ubiquitin ligases by suppressing the activities of NF-κB and FOXO. … JTT also increased IGF-1 serum levels, as well as mRNA Sirt1 levels in GA. … The muscle fiber cross-sectional area of GA was correlated with the mRNA levels of Sirt1 in GA. … This effect may be associated with the increased expression levels of Sirt1 and IGF-1 by JTT. …

Biological and Pharmaceutical Bulletin 44(1), 32-38, 2021

J-STAGE
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Resveratrol and its dimers ε‐viniferin and δ‐viniferin in red wine protect vascular endothelial cells by a similar mechanism with different potency and efficacy

吉田滋樹 , 宮崎均 , Che Wei Wu , Yoshihiro Nakamoto , Takumaru Hisatome , Shigeki YOSHIDA , Hitoshi MIYAZAKI

… When VECs were exposed to each compound, endothelial NO synthase was activated and the expression of sirtuin 1 (SIRT1) and HO‐1 was induced. … Addition of the SIRT1 and HO‐1 inhibitors EX527 and ZnPPiX, respectively, suppressed wound repair stimulated by the three compounds, demonstrating that SIRT1 and HO‐1 are involved in these wound repair processes. …

Kaohsiung journal of medical sciences 36(7), 535-542, 2020-07

IR
3

The Protective Effect of Chlorogenic Acid on Vascular Senescence via the Nrf2/HO-1 Pathway

Hada Yoshiko , Uchida Haruhito A. , Otaka Nozomu , Onishi Yasuhiro , Okamoto Shugo , Nishiwaki Mariko , Takemoto Rika , Takeuchi Hidemi , Wada Jun

… CGA administration attenuated vascular senescence in a dose-dependent manner, in association with the increase of Sirtuin 1 (Sirt1) and endothelial nitric oxide synthase (eNOS), and with the decrease of p-Akt, PAI-1, p53, and p21. …

International Journal of Molecular Sciences 21(12), 4527, 2020-06-25

IR
4

LABORATORY INVESTIGATION : Axonal protection by a small molecule SIRT1 activator, SRT2104, with alteration of autophagy in TNF-induced optic nerve degeneration

Kitaoka Yasushi , Sase Kana , Tsukahara Chihiro , Fujita Naoki , Tokuda Naoto , Kogo Jiro , Takagi Hitoshi

Japanese journal of ophthalmology : the official international journal of the Japanese Ophthalmological Society 64(3), 298-303, 2020-05
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Molecular Mechanism for the Autophagy-Inducing Action of Glucosamine, a Food with Functional Claims, in Chondrocytes

NAKAMURA KAHO , IGARASHI MAMORU , NAGAOKA ISAO

… Furthermore, it has been reported that sirtuin (SIRT) 1, known as a longevity gene, induces autophagy 3). … Previously, we revealed that glucosamine, a functional food, which is widely used for the treatment of OA, enhances the expression of SIRT1 in human chondrocyte line 4). …

Juntendo Medical Journal 66(6), 478-479, 2020

J-STAGE
6

Schisandrin ameliorates cognitive deficits, endoplasmic reticulum stress and neuroinflammation in streptozotocin (STZ)-induced Alzheimer's disease rats

Song Lin , Piao Zhongyuan , Yao Lifen , Zhang Limei , Lu Yichan

… Further study suggested a remarkable decrease in the expressions of ER stress maker proteins like C/EBP-homologous protein, glucose-regulated protein 78 and cleaved caspase-12 in the presence of schisandrin, meanwhile the up-regulation of sirtuin 1 (SIRT1) was also observed in the same group. … In conclusion, schisandrin ameliorated STZ-induced cognitive dysfunction, ER stress and neuroinflammation which may be associated with up-regulation of SIRT1. …

Experimental Animals 69(3), 363-373, 2020

J-STAGE
7

Rikkunshito attenuates induction of epithelial-mesenchymal switch via activation of Sirtuin1 in ovarian cancer cells

Kanda Ranka , Ayabe Takuya , Miyagawa Yuko , Wada-Hiraike Osamu , Hiraike Haruko , Fukui Shiho , Nagasaka Kazunori , Ryo Eiji , Fujii Tomoyuki , Osuga Yutaka

… Considering that increased ghrelin signaling by Rikkunshito could enhance sirtuin1 (SIRT1) activity in nervous system, we aimed to investigate the effect of Rikkunshito in ovarian cancer cells. … To investigate the involvement of SIRT1 by Rikkunshito in SKOV3 cancer cells, endogenous expression of SIRT1 was depleted using small interfering RNA (siRNA). …

Endocrine Journal 67(4), 379-386, 2020

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8

To Elucidate the Inhibition of Excessive Autophagy of Rhodiola crenulata on Exhaustive Exercise-Induced Skeletal Muscle Injury by Combined Network Pharmacology and Molecular Docking

Li Xuanhao , Hou Ya , Wang Xiaobo , Zhang Ying , Meng Xianli , Hu Yao , Zhang Yi

… could suppress the expression of Ubiquitin-like protein ATG12 (ATG12), Beclin-1 (BECN1), and Serine/threonine-protein kinase ULK1 (ULK1), while increasing the expression of MTOR, NAD-dependent protein deacetylase sirtuin-1 (SIRT1), and Microtubule-associated protein tau (MAPT). …

Biological and Pharmaceutical Bulletin 43(2), 296-305, 2020

J-STAGE Ichushi Web
9

Functional analysis of glucosamine-induced autophagy in chondrocytes [in Japanese]

Igarashi Mamoru , Nakamura Kaho , Sakamoto Koji , Nagaoka Isao

… Moreover, GlcN significantly increased the protein level of SIRT1. … Importantly, the GlcN-induced increase of LC3-II protein was inhibited by EX527 (a SIRT1 inhibitor). … Together these observations suggest that GlcN increases the expression of SIRT1 and possibly induces autophagy through the suppression of p53 activity in chondrocytes independent of mTOR, thereby exhibiting the chondroprotective action. …

Functional Food Research 15(0), 29-33, 2019

J-STAGE Ichushi Web
10

Effect of low-concentration amyloid-β 1–42 (Aβ42) on human neuroblastoma SH-SY5Y cell viability: neuroprotective potential of combination use with carnosic acid, rebamipide, edaravone, and resveratrol

Yoshida Hidemi , Hashimoto Yuko , Fukushima Takashi , Tanji Kunikazu , Matsumiya Tomoh , Seya Kazuhiko , Kawaguchi Shogo , Imaizumi Tadaatsu

… The "CRER" blend induced the expression of Aβ-degrading enzymes including matrix metalloproteinase-14 (MMP-14) and neprilysin, while also enhancing the expression of the inducible α-secretase TACE (tumor necrosis factor-α-converting enzyme), sirtuin 1 (SIRT1), and brain-derived neurotrophic factor (BDNF). … Collectively, our results indicate that the "CRER" may aid in the prevention of Aβ toxicity by enhancing MMP-14, neprilysin, TACE, SIRT1, and BDNF. …

Hirosaki Medical Journal 70(1), 24-38, 2019

IR J-STAGE Ichushi Web
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Lycium barbarum polysaccharide enhances development of previously-cryopreserved murine two-cell embryos via restoration of mitochondrial function and down-regulated generation of reactive oxygen species

YANG Lei , GAO Zhen , LEI Lanjie , LV Qizhuang , ZHAO Qihan , LI Lixin , CAO Xiaoming , FU Wenxue

… Results indicate that LBP enhances development of such embryos, and that potential mechanisms include: (1) mitochondrial function enhancement via altering mitochondrial distribution and increasing MMP, ATP production, mtDNA copy number, and expression of genes involved in mitochondrial biogenesis and energy metabolism (NAD-dependent deacetyltransferase sirtuin-1 (SIRT1) and phosphorylated adenosine monophosphate-activated protein kinase (pAMPK)); …

Journal of Reproduction and Development 65(2), 163-170, 2019

J-STAGE Ichushi Web
12

The Essential Role of SIRT1 in Hypothalamic-Pituitary Axis

Yamamoto Masaaki , Takahashi Yutaka

… Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylase that is activated in response to calorie restriction (CR). … SIRT1 is involved in cellular processes via the deacetylation of histone as well as various transcription factors and signal transduction molecules and thereby modulates the endocrine/metabolic functions. …

Frontiers in Endocrinology (9), 605, 2018-10-23

IR
13

AMPK Mediates Muscle Mass Change But Not the Transition of Myosin Heavy Chain Isoforms during Unloading and Reloading of Skeletal Muscles in Mice

Egawa Tatsuro , Ohno Yoshitaka , Goto Ayumi , Yokoyama Shingo , Hayashi Tatsuya , Goto Katsumasa

5′AMP-activated protein kinase (AMPK) plays an important role in the regulation of skeletal muscle mass and fiber-type distribution. However, it is unclear whether AMPK is involved in muscle mass chan …

International Journal of Molecular Sciences 19(10), 2018-10

IR
14

Sirtuins and ageing [in Japanese]

山縣和也

内分泌・糖尿病・代謝内科 = Endocrinology, diabetology & metabolism 46(1), 21-25, 2018-01

Ichushi Web
15

Resveratrol regulates the alternative splicing of tau exon 10 to improve learning and memory in hTau mice

Qian Wei , Qian Shuo , Gu Jianlan , Huang Qin

… Sirt1, one member in mammalian Sirtuin family, is connected closely with age-related diseases such as AD. … Resveratrol, a polyphenol found in wines, was reported to be an activator of Sirt1 in vivo and in vitro. … Methods: By co-immunoprecipitation, GST pull down and confocal, we studied the interaction between Sirt1 and 9G8. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), PO1-1-2, 2018

J-STAGE
16

Development of Anti-aging Compounds that Target Potential Aging Control Signaling Pathways [in Japanese]

WANG Zi , OHATA Yoshihisa , CHIBA Takuya

… These signals, which include insulin/insulin-like growth factor-1 (IGF-1), sirtuin 1 (SIRT1) and, mammalian target of rapamycin (mTOR) signaling pathways, appear to be evolutionally conserved among these organisms. …

Oleoscience 18(2), 55-60, 2018

J-STAGE Ichushi Web
17

The role of sirtuin in depression and anxiety, and its implication for the development of therapeutic drugs [in Japanese]

Uchida Shusaku

… Recent studies have suggested that histone deacetylases SIRTs-mediated gene transcription and/or SIRT1-dependent regulation of cellular homeostasis have important roles in the pathophysiology and the treatment of depression. … Genetic studies suggest that the SIRT1 gene is associated with mood and anxiety disorders. …

Japanese Journal of Biological Psychiatry 29(2), 69-72, 2018

J-STAGE Ichushi Web
18

Dysregulation of BSEP and MRP2 May Play an Important Role in Isoniazid-Induced Liver Injury via the SIRT1/FXR Pathway in Rats and HepG2 Cells

Qu Xiaoyu , Zhang Yueming , Zhang Sixi , Zhai Jinghui , Gao Huan , Tao Lina , Song Yanqing

… Sirtuin 1 (SIRT1) and farnesoid X receptor (FXR) were also determined. … The SIRT1/FXR pathway was identified as being important for the down-regulation of transporters. … In summary, our study indicated that the down-regulation of BSEP and MRP2 represents one mechanism of INH-induced liver injury and the down-regulation of SIRT1/FXR may be a key regulator. …

Biological and Pharmaceutical Bulletin 41(8), 1211-1218, 2018

J-STAGE Ichushi Web
19

Serum containing Buyang Huanwu decoction prevents age-associated migration and invasion of human vascular smooth muscle cells by up regulating SIRT1 expression

Zhang Li , Wei Chunshan , Ruan Yunjun , Zhang Yanan , Zhou Yuliang , Lei Da

… angiotensin II (Ang II)-induced senescence model to study the effects of serum containing BYHWD (BYHWS) on the migratory and invasive capacities, matrix metalloprotease type 2 (MMP-2) expression and modulation of sirtuin1 (SIRT1) signaling in human aorta VSMCs (HA-VAMCs). … In addition, manipulation of SIRT1 by either over-expression or siRNA knockdown ameliorated or promoted cellular migration and invasion, respectively. …

BioScience Trends 12(3), 282-290, 2018

J-STAGE Ichushi Web
20

Detection of Sirtuin-1 protein expression in peripheral blood leukocytes in dogs

YOSHIMURA Kuniko , MATSUU Aya , SASAKI Kai , MOMOI Yasuyuki

… Sirtuin-1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylase with a large number of protein substrates. … The objective of this study was to enable the evaluation of SIRT1 expression in peripheral blood mononuclear cells (PBMCs) from dogs by flow cytometry. …

Journal of Veterinary Medical Science 80(7), 1068-1076, 2018

J-STAGE Ichushi Web

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